公开(公告)号：US20050222087A1

公开(公告)日：2005-10-06

申请号：US10512804

申请日：2003-04-22

申请人： Philip Beachy ,  James Chen ,  Anssi Taipale

发明人： Philip Beachy ,  James Chen ,  Anssi Taipale

IPC分类号： A61K31/135 ,  A61K31/4184 ,  A61K31/44 ,  A61K31/4418 ,  A61K31/4422 ,  A61K31/443 ,  A61K31/444 ,  A61K31/454 ,  A61K31/4545 ,  A61K31/496 ,  A61K31/5377 ,  A61K31/675 ,  A61K31/695 ,  A61P7/00 ,  A61P11/08 ,  A61P15/08 ,  A61P17/00 ,  A61P17/14 ,  A61P21/00 ,  A61P25/00 ,  A61P35/00 ,  A61P43/00

CPC分类号： A61K31/454 ,  A61K31/135 ,  A61K31/4184 ,  A61K31/44 ,  A61K31/4418 ,  A61K31/4422 ,  A61K31/443 ,  A61K31/444 ,  A61K31/496 ,  A61K31/675 ,  A61K31/695

摘要： The present invention makes available methods and reagents for inhibiting aberrant growth states resulting from hedgehog gain-of-function, ptc loss-of-function or smoothened gain-of-function comprising contacting the cell with a hedgehog antagonist, such as a small molecule, in a sufficient amount to aberrant growth state, e.g., to agonize a normal ptc pathway or antagonize smoothened or hedgehog activity. Such methods and reagents may also inhibit the hedgehog pathway in normal cells, e.g., where normal levels of hedgehog signalling are unwanted.

摘要翻译： 本发明提供用于抑制由刺猬获得功能，功能丧失功能或平滑增益功能引起的异常生长状态的可用方法和试剂，包括使细胞与刺猬蛋白拮抗剂如小分子接触， 足够量的异常生长状态，例如，激发正常的ptc途径或拮抗平滑或刺猬活性。 这些方法和试剂也可以抑制正常细胞中的刺猬蛋白通路，例如其中正常水平的刺猬蛋白信号传导是不需要的。

公开(公告)号：US20050176560A1

公开(公告)日：2005-08-11

申请号：US10900227

申请日：2004-07-28

申请人： James Chen

发明人： James Chen

IPC分类号： A63B15/02 ,  A63B21/005 ,  A63B21/06 ,  A63B71/00

CPC分类号： A63B21/00192 ,  A63B21/00065 ,  A63B21/0052 ,  A63B21/0626 ,  A63B24/0087 ,  Y10S482/903

摘要： A linear magnetic damper includes a magnetically attractive rail, a damper body movable along the magnetically attractive rail and having a longitudinal passage, which accommodates the magnetically attractive rail, and having a plurality of openings symmetrically formed at two sides thereof and respectively arranged in alignment, and a plurality of magnetic members respectively mounted in the openings at two sides of the damper body for applying a magnetic force to the magnetically attractive rail.

摘要翻译： 线性磁阻尼器包括磁吸引导轨，阻尼体，其沿着磁吸引轨可移动并具有纵向通道，该纵向通道容纳磁性吸引轨，并且具有对称地形成在其两侧并分别排列成对的多个开口， 以及多个磁性构件，分别安装在所述阻尼器主体的两侧的所述开口中，用于将磁力施加到所述磁性吸引力轨道。

公开(公告)号：US20050159273A1

公开(公告)日：2005-07-21

申请号：US10834832

申请日：2004-04-30

申请人： James Chen

发明人： James Chen

IPC分类号： A63B22/00 ,  A63B22/02

CPC分类号： A63B22/02 ,  A63B2210/50

摘要： A foldable treadmill includes a base frame, a tread base having a roller assembly provided at its front side for reciprocating on the base frame, two supports each having two ends respectively pivoted to the base frame and the tread base, and a plurality of spring members connected between the base frame and the tread base for pulling the tread base to turn the tread base about the pivoted point at the supports to the received position while a rear side of the tread base is lifted from the floor by an external force.

