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    APPARATUS AND METHOD FOR SEPARATING SINGLE CELLS
    81.
    发明申请
    APPARATUS AND METHOD FOR SEPARATING SINGLE CELLS 审中-公开

    公开(公告)号：US20190227021A1

    公开(公告)日：2019-07-25

    申请号：US16311619

    申请日：2015-05-14

    申请人： INJE UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION

    发明人： Ki-Ho Han ,  Jin-Ho Kim

    IPC分类号： G01N27/30 ,  B01L3/00

    摘要： The present invention relates to an apparatus and a method for separating single cells, and the apparatus includes: a fluid channel which has an upper panel and a lower panel and has a flow path which is formed between the upper panel and the lower panel and configured to convey a sample including a single cell; a single cell measuring unit which includes first and second electrodes which are provided on the fluid channel so as to be spaced apart from each other at a predetermined interval and apply electrical signals to the sample being conveyed through the flow path of the fluid channel, and a detection electrode which is provided between the first electrode and the second electrode and detects the single cell in the sample being conveyed through the flow path, such that the single cell measuring unit applies the electrical signals to the sample being conveyed through the flow path, detects the electrical signals of the sample to which the electrical signals are applied, and detects whether there is the single cell in the sample; and a single cell separation control device which outputs a single cell separation control signal when the single cell is detected by the detection electrode. Therefore, there is an effect of effectively separating, within a short time, the single cells from the sample including the single cells.

    SEMICYLINDRICAL OSTEOTOMY DEVICE
    83.
    发明申请
    SEMICYLINDRICAL OSTEOTOMY DEVICE 审中-公开

    公开(公告)号：US20190167277A1

    公开(公告)日：2019-06-06

    申请号：US16321044

    申请日：2017-08-10

    申请人： INJE UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION

    发明人： Sang Won MOON ,  Sung Hyuk MOON

    IPC分类号： A61B17/16 ,  A61B17/17

    摘要： Provided is a semi-cylindrical osteotomy device including: a guide portion where a tibia accommodating space in which a tibia is accommodated is formed; a cutter portion moving in the tibia accommodating space and cutting the tibia while moving along an inner circumferential surface of the guide portion; and a driving unit driving the cutter portion. According to the semi-cylindrical osteotomy device, stability of a surgery is increased by inserting the guide portion by approaching a side surface of the tibia to minimize an exposed portion of a bone. Also, a wire saw moves along a slit of the guide portion, and thus a cut bone surface of a semi-cylindrical shape is easily and quickly formed.

    CANNULATED SCREW
    85.
    发明申请
    CANNULATED SCREW 审中-公开

    公开(公告)号：US20190021775A1

    公开(公告)日：2019-01-24

    申请号：US16066671

    申请日：2016-07-22

    申请人： INJE UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION

    发明人： Yonguk KWON

    IPC分类号： A61B17/86 ,  A61B17/88

    摘要： A cannulated screw includes: a body portion that comprises a screw thread formed by protruding along an outer surface and has a through-hole at a center of the body portion; and a head portion that has one side surface combined to one end of the body portion, another side surface formed in a curved surface in which a center portion has a concave shape, and a connection hole communicating with the through-hole at a center of the head portion.

    PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING OCULAR SURFACE DISEASE
    88.
    发明申请
    PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING OCULAR SURFACE DISEASE 有权
    用于预防或治疗眼部表面疾病的药物组合物

    公开(公告)号：US20160215018A1

    公开(公告)日：2016-07-28

    申请号：US14979511

    申请日：2015-12-27

    申请人： INJE UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION

    发明人： Jae Wook Yang ,  Hye Sook Lee ,  Ji Hyun Lee ,  Yoon Jin Lee

    IPC分类号： C07K7/06

    CPC分类号： C07K7/06 ,  A61K9/0048 ,  A61K38/00 ,  C07K14/78

    摘要： A pharmaceutical composition for preventing or treating an ocular surface disease is disclosed, wherein the pharmaceutical composition includes, as an active component, collagen type II α1 based peptide GQDGLAGPK isolated from chondrocyte-derived extracellular matrix (CDEM). In an alkaline burn animal mode treated with peptide GQDGLAGPK, the occurrence of corneal opacification is reduced as well as the expression of angiogenic factors (e.g., CD31 and VEGF). In addition, the expression of inflammatory markers (e.g., macrophages, TNFα, ICAM-1, VCAM-1, and MMP-9) is reduced while the expression of inflammation-inducing factor (e,g,, NF-κB) is suppressed. The peptide GQDGLAGPK according to the present invention may be applied to a pharmaceutical composition for preventing or treating an ocular surface disease (e.g., a corneal disease).

    摘要翻译： 公开了用于预防或治疗眼表疾病的药物组合物，其中所述药物组合物包含作为活性成分的从软骨细胞衍生的细胞外基质（CDEM）分离的II型α1基肽GQDGLAGPK。 在用肽GQDGLAGPK处理的碱性烧伤动物模式中，角膜混浊的发生以及血管生成因子（例如CD31和VEGF）的表达降低。 此外，炎性标志物（例如，巨噬细胞，TNFα，ICAM-1，VCAM-1和MMP-9）的表达减少，而炎症诱导因子（e，g，NF-κB）的表达被抑制 。 根据本发明的肽GQDGLAGPK可以用于预防或治疗眼表疾病（例如角膜疾病）的药物组合物。

    CELL MODEL FOR NEOVASCULAR DISEASES USING EBV-INFECTED HUMAN CORNEAL EPITHELIAL CELLS
    89.
    发明申请
    CELL MODEL FOR NEOVASCULAR DISEASES USING EBV-INFECTED HUMAN CORNEAL EPITHELIAL CELLS 有权
    使用EBV感染的人角膜上皮细胞的新生血管疾病细胞模型

    公开(公告)号：US20160116458A1

    公开(公告)日：2016-04-28

    申请号：US14894522

    申请日：2013-12-18

    申请人： INJE UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION

    发明人： Dae Young HUR ,  Ga Bin PARK ,  Yeong Seok KIM ,  Dae Jin KIM ,  Seong Han KIM ,  Hyun Kyung LEE ,  Jae Wook YANG

    IPC分类号： G01N33/50 ,  G01N33/569 ,  C12N5/079

    CPC分类号： G01N33/5047 ,  C12N5/0621 ,  G01N33/5044 ,  G01N33/56994 ,  G01N2333/05 ,  G01N2800/16 ,  G01N2800/7014

    摘要： The present invention relates to a cell model for diseases associated with corneal neovascularization by using Epstein Barr virus (EBV)-infected human corneal epithelial cells (HCECs). Provided are a method for preparing a cell model for diseases associated with corneal neovascularization by using EBV-infected HCECs, the method including: infecting HCECs with EBV; culturing the infected HCECs; and determining whether the cultured HCECs are infected with EBV. In addition, provided is a method for screening diseases associated with corneal neovascularization prepared by the cell model for diseases associated with corneal neovascularization.

    摘要翻译： 本发明涉及通过使用爱泼斯坦巴尔病毒（EBV）感染的人角膜上皮细胞（HCECs）与角膜新血管形成相关的疾病的细胞模型。 提供一种通过使用EBV感染的HCEC制备与角膜新生血管形成相关疾病的细胞模型的方法，所述方法包括：用EBV感染HCEC; 培养受感染的HCECs; 并确定培养的HCECs是否被EBV感染。 此外，提供了用于筛选与由角膜新生血管形成相关的疾病的细胞模型制备的角膜新生血管形成相关疾病的方法。