公开(公告)号：US07603031B1

公开(公告)日：2009-10-13

申请号：US11167540

申请日：2005-06-27

申请人： George Viaud ,  Ken Budris ,  Doug Canfield ,  Dennis DaSilva ,  Jim Dornbusch ,  John Robinson

发明人： George Viaud ,  Ken Budris ,  Doug Canfield ,  Dennis DaSilva ,  Jim Dornbusch ,  John Robinson

IPC分类号： G03B15/03 ,  H04N5/222 ,  A61B6/00

CPC分类号： G03B15/03 ,  A61B5/0059 ,  A61B5/441 ,  G03B7/16 ,  G03B2215/0557

摘要： A multi-flash photography system provides a dynamically-configurable lighting environment for a single exposure that is created and shaped through the sequentially firing of various light sources with different lighting characteristics controlled in accordance with both a programmed template specifying the flash type, position, firing order, and output intensity, as well as optical processing requirements such as filtering, polarizing, etc., and a shared photometric detector located sufficiently close to the subject being photographed to ensure that the light seen by the detector is substantially the same as the light received at the subject.

摘要翻译： 多闪光摄影系统为单次曝光提供动态可配置的照明环境，通过依次指定闪光灯类型，位置，发射的编程模板控制不同照明特性的各种光源的顺序点火 顺序和输出强度以及诸如滤波，偏振等的光学处理要求，以及与被拍摄的物体充分接近的共享光度检测器，以确保检测器所看到的光基本上与光线相同 收到的主题。

公开(公告)号：US07569541B2

公开(公告)日：2009-08-04

申请号：US10559010

申请日：2004-06-02

申请人： Gerd Pluschke ,  Ursula Kienzl ,  John Robinson ,  Rinaldo Zurbriggen

发明人： Gerd Pluschke ,  Ursula Kienzl ,  John Robinson ,  Rinaldo Zurbriggen

IPC分类号： A61K38/12

CPC分类号： G01N33/56911 ,  A61K38/00 ,  A61K39/00 ,  A61K39/015 ,  C07K7/56 ,  C07K16/205 ,  Y02A50/412 ,  Y02A50/58

摘要： The present invention relates to methods for synthesizing conformationally constrained peptides and cyclic peptidomimetics obtainable by these methods which are conformationally constrained due an internal cross-link. This cross-link is formed between the side chain of an amino acid residue or analog and a (2S, 4S)4-functionalized proline residue. The invention further relates to the use of (2S, 4S)-4-functionalized proline residues as building units in the synthesis of such peptidomimetics and to the use thereof as antigens, alone or in combination with suitable immunopotentiating delivery systems, for example immunopotentiating reconstituted influenza virosomes to elicit an immune response in a mammal. Moreover, the invention also relates to pharmaceutical compositions containing the same.

摘要翻译： 本发明涉及通过这些方法获得的构象约束肽和循环肽模拟物的方法，其由于内部交联而被构象约束。 这种交联在氨基酸残基或类似物的侧链与（2S，4S）4-官能化的脯氨酸残基之间形成。 本发明还涉及（2S，4S）-4-官能化的脯氨酸残基作为构建单元在合成这种肽模拟物中的用途，以及其作为抗原的单独使用或与合适的免疫增强递送系统组合的用途，例如免疫增强重建 流感病毒体引起哺乳动物的免疫反应。 此外，本发明还涉及含有该组合物的药物组合物。

公开(公告)号：US20090092827A1

公开(公告)日：2009-04-09

申请号：US12299022

申请日：2007-05-01

申请人： John Robinson

发明人： John Robinson

IPC分类号： B32B27/32 ,  B32B27/00 ,  C09D171/10 ,  C09D127/12

CPC分类号： C08G65/4012 ,  C08G2650/40 ,  C08L27/12 ,  C08L27/18 ,  C08L71/00 ,  C09D171/10 ,  Y10T428/273 ,  Y10T428/3154 ,  C08L2666/04

摘要： An assembly comprises a part for example a part of an item of cookware, bakeware, domestic appliance or the like which is subjected to a wear means in use such that the wear means may abrade the outer surface of the part. The part is provided with an outer surface which comprises a polyaryletherketone polymer, especially polyetheretherketone, and a fluoropolymer. Such a combination is found to exhibit superior wear properties over other known materials.

