Method for imaging malignant tumors using carbon 13 with MRI

    公开(公告)号:US06521210B2

    公开(公告)日:2003-02-18

    申请号:US09736526

    申请日:2000-12-13

    申请人: Tihiro Ohkawa

    发明人: Tihiro Ohkawa

    IPC分类号: A61B5055

    摘要: In accordance with the present invention, a method for imaging a malignancy in a patient, in situ, requires feeding the patient a nutrient that is enriched with carbon 13 (13C). This feeding step can be accomplished either orally or intravenously, and can last for approximately 24 hours. Magnetic Resonance Imaging (MRI) techniques are then used on the patient with rf energy that is tuned to the nuclear resonance of 13C. An image of selected tissue in the patient is thereby created, and this image is thereafter evaluated for any concentrations of 13C that will delineate a malignancy. If present, the malignancy can then be treated. A subsequent (feeding)/(MRI imaging) procedure may be performed. The image that is created in this subsequent procedure can then be compared with the image that was created in the first procedure to determine the efficacy of the treatment, or to determine a growth rate for the malignancy.

    Electromagnetic mass distiller
    82.
    发明授权
    Electromagnetic mass distiller 失效
    电磁质量蒸馏器

    公开(公告)号:US06294781B1

    公开(公告)日:2001-09-25

    申请号:US09298543

    申请日:1999-04-23

    申请人: Tihiro Ohkawa

    发明人: Tihiro Ohkawa

    IPC分类号: H01J4928

    CPC分类号: H01J49/28

    摘要: A device for segregating high-mass particles in a multi-species plasma from lower-mass particles has a chamber surrounded by a hollow annular shaped enclosure which defines a central axis. In a radial direction outwardly from the axis, the chamber includes a light mass collection section that is in fluid communication, through an intermediate section, with a filter section. A magnetic field, Bz, is oriented parallel to the central axis in the filter section, and the filter section has an outer wall which is at a distance slightly greater than a distance “a” from the central axis. An electric field is crossed with the magnetic field and is perpendicular to the central axis in the filter section. Further, there is zero potential on the outer wall of the filter section while there is a positive potential “V” on the inner wall of the filter section. At least if one plasma source injects a multi-species plasma into the filter section for interaction with the crossed magnetic and electric fields to eject high-mass particles into contact with the outer wall, while low-mass particles are prevented from doing so. High-mass particles are differentiated from low-mass particles by a predetermined value Mc, where Mc=ea2(Bz)2/8V.

    摘要翻译: 用于分离来自较低质量颗粒的多种类等离子体中的高质量颗粒的装置具有由限定中心轴线的中空环形外壳围绕的室。 在从轴线向外的径向方向上,腔室包括通过中间部分与过滤器部分流体连通的光质收集部分。 磁场Bz在过滤器部分中平行于中心轴线定向,并且过滤器部分具有一个远离距离中心轴距离“a”更远的外壁。 电场与磁场交叉并垂直于过滤器部分的中心轴线。 此外,在过滤器部分的内壁上存在正电位“V”的情况下,在过滤器部分的外壁上存在零电位。 至少如果一个等离子体源将多种类的等离子体注入到过滤器部分中以与交叉磁场和电场相互作用,以将高质量粒子喷射到与外壁接触的同时,防止低质量粒子这样做。 高质量颗粒与低质量颗粒分开预定值Mc,其中Mc = ea2(Bz)2 / 8V。

    Negative ion filter
    83.
    发明授权
    Negative ion filter 有权
    负离子过滤器

    公开(公告)号:US06251281B1

    公开(公告)日:2001-06-26

    申请号:US09451693

    申请日:1999-11-30

    申请人: Tihiro Ohkawa

    发明人: Tihiro Ohkawa

    IPC分类号: B03C100

    摘要: A plasma filter for separating positive ions from negative ions in a multi-species plasma includes a cylindrical shaped chamber. Magnetic coils surrounding the chamber generate a magnetic field that is aligned substantially parallel to the chamber's longitudinal axis. An electrode generates an electric field that is substantially perpendicular to the magnetic field to create crossed magnetic and electric fields inside the chamber. The inward directed electric field has a negative potential on the longitudinal axis and a substantially zero potential at the wall of the chamber. An injector injects the multi-species plasma into said chamber to interact with said crossed magnetic and electric fields. With the chamber wall at a distance “a” from the longitudinal axis, a magnitude “Bz” for the magnetic field, a negative potential for the electric field of “Vctr” along the axis and a substantially zero potential at the wall, a cut-off mass to charge ratio is calculated Mc/e=a2(Bz)2/8Vctr, such that negative ions having a mass M1(−)/e greater than Mc/e will be ejected from the chamber for collection off the chamber wall, while all positive ions will be confined in the chamber for transit through the chamber for collection outside the chamber.

