公开(公告)号：US07218655B2

公开(公告)日：2007-05-15

申请号：US11245451

申请日：2005-10-07

Applicant: Sean Xiaolu Wang ,  Qun Li ,  Rongsheng Tian

Inventor： Sean Xiaolu Wang ,  Qun Li ,  Rongsheng Tian

IPC: H01S3/13 ,  H01S3/10

CPC classification number: H01S3/1312 ,  H01S3/09415 ,  H01S3/109 ,  H01S5/141

Abstract: A temperature insensitive diode-pumped solid state laser is disclosed in this invention. The components of the laser are optimized with temperature insensitive design, making the laser capable of operating in a wide temperature range without using any cooling/heating system to maintain the temperature of its components.

Abstract translation: 在本发明中公开了一种温度不敏感的二极管泵浦固态激光器。 激光器的组件通过温度不敏感设计进行了优化，使得激光器能够在宽的温度范围内工作，而无需使用任何冷却/加热系统来维持其部件的温度。

公开(公告)号：US20230398371A1

公开(公告)日：2023-12-14

申请号：US18204433

申请日：2023-06-01

Applicant: Ross Lefkowitz ,  Brian Pryor ,  Sean Xiaolu Wang

Inventor： Ross Lefkowitz ,  Brian Pryor ,  Sean Xiaolu Wang

IPC: A61N5/06

CPC classification number: A61N5/0613 ,  A61N2005/0606 ,  A61N2005/0653

Abstract: The photo therapy apparatus of the present invention comprises one or more light sources which are integrated with a molar bite block for providing photobiomodulation therapy to the oral mucosa of a cancer patient suffering from (or at risk of) Oral Mucositis. The light sources can be either internal, or external to the bite block, and either lasers, light emitting diodes (LEDs), lamps, or any other types of light sources which produce therapeutic light in a desired wavelength range. The therapeutic light is delivered through the bite block to the oral mucosa. The delivered light produces a photochemical and photophysical process e.g. increase the blood flow and circulation. This photochemical and photophysical process helps to reduce the incidence and severity of oral mucositis in cancer patients and helps improve outcomes of cancer therapy.

公开(公告)号：US20210220662A1

公开(公告)日：2021-07-22

申请号：US17143442

申请日：2021-01-07

Applicant: Dan Liu ,  Sean Xiaolu Wang

Inventor： Dan Liu ,  Sean Xiaolu Wang

IPC: A61N1/44 ,  H05H1/46 ,  H05H1/24

Abstract: This invention discloses a cold plasma therapy device with enhanced safety. The plasma therapy device comprises a dielectric barrier made of a material with high dielectric constant (i.e., relative permittivity). Hence the thickness of the dielectric barrier can be increased to produce similar plasma intensity in comparison to a dielectric barrier with a low dielectric constant. The increased thickness enhances the mechanical durability of the dielectric barrier. When the thickness of the dielectric barrier is larger than the maximum discharge gap of the ambient air (or the supplied gas medium) under the voltage applied, no arc discharge will be produced even when there is a crack across the thickness of the dielectric barrier. This minimizes the risk of subject tissue damage from possible electric shocks.

公开(公告)号：US10832110B2

公开(公告)日：2020-11-10

申请号：US16178745

申请日：2018-11-02

Applicant: Gonzalo R. Arce ,  Gonzalo Garateguy ,  Sean Xiaolu Wang ,  Daniel L. Lau

Inventor： Gonzalo R. Arce ,  Gonzalo Garateguy ,  Sean Xiaolu Wang ,  Daniel L. Lau

IPC: G06K19/06

Abstract: The present invention embodies a technique, referred to as Secure QR Codes, which not only provides aesthetically enhanced QR codes but also allows for security. It can embed a standard black and white QR code, referred to as a public QR code, and a secret QR code, both into a secure QR code. The secure QR code produced is composed of colored cells. The public black and white QR code must first be, either aesthetically enhanced into an enhanced colored QR code, or transformed into a colored QR code with cells of uniform color obtained by transforming each of the black and white cells of the public QR code into cells that takes a color from a subset of possible colors, such that the luminance of each colored cell approximates accurately the black or white luminance values of the public QR code.