摘要翻译： 组件包括例如炊具，烤盘，家用电器等的一部分的部件，其经受使用中的磨损装置，使得磨损装置可能磨损部件的外表面。 该部件设置有包含聚芳醚酮聚合物，特别是聚醚醚酮和含氟聚合物的外表面。 发现这种组合与其它已知材料相比表现出优异的耐磨性。

公开(公告)号：US20080073589A1

公开(公告)日：2008-03-27

申请号：US11686871

申请日：2007-03-15

申请人： Michael Adel ,  John Robinson ,  Pavel Izikson ,  Brad Eichelberger ,  Amir Widmann ,  Atsuhiko Kato

发明人： Michael Adel ,  John Robinson ,  Pavel Izikson ,  Brad Eichelberger ,  Amir Widmann ,  Atsuhiko Kato

IPC分类号： G21K5/10

CPC分类号： G03F7/70458 ,  G03F7/70525 ,  G03F7/706 ,  G03F9/7046

摘要： A method for optimizing alignment performance in a fleet of exposure systems involves characterizing each exposure system in a fleet of exposure systems to generate a set of distinctive distortion profiles associated with each exposure system. The set of distinctive distortion profiles are stored in a database. A wafer having reference pattern formed thereon is provided for further pattern fabrication and an exposure system is selected from the fleet to fabricate a next layer on the wafer. Linear and higher order parameters of the selected exposure system are adjusted using the distinctive distortion profiles to model the distortion of the reference pattern. Once the exposure system is adjusted, it is used to form a lithographic pattern on the wafer.

摘要翻译： 用于优化曝光系统队列中的对准性能的方法涉及表征曝光系统中的每个曝光系统，以产生与每个曝光系统相关联的一组独特的失真曲线。 一组有特色的失真简档存储在数据库中。 提供具有形成在其上的参考图案的晶片用于进一步的图案制造，并且从车队中选择曝光系统以在晶片上制造下一层。 使用不同的失真曲线来调整所选曝光系统的线性和高阶参数以对参考图案的失真进行建模。 一旦调整曝光系统，就用于在晶片上形成平版印刷图案。

公开(公告)号：US07310789B2

公开(公告)日：2007-12-18

申请号：US11510147

申请日：2006-08-24

申请人： Joel L. Seligson ,  Mark Ghinovker ,  John Robinson ,  Pavel Izikson ,  Michael E. Adel ,  Boris Simkin ,  David Tulipman ,  Vladimir Levinski

发明人： Joel L. Seligson ,  Mark Ghinovker ,  John Robinson ,  Pavel Izikson ,  Michael E. Adel ,  Boris Simkin ,  David Tulipman ,  Vladimir Levinski

IPC分类号： G06F17/50

CPC分类号： G03F7/705 ,  G03F7/70516 ,  G03F7/70633

摘要： Disclosed are apparatus and methods for obtaining and analyzing various unique metrics or “target diagnostics” from one or more semiconductor overlay targets. In one embodiment, an overlay target is measured to obtain one or both of two specific types of target diagnostic information, systematic error metrics and/or random noise metrics. The systematic error metrics generally quantify asymmetries of the overlay target, while the random noise metrics quantify and/or qualify the spatial noise that is proximate to or associated with the overlay target.

摘要翻译： 公开了用于从一个或多个半导体覆盖目标获取和分析各种独特度量或“目标诊断”的装置和方法。 在一个实施例中，测量覆盖目标以获得两种特定类型的目标诊断信息，系统误差度量和/或随机噪声度量中的一种或两种。 系统误差度量通常量化覆盖目标的不对称性，而随机噪声度量量化和/或限定与覆盖目标邻近或相关联的空间噪声。

