利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

138 条记录 (耗时 0.056 秒)

    Enzymatic detection techniques
    81.
    发明申请
    Enzymatic detection techniques 有权
    酶检测技术

    公开(公告)号：US20070238102A1

    公开(公告)日：2007-10-11

    申请号：US11399687

    申请日：2006-04-06

    申请人： Xuedong Song

    发明人： Xuedong Song

    IPC分类号： C12Q1/68 ,  G01N33/53 ,  C12Q1/48 ,  C12M3/00

    CPC分类号： C12Q1/00 ,  G01N33/558

    摘要： A diagnostic test kit for detecting the presence or quantity of an enzyme or enzyme inhibitor is provided. The diagnostic kit utilizes substrate conjugates to facilitate the detection of the enzyme or enzyme inhibitor via direct detection of the substrate and/or a product formed in an enzyme-catalyzed reaction of the substrate. The substrate conjugates include a substrate joined (e.g., covalently bonded, physically adsorbed, etc.) to a reporter. In one embodiment, for example, a peptide, protein, or glycoprotein substrate is joined to a reporter (e.g., dyed latex particle). In this embodiment, the substrate provides a cleavage target for an enzyme. Specifically, upon contacting the substrate conjugate, the enzyme catalyzes a reaction with the substrate and forms a product conjugate that includes the product of the enzyme catalyzed reaction joined to the reporter. The signal exhibited by the reporters may then be used to indicate the presence or quantity of an enzyme or enzyme inhibitor within the test sample.

    摘要翻译： 提供了用于检测酶或酶抑制剂的存在或数量的诊断测试试剂盒。 诊断试剂盒利用底物缀合物，以便通过直接检测底物和/或在酶催化的底物反应中形成的产物来促进酶或酶抑制剂的检测。 底物缀合物包括与报告物结合（例如共价键合，物理吸附等）的底物。 在一个实施方案中，例如，将肽，蛋白质或糖蛋白底物与报告物（例如，染色的胶乳颗粒）连接。 在该实施方案中，底物提供酶的切割靶。 具体地说，在接触底物缀合物时，酶催化与底物的反应，并形成包含与报告物连接的酶催化反应的产物的产物缀合物。 记者所展示的信号可用于指示测试样品中酶或酶抑制剂的存在或数量。

    Magnetic enzyme detection techniques
    83.
    发明申请
    Magnetic enzyme detection techniques 有权
    磁性酶检测技术

    公开(公告)号：US20060057661A1

    公开(公告)日：2006-03-16

    申请号：US10881316

    申请日：2004-06-30

    申请人： Xuedong Song ,  Shu-Ping Yang ,  Rosann Kaylor

    发明人： Xuedong Song ,  Shu-Ping Yang ,  Rosann Kaylor

    IPC分类号： C12Q1/68 ,  C12Q1/26

    CPC分类号： G01N33/558 ,  C12Q1/04 ,  G01N33/543 ,  G01N33/54326 ,  G01N33/58 ,  G01N33/68

    摘要： A diagnostic test kit for detecting the presence or quantity of an enzyme or enzyme inhibitor is provided. The diagnostic kit utilizes reactive complexes to facilitate the detection of the enzyme or enzyme inhibitor. The reactive complexes include a substrate joined (e.g., covalently bonded, physically adsorbed, etc.) to a reporter and magnetic substance. In one embodiment, for example, a peptide, protein, or glycoprotein substrate is joined to a reporter (e.g., dyed latex particle) and magnetic particle. In this embodiment, the substrate provides a cleavage target for a proteolytic enzyme. Specifically, upon contacting the reactive complexes, the proteolytic enzyme cleaves the substrate and releases the reporter and/or magnetic particle. The signal exhibited by the released reporters may then be used to indicate the presence or quantity of an enzyme or enzyme inhibitor within the test sample.

    摘要翻译： 提供了用于检测酶或酶抑制剂的存在或数量的诊断测试试剂盒。 诊断试剂盒利用反应性配合物来促进酶或酶抑制剂的检测。 反应性配合物包括与报告物和磁性物质连接（例如共价键合，物理吸附等）的底物。 在一个实施方案中，例如，将肽，蛋白质或糖蛋白底物连接到报告物（例如，染色的胶乳颗粒）和磁性颗粒。 在该实施方案中，底物提供蛋白水解酶的切割靶。 具体地，当与反应性配合物接触时，蛋白水解酶切割底物并释放报告物和/或磁性颗粒。 由释放的记者展示的信号可以用于指示测试样品中酶或酶抑制剂的存在或数量。

    Membrane-based lateral flow assay devices that utilize phosphorescent detection
    85.
    发明申请
    Membrane-based lateral flow assay devices that utilize phosphorescent detection 审中-公开
    利用磷光检测的基于膜的侧流测定装置

    公开(公告)号：US20050112703A1

    公开(公告)日：2005-05-26

    申请号：US10718989

    申请日：2003-11-21

    申请人： Xuedong Song

    发明人： Xuedong Song

    IPC分类号： C07D487/22 ,  C12M1/34 ,  G01N33/53 ,  G01N33/537 ,  G01N33/543 ,  G01N33/558 ,  G01N33/58

    CPC分类号： G01N33/558 ,  G01N21/6428 ,  G01N33/5302 ,  G01N33/54313 ,  G01N33/54393 ,  G01N33/582 ,  G01N33/587 ,  Y10S435/805 ,  Y10S435/81 ,  Y10S435/97 ,  Y10S436/805 ,  Y10S436/81

    摘要： A lateral flow, membrane-based assay device for detecting the presence or quantity of an analyte residing in a test sample is provided. The device utilizes phosphorescence to detect the signals generated by excited phosphorescent labels. The labels may have a long emission lifetime so that background interference from many sources, such as scattered light and autofluorescence, is practically eliminated during detection. In addition, the phosphorescent labels may be encapsulated within particles to shield the labels from quenchers, such as oxygen or water, which might disrupt the phosphorescent signal.

