公开(公告)号：US07910321B2

公开(公告)日：2011-03-22

申请号：US12235837

申请日：2008-09-23

申请人： Jian Ni ,  Craig A. Rosen ,  Reiner L. Gentz ,  Sally Doreen P. Lyn ,  Mark Hurle

发明人： Jian Ni ,  Craig A. Rosen ,  Reiner L. Gentz ,  Sally Doreen P. Lyn ,  Mark Hurle

IPC分类号： G01N33/48 ,  G01N33/53 ,  G01N33/563 ,  G01N33/577

CPC分类号： C07K14/7151

摘要： The present invention relates to novel members of the Tumor Necrosis Factor family of receptors. The invention provides isolated nucleic acid molecules encoding a human TR2 receptor and two splice variants thereof. TR2 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of TR2 receptor activity. Also provided are diagnostic methods for detecting disease states related to the aberrant expression of TR2 receptors. Further provided are therapeutic methods for treating disease states related to aberrant proliferation and differentiation of cells which express the TR2 receptors.

摘要翻译： 本发明涉及肿瘤坏死因子家族受体的新成员。 本发明提供编码人TR2受体的分离的核酸分子及其两个剪接变体。 还提供TR2多肽，载体，宿主细胞和用于制备它们的重组方法。 本发明还涉及用于鉴定TR2受体活性的激动剂和拮抗剂的筛选方法。 还提供了用于检测与TR2受体的异常表达相关的疾病状态的诊断方法。 还提供了治疗与表达TR2受体的细胞的异常增殖和分化相关的疾病状态的治疗方法。

公开(公告)号：US07476384B2

公开(公告)日：2009-01-13

申请号：US11076187

申请日：2005-03-10

申请人： Jian Ni ,  Craig A. Rosen ,  James Pan ,  Reiner L. Gentz ,  Vishva M. Dixit

发明人： Jian Ni ,  Craig A. Rosen ,  James Pan ,  Reiner L. Gentz ,  Vishva M. Dixit

IPC分类号： A61K39/395 ,  A61K38/21 ,  C07K14/56 ,  C07K14/705

CPC分类号： C07K14/70578

摘要： The present invention relates to novel Death Domain Containing Receptor-4 (DR4) proteins which are members of the tumor necrosis factor (TNF) receptor family. In particular, isolated nucleic acid molecules are provided encoding the human DR4 proteins. DR4 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of DR4 activity and methods for using DR4 polynucleotides and polypeptides. The invention also relates to the treatment of diseases associated with reduced or increased levels of apoptosis using antibodies specific for DR4, which may be agonists and/or antagonists of DR4 activity.

摘要翻译： 本发明涉及作为肿瘤坏死因子（TNF）受体家族成员的新的含有死亡域的受体-4（DR4）蛋白。 特别地，提供编码人DR4蛋白的分离的核酸分子。 还提供了DR4多肽，载体，宿主细胞和用于制备它们的重组方法。 本发明还涉及用于鉴定DR4活性的激动剂和拮抗剂的筛选方法以及使用DR4多核苷酸和多肽的方法。 本发明还涉及使用DR4特异性抗体（其可以是DR4活性的激动剂和/或拮抗剂）的减少或增加的细胞凋亡相关疾病的治疗。

公开(公告)号：US20080241155A1

公开(公告)日：2008-10-02

申请号：US12010108

申请日：2008-01-18

申请人： Jian Ni ,  Craig A. Rosen ,  James G. Pan ,  Reiner L. Gentz ,  Vishva M. Dixit

发明人： Jian Ni ,  Craig A. Rosen ,  James G. Pan ,  Reiner L. Gentz ,  Vishva M. Dixit

IPC分类号： A61K39/395 ,  C12N5/06 ,  A61P35/00 ,  A61P31/12

CPC分类号： C07K14/70578 ,  A01K2267/035 ,  C07K16/2878 ,  C07K2319/30

摘要： The present invention relates to novel Death Domain Containing Receptor-4 (DR4) proteins which are members of the tumor necrosis factor (TNF) receptor family. In particular, isolated nucleic acid molecules are provided encoding the human DR4 proteins. DR4 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of DR4 activity and methods for using DR4 polynucleotides and polypeptides. The invention also relates to the treatment of diseases associated with reduced or increased levels of apoptosis using antibodies specific for DR4, which may be agonists and/or antagonists of DR4 activity.