公开(公告)号：US20070138421A1

公开(公告)日：2007-06-21

申请号：US11312136

申请日：2005-12-20

申请人： Jeffrey Gibson ,  John Robinson ,  Jeffrey Iott ,  Jeffrey Belz

发明人： Jeffrey Gibson ,  John Robinson ,  Jeffrey Iott ,  Jeffrey Belz

IPC分类号： F16K31/02

CPC分类号： E03C1/057

摘要： An electronic faucet includes a control that has at least three different modes of operation. The control has an auto or normal mode of operation where fluid flows for a predetermined amount of time when a sensor detects an object adjacent to the electronic faucet. The control has an “off” mode where system electronics are disabled such that fluid cannot flow, and the control has an “on” mode where fluid is constantly flowing. A mechanical or electronic selector is selectively actuated to place the control in one of the auto, off, or on modes.

摘要翻译： 电子水龙头包括具有至少三种不同操作模式的控制。 当传感器检测到与电子水龙头相邻的物体时，控制器具有自动或正常操作模式，其中流体流动预定时间量。 控制器具有“关闭”模式，其中禁用系统电子设备，使得流体不能流动，并且控制器具有流体不断流动的“开”模式。 选择性地致动机械或电子选择器以将控制置于自动，关闭或打开模式之一中。

公开(公告)号：US20070084877A1

公开(公告)日：2007-04-19

申请号：US11249376

申请日：2005-10-14

申请人： Richard Albert ,  Dan Bowen ,  Bryan Collins ,  Aron Lewis ,  Paul Miller ,  Charles Percy ,  John Robinson ,  William Roe ,  Russell Watts

发明人： Richard Albert ,  Dan Bowen ,  Bryan Collins ,  Aron Lewis ,  Paul Miller ,  Charles Percy ,  John Robinson ,  William Roe ,  Russell Watts

IPC分类号： G07F11/16

CPC分类号： G07F11/16

摘要： A vending machine includes first and second integrated dispensing systems mounted at front portions of adjacent product shelf dividers establishing at least first, second and third product queues. Each of the first and second dispensing systems includes first and second release mechanisms having a plurality of hinged plates supported by a frame. The plurality of hinged plates are selectively shifted into and out of corresponding ones of the first, second and third product queues, such that each product queue has associated therewith two opposing release mechanisms. Preferably, at least one of the first and second release mechanisms for each dispensing system includes a queue spacing member which is mounted to one of the hinged plates and projects into the product queue to establish a desired spacing between the release mechanisms.

摘要翻译： 自动售货机包括安装在相邻产品货架隔板的前部的第一和第二集成分配系统，其建立至少第一，第二和第三产品排队。 第一和第二分配系统中的每一个包括具有由框架支撑的多个铰接板的第一和第二释放机构。 多个铰接板选择性地移入和移出第一，第二和第三产品队列中的相应的一个，使得每个产品队列具有与其相对的两个相对的释放机构。 优选地，用于每个分配系统的第一和第二释放机构中的至少一个包括队列间隔构件，其被安装到铰链板中的一个并且突出到产品队列中以在释放机构之间建立期望的间隔。

公开(公告)号：US20070025835A1

公开(公告)日：2007-02-01

申请号：US11159453

申请日：2005-06-22

申请人： Richard Gockel ,  John Robinson

发明人： Richard Gockel ,  John Robinson

IPC分类号： F03B11/00

CPC分类号： F01D25/125 ,  F05D2240/55 ,  F05D2300/224 ,  Y02T50/675

摘要： The invention relates to a system of shaft sealing for a turbine engine. Carbon-ring seals placed on pressurized bearing compartments are adapted to operate on ceramic runners which are cooled by lubricating fluid. The runners are closed at one end so that fluid does not enter an interface between the runner and the seal. The seal is held in place in a cylindrical seal housing with an inwardly projecting seal retention wall. An internally cooled seal housing is provided having an enclosed annular cooling groove is formed in the wall. Fluid is circulated through the groove to provide cooling of the seal housing and the carbon-ring seal. The circulated fluid is provided from the same source as fluid that is circulated to lubricate bearings on the engine. However, a separately controlled fluid delivery system is employed so that a rate of flow of fluid to the seal housing can be specifically controlled. Cooling effects of circulated fluid are made available to the seal housing even though there is no fluid directed at a shaft-seal interface. Undesirable churning and fluid loss also may be reduced.

