公开(公告)号：US5049589A

公开(公告)日：1991-09-17

申请号：US452436

申请日：1989-12-19

Applicant: David Lavie ,  Michel Revel ,  Dalia Rotman ,  Vincent Vande Velde

Inventor： David Lavie ,  Michel Revel ,  Dalia Rotman ,  Vincent Vande Velde

IPC: A61K31/12 ,  A61K45/08

CPC classification number: A61K31/12

Abstract: The invention relates to antiviral compositions of matter containing as active ingredient hypericin or pseudohypericin. The novel compositions are of special use in the treatment of, and alleviation of symptons of various diseases caused by viruses such as vesicular stomatitis, influenza, herpes simplex, HSV-1 and HSV-2. The mode of activity seems to be by inhibition of RNA synthesis and interfering with virus replication. The pharmaceutical compositions can be applied by a variety of routes. Topical applications have proved to be effective against a variety of viral afflictions.

公开(公告)号：US4861705A

公开(公告)日：1989-08-29

申请号：US922021

申请日：1986-10-22

Applicant: Shlomo Margel

Inventor： Shlomo Margel

IPC: B01D15/00 ,  B01J20/22 ,  B01J39/18 ,  B01J41/10 ,  C07K1/22 ,  C07K14/42 ,  C07K14/62 ,  C07K14/76 ,  C07K16/06 ,  C08L5/12 ,  C12N9/76 ,  G01N33/543

CPC classification number: G01N33/5434 ,  B01D15/00 ,  B01J20/22 ,  B01J39/18 ,  B01J41/10 ,  C07K1/22 ,  C07K14/42 ,  C07K14/62 ,  C07K14/76 ,  C07K16/065 ,  C08L5/12 ,  C12N9/6427 ,  G01N33/54313 ,  B01D15/3804 ,  G01N2400/32 ,  G01N2446/10 ,  G01N2446/86 ,  Y10S435/803

Abstract: There are provided magnetic and non-magnetic agarose and agar polyaldehyde beads with diameters ranging from 40 microns up to 1 cm, and processes for the synthesis of such beads. The polyaldehyde compounds e.g. polyacrolein, polymethacrolein or polyglutaraldehyde, were used as microspheres or as powders. The agarose-polyaldehyde beads are capable of covalently binding in a single step, through their aldehyde groups, compounds containing primary amino groups or thiol groups, such as proteins, antibodies, enzymes and drugs. The beads are useful for various biological applications e.g. affinity chromatography, hemoperfusion, ion exchange resins, cell labeling, diagnostic purposes and cell separation.

Abstract translation: 提供直径范围从40微米至1厘米的磁性和非磁性琼脂糖和琼脂聚醛珠，以及用于合成这种珠的方法。 多醛化合物例如 聚丙烯醛，聚甲基丙烯醛或聚戊二醛用作微球或粉末。 琼脂糖 - 多醛珠能够在单一步骤中通过其醛基，含有伯氨基或硫醇基团的化合物如蛋白质，抗体，酶和药物共价结合。 珠可用于各种生物应用，例如 亲和层析，血液灌注，离子交换树脂，细胞标记，诊断目的和细胞分离。

公开(公告)号：US4533252A

公开(公告)日：1985-08-06

申请号：US381767

申请日：1982-05-25

Applicant: David Cahen ,  Shmuel Malkin ,  Benjamin Horwitz ,  Gerard Bults

Inventor： David Cahen ,  Shmuel Malkin ,  Benjamin Horwitz ,  Gerard Bults

IPC: G01N21/17 ,  G02F

CPC classification number: G01N21/1702 ,  G01N2021/8466

Abstract: A portable device for photoacoustic spectroscopy of plants and other photosynthetic tissues, cells and organelles is provided. There is further provided a method of measuring photosynthesis of such tissues, cells and organelles.