摘要翻译： 本发明涉及作为肿瘤坏死因子（TNF）受体家族成员的新的含有死亡域的受体-4（DR4）蛋白。 特别地，提供编码人DR4蛋白的分离的核酸分子。 还提供了DR4多肽，载体，宿主细胞和用于制备它们的重组方法。 本发明还涉及用于鉴定DR4活性的激动剂和拮抗剂的筛选方法以及使用DR4多核苷酸和多肽的方法。 本发明还涉及使用DR4特异性抗体（其可以是DR4活性的激动剂和/或拮抗剂）的减少或增加的细胞凋亡相关疾病的治疗。

公开(公告)号：US06743625B2

公开(公告)日：2004-06-01

申请号：US09874138

申请日：2001-06-06

申请人： Jian Ni ,  Reiner L. Gentz ,  Guo-Liang Yu ,  Craig A. Rosen

发明人： Jian Ni ,  Reiner L. Gentz ,  Guo-Liang Yu ,  Craig A. Rosen

IPC分类号： C07K14705

CPC分类号： C07K14/7151 ,  A61K38/00 ,  A61K39/395 ,  C07K14/70578 ,  C07K2319/00 ,  C07K2319/30 ,  A61K2300/00

摘要： The present invention relates to novel Death Domain Containing Receptor-5 (DR5) proteins which are members of the tumor necrosis factor (TNF) receptor family, and have now been shown to bind TRAIL. In particular, isolated nucleic acid molecules are provided encoding the human DR5 proteins. DR5 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying antagonists and antagonists of DR5 activity.

摘要翻译： 本发明涉及作为肿瘤坏死因子（TNF）受体家族的成员的新的含有死亡域的受体-5（DR5）蛋白，现在已经显示结合TRAIL。 特别地，提供编码人DR5蛋白的分离的核酸分子。 还提供了DR5多肽，载体，宿主细胞以及用于制备它们的重组方法。 本发明还涉及用于鉴定DR5活性的拮抗剂和拮抗剂的筛选方法。

公开(公告)号：US06667390B2

公开(公告)日：2003-12-23

申请号：US09756854

申请日：2001-01-10

申请人： Jian Ni ,  Guo-Liang Yu ,  Ping Fan ,  Reiner L. Gentz

发明人： Jian Ni ,  Guo-Liang Yu ,  Ping Fan ,  Reiner L. Gentz

IPC分类号： C07K14715

CPC分类号： C07K14/70578 ,  A61K38/00 ,  C07K14/4747 ,  C07K14/7151 ,  C12N2799/026

摘要： The present invention relates to a novel member of the tumor necrosis factor family of receptors. In particular, isolated nucleic acid molecules are provided encoding the human TR9 receptor. TR9 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of TR9 receptor activity.

公开(公告)号：US06590088B1

公开(公告)日：2003-07-08

申请号：US08896537

申请日：1997-07-18

申请人： Jian Ni ,  Reiner L. Gentz ,  Craig A. Rosen

发明人： Jian Ni ,  Reiner L. Gentz ,  Craig A. Rosen

IPC分类号： C07H2104

CPC分类号： C07K14/70596

摘要： The present invention concerns a novel CD33-like protein. In particular, isolated nucleic acid molecules are provided encoding the CD33-like protein. Recombinant CD33-like polypeptides are also provided as are recombinant vectors and host cells. The invention further provides methods useful during tumor or inflammatory disease diagnosis or prognosis and therapeutic treatments targeting cells expressing CD33-like polypeptides.

公开(公告)号：US06448044B2

公开(公告)日：2002-09-10

申请号：US08832488

申请日：1997-04-03

申请人： Jian Ni ,  Haodong Li ,  Guo-Liang Yu ,  Reiner L. Gentz

发明人： Jian Ni ,  Haodong Li ,  Guo-Liang Yu ,  Reiner L. Gentz

IPC分类号： C12P2102

CPC分类号： C07K16/28 ,  A61K38/00 ,  C07K14/52

摘要： The invention relates to NKAF II polypeptides, polynucleotides encoding the polypeptides, methods for producing the polypeptides, in particular by expressing the polynucleotides, and agonists and antagonists of the polypeptides. The invention further relates to methods for utilizing such polynucleotides, polypeptides, agonists and antagonists for applications, which relate, in part, to research, diagnostic and clinical arts.