摘要翻译： 本发明涉及一种用于涡轮发动机的轴封的系统。 放置在加压轴承隔间上的碳环密封件适用于由润滑流体冷却的陶瓷流道。 流道在一端封闭，使得流体不会进入流道和密封件之间的界面。 密封件被保持在具有向内突出的密封保持壁的圆柱形密封壳体中的适当位置。 提供内部冷却的密封壳体，其在壁中形成有封闭的环形冷却槽。 流体通过凹槽循环，以提供密封壳体和碳环密封件的冷却。 循环流体与作为循环润滑发动机轴承的流体相同的来源提供。 然而，采用单独控制的流体输送系统，以便可以特别地控制流体到密封壳体的流动速率。 循环流体的冷却效果可用于密封壳体，即使没有流体指向轴封界面。 不希望的搅拌和流体损失也可能减少。

公开(公告)号：US20060258564A1

公开(公告)日：2006-11-16

申请号：US10559010

申请日：2004-06-02

申请人： Gerd Pluschke ,  Ursula Kienl ,  John Robinson ,  Rinaldo Zurbriggen

发明人： Gerd Pluschke ,  Ursula Kienl ,  John Robinson ,  Rinaldo Zurbriggen

IPC分类号： A61K38/12 ,  C07K7/64

CPC分类号： G01N33/56911 ,  A61K38/00 ,  A61K39/00 ,  A61K39/015 ,  C07K7/56 ,  C07K16/205 ,  Y02A50/412 ,  Y02A50/58

摘要： The present invention relates to methods for synthesizing conformationally constrained peptides and cyclic peptidomimetics obtainable by these methods which are conformationally constrained due an internal cross-link. This cross-link is formed between the side chain of an amino acid residue or analog and a (2S, 4S)4-functionalized proline residue. The invention further relates to the use of (2S, 4S)-4-functionalized proline residues as building units in the synthesis of such peptidomimetics and to the use thereof as antigens, alone or in combination with suitable immunopotentiating delivery systems, for example immunopotentiating reconstituted influenza virosomes to elicit an immune response in a mammal. Moreover, the invention also relates to pharmaceutical compositions containing the same.

公开(公告)号：US20060234923A1

公开(公告)日：2006-10-19

申请号：US10550778

申请日：2003-05-02

申请人： Jurg Zumbrunn ,  Steven Demarco ,  Sergio Lociuro ,  Daniel Obrecht ,  Barbara Romagnoli ,  John Robinson

发明人： Jurg Zumbrunn ,  Steven Demarco ,  Sergio Lociuro ,  Daniel Obrecht ,  Barbara Romagnoli ,  John Robinson

IPC分类号： A61K38/12 ,  C07K7/64

CPC分类号： C07K7/06 ,  C07K7/08 ,  C07K14/001

摘要： Template-fixed β-hairpin peptidomimetics of the General Formula (I); wherein Z1 and Z2 are template-fixed chains of 4 and 6 or 5 and 7 α-amino acid residues which, depending on their positions in the chain are Gly, or Pro, or of certain types which, as the remaining symbols in the above formula, are defined in the description and the claims, and salts thereof, have the property to prevent or to reduce HIV infections or to inhibit the growth of cancer cells or to inhibit inflammation. They can be used as medicaments to treat or prevent HIV infections and/or cancer or inflammatory disorders. These β-sheet peptidomimetics can be manufactured by a process which is based on a mixed solid- and solution phase synthetic strategy.

摘要翻译： 通式（I）的模板固定的β-发夹肽模拟物; 其中Z 1和Z 2是4和6或5和7个α-氨基酸残基的模板固定链，根据其在链中的位置是Gly， 或Pro，或某些类型，其作为上述公式中的其余符号在说明书和权利要求书及其盐中定义，具有预防或减少HIV感染或抑制癌细胞生长或 以抑制炎症。 它们可用作治疗或预防艾滋病毒感染和/或癌症或炎性疾病的药物。 这些β-折叠肽模拟物可以通过基于混合固相和溶液相合成策略的方法制造。