    摘要翻译: 用于在多种类等离子体中分离正离子与负离子的等离子体过滤器包括圆柱形室。 围绕室的磁性线圈产生基本上平行于室的纵向轴线排列的磁场。 电极产生基本上垂直于磁场的电场,以在室内产生交叉的磁场和电场。 向内导电的电场在纵轴上具有负电位,并且在室的壁处具有基本上为零的电位。 喷射器将多物质等离子体注入到所述室中以与所述交叉磁场和电场相互作用。 在室壁距离纵轴距离“a”的距离处,磁场的幅度“Bz”,沿着轴线的“Vctr”的电场的负电位和在壁处的基本零电势,切割 计算出质量与电荷的比例为Mc / e = a2(Bz)2 / 8Vctr,使得具有大于Mc / e的质量M1( - )/ e的负离子将从室中排出以收集室壁 而所有正离子将被限制在腔室中,用于通过腔室运输以在室外收集。

    Centrifugal filter for multi-species plasma
    84.
    发明授权
    Centrifugal filter for multi-species plasma 有权
    用于多品种血浆的离心过滤器

    公开(公告)号:US06217776B1

    公开(公告)日:2001-04-17

    申请号:US09479276

    申请日:2000-01-05

    申请人: Tihiro Ohkawa

    发明人: Tihiro Ohkawa

    IPC分类号: B03C100

    摘要: A centrifugal filter for separating low-mass particles from high-mass particles in a rotating multi-species plasma includes a pair of annular shaped coaxially oriented conductors. The conductors are both aligned along a central axis and are spaced apart to create a plasma passageway between them. In this configuration, the conductors generate respective magnetic field components which interact to create a magnetic field having an increased magnitude in the passageway and a decreased magnitude along the central axis. The filter also includes an electric field which has a positive potential along the central axis and a decreasing potential in an outwardly radial direction from the central axis. Specifically, this electric field is crossed with the magnetic field in the passageway to confine low-mass particles in the passageway and to eject high-mass particles from the passageway. The particular configuration of the magnetic field for these crossed fields improves efficacy in the separation of the high-mass from the low-mass particles by requiring greater forces for the ejection of particles from the plasma.

    摘要翻译: 用于在旋转多品种等离子体中分离低质量颗粒与高质量颗粒的离心过滤器包括一对环形同轴取向的导体。 导体沿着中心轴线对齐并且间隔开以在它们之间产生等离子体通道。 在这种配置中,导体产生相应的磁场分量,其相互作用以产生在通道中具有增加的幅度的磁场,并且沿着中心轴线的幅度减小。 滤波器还包括沿着中心轴线具有正电位的电场和从中心轴线向外径向减小的电位。 具体地,该电场与通道中的磁场交叉,以限制通道中的低质量颗粒并从通道喷射高质量颗粒。 用于这些交叉场的磁场的特定配置通过需要较大的力来从等离子体喷射来提高高质量与低质量颗粒的分离效率。

    Toroidal plasma mass filter
    85.
    发明授权
    Toroidal plasma mass filter 失效
    环形等离子体质量过滤器

    公开(公告)号:US06214223B1

    公开(公告)日:2001-04-10

    申请号:US09354358

    申请日:1999-07-14

    申请人: Tihiro Ohkawa

    发明人: Tihiro Ohkawa

    IPC分类号: B03C100

    摘要: A toroidal shaped plasma mass filter for separating heavy mass ions (M2) from light mass ions (M1) includes a platform having an annular shaped surface with a circular axis of rotation located midway between the inner and outer circumferences of the platform. An arched wall covers the platform to create a plasma chamber with the wall at least at a distance “a” from the axis of rotation. A plasma source is mounted on the platform in the chamber between the axis of rotation and the wall to generate a multi-species containing light mass particles (M1) and heavy mass particles (M2). In the chamber, the toroidal component, B&phgr;, of a helical magnetic field, B, is crossed with an electrical field, Er, having a positive potential Vctr along the axis of rotation. The crossed magnetic and electric fields thus rotate the multi-species plasma around the axis of rotation, and thereby separate the light mass particles (M1) from the heavy mass particles (M2) in accordance with the expression Mc=ea2B&phgr;2/8Vctr. In this expression Mc is selected as a cut-off mass that is greater than M1 and less than M2 (M1

