公开(公告)号：US08987473B2

公开(公告)日：2015-03-24

申请号：US13982200

申请日：2012-01-30

申请人： Keita Nagai ,  Koh Nagasawa ,  Hirobumi Takahashi ,  Motoaki Baba ,  Shinichi Fujioka ,  Eri Kondoh ,  Kenichi Tanaka ,  Yoshiki Itoh

发明人： Keita Nagai ,  Koh Nagasawa ,  Hirobumi Takahashi ,  Motoaki Baba ,  Shinichi Fujioka ,  Eri Kondoh ,  Kenichi Tanaka ,  Yoshiki Itoh

IPC分类号： C07D471/04 ,  C07D413/06 ,  C07D409/06 ,  C07D235/08 ,  C07D209/08 ,  C07D209/30 ,  C07D231/56 ,  C07D235/10 ,  C07D401/06 ,  C07D405/06 ,  C07D235/06 ,  C07D403/04

CPC分类号： C07D471/04 ,  C07D209/08 ,  C07D209/12 ,  C07D209/30 ,  C07D231/56 ,  C07D235/06 ,  C07D235/08 ,  C07D235/10 ,  C07D401/06 ,  C07D403/04 ,  C07D405/06 ,  C07D409/06 ,  C07D413/06

摘要： The present invention relates to a compound that has URAT1 inhibitory action, and a URAT1 inhibitor, a blood uric acid level-reducing agent and a pharmaceutical composition comprising the compound. More specifically, the present invention relates to a compound represented by Formula (I) below. [in the formula, R1 is -Q1-A1 and the like; is a double bond or a single bond; when is a double bond, W1 is a nitrogen atom or a group represented by the general formula: ═C(Ra)—, and W2 is a nitrogen atom or a group represented by the general formula: ═C(Rb)—; when is a single bond, W1 is a group represented by the general formula: —C(Raa)(Rab)— or a group represented by the general formula: —(C═O)—, and W2 is a group represented by the general formula: —C(Rba)(Rbb)—, a group represented by the general formula: —(C═O)— or a group represented by the general formula: —N(Rbc)—; W3, W4 and W5 are each independently a nitrogen atom or a methine group and the like that may have a substituent; X is a single bond, an oxygen atom and the like; Y is a single bond or (CRYiRYi′)n; and Z is a hydroxyl group or COOR2 and the like.

摘要翻译： 本发明涉及具有URAT1抑制作用的化合物和URAT1抑制剂，血液尿酸水平降低剂和包含该化合物的药物组合物。 更具体地，本发明涉及由下式（I）表示的化合物。 [式中，R1为-Q1-A1等; 是双键或单键; 当是双键时，W1是氮原子或由通式：= C（Ra） - 表示的基团，并且W 2是氮原子或由通式表示的基团：= C（R b） - ; 当是单键时，W1是由通式-C（Raa）（Rab）表示的基团或由通式表示的基团 - （C = O） - ，并且W 2是由 -C（Rba）（Rbb） - ，由通式表示的基团：（C = O） - 或由通式-N（Rbc） - 表示的基团。 W3，W4和W5各自独立地为可以具有取代基的氮原子或次甲基等; X是单键，氧原子等; Y是单键或（CRYiRYi'）n; Z为羟基或COOR 2等。

公开(公告)号：US08854516B2

公开(公告)日：2014-10-07

申请号：US13437637

申请日：2012-04-02

申请人： Kenichi Tanaka

发明人： Kenichi Tanaka

IPC分类号： H04N5/335 ,  H04N5/378 ,  H04N5/374

CPC分类号： H04N5/3742 ,  H01L27/14612 ,  H01L27/14643 ,  H04N5/2253 ,  H04N5/335 ,  H04N5/3698 ,  H04N5/3741 ,  H04N5/37455 ,  H04N5/37457 ,  H04N5/378

摘要： A solid-state imaging device and a camera system are disclosed. The solid-state imaging device includes a pixel unit and a pixel signal readout circuit. The pixel signal readout circuit includes a plurality of comparators disposed to correspond to a pixel column array, and a plurality of counters. Each counter includes a first amplifier, a second amplifier, and a mirror circuit to from a current mirror in parallel with the second amplifier. The first amplifier includes differential transistors, initializing switches connected between gates and collectors of the differential transistors, and first and second capacitors connected to each of the gates of the differential transistors. The second amplifier includes an initializing switch and a third capacitor. The mirror circuit includes a gate input transistor whose gate is inputted with a voltage sampled by the first amplifier or a voltage sampled by the second amplifier.