Abstract translation: 提供了一种用于植物和其他光合组织，细胞和细胞器的光声光谱的便携式装置。 还提供了测量这些组织，细胞和细胞器的光合作用的方法。

公开(公告)号：US4298384A

公开(公告)日：1981-11-03

申请号：US58707

申请日：1979-07-18

Applicant: Yael Allingham ,  David Vofsi

Inventor： Yael Allingham ,  David Vofsi

IPC: A01N41/12 ,  C09D5/08 ,  C09D5/16 ,  C09D5/14

CPC classification number: C09D5/1625 ,  Y10S428/907 ,  Y10T428/662

Abstract: The present invention relates to antifouling paints for marine use comprising a conventional paint base containing as active ingredient a compound of the formula ##STR1## wherein X is selected from chlorine and bromine,Y is selected from hydrogen and lower alkyl, andZ is selected from --COOR wherein R is lower alkyl, and --CN, possibly in combination with a conventional antifouling agent, and to the protection of marine structures and marine vessels which comprises applying such an antifouling paint to such structures and vessels.

Abstract translation: 本发明涉及用于海洋用途的防污涂料，其包含常规油漆基料，其含有作为活性成分的下式化合物，其中X选自氯和溴，Y选自氢和低级烷基，Z选自 -COOR，其中R是低级烷基，-CN，可能与常规的防污剂组合，以及保护海洋结构和海洋容器，其包括将这种防污涂料应用于这种结构和容器。

公开(公告)号：US4115949A

公开(公告)日：1978-09-26

申请号：US800521

申请日：1977-05-25

Applicant: Mordhay Avron ,  Ami Ben-Amotz

Inventor： Mordhay Avron ,  Ami Ben-Amotz

IPC: C12N1/00 ,  C12N1/12 ,  C12P7/20 ,  C12P21/00 ,  C12P23/00 ,  C12R1/89 ,  A01G7/00 ,  A01G33/02

CPC classification number: C12R1/89 ,  C12N1/12 ,  C12P23/00 ,  C12P7/20 ,  Y02P60/247

Abstract: A process for the production of glycerol and proteinous substances of nutritive value which comprises cultivating algae of the Dunaliella species in a nutrient medium containing the mineral requirements of growth of the algae, said nutrient medium having a sodium chloride content of at least 1.5 M, the cultivation being effected while an adequate supply of carbon dioxide is provided and continued until a maximum concentration of algae is obtained, and continuing the cultivation of the algae in a nutrient medium having a content of sodium chloride of at least 3 M, cultivating the algae in this second nutrient medium until a high glycerol content is established, harvesting the algae, recovering from same the glycerol, and recovering the residue having a high protein content.

Abstract translation: 一种用于生产营养价值的甘油和蛋白质物质的方法，其包括在含有藻类生长矿物质的营养培养基中培养杜氏盐藻藻类，所述营养培养基的氯化钠含量至少为1.5M， 在充分供应二氧化碳的同时进行培养，并持续直到获得最大浓度的藻类，并且在含有至少3M氯化钠的营养培养基中继续培养藻类，培养藻类 这种第二营养培养基直到建立高甘油含量，收获藻类，从甘油中回收，并回收具有高蛋白质含量的残余物。

公开(公告)号：US08802675B2

公开(公告)日：2014-08-12

申请号：US13146975

申请日：2010-01-31

Applicant: Moussa B. H. Youdim ,  Mati Fridkin ,  Hailin Zheng

Inventor： Moussa B. H. Youdim ,  Mati Fridkin ,  Hailin Zheng

IPC: A01N43/64 ,  A61K31/53 ,  A01N43/58 ,  A01N43/60 ,  A61K31/50 ,  A61K31/495 ,  A61K31/497 ,  A01N43/54 ,  A61K31/517 ,  A01N43/42 ,  A61K31/47 ,  A01N43/40 ,  A61K31/445 ,  A01N47/10 ,  A61K31/27 ,  A01N33/02 ,  A61K31/135 ,  A61K31/13 ,  C07D253/08 ,  C07D487/00 ,  C07D239/72 ,  C07D241/36 ,  C07D401/00 ,  C07D215/16 ,  C07D405/00 ,  C07D409/00 ,  C07D411/00 ,  C07D413/00 ,  C07D417/00 ,  C07D419/00 ,  C07D421/00 ,  C07C211/00

CPC classification number: C07C259/10 ,  C07C211/38 ,  C07C271/40 ,  C07C2602/08 ,  C07C2603/74 ,  C07D215/34 ,  C07D401/06 ,  C07D401/12