    摘要翻译: 用于从轻质离子(M1)分离重质离子(M2)的环形等离子体质量过滤器包括具有环形表面的平台,该平台具有位于平台的内外周之间的中间的旋转轴线。 拱形壁覆盖平台以形成等离子体室,其中壁至少距离旋转轴线为“a”。 等离子体源安装在旋转轴和壁之间的室中的平台上,以产生含有光质粒子(M1)和重质粒子(M2)的多物质。 在腔室中,螺旋磁场B的环形部件Bphi与沿着旋转轴线具有正电位Vctr的电场Er交叉。 交叉的磁场和电场因此围绕旋转轴旋转多种类等离子体,从而根据表达式Mc = ea2Bphi2 / 8Vctr将轻质粒子(M1)与重质粒子(M2)分离。 在该表达式中,Mc被选为大于M1且小于M2的临界质量(M1

    High density plasma formation using whistler mode excitation in a
reduced cross-sectional area formation tube
    86.
    发明授权
    High density plasma formation using whistler mode excitation in a reduced cross-sectional area formation tube 失效
    在减少的截面积形成管中使用吹口哨模式激发的高密度等离子体形成

    公开(公告)号:US5361016A

    公开(公告)日:1994-11-01

    申请号:US10553

    申请日:1993-01-28

    摘要: A long plasma formation tube is imbedded in a high magnetic field, with magnetic field lines passing axially through the tube, and with the tube being placed proximate or inside of a resonant cavity. Electromagnetic energy resonates in the resonant cavity representing stored microwave energy. The power density of the stored microwave energy is a function of the cross-sectional area of the resonant cavity. A portion of the stored microwave energy is concentrated to increase its power density, and coupled into the plasma formation tube, which tube has a smaller cross-sectional area than the resonant cavity. The coupled energy excites a whistler wave in the plasma formation tube that forms the plasma within the tube. In one embodiment, the stored microwave power is concentrated by funneling it through a metallic iris that forms one end of the resonant cavity, with a tip of the plasma formation tube being positioned near the metallic iris. In another embodiment, the plasma formation tube is positioned coaxially within the resonant cavity and the stored microwave energy is drawn into the plasma formation tube as plasma begins to form therein because the forming plasma represents a dominant power loss (load) for the stored energy.

    摘要翻译: 长的等离子体形成管嵌入高磁场中,磁场线轴向通过管,并且管被放置在谐振腔的近处或内部。 谐振腔中的电磁能量共振表示存储的微波能量。 存储的微波能量的功率密度是谐振腔的横截面面积的函数。 存储的微波能量的一部分被集中以增加其功率密度,并且耦合到等离子体形成管中,该管具有比谐振腔更小的横截面面积。 耦合能量激发等离子体形成管中的吹口哨波,其在管内形成等离子体。 在一个实施例中,通过将存储的微波功率通过其形成谐振腔的一端的金属虹膜而集中,等离子体形成管的尖端位于金属虹膜附近。 在另一个实施例中,等离子体形成管同轴地位于谐振腔内,并且由于形成等离子体代表存储能量的主要功率损耗(负载),存储的微波能量被吸入等离子体形成管中。

    Corona discharge treatment
    87.
    发明授权
    Corona discharge treatment 失效
    电晕放电处理

    公开(公告)号:US5194291A

    公开(公告)日:1993-03-16

    申请号:US689295

    申请日:1991-04-22

    IPC分类号: C23C16/505 H01T19/00

    CPC分类号: H01T19/00 C23C16/505

    摘要: Corona discharge treatment apparatus for treating or coating a surface of a conductive substrate includes a high voltage radio frequency power supply and a cable having a number of flexible conductors and other components. The cable has a first end connected to the power supply and a second end wherein the other cable components have been removed and the conductors extend from the remainder of the cable. The free ends of the conductors at the second end are disposed in a general non-parallel arrangement and the free end of each conductor is held in a separate insulator which extends beyond the free end it holds. Each free end is movable independently of the other free ends. The conductive substrate is held beneath the cable second end so that the upper surface is engaged by the insulators. The conductive substrate is grounded, and relative movement is effected between the second cable end and the conductive substrate while a gas mixture is introduced into the area of engagement between the upper surface and insulators.

