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公开(公告)号：US12085528B2
公开(公告)日：2024-09-10
申请号：US16311619
申请日：2015-05-14
Inventor： Ki-Ho Han , Jin-Ho Kim
IPC: G01N27/30 , B01L3/00 , B01L3/02 , C12M1/00 , C12M1/34 , C12M1/42 , G01N15/01 , G01N15/10 , G01N15/14
CPC classification number: G01N27/30 , B01L3/502715 , B01L3/50273 , B01L3/502753 , B01L3/502761 , C12M1/34 , C12M1/42 , C12M47/04 , G01N15/10 , B01L3/0241 , B01L2200/0642 , B01L2200/0668 , B01L2300/0645 , B01L2300/0654 , B01L2400/0487 , G01N15/01 , G01N2015/1024 , G01N2015/1029 , G01N15/1459
Abstract: An apparatus and method for separating single cells. The apparatus includes: a fluid channel having an upper panel, a lower panel, and a flow path formed therebetween that is configured to convey a sample including a single cell; a single cell measuring unit including first and second electrodes provided on the fluid channel in a predetermined spaced relationship for applying electrical signals to the sample in the flow path, and a detection electrode provided between the first and second electrodes to detect the single cell in the sample in the flow path, such that the single cell measuring unit applies the electrical signals to the sample in the flow path, detects the electrical signals of the sample, and detects whether there is the single cell in the sample; and a single cell separation control device which outputs a single cell separation control signal when the single cell is detected by the detection electrode.
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Patent Agency Ranking
2.发明授权公开(公告)号：US12019094B2
公开(公告)日：2024-06-25
申请号：US16603013
申请日：2017-08-21
Inventor： Ki-Ho Han , Jin-Ho Kim
CPC classification number: G01P5/12 , B01L3/502715 , B01L2200/0689 , B01L2300/0627 , B01L2300/0645 , B01L2300/0663 , B01L2300/12 , B01L2300/14 , B01L2300/1805
Abstract: Provided is a device for measuring a microfluid flow velocity, having a structure separable by an ultra-thin film, the device including a first panel including a flow velocity measurement structure configured to measure a flow velocity of a fluid, a second panel configured to be separated from the first panel and including a microfluid channel through which a sample passes, and the ultra-thin film formed in a portion where the first panel and the second panel adjoin each other, the ultra-thin film being configured to separate the first panel and the second panel so that the sample passing through the microfluid channel does not come into direct contact with the flow velocity measurement structure, in which the first panel including the flow velocity measurement structure is usable multiple times repeatedly.
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公开(公告)号：US12105116B2
公开(公告)日：2024-10-01
申请号：US17144301
申请日：2021-01-08
Inventor： Ki-Ho Han , Hyung-Seok Cho , Jin-Ho Kim
CPC classification number: G01P5/12 , B01L3/502707 , B01L3/502746 , G01F1/692 , B01L3/502723 , B01L2200/0684 , B01L2200/12 , B01L2300/0645 , B01L2300/0681 , B01L2300/0816 , B01L2300/0887 , B01L2300/123 , B01L2300/165 , B01L2300/1827 , B01L2400/049 , B01L2400/086
Abstract: A disposable flow velocity measuring device including: a first panel having a flow velocity measuring structure, and having additional micro protrusion patterns formed around the flow velocity measuring structure; a second panel separated from the first panel, and including a fluid channel through which a sample passes; a porous ultra-thin film formed on a portion, at which the first panel and the second panel come in contact with each other, so that the sample passing through the fluid channel does not directly come in contact with the flow velocity measuring structure, thereby separating the first panel and the second panel and removing micro-air bubbles included in the fluid passing through the fluid channel; a non-porous ultra-thin film formed in a partial region of the porous ultra-thin film; and a negative pressure forming unit for applying negative pressure in order to adsorb the first panel and the second panel.
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公开(公告)号：US20240280604A1
公开(公告)日：2024-08-22
申请号：US18649988
申请日：2024-04-29
Inventor： Ki-Ho HAN , Hyung-Seok Cho , Jin-Ho Kim
CPC classification number: G01P5/12 , B01L3/502707 , B01L3/502746 , G01F1/692 , B01L2200/0684 , B01L2200/12 , B01L2300/123 , B01L2300/165 , B01L2400/086
Abstract: A disposable flow velocity measuring device including: a first panel having a flow velocity measuring structure, and having additional micro protrusion patterns formed around the flow velocity measuring structure; a second panel separated from the first panel, and including a fluid channel through which a sample passes; a porous ultra-thin film formed on a portion, at which the first panel and the second panel come in contact with each other, so that the sample passing through the fluid channel does not directly come in contact with the flow velocity measuring structure, thereby separating the first panel and the second panel and removing micro-air bubbles included in the fluid passing through the fluid channel; a non-porous ultra-thin film formed in a partial region of the porous ultra-thin film; and a negative pressure forming means for applying negative pressure in order to adsorb the first panel and the second panel.
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公开(公告)号：US12059678B2
公开(公告)日：2024-08-13
申请号：US17281297
申请日：2019-11-19
Inventor： Ki-Ho Han , Jin-Ho Kim
IPC: B01L3/00
CPC classification number: B01L3/502715 , B01L3/502761 , B01L2200/0652 , B01L2300/0645 , B01L2300/0816 , B01L2300/0848 , B01L2300/0861 , B01L2300/0887 , B01L2300/1827 , B01L2400/043 , B01L2400/0487
Abstract: Provided is a microfluidic device including a lower panel including flow velocity measuring structures for measuring a flow velocity of a fluid; an upper panel separated from the lower panel and including a microfluidic channel through which a sample passes; a thin film provided at a portion where the lower panel and the upper panel adjoin each other in order to prevent the sample passing through the microfluidic channel from coming into direct contact with the flow velocity measuring structures, the thin film being configured to separate the lower panel and the upper panel to enable the lower panel to be repeatedly used multiple times; a specific functional unit configured to perform a specific operation on the sample passing through the microfluidic channel; and a negative pressure forming means configured to suck the lower panel and the upper panel with a negative pressure.
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公开(公告)号：US20190227021A1
公开(公告)日：2019-07-25
申请号：US16311619
申请日：2015-05-14
Inventor： Ki-Ho Han , Jin-Ho Kim
Abstract: The present invention relates to an apparatus and a method for separating single cells, and the apparatus includes: a fluid channel which has an upper panel and a lower panel and has a flow path which is formed between the upper panel and the lower panel and configured to convey a sample including a single cell; a single cell measuring unit which includes first and second electrodes which are provided on the fluid channel so as to be spaced apart from each other at a predetermined interval and apply electrical signals to the sample being conveyed through the flow path of the fluid channel, and a detection electrode which is provided between the first electrode and the second electrode and detects the single cell in the sample being conveyed through the flow path, such that the single cell measuring unit applies the electrical signals to the sample being conveyed through the flow path, detects the electrical signals of the sample to which the electrical signals are applied, and detects whether there is the single cell in the sample; and a single cell separation control device which outputs a single cell separation control signal when the single cell is detected by the detection electrode. Therefore, there is an effect of effectively separating, within a short time, the single cells from the sample including the single cells.
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