公开(公告)号：US10746658B1

公开(公告)日：2020-08-18

申请号：US16662180

申请日：2019-10-24

Applicant: Qun Li ,  Sean Xiaolu Wang

Inventor： Qun Li ,  Sean Xiaolu Wang

IPC: G01J3/30 ,  G01N21/71 ,  G01J3/443

Abstract: This invention discloses a method for material identification by analyzing the LIBS spectrum of the sample. The LIBS spectrum is pre-processed to equalize the contribution of elements with strong and weak emission lines. In the meantime, the number of spectral variables is reduced to enhance the specificity and minimize the influence of instrument noise. Commonly used spectrum identification and library search algorithms are then applied to the pre-processed LIBS spectrum for material identification.

公开(公告)号：US09909923B2

公开(公告)日：2018-03-06

申请号：US14845980

申请日：2015-09-04

Applicant: Sean Xiaolu Wang ,  Qun Li

Inventor： Sean Xiaolu Wang ,  Qun Li

IPC: G01J3/443 ,  G01J3/10 ,  G01J3/02 ,  G01J3/06 ,  G01J3/28

CPC classification number: G01J3/443 ,  G01J3/0208 ,  G01J3/06 ,  G01J3/10 ,  G01J3/28

Abstract: This invention discloses a laser induced breakdown spectroscopy (LIBS) apparatus based on a high repetition rate pulsed laser. The laser produces a train of laser pulses at a high repetition rate in the kHz or even higher range. When the laser beam hits the sample, it generates several thousands of micro-plasmas per second. Synchronized miniature CCD array optical spectrometer modules collect the LIBS signal from these micro-plasmas. By adjusting the integration time of the spectrometer to cover a plurality of periods of the laser pulse train, the spectrometer integrates the LIBS signal produced by this plurality of laser pulses. Hence the intensity of the obtained LIBS spectrum can be greatly improved to increase the signal-to-noise ratio (SNR) and lower the limit of detection (LOD). In addition, the influence of pulse to pulse variation of the laser is minimized since the obtained LIBS spectrum is the spectrum of a plurality of micro-plasmas produced by a plurality of laser pulses. The high repetition rate laser also makes it possible for fast scanning the laser beam over the sample surface such that an average spectrum of the sample is collected to overcome the sample non-uniformity issue or for performing spectral imaging of the sample by correlating the obtained LIBS spectrum with the position of the scanning laser beam.

公开(公告)号：US20170076127A1

公开(公告)日：2017-03-16

申请号：US15259460

申请日：2016-09-08

Applicant: Gonzalo R. Arce ,  Gonzalo Garateguy ,  Sean Xiaolu Wang ,  Daniel L. Lau

Inventor： Gonzalo R. Arce ,  Gonzalo Garateguy ,  Sean Xiaolu Wang ,  Daniel L. Lau

IPC: G06K7/14 ,  G06K1/12 ,  G06K19/06

CPC classification number: G06K19/06056

Abstract: The present invention embodies a technique, referred to as Secure QR Codes, which not only provides aesthetically enhanced QR codes but also allows for security. It can embed a standard black and white QR code, referred to as a public QR code, and a secret QR code, both into a secure QR code. The secure QR code produced is composed of colored cells. The public black and white QR code must first be, either aesthetically enhanced into an enhanced colored QR code, or transformed into a colored QR code with cells of uniform color obtained by transforming each of the black and white cells of the public QR code into cells that takes a color from a subset of possible colors, such that the luminance of each colored cell approximates accurately the black or white luminance values of the public QR code.