    摘要翻译: 用于处理或涂覆导电基板的表面的电晕放电处理装置包括高压射频电源和具有多个柔性导体和其它部件的电缆。 电缆具有连接到电源的第一端和第二端,其中其它电缆部件已被移除,并且导体从电缆的其余部分延伸。 导体在第二端的自由端设置在一般的非平行布置中,并且每个导体的自由端保持在分开的绝缘体中,该绝缘体延伸超过其保持的自由端。 每个自由端可独立于其他自由端移动。 导电基板被保持在电缆第二端下方,使得上表面被绝缘体接合。 导电基板接地,并且在第二电缆端和导电基板之间进行相对运动,同时将气体混合物引入到上表面和绝缘体之间的接合区域中。

    Quasi-open magnet configuration for use in magnetic resonance imaging
    88.
    发明授权
    Quasi-open magnet configuration for use in magnetic resonance imaging 失效
    用于磁共振成像的准开放磁体配置

    公开(公告)号:US5117188A

    公开(公告)日:1992-05-26

    申请号:US605563

    申请日:1990-10-29

    申请人: Tihiro Ohkawa

    发明人: Tihiro Ohkawa

    IPC分类号: G01R33/38 G01R33/3873

    CPC分类号: G01R33/3808 G01R33/3873

    摘要: A magnet system used for magnetic resonance imaging comprises a magnetic coil energizable to establish a magnetic field and a contoured insert of ferromagnetic material positioned within the coil. The insert is substantially dish-shaped and has a top surface contoured with radial transitions from a flat portion, to a concave portion, to a convex portion, to provide a uniform magnetic field within a target zone located at the center of the front surface. A method is also disclosed for determining the proper contour to achieve high uniform magnetic field within the target zone.

    摘要翻译: 用于磁共振成像的磁体系统包括可激励以建立磁场的磁性线圈和位于线圈内的铁磁材料的轮廓插入物。 插入件基本上是碟形的并且具有从平坦部分到凹部到凸部的径向过渡的顶表面,以在位于前表面的中心的目标区域内提供均匀的磁场。 还公开了一种用于确定适当轮廓以在目标区域内实现高均匀磁场的方法。

    Deposition of synthetic diamonds
    89.
    发明授权
    Deposition of synthetic diamonds 失效
    沉积人造钻石

    公开(公告)号:US5023109A

    公开(公告)日:1991-06-11

    申请号:US403284

    申请日:1989-09-06

    摘要: Synthetic diamond crystals and films are deposited on a pair of uniformly spaced apart facing plates made of silicon, molybdenum or boron in elemental, nitride or carbide form. The plates are suitably supported within a totally thermally insulated chamber where a pressure of about 10 torr or less is maintained in the form of an atmosphere which includes a carbon source and a major portion of hydrogen, and preferably includes oxygen in equal amount to the carbon. By supplying sufficient microwave power to create a plasma and a uniform temperature of about 950.degree. C. at the plate surfaces, diamond crystals economically grow on the surfaces of the facing plates. Preferably, either the plates or the backing sections thereof have a relatively high thermal conductivity so as to maintain a uniform temperature across the entire plate surface areas.

    摘要翻译: 将合成金刚石晶体和薄膜沉积在由硅,钼或硼以元素,氮化物或碳化物形式制成的一对均匀间隔开的面对板上。 板被适当地支撑在完全绝热的室中,其中约10托或更低的压力保持为包括碳源和大部分氢气的气氛的形式,并且优选地包括等于碳的氧 。 通过提供足够的微波功率以在板表面产生等离子体和约950℃的均匀温度,金刚石晶体在面板的表面上经济地生长。 优选地,板或其背衬部分具有相对高的导热性,以便在整个板表面区域上保持均匀的温度。

    Acoustically fluidized bed of fine particles
    90.
    发明授权
    Acoustically fluidized bed of fine particles 失效
    声流化床细颗粒

    公开(公告)号:US4948497A

    公开(公告)日:1990-08-14

    申请号:US195203

    申请日:1988-05-18

    申请人: Tihiro Ohkawa

    发明人: Tihiro Ohkawa

    IPC分类号: B01J8/40 B07B13/04 B07B13/08

    CPC分类号: B07B13/08 B01J8/40 B07B13/04

    摘要: An apparatus to acoustically fluidize a bed of fine particles comprises a generally box-shaped hollow chamber. An acoustic source is located at the bottom of the chamber and a convection inhibiting heater is located at the top of the chamber. An acoustic wave is directed from the source into the chamber to levitate and suspend fine particles within the chamber at determinable distances from the acoustic source according to the intensity and frequency of the acoustic wave.

    摘要翻译: 用于使细颗粒床声学流化的装置包括通常为箱形的中空室。 声源位于腔室的底部,并且对流抑制加热器位于腔室的顶部。 根据声波的强度和频率,将声波从源引导到腔室中,以便以与声源可确定的距离悬浮并悬浮在腔室内的细颗粒。