摘要翻译： 公开了一种固态成像装置和照相机系统。 固态成像装置包括像素单元和像素信号读出电路。 像素信号读出电路包括与像素列阵列对应配置的多个比较器和多个计数器。 每个计数器包括与第二放大器并联的来自电流镜的第一放大器，第二放大器和镜电路。 第一放大器包括差分晶体管，连接在差分晶体管的栅极和集电极之间的初始化开关以及连接到差分晶体管的每个栅极的第一和第二电容器。 第二放大器包括初始化开关和第三电容器。 镜电路包括栅极输入晶体管，栅极输入由第一放大器采样的电压或由第二放大器采样的电压。

公开(公告)号：US20140234749A1

公开(公告)日：2014-08-21

申请号：US14346377

申请日：2012-09-06

申请人： Yukihito Tanaka ,  Kazuo Nunukawa ,  Hiroshi Sohma ,  Kenichi Tanaka ,  Naoki Mitsuta ,  Masashi Sugishita ,  Daisuke Okonogi

发明人： Yukihito Tanaka ,  Kazuo Nunukawa ,  Hiroshi Sohma ,  Kenichi Tanaka ,  Naoki Mitsuta ,  Masashi Sugishita ,  Daisuke Okonogi

IPC分类号： H01M8/10

CPC分类号： H01M8/1004 ,  H01M8/0267 ,  H01M8/0271 ,  H01M8/0273 ,  H01M8/0276 ,  H01M8/0284 ,  H01M8/0286 ,  H01M2008/1095

摘要： An electrolyte membrane-electrode structure with a resin frame is provided with: an electrolyte membrane-electrode structure that is provided with an anode-side electrode and a cathode-side electrode, with a solid polymer electrolyte membrane being held therebetween; and a resin frame member that is arranged around the outer periphery of the solid polymer electrolyte membrane. An intermediate layer is continuously arranged: between an outer peripheral end portion of the cathode-side electrode and a first inner peripheral end portion of the resin frame member; on an outer peripheral end portion of the solid polymer electrolyte membrane, said outer peripheral end portion being exposed outside the outer peripheral end portion of the cathode-side electrode; and between an outer peripheral end portion of the anode-side electrode and a second inner peripheral end portion of the resin frame member.

摘要翻译： 具有树脂框架的电解质膜 - 电极结构设置有设置有阳极侧电极和阴极侧电极的固体高分子电解质膜的电解质膜 - 电极结构， 以及设置在固体聚合物电解质膜的外周周围的树脂框架构件。 中间层连续地布置在阴极侧电极的外周端部和树脂框架构件的第一内周端部之间; 在固体聚合物电解质膜的外周端部上，外周端部暴露在阴极侧电极的外周端部外侧， 并且在阳极侧电极的外周端部和树脂框架部件的第二内周端部之间。

公开(公告)号：US08808942B2

公开(公告)日：2014-08-19

申请号：US12712739

申请日：2010-02-25

申请人： Satoru Terada ,  Hiroshi Sohma ,  Kenichi Tanaka

发明人： Satoru Terada ,  Hiroshi Sohma ,  Kenichi Tanaka

IPC分类号： H01M8/02 ,  C09J183/12 ,  H01M8/10 ,  C08G77/12 ,  C08G77/24 ,  H01M4/88 ,  C08G77/46

CPC分类号： H01M8/0273 ,  C08G77/12 ,  C08G77/24 ,  C08G77/46 ,  C08L83/00 ,  C09J183/12 ,  H01M4/8807 ,  H01M4/881 ,  H01M8/0284 ,  H01M8/0297 ,  H01M8/1004 ,  Y02E60/521

摘要： An adhesive suitable for solid polymer fuel cells is provided that has sufficient bond durability, so that the solid polymer electrolyte membrane and the gas diffusion layer do not separate, even with the solid polymer electrolyte fuel cell repeatedly wetting and drying, and changing in dimension. An adhesive including a base compound, a cross-linking agent, an adhesion promoting agent, and a reaction catalyst is employed using a specific base compound having alkenyl groups, and a specific cross-linking agent having Si—H groups, in which the ratio of moles of the above Si—H group relative to moles of the above alkenyl group (moles of Si—H group/moles of alkenyl group) is adjusted to the range of 1.0 to 5.0.