Abstract: Multifunctional compounds are provided, comprising two or more functional moieties selected from: (i) a moiety that imparts an iron chelator function; (ii) a moiety that imparts a neuroprotective function; (iii) a moiety that imparts combined antiapoptotic, neuroprotective and/or neurorestorative functions; (iv) a moiety that imparts brain MAO inhibition, preferably with little or no MAO inhibition in liver and small intestine; (v) a moiety that imparts cholinesterase inhibitory function; and (vi) a moiety that imparts an N-methyl-D-aspartic acid receptor (NMDAR) inhibition, and pharmaceutically acceptable salts and optical isomers thereof. The multifunctional compounds are useful in the treatment or prevention of diseases, disorders or conditions that can be prevented and/or treated by iron chelation therapy, and/or neuroprotection and/or neurorestoration, and/or apoptosis inhibition and/or MAO inhibition and/or cholinesterase inhibition and/or NMADR inhibition. The present invention encompasses compounds of the formulas I to VI.

Abstract translation: 提供多官能化合物，其包含两个或多个选自以下的官能部分：（i）赋予铁螯合剂功能的部分; （ii）赋予神经保护功能的部分; （iii）赋予组合的抗细胞凋亡，神经保护和/或神经恢复功能的部分; （iv）赋予脑MAO抑制的部分，优选在肝脏和小肠中几乎没有MAO抑制作用; （v）赋予胆碱酯酶抑制功能的部分; 和（vi）赋予N-甲基-D-天冬氨酸受体（NMDAR）抑制的部分及其药学上可接受的盐和旋光异构体。 多官能化合物可用于治疗或预防可通过铁螯合治疗和/或神经保护和/或神经恢复，和/或凋亡抑制和/或MAO抑制和/或MAO抑制和/或治疗的/ 或胆碱酯酶抑制和/或NMADR抑制。 本发明包括式I至VI的化合物。

公开(公告)号：US20130043138A1

公开(公告)日：2013-02-21

申请号：US13593009

申请日：2012-08-23

Applicant: Jacob KARNI ,  Gidon Ferdiman ,  Yury Alioshin

Inventor： Jacob KARNI ,  Gidon Ferdiman ,  Yury Alioshin

IPC: C25B1/10 ,  C25B9/08

CPC classification number: C25B1/003 ,  C01B3/04 ,  C01B3/042 ,  C01B13/0203 ,  C01B13/0207 ,  C01B13/0251 ,  C01B2210/0053 ,  C25B9/08 ,  Y02E60/364 ,  Y02E60/366 ,  Y02P20/134

Abstract: The present invention relates to a system comprising a heat source to provide heat at the desired temperature and energy field (e.g. a solar concentrator); an electron source configured and operable to emit electrons; an electric field generator generating an electric field adapted to supply energy sufficient to dissociate gas molecules; and a reaction gas chamber configured and operable to cause interaction between the electrons with the molecules, such that the electrons dissociate the molecules to product compound and ions via dissociative electrons attachment (DEA) within the chamber.

Abstract translation: 本发明涉及一种包括在所需温度和能量场（例如太阳能集中器）提供热量的热源的系统; 配置并可操作以发射电子的电子源; 产生适于提供足以解离气体分子的能量的电场的电场发生器; 以及反应气室，其配置和操作以引起电子与分子之间的相互作用，使得电子通过室内的离散电子附着（DEA）将分子解离成产物化合物和离子。

公开(公告)号：US08288945B2

公开(公告)日：2012-10-16

申请号：US12880107

申请日：2010-09-12

Applicant: Ron Naaman ,  Ben Golan ,  Zeev Fradkin ,  Adam Winkleman ,  Dan Oron

Inventor： Ron Naaman ,  Ben Golan ,  Zeev Fradkin ,  Adam Winkleman ,  Dan Oron

IPC: H01J40/06 ,  H01J9/12

CPC classification number: B81C1/00206 ,  B81C1/00031 ,  B81C2201/0132 ,  B81C2201/115 ,  G03F7/40

Abstract: A method for fabrication of substrate having a nano-scale surface roughness is presented. The method comprises: patterning a surface of a substrate to create an array of spaced-apart regions of a light sensitive material; applying a controllable etching to the patterned surface, said controllable etching being of a predetermined duration selected so as to form a pattern with nano-scale features; and removing the light sensitive material, thereby creating a structure with the nano-scale surface roughness. Silanizing such nano-scale roughness surface with hydrophobic molecules results in the creation of super-hydrophobic properties characterized by both a large contact angle and a large tilting angle. Also, deposition of a photo-active material on the nano-scale roughness surface results in a photocathode with enhanced photoemission yield. This method also provides for fabrication of a photocathode insensitive to polarization of incident light.

