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133 条记录 (耗时 0.061 秒)

    Biologic cabling
    81.
    发明授权
    Biologic cabling 失效
    生物布线

    公开(公告)号：US06238429B1

    公开(公告)日：2001-05-29

    申请号：US09072819

    申请日：1998-05-05

    申请人： H. Toby Markowitz ,  Maura G. Donovan ,  Khawar Mehdi

    发明人： H. Toby Markowitz ,  Maura G. Donovan ,  Khawar Mehdi

    IPC分类号： A61N105

    CPC分类号： A61N1/05

    摘要： A length of living conductive cells may be injected directly or may be grown to be attached to a fibrous matrix of material that provides for flexible structure so as to deliver a stimulation signal from one end of the biologic cable to the other to induce a physiologic reaction in body tissue.

    摘要翻译： 活体导电细胞的长度可以直接注射或者可以生长以附着到提供柔性结构的材料的纤维基质上，以将刺激信号从生物电缆的一端传递到另一端以诱导生理反应 在身体组织。

    Method and apparatus for variable rate cardiac stimulation
    82.
    发明授权
    Method and apparatus for variable rate cardiac stimulation 失效
    可变率心脏刺激的方法和装置

    公开(公告)号：US5725561A

    公开(公告)日：1998-03-10

    申请号：US489262

    申请日：1995-06-09

    申请人： John C. Stroebel ,  Michael F. Hess ,  H. Toby Markowitz

    发明人： John C. Stroebel ,  Michael F. Hess ,  H. Toby Markowitz

    IPC分类号： A61N1/365 ,  A61N1/362 ,  A61N1/368

    CPC分类号： A61N1/3622 ,  A61N1/368

    摘要： A method and apparatus for variable rate cardiac stimulation, wherein sudden drops in the rate of delivery of stimulation pulses are avoided by means of rate smoothing and peak rate support functions. In one embodiment, circuitry in a cardiac pulse generator detects atrial events and maintains an updated value of the A-A time intervals between certain atrial events. If a preset ratio or total of these A-A intervals are found to have been shorter than the updated value by at a least a predetermined amount of time, a rate smoothing function is activated wherein the rate of delivery of stimulating pulses is prevented from changing, from cycle to cycle, by more than a predetermined maximum amount. A peak rate support function preferably employs the same updated value in the computation of "escape" intervals. Following the latest A-A interval, if that A-A interval is less than the updated value, then the updated value is used as the new escape interval. If the latest A-A interval is greater than or equal to the updated value but less than the previous updated value, the current escape interval is used as the new escape interval. If the latest A-A interval is less than both the previous updated value and the current updated value, the value updated is used as the new escape interval, and the pulse generator enters a decay mode wherein the escape interval is gradually and incrementally lengthened to prevent sudden changes in the rate of delivery of stimulation pulses.

    摘要翻译： 用于可变速率心脏刺激的方法和装置，其中通过速率平滑和峰值速率支持功能来避免刺激脉冲的传送速率的突然下降。 在一个实施例中，心脏脉搏发生器中的电路检测心房事件并维持某些心房事件之间的A-A时间间隔的更新值。 如果这些AA间隔的预设比例或总和被发现至少比预定时间量更新的值短，则激活速率平滑功能，其中防止刺激脉冲的传送速率从 循环到循环，超过预定的最大量。 峰值速率支持功能优选地在计算“逃逸”间隔时使用相同的更新值。 按照最新的A-A间隔，如果A-A间隔小于更新的值，则更新的值将用作新的转义间隔。 如果最新的A-A间隔大于或等于更新值但小于先前更新的值，则将使用当前转义间隔作为新的转义间隔。 如果最近的AA间隔小于先前更新值和当前更新值，则更新的值被用作新的转义间隔，并且脉冲发生器进入衰减模式，其中逃逸间隔逐渐且逐渐地延长以防止突然 刺激脉冲传送速率的变化。

    Pacemaker adapted to prefer underlying sinus rhythm over other rate responsive indicator
    83.
    发明授权
    Pacemaker adapted to prefer underlying sinus rhythm over other rate responsive indicator 失效
    起搏器适应于比其他速率响应指示器更好的基础窦性心律