摘要翻译： 提供了适用于固体聚合物燃料电池的粘合剂，其具有足够的粘合耐久性，使得固体聚合物电解质膜和气体扩散层即使在固体聚合物电解质燃料电池反复润湿和干燥以及尺寸变化的情况下也不分离。 使用具有烯基的特定碱性化合物和具有Si-H基的特定交联剂使用包含碱性化合物，交联剂，粘合促进剂和反应催化剂的粘合剂，其中比例 上述Si-H基的摩尔数相对于上述链烯基的摩尔数（Si-H基的摩尔数/烯基的摩尔数）的摩尔数被调节至1.0〜5.0的范围。

公开(公告)号：US08753011B2

公开(公告)日：2014-06-17

申请号：US12443909

申请日：2007-09-28

申请人： Yoshinori Nanba ,  Kenichi Tanaka

发明人： Yoshinori Nanba ,  Kenichi Tanaka

IPC分类号： B65D33/16 ,  A44B1/04

CPC分类号： B65D33/2508 ,  B31B70/8132 ,  B65D33/2533 ,  Y10T24/2534

摘要： A belt-shaped base of a male member of a zipper tape attached on an inner surface of a bag body includes a main body provided with an engagement portion, a thin portion connected to an opening-side of the main body, a thick portion connected to an opening-side of the thin portion and a projecting portion provided on the thick portion. A female member is also provided with the same arrangement. When the zipper tape is fused with the bag body, a gap is provided between the thin portion and a film of the bag body and between the thin portion and a film of the bag body, so that the thin portions are easily bent.

摘要翻译： 安装在袋体的内表面上的卡扣带的阳构件的带状基座包括主体，该主体设置有接合部，连接到主体的开口侧的薄部，连接有厚壁部 到薄壁部分的开口侧和设置在厚壁部分上的突出部分。 女性成员也具有相同的安排。 当拉链带与袋体熔合时，在薄片部分和袋体的薄膜之间以及袋体的薄部分和薄膜之间设置有间隙，使得薄部分容易弯曲。

公开(公告)号：US08673845B2

公开(公告)日：2014-03-18

申请号：US13386582

申请日：2010-07-28

申请人： Nahoko Kobayashi ,  Tetsuhiko Yoshida ,  Mikio Niwa ,  Kenichi Tanaka

发明人： Nahoko Kobayashi ,  Tetsuhiko Yoshida ,  Mikio Niwa ,  Kenichi Tanaka

IPC分类号： A61K38/02 ,  A61K38/18 ,  C12N5/02

CPC分类号： A61K31/366 ,  A61K31/22 ,  A61K31/397 ,  A61K31/40 ,  A61K45/06 ,  A61K47/64 ,  C07K7/06 ,  A61K2300/00

摘要： The method for transferring a foreign substance provided by the present invention includes the steps of: preparing a construct for transferring a foreign substance that contains a carrier peptide fragment including either the amino acid sequence WRRQARFK (SEQ ID NO. 1) or any amino acid sequence formed by the substitution, deletion, and/or addition (insertion) of 1, 2, or 3 amino acid residues in the amino acid sequence, and a foreign substance of interest that is bonded to the N-terminus and/or C-terminus of the carrier peptide fragment; supplying the construct for transferring a foreign substance to a test sample that contains a target eukaryotic cell; and incubating the test sample that has been supplied with the construct for transferring a foreign substance to thereby transfer the construct into the eukaryotic cell in the test sample.

摘要翻译： 由本发明提供的转移异物的方法包括以下步骤：制备含有包含氨基酸序列WRRQARFK（SEQ ID NO.1）或任何氨基酸序列的载体肽片段的异物转移构建体 通过氨基酸序列中1,2或3个氨基酸残基的取代，缺失和/或添加（插入）形成，以及与N末端和/或C末端键合的目的异物 的载体肽片段; 提供用于将异物转移到含有目标真核细胞的测试样品的构建体; 并将已经提供的用于转移异物的构建物的测试样品孵育，从而将构建体转移到测试样品中的真核细胞中。

公开(公告)号：US08459870B2

公开(公告)日：2013-06-11

申请号：US12738875

申请日：2008-10-16

申请人： Ryo Katada ,  Hiroko Shioda ,  Kenichi Tanaka

发明人： Ryo Katada ,  Hiroko Shioda ,  Kenichi Tanaka

IPC分类号： B65D33/16

CPC分类号： B65D33/2508

摘要： A packaging bag has a zipper including a pair of male member and a female member that are engageable with each other. The male member includes: a belt-shaped male base element provided on a packaging bag body; and a male engaging portion projecting from the belt-shaped male base element. The female member includes: a belt-shaped female base element located at a position opposed to the belt-shaped male base element; and a female engaging portion projecting from the belt-shaped female base element, the male engaging portion and the female engaging portion being disengageably engaged to form an engaging portion. The belt-shaped male base element and the belt-shaped female base element are made of a resin of which tensile modulus of elasticity is in a range of 700 MPa to 1600 MPa. The engaging portion is made of a resin of which tensile modulus of elasticity is in a range of 110 MPa to 560 MPa.