摘要翻译： 一种可折叠的跑步机，包括一个底架，一个胎面基座，其前侧具有一个滚轮组件，用于在基座上往复运动，两个支承件分别具有两个端部，分别枢转到底架和胎面基座;以及多个弹簧件 连接在基架和胎面基座之间，用于拉动胎面基座，以使胎面基部围绕支撑件的枢转点转动到接收位置，而胎面基座的后侧通过外力从地板提升。

公开(公告)号：US20050131510A1

公开(公告)日：2005-06-16

申请号：US10888572

申请日：2004-07-09

申请人： James Chen ,  David Shine ,  Gary Lichttenegger ,  Zihong Guo ,  Phillip Burwell ,  Steven Daly

发明人： James Chen ,  David Shine ,  Gary Lichttenegger ,  Zihong Guo ,  Phillip Burwell ,  Steven Daly

IPC分类号： A61B17/22 ,  A61M20060101 ,  A61N1/05 ,  A61N5/06

CPC分类号： A61N5/062 ,  A61B2017/22051 ,  A61N5/0601 ,  A61N2005/0652

摘要： Light generating devices for illuminating portions of vascular tissue to administer photodynamic therapy, and usable with, or including a distal protection device. A first device includes a hollow tip, a flushing lumen, a guidewire lumen, and at least one of a light source, and a hollow light transmissive shaft that is adapted to accommodate a light source. If desired, the device can include a balloon, so that a portion of a body lumen between the balloon and the distal protection device is isolated when the balloon is inflated. A second device includes inner and outer catheters, the outer catheter including a balloon, and the inner catheter including a light source and distal protection device comprising a shape memory polymer. Yet another device is a catheter having two balloons and a sleeve extending therebetween. Within the sleeve, the catheter includes a light source and an expanding member.

摘要翻译： 用于照射血管组织的部分以施用光动力学治疗并且可用于或包括远侧保护装置的光产生装置。 第一装置包括中空尖端，冲洗腔，导丝管腔以及适于容纳光源的光源和中空透光轴中的至少一个。 如果需要，装置可以包括气囊，使得当球囊膨胀时，球囊和远侧保护装置之间的体腔的一部分被隔离。 第二装置包括内导管和外导管，外导管包括气囊，并且内导管包括光源和包括形状记忆聚合物的远端保护装置。 另一个装置是具有两个气囊的导管和在它们之间延伸的套管。 在套管内，导管包括光源和扩张构件。

公开(公告)号：US20050128742A1

公开(公告)日：2005-06-16

申请号：US10888567

申请日：2004-07-08

申请人： James Chen ,  Zihong Guo ,  Gary Lichttenegger ,  David Shine ,  Phillip Burwell

发明人： James Chen ,  Zihong Guo ,  Gary Lichttenegger ,  David Shine ,  Phillip Burwell

IPC分类号： A61B20060101 ,  A61N5/06 ,  A61N5/067 ,  A61N5/10 ,  F21S2/00

CPC分类号： A61N5/0601 ,  A61M2025/1047 ,  A61N5/062 ,  A61N2005/0652 ,  A61N2005/1003

摘要： A light generating device for illuminating tissue adjacent to a body lumen while a distal end of the device is centered in the lumen, to render photodynamic therapy. The device can either occlude or displace bodily fluid, both without the use of a balloon. In one embodiment, a flushing lumen has a port adjacent to an array of light sources, to displace bodily fluid that might otherwise absorb light. Another embodiment employs a centering member that moves between a first position and a second position. The centering member centers the device in the lumen and preferably is formed of a shape memory material. In yet another embodiment, the device includes an outer sheath and an inner member that are independently positionable, enabling the centering member to be selectively positionable. The centering member can be non porous, such that the centering member also occludes fluid flow.

摘要翻译： 一种发光装置，用于在装置的远端位于管腔中心的同时照射邻近体腔的组织，以进行光动力学治疗。 该装置可以封闭或移动体液，而不使用气球。 在一个实施例中，冲洗内腔具有与光源阵列相邻的端口，以移位否则可能吸收光的体液。 另一实施例采用在第一位置和第二位置之间移动的定心构件。 定心构件将装置居中在内腔中，并且优选地由形状记忆材料形成。 在另一个实施例中，该装置包括可独立定位的外护套和内部构件，使得定心构件能够选择性地定位。 定心构件可以是非多孔的，使得定心构件也阻塞流体流动。