    公开(公告)号：US5674257A

    公开(公告)日：1997-10-07

    申请号：US611357

    申请日：1996-03-05

    申请人： John C. Stroebel ,  H. Toby Markowitz

    发明人： John C. Stroebel ,  H. Toby Markowitz

    IPC分类号： A61N1/365 ,  A61N1/368

    CPC分类号： A61N1/368 ,  A61N1/36585

    摘要： A dual chamber, rate-responsive pacemaker for pacing a patient's heart novelly allows tracking of the patient's sinus rate when the sinus rate is slightly less than the sensor rate; i.e., within a predetermined "Sinus Preference Window Maximum Rate Drop." Pacing at the sensor rate occurs when the sensor rate exceeds the sinus rate by more than the Sinus Preference Window Maximum Rate Drop. In the preferred embodiment a Sinus Preference Window, which occurs at the end of the ventricle-to-atrium interval, is decremented with successive heart beats by a programmable delta to increase the pacing rate until the Sinus Preference Window reaches zero, in which case the pacemaker paces at the sensor rate. The Sinus Preference Window is reset to its maximum value upon either the detection of an atrial sensed event, or upon the expiration of a programmable Sinus Check Interval. The pacemaker paces at the sinus rate or the maximum rate drop rate, whichever is faster, for a number of recovery beats, and then increments the pacing rate up to the sensor rate.

    摘要翻译： 双室，速率响应的心脏起搏器用于起搏患者的心脏新颖地允许跟踪患者的窦速率，当窦速率略低于传感器速率时; 即在预定的“窦性偏好窗口最大速率下降”内。 当传感器速率超过窦性速率超过窦性偏好窗口最大速率下降时，会以传感器速率进行起搏。 在优选实施例中，在心室至心房间隔的末端发生的窦偏好窗口以连续的心跳减少可编程的增量以增加起搏速率直到窦偏好窗口达到零，在这种情况下 起搏器以传感器速率步进。 当检测到心房感应事件时，或者在可编程窦性检查间隔期满时，窦偏好窗口被重置为最大值。 起搏器以窦速率或最大速率下降速率（以更快者为准）起搏，以进行多次恢复搏动，然后将起搏速率递增至传感器速率。

    Airway feedback measurement system responsive to detected inspiration and obstructive apnea event
    84.
    发明授权
    Airway feedback measurement system responsive to detected inspiration and obstructive apnea event 失效
    对检测到的启发和阻碍APNEA事件的航空反馈测量系统

    公开(公告)号：US5174287A

    公开(公告)日：1992-12-29

    申请号：US706165

    申请日：1991-05-28

    申请人： Michael J. Kallok ,  H. Toby Markowitz

    发明人： Michael J. Kallok ,  H. Toby Markowitz

    IPC分类号： A61B5/08 ,  A61N1/36 ,  A61N1/365

    CPC分类号： A61N1/3601

    摘要： An improved apparatus for and method of providing feedback to an implantable pulse generator to treat obstructive sleep apnea. Sensors monitor the electrical activity associated with contractions of the diaphragm. The pressure within the thorax and the upper airway are also measured. Whenever electrical activity of the diaphragm suggests that an inspiration cycle is in progress and the pressure sensors show an abnormal pressure differential across the airway, the presence of obstructive sleep apenea is assumed and electrical stimulation is applied to the musculature of the upper airway.

    摘要翻译： 一种用于向可植入脉冲发生器提供反馈以治疗阻塞性睡眠呼吸暂停的改进的装置和方法。 传感器监测与隔膜收缩相关的电活动。 也测量胸腔和上呼吸道内的压力。 无论何时隔膜的电活动表明启动循环正在进行，压力传感器显示气道两侧的异常压力差异，则假设存在阻塞性睡眠apenea，并且电刺激应用于上呼吸道的肌肉组织。

    Method and system for detecting and treating junctional rhythms
    88.
    发明授权
    Method and system for detecting and treating junctional rhythms 有权
    连接节律的检测和处理方法和系统

    公开(公告)号：US08108043B2

    公开(公告)日：2012-01-31

    申请号：US12686082

    申请日：2010-01-12

    申请人： H. Toby Markowitz ,  Matthew Harris ,  Trina Ann Brand

    发明人： H. Toby Markowitz ,  Matthew Harris ,  Trina Ann Brand

    IPC分类号： A61N1/362

    CPC分类号： A61N1/3627 ,  A61N1/3622 ,  A61N1/365 ,  A61N1/368 ,  A61N1/3682 ,  A61N1/3684

    摘要： A method and an apparatus for treating cardiac arrhythmias are provided. An interval between first and second consecutive beats of a heart, having first and second chamber types, is determined. The heart is paced at a first rate if the first beat is from the first chamber type and the second beat is from the second chamber type and the interval is less than a predetermined amount of time or if the first and second beats are both from the second chamber type. The heart is paced at a second rate if the first beat is from the first chamber type and the second beat is from the second chamber type and the interval is more than the predetermined amount of time.