摘要翻译： 包装袋具有包括可以彼此接合的一对阳构件和阴构件的拉链。 阳构件包括：设置在包装袋主体上的带状阳基座元件; 以及从所述带状阳基体突出的阳接合部。 阴构件包括：位于与带状阳基座元件相对的位置处的带状阴基座元件; 以及从所述带状阴基座元件突出的阴接合部，所述阳接合部和所述阴接合部可分离地接合以形成接合部。 带状阳基体和带状阴基体元件由拉伸弹性模量在700MPa至1600MPa的范围内的树脂制成。 接合部由拉伸弹性模量在110MPa〜560MPa的范围内的树脂构成。

公开(公告)号：US08421359B2

公开(公告)日：2013-04-16

申请号：US12800980

申请日：2010-05-27

申请人： Kenichi Tanaka ,  Yoshihiro Wanda

发明人： Kenichi Tanaka ,  Yoshihiro Wanda

IPC分类号： H01J7/44

CPC分类号： H01J5/54 ,  H01J61/52 ,  H01J61/56

摘要： A discharge lamp unit constitutes circuit components including self-heating components that radiate the heat, i.e., a circuit board and a DC/DC transformer, and a heat radiation member. The heat radiation member made of metal is arranged in a portion between the self-heating components and the other components, so as to cover at least a portion of the self-heating component. In the discharge lamp unit, the heat produced by the self-heating components can be absorbed by the heat radiation member before the conducting heat reaches the circuit components other than the self-heat components. As a result, the heat produced by the self-heating components can be effectively radiated away.

摘要翻译： 放电灯单元构成包括辐射热的自加热部件，即电路板和DC / DC变压器以及散热构件的电路部件。 由金属制成的散热构件被布置在自加热部件和其它部件之间的一部分中，以便覆盖至少一部分自加热部件。 在放电灯单元中，在热传导热量达到除了自热部件之外的电路部件之前，由自热部件产生的热可以被散热部件吸收。 结果，可以有效地辐射由自加热部件产生的热量。

公开(公告)号：US08149309B2

公开(公告)日：2012-04-03

申请号：US12259707

申请日：2008-10-28

申请人： Kenichi Tanaka

发明人： Kenichi Tanaka

IPC分类号： H04N5/335 ,  H04N5/225

CPC分类号： H04N5/3742 ,  H01L27/14612 ,  H01L27/14643 ,  H04N5/2253 ,  H04N5/335 ,  H04N5/3698 ,  H04N5/3741 ,  H04N5/37455 ,  H04N5/37457 ,  H04N5/378

摘要： A solid-state imaging device and a camera system are disclosed. The solid-state imaging device includes a pixel unit and a pixel signal readout circuit. The pixel signal readout circuit includes a plurality of comparators disposed to correspond to a pixel column array, and a plurality of counters. Each counter includes a first amplifier, a second amplifier, and a mirror circuit to from a current mirror in parallel with the second amplifier. The first amplifier includes differential transistors, initializing switches connected between gates and collectors of the differential transistors, and first and second capacitors connected to each of the gates of the differential transistors. The second amplifier includes an initializing switch and a third capacitor. The mirror circuit includes a gate input transistor whose gate is inputted with a voltage sampled by the first amplifier or a voltage sampled by the second amplifier.

摘要翻译： 公开了一种固态成像装置和照相机系统。 固态成像装置包括像素单元和像素信号读出电路。 像素信号读出电路包括与像素列阵列对应配置的多个比较器和多个计数器。 每个计数器包括与第二放大器并联的来自电流镜的第一放大器，第二放大器和镜电路。 第一放大器包括差分晶体管，连接在差分晶体管的栅极和集电极之间的初始化开关以及连接到差分晶体管的每个栅极的第一和第二电容器。 第二放大器包括初始化开关和第三电容器。 镜电路包括栅极输入晶体管，栅极输入由第一放大器采样的电压或由第二放大器采样的电压。

公开(公告)号：US08024969B2

公开(公告)日：2011-09-27

申请号：US12149666

申请日：2008-05-06

申请人： Yasunori Kawaguchi ,  Kenichi Tanaka ,  Toshio Oike

发明人： Yasunori Kawaguchi ,  Kenichi Tanaka ,  Toshio Oike

IPC分类号： G01F23/00

CPC分类号： G01F23/363

摘要： A liquid level detection device includes a sensor provided in a container which stores a liquid therein and having a variable resistance which changes a resistance value in association with a change of liquid level to output a voltage signal according to the resistance value of the variable resistance when a voltage is applied thereto, and a power supply circuit applying the voltage to the sensor intermittently on a predetermined cycle. A conducting time during which the power supply circuit applies the voltage to the sensor is equal to or less than 40 ms per cycle.

摘要翻译： 液面检测装置包括设置在容器中的传感器，其中存储有液体并具有可变电阻，该可变电阻改变与液位变化相关的电阻值，以根据可变电阻的电阻值输出电压信号， 向其施加电压，以及以预定周期间歇地向传感器施加电压的电源电路。 电源电路向传感器施加电压的导通时间等于或小于每个周期40ms。