    摘要翻译： 提供了用于检测驻留在测试样品中的分析物的存在或量的侧向流动的基于膜的测定装置。 该器件利用磷光来检测激发的磷光标记产生的信号。 标签可能具有长的发光寿命，从而在检测期间实际上消除了许多来源的背景干扰，例如散射光和自发荧光。 此外，磷光标记物可以被包封在颗粒内以将标记物遮蔽猝灭剂，例如氧气或水，这可能会破坏磷光信号。

    Absorbent products with wetness sensors
    86.
    发明授权
    Absorbent products with wetness sensors 有权
    带湿度传感器的吸湿产品

    公开(公告)号：US09554948B2

    公开(公告)日：2017-01-31

    申请号：US12491701

    申请日：2009-06-25

    申请人： Xuedong Song ,  Andrew M. Long ,  WanDuk Lee ,  Jun Mo Gil

    发明人： Xuedong Song ,  Andrew M. Long ,  WanDuk Lee ,  Jun Mo Gil

    IPC分类号： A61F13/15 ,  A61F13/42

    CPC分类号： A61F13/42 ,  Y10T428/24934 ,  Y10T428/31993

    摘要： A sensor that is sensitive to the presence of aqueous-based fluids is described. The sensor has a wetness indicating material immobilized or printed on a substrate. The indicating material contains at least one electron-donating leuco dye and one electron deficient receptor, and exhibits a visual signal (e.g., vivid or strong color intensity) in a dry state, which fades or disappears when in contact with a water-containing liquid. An absorbent article incorporating such a sensor to communicate to a user that the article has been exposed to water-containing fluids is also described.

    摘要翻译： 描述了对含水基流体的存在敏感的传感器。 传感器具有固定或印刷在基底上的湿指示材料。 指示材料含有至少一种给电子无色染料和一种缺电子受体，并且在干燥状态下呈现视觉信号（例如，生动或强烈的色彩强度），当与含水液体接触时，该信号消失或消失 。 还描述了一种吸收制品，其结合了这种传感器，以向使用者传达物品已经暴露于含水流体。

    Diagnostic test kits employing an internal calibration system
    87.
    发明授权
    Diagnostic test kits employing an internal calibration system 有权
    使用内部校准系统的诊断测试套件

    公开(公告)号：US08932878B2

    公开(公告)日：2015-01-13

    申请号：US13076497

    申请日：2011-03-31

    申请人： Xuedong Song ,  Chibuese Obi Chidebelu-Eze ,  Rosann Marie Mathews Kaylor

    发明人： Xuedong Song ,  Chibuese Obi Chidebelu-Eze ,  Rosann Marie Mathews Kaylor

    IPC分类号： G01N33/558

    CPC分类号： G01N33/558 ,  Y10T436/10 ,  Y10T436/105831

    摘要： A diagnostic test kit that employs a lateral flow assay device and a plurality of assay reagents for detecting a test analyte within a test sample is disclosed. The assay reagents include detection probes that are capable of producing a detection signal representing the presence or quantity of the test analyte in the test sample. To further enhance detection accuracy, calibration probes are also used that are capable of producing a calibration signal representing the presence or quantity of a calibration analyte. The calibration signal may be utilized to calibrate the detection signal.

    摘要翻译： 公开了一种使用横向流动测定装置和用于检测测试样品内的测试分析物的多种测定试剂的诊断测试试剂盒。 测定试剂包括能够产生表示测试样品中测试分析物的存在或数量的检测信号的检测探针。 为了进一步提高检测精度，还可以使用能够产生表示校准分析物的存在或数量的校准信号的校准探针。 校准信号可用于校准检测信号。

    Color-changing composition and material
    90.
    发明授权
    Color-changing composition and material 有权
    变色组合物和材料

    公开(公告)号：US08754005B2

    公开(公告)日：2014-06-17

    申请号：US13596605

    申请日：2012-08-28

    申请人： JunMo Gil ,  Ning Wei ,  JinHo Ryu ,  Xuedong Song

    发明人： JunMo Gil ,  Ning Wei ,  JinHo Ryu ,  Xuedong Song

    IPC分类号： B41M1/40 ,  B41M5/00 ,  A61F13/42 ,  A61L15/56 ,  G01N21/81 ,  G01N31/22

    CPC分类号： C09D11/50 ,  A61F13/42 ,  A61F2013/422 ,  C09D11/037

    摘要： The present disclosure relates to a color-changing composition and to a substrate having the color-changing compositions disposed thereon. The color-changing composition includes a leuco dye, a color-developer and a desensitizer. The color-changing composition changes from a colorless or largely colorless composition to color upon being wetted with an aqueous liquid. The color-changing composition remains colorless or largely colorless prior to exposure to high relative humidity conditions.

    摘要翻译： 本公开涉及一种变色组合物和其上设置有变色组合物的基底。 变色组合物包括无色染料，显色剂和脱敏剂。 颜色变化组合物在用含水液体润湿时从无色或基本无色的组合物变为颜色。 变色组合物在暴露于高相对湿度条件之前保持无色或大部分无色。