Abstract translation: 本发明体现了一种称为安全QR码的技术，其不仅提供美观增强的QR码，而且还允许安全性。 它可以嵌入标准的黑白QR码，被称为公众QR码和秘密QR码，两者都可以嵌入到安全的QR码中。 产生的安全QR码由彩色细胞组成。 公众黑白QR码必须首先在美学上增强为增强的彩色QR码，或者通过将公开QR码的每个黑白细胞转换成细胞而获得的均匀颜色的细胞变换成彩色QR码 其从可能颜色的子集中获取颜色，使得每个有色单元的亮度准确地近似公开QR码的黑色或白色亮度值。

公开(公告)号：US20170045459A1

公开(公告)日：2017-02-16

申请号：US15235170

申请日：2016-08-12

Applicant: Sean Xiaolu Wang ,  Qun Li

Inventor： Sean Xiaolu Wang ,  Qun Li

IPC: G01N21/71

CPC classification number: G01N21/718 ,  G01J3/0208 ,  G01J3/10 ,  G01J3/28 ,  G01J3/2803 ,  G01J3/443 ,  G01N2201/0612 ,  G01N2201/129

Abstract: This invention discloses a laser induced breakdown spectroscopy (LIBS) apparatus based on high repetition rate pulsed laser. The laser produces a train of laser pulses at a high repetition rate in the kHz (or even higher) range. When the laser beam hits the biological sample, it generates several thousands of micro-plasmas per second. Synchronized miniature CCD array optical spectrometer modules collect the LIBS signal from these micro-plasmas. By adjusting the integration time of the spectrometer to cover a plurality of periods of the laser pulse train, the spectrometer integrates the LIBS signal produced by this plurality of laser pulses. Hence the intensity of the obtained LIBS spectrum can be greatly improved to increase the signal-to-noise ratio (SNR) and lower the level of detection (LOD).

Abstract translation: 本发明公开了一种基于高重复率脉冲激光的激光诱导击穿光谱（LIBS）装置。 激光器在kHz（或甚至更高）的范围内以高重复率产生一串激光脉冲。 当激光束撞击生物样品时，它每秒产生数千个微等离子体。 同步微型CCD阵列光谱仪模块从这些微等离子体收集LIBS信号。 通过调整光谱仪的积分时间来覆盖激光脉冲串的多个周期，光谱仪将由多个激光脉冲产生的LIBS信号进行积分。 因此，可以大大提高获得的LIBS频谱的强度，以增加信噪比（SNR）并降低检测电平（LOD）。

公开(公告)号：US09504847B2

公开(公告)日：2016-11-29

申请号：US12964779

申请日：2010-12-10

Applicant: Brian Pryor ,  Sean Xiaolu Wang

Inventor： Brian Pryor ,  Sean Xiaolu Wang

IPC: A61N5/06

CPC classification number: A61N5/0613 ,  A61N2005/0644

Abstract: An improved method for performing phototherapy. The method comprises a step of applying a supplement to the patient before/after light treatment, which produces nitric oxide in the subject biological tissue to be treated. The nitric oxide serves as signaling molecules to cause vasodilatation and increase blood flow and micro-circulation in the biological tissue so as to enhance the effect and reduce the required treatment time of phototherapy.

Abstract translation: 一种改进的光疗方法。 该方法包括在光治疗之前/之后向患者施加补充物的步骤，其在待治疗的对象生物组织中产生一氧化氮。 一氧化氮作为信号分子引起血管扩张，增加生物组织中的血液流动和微循环，从而增强效果，减少光疗所需的治疗时间。

公开(公告)号：US20160279436A1

公开(公告)日：2016-09-29

申请号：US14665251

申请日：2015-03-23

Applicant: Sean Xiaolu Wang ,  Luis De Taboada ,  Brian Pryor

Inventor： Sean Xiaolu Wang ,  Luis De Taboada ,  Brian Pryor

IPC: A61N5/06

CPC classification number: A61N5/06 ,  A61N2005/0627 ,  A61N2005/063 ,  A61N2005/0644 ,  A61N2005/0659 ,  A61N2005/067

Abstract: A phototherapy apparatus with precise dosage control is disclosed. The phototherapy apparatus incorporates means for tracking any combination of the following: position, direction of motion, velocity, or acceleration of the therapeutic light beam over the treatment area. The delivered light dosage is calculated based on these parameters and the intensity of the laser beam.

Abstract translation: 公开了具有精确剂量控制的光疗装置。 光疗装置包括用于跟踪治疗区域上的治疗光束的位置，运动方向，速度或加速度的任何组合的装置。 基于这些参数和激光束的强度来计算传递的光剂量。