公开(公告)号：US20050054524A1

公开(公告)日：2005-03-10

申请号：US10659159

申请日：2003-09-10

申请人： Pascaline Tran ,  James Chen ,  Gerard Lapadula ,  Marc Blute

发明人： Pascaline Tran ,  James Chen ,  Gerard Lapadula ,  Marc Blute

IPC分类号： B01D53/86 ,  B01J23/648 ,  B01J37/02

CPC分类号： B01D53/8634 ,  B01J23/6482 ,  B01J37/0205 ,  B01J37/0225 ,  B01J37/0244

摘要： The invention pertains to a layered ammonia oxidation catalyst. The layered catalyst causes ammonia to be selectively oxidized in the presence of an oxidant such as air, while minimizing the formation of nitrogen oxides (NOx). The layered catalyst comprises a refractory oxide support such as gamma alumina upon which a platinum component is deposited and a vanadia component is deposited on the platinum. The catalyst is preferably disposed on a substrate such as a metal foil whose surface contains a “herringbone” pattern.

摘要翻译： 本发明涉及层状氨氧化催化剂。 层状催化剂在氧化剂例如空气的存在下使氨选择性氧化，同时最小化氮氧化物（NOx）的形成。 层状催化剂包括耐火氧化物载体，例如γ氧化铝，在其上沉积铂组分，并且在铂上沉积氧化钒组分。 催化剂优选设置在表面包含“人字形”图案的金属箔等基板上。

公开(公告)号：US06815841B1

公开(公告)日：2004-11-09

申请号：US09433499

申请日：1999-11-03

申请人： William P. Brown ,  James Chen ,  Carl S. Reid ,  Demetrios Thanopoulos ,  Stephen J. Whitney

发明人： William P. Brown ,  James Chen ,  Carl S. Reid ,  Demetrios Thanopoulos ,  Stephen J. Whitney

IPC分类号： B60Q100

CPC分类号： H01H85/205 ,  H01H85/046 ,  H01H85/47 ,  H01H2085/0555 ,  H01H2085/208

摘要： A fuse arrangement for use in a vehicle is provided having a configuration wherein a common bus terminal connected to a voltage supply is connected to terminals of one or more axial fuses. The other fuse terminals are, in turn, connected to a wiring harness that is located on an opposite side of the fuse box from the common bus terminal in a base of a fuse box. Additionally, the present invention includes a fuse array including a planar substrate with fuses constructed on the substrate by film metallization. Furthermore, the invention includes a carrier strip used for packaging automotive fuses that is made of a flexible material capable of being rolled into a package for shipping to an end user. The invention also includes a mini fuse having reduced terminal spacing for use in vehicles with mixed voltage systems wherein the reduced terminal spacing fuse is used for a particular voltage.

公开(公告)号：US06686667B2

公开(公告)日：2004-02-03

申请号：US10128276

申请日：2002-04-24

申请人： James Chen ,  Rong-Huei Wang

发明人： James Chen ,  Rong-Huei Wang

IPC分类号： H01L2302

CPC分类号： H01L31/0203 ,  H01L27/14618 ,  H01L2224/48091 ,  H01L2224/73265 ,  H01L2924/3025 ,  H01L2924/00014 ,  H01L2924/00

摘要： A non-ceramic image sensor semiconductor package with improved moisture resistance, lower cost, and higher reliability is provided. A semiconductor chip with a vision chip active area is attached to a multi-layer resin mask organic substrate. A plurality of bonding wires are attached between parts of the semiconductor chip and the multi-layer resin mask organic substrate to create selective electrical connections. A castellation is formed to create a riser surrounding the semiconductor chip. The height of the castellations can be made to a desired height so that proper clearance of the semiconductor chip and the glass window is achieved. A transparent window is placed on the top of the castellations. A liquid encapsulant is formed to protectively seal the non-ceramic image sensor semiconductor package thereby shielding the semiconductor chip and vision chip active area from the external environment. Because the same or similar materials are used in the package, the adhesion between these parts is very strong, thus providing a highly reliable device at a lower cost.