    摘要翻译： 提供了一种治疗心律失常的方法和装置。 确定具有第一和第二室类型的心脏的第一和第二连续节拍之间的间隔。 如果第一节拍来自第一室型，并且第二节拍来自第二室型，并且间隔小于预定量的时间，或者如果第一和第二节拍都来自第一室，则心脏以第一速度进行起搏 第二室型。 如果第一搏动来自第一腔室类型，第二搏动来自第二腔室类型，并且间隔大于预定时间量，心脏以第二速度进行起搏。

    Method and system for detecting and treating junctional rhythms
    89.
    发明授权
    Method and system for detecting and treating junctional rhythms 有权
    连接节律的检测和处理方法和系统

    公开(公告)号：US07647105B2

    公开(公告)日：2010-01-12

    申请号：US11565188

    申请日：2006-11-30

    申请人： H. Toby Markowitz ,  Matthew Harris ,  Trina Ann Brand

    发明人： H. Toby Markowitz ,  Matthew Harris ,  Trina Ann Brand

    IPC分类号： A61N1/362

    CPC分类号： A61N1/3627 ,  A61N1/3622 ,  A61N1/365 ,  A61N1/368 ,  A61N1/3682 ,  A61N1/3684

    摘要： A method and an apparatus for treating cardiac arrhythmias are provided. An interval between first and second consecutive beats of a heart, having first and second chamber types, is determined. The heart is paced at a first rate if the first beat is from the first chamber type and the second beat is from the second chamber type and the interval is less than a predetermined amount of time or if the first and second beats are both from the second chamber type. The heart is paced at a second rate if the first beat is from the first chamber type and the second beat is from the second chamber type and the interval is more than the predetermined amount of time.

    摘要翻译： 提供了一种治疗心律失常的方法和装置。 确定具有第一和第二室类型的心脏的第一和第二连续节拍之间的间隔。 如果第一节拍来自第一室型，并且第二节拍来自第二室型，并且间隔小于预定量的时间，或者如果第一和第二节拍都来自第一室，则心脏以第一速度进行起搏 第二室型。 如果第一搏动来自第一腔室类型，第二搏动来自第二腔室类型，并且间隔大于预定时间量，心脏以第二速度进行起搏。

    Implantable medical device and method for delivering therapy for sleep-disordered breathing
    90.
    发明授权
    Implantable medical device and method for delivering therapy for sleep-disordered breathing 有权
    植入式医疗装置和方法，用于为睡眠呼吸障碍提供治疗

    公开(公告)号：US07130687B2

    公开(公告)日：2006-10-31

    申请号：US10693375

    申请日：2003-10-24

    申请人： Yong K. Cho ,  H. Toby Markowitz

    发明人： Yong K. Cho ,  H. Toby Markowitz

    IPC分类号： A61N1/362

    CPC分类号： A61N1/3601 ,  A61B5/08 ,  A61B5/082 ,  A61N1/36521 ,  A61N1/36557

    摘要： An implantable medical device delivers augmentation therapy to intervene in a pattern of sleep-disordered breathing. Augmentation therapy includes the delivery of electrical stimulation to cardiac tissue above and/or below a capture threshold. PESP and NES/CCM are possible augmentation therapies that are used alone or in combination. In addition, augmentation therapies can be used with other pacing therapies such as atrial overdrive pacing and atrial coordinated pacing as a therapy for sleep-disordered breathing.

    摘要翻译： 可植入的医疗装置提供增强疗法以介入睡眠呼吸障碍的模式。 增强疗法包括将电刺激递送到高于和/或低于捕获阈值的心脏组织。 PESP和NES / CCM是单独使用或组合使用的可能的增强疗法。 此外，增强疗法可以与其他起搏疗法一起使用，例如心房超速起搏和心房协调起搏作为睡眠呼吸障碍的治疗方法。