摘要翻译： 本发明涉及NKAF II多肽，编码多肽的多核苷酸，产生多肽的方法，特别是通过表达多核苷酸，多肽的激动剂和拮抗剂。 本发明还涉及用于应用的这些多核苷酸，多肽，激动剂和拮抗剂的方法，其部分涉及研究，诊断和临床领域。

公开(公告)号：US06329169B1

公开(公告)日：2001-12-11

申请号：US09043646

申请日：1998-09-09

申请人： Jian Ni ,  Guo-Liang Yu ,  Reiner L. Gentz

发明人： Jian Ni ,  Guo-Liang Yu ,  Reiner L. Gentz

IPC分类号： C12P2102

CPC分类号： G01N33/57415 ,  A61K38/00 ,  C07K14/475

摘要： The invention relates to cytostatin II growth modulatory peptides, polynucleotides encoding the polypeptides, methods for producing the polypeptides, in particular by expressing the polynucleotides, and agonists and antagonists of the polypeptides. The invention further relates to methods for utilizing such polynucleotides, polypeptides, agonists and antagonists for applications which are related, in part, to research, diagnostic and clinical arts.

摘要翻译： 本发明涉及细胞抑制素II生长调节肽，编码多肽的多核苷酸，特别是通过表达多核苷酸产生多肽的方法，多肽的激动剂和拮抗剂。 本发明还涉及利用这些多核苷酸，多肽，激动剂和拮抗剂用于部分与研究，诊断和临床领域有关的应用的方法。

公开(公告)号：US06300477B1

公开(公告)日：2001-10-09

申请号：US09241376

申请日：1999-02-02

申请人： Jian Ni ,  Reiner L. Gentz ,  Guo-Liang Yu ,  Craig A. Rosen

发明人： Jian Ni ,  Reiner L. Gentz ,  Guo-Liang Yu ,  Craig A. Rosen

IPC分类号： C07K1618

CPC分类号： C07K14/8139 ,  A61K38/00

摘要： Disclosed are antibodies and antibody fragments that bind to novel human CysE polypeptides. Also provided are methods for producing the antibodies. Also disclosed are methods for utilizing such antibodies and antibody fragments for the purification and analysis of CysE polypeptides, as well as the diagnosis and treatment of CysE polypeptide associated diseases.

摘要翻译： 公开了结合新的人CysE多肽的抗体和抗体片段。 还提供了用于产生抗体的方法。 还公开了利用这些抗体和抗体片段来纯化和分析CysE多肽的方法，以及CysE多肽相关疾病的诊断和治疗。

公开(公告)号：US5919658A

公开(公告)日：1999-07-06

申请号：US832535

申请日：1997-04-03

申请人： Jian Ni ,  Haodong Li ,  Guo-Liang Yu ,  Reiner L. Gentz

发明人： Jian Ni ,  Haodong Li ,  Guo-Liang Yu ,  Reiner L. Gentz

IPC分类号： A61K38/00 ,  C07K14/81 ,  C12P21/06 ,  C07H21/04 ,  C12N5/00 ,  C12N15/00

CPC分类号： C07K14/8139 ,  A61K38/00 ,  C07K2319/00

摘要： The invention relates to cystatin F polypeptides, polynucleotides encoding the polypeptides, methods for producing the polypeptides, in particular by expressing the polynucleotides, and agonists and antagonists of the polypeptides. The invention further relates to methods for utilizing such polynucleotides, polypeptides, agonists and antagonists for applications, which relate, in part, to research, diagnostic and clinical arts.

摘要翻译： 本发明涉及半胱氨酸蛋白酶抑制剂F多肽，编码多肽的多核苷酸，产生多肽的方法，特别是通过表达多核苷酸，多肽的激动剂和拮抗剂。 本发明还涉及用于应用的这些多核苷酸，多肽，激动剂和拮抗剂的方法，其部分涉及研究，诊断和临床领域。