摘要翻译： 提供了具有改进的耐湿性，低成本和更高可靠性的非陶瓷图像传感器半导体封装。 具有视觉芯片有源面积的半导体芯片附着到多层树脂掩模有机衬底上。 在半导体芯片的多个部分和多层树脂掩模有机基板之间安装多根接合线以产生选择性的电连接。 形成一个城堡，以形成围绕半导体芯片的立管。 可以将蓖麻的高度制成期望的高度，从而实现半导体芯片和玻璃窗的适当的间隙。 一个透明的窗户放置在城堡的顶部。 形成液体密封剂以保护性地密封非陶瓷图像传感器半导体封装，从而将半导体芯片和视觉芯片有源区域与外部环境隔离。 由于在封装中使用相同或相似的材料，所以这些部件之间的粘合性非常强，从而以较低的成本提供高度可靠的装置。

公开(公告)号：US06652420B2

公开(公告)日：2003-11-25

申请号：US09924091

申请日：2001-08-08

申请人： James Chen

发明人： James Chen

IPC分类号： A63B2100

CPC分类号： A63B23/12 ,  A63B21/0628 ,  A63B21/4017 ,  A63B21/4035 ,  A63B23/03541 ,  A63B23/1209 ,  A63B2023/003

摘要： A grip structure is designed for use in an exercise device and is formed of a main body, a grip rod, and two slide blocks disposed at two ends of the grip rod. The main body is of a ring-shaped construction and is provided with a groove. The main body is fastened with a predetermined portion of the operation rod of the exercise device. The slide blocks are slidably received in the groove of the main body. The grip rod can be adjusted 360 degrees in relation to the main body, thereby enabling a change in direction in which the grip rod is held fast by an exerciser.

摘要翻译： 抓握结构设计用于锻炼装置，并且由主体，把手杆和设置在把手的两端的两个滑动块构成。 主体为环状结构，设有凹槽。 主体用锻炼装置的操作杆的预定部分固定。 滑动块可滑动地容纳在主体的凹槽中。 把手杆可以相对于主体调节360度，从而能够通过锻炼者快速地握持把手的方向改变。

公开(公告)号：US06573595B1

公开(公告)日：2003-06-03

申请号：US10128272

申请日：2002-04-24

申请人： James Chen ,  Rong-Huei Wang

发明人： James Chen ,  Rong-Huei Wang

IPC分类号： H01L2304

CPC分类号： H01L23/3128 ,  H01L23/49816 ,  H01L23/49861 ,  H01L24/48 ,  H01L2224/05599 ,  H01L2224/45099 ,  H01L2224/48091 ,  H01L2224/48227 ,  H01L2224/73265 ,  H01L2224/8547 ,  H01L2924/00014 ,  H01L2924/01078 ,  H01L2924/01079 ,  H01L2924/14 ,  H01L2924/15311 ,  H01L2924/181 ,  H01L2924/3025 ,  H01L2924/00012 ,  H01L2224/45015 ,  H01L2924/207 ,  H01L2924/00

摘要： The present invention provides a ball grid array semiconductor package having a resin coated metal core substrate. The semiconductor device comprises a resin coated metal core substrate, solder balls, chip adhesive material, at least one semiconductor chip, bonding wires, and encapsulant. The metal core is made from a conductive material, for example, a metal lead frame and coated with a resin to form a resin covered metal core substrate structure. The resin coating covers both sides of the metal core except for selected areas of the metal core, such as where it is desired to attach the bonding wires or the solder balls. A liquid encapsulant is formed to cover desired areas of the resin coated substrate, bonding wires, adhesive material, and the semiconductor chip. Since the outer surface of the substrate is substantially of resin material, the adhesion between the substrate and the encapsulant is much stronger than if a standard conventional substrate was used. Due to the resin coated metal core, the semiconductor device has improved thermal performance, higher reliability, and lower cost.

摘要翻译： 本发明提供一种具有树脂涂覆的金属芯基板的球栅阵列半导体封装。 半导体器件包括树脂涂覆的金属芯基板，焊球，芯片粘合材料，至少一个半导体芯片，接合线和密封剂。 金属芯由导电材料制成，例如金属引线框架，并用树脂涂覆以形成树脂覆盖的金属芯基板结构。 树脂涂层覆盖除了金属芯的选定区域之外的金属芯的两侧，例如需要附接接合线或焊球的那些区域。 形成液体密封剂以覆盖树脂涂覆的基底，接合线，粘合剂材料和半导体芯片的所需区域。 由于基板的外表面基本上是树脂材料，所以基板和密封剂之间的粘合力比使用标准的常规基板要强得多。 由于树脂涂覆的金属芯，半导体器件具有改善的热性能，更高的可靠性和更低的成本。