Abstract translation: 提出了一种具有纳米级表面粗糙度的基板的制造方法。 该方法包括：图案化基板的表面以产生光敏材料的间隔开的区域的阵列; 对所述图案化表面施加可控制的蚀刻，所述可控蚀刻具有预定的持续时间，以便形成具有纳米尺度特征的图案; 并去除感光材料，从而产生具有纳米级表面粗糙度的结构。 用疏水分子对这样的纳米级粗糙表面进行硅烷化，导致产生了以接触角大和倾斜角大的特征的超疏水特性。 而且，在纳米级粗糙度表面上沉积光活性材料导致光电阴极具有增强的光电转换率。 该方法还提供对入射光的极化不敏感的光电阴极的制造。

公开(公告)号：US08268138B2

公开(公告)日：2012-09-18

申请号：US13010582

申请日：2011-01-20

Applicant: Jacob Karni ,  Gidon Ferdiman ,  Yury Alioshin

Inventor： Jacob Karni ,  Gidon Ferdiman ,  Yury Alioshin

IPC: C25B9/08 ,  C25B1/10

CPC classification number: C25B1/003 ,  C01B3/04 ,  C01B3/042 ,  C01B13/0203 ,  C01B13/0207 ,  C01B13/0251 ,  C01B2210/0053 ,  C25B9/08 ,  Y02E60/364 ,  Y02E60/366 ,  Y02P20/134

Abstract: The present invention relates to a system comprising a heat source to provide heat at the desired temperature and energy field (e.g. a solar concentrator); an electron source configured and operable to emit electrons; an electric field generator generating an electric field adapted to supply energy sufficient to dissociate gas molecules; and a reaction gas chamber configured and operable to cause interaction between the electrons with the molecules, such that the electrons dissociate the molecules to product compound and ions via dissociative electrons attachment (DEA) within the chamber.

Abstract translation: 本发明涉及一种包括在所需温度和能量场（例如太阳能集中器）提供热量的热源的系统; 配置并可操作以发射电子的电子源; 产生适于提供足以解离气体分子的能量的电场的电场发生器; 以及反应气室，其配置和操作以引起电子与分子之间的相互作用，使得电子通过室内的离散电子附着（DEA）将分子解离成产物化合物和离子。

公开(公告)号：US08217384B2

公开(公告)日：2012-07-10

申请号：US12911641

申请日：2010-10-25

Applicant: Alexander Finkelstein ,  Maxim Khodas ,  Arcadi Shehter

Inventor： Alexander Finkelstein ,  Maxim Khodas ,  Arcadi Shehter

IPC: H01L31/00

CPC classification number: H01L29/205 ,  H01L29/66984

Abstract: A device and method for manipulating a direction of motion of current carriers are presented. The device comprises a structure containing a two-dimensional gas of current carriers configured to define at least one region of inhomogeneity which is characterized by a substantially varying value of at least one parameter from the following: a spin-orbit coupling constant, density of the spin carriers, and a mobility of the gas. The device may be configured and operable to perform spin manipulation of a flux of the spin carrying current carriers to provide at least one of the following types of deviation of said spin-carrying current: spin dependent refraction, spin dependent reflection and spin dependent diffraction on desired deviation angles of a direction of motion of the spin-carrying current carriers being incident on said at least one region of inhomogeneity. The device may also be configured and operable to allow emission of the current carriers from a diffusive region at one side of the region of inhomogeneity to a ballistic region at the opposite side of the region of inhomogeneity to provide the current carriers propagation in multiple directions in the ballistic region with a wide angular range of these directions.

Abstract translation: 提出了一种用于操纵电流载体的运动方向的装置和方法。 该装置包括含有电流载流子的二维气体的结构，该二维气体被配置为限定至少一个不均匀性区域，其特征在于基本上变化了来自以下的至少一个参数的值：自旋轨道耦合常数， 自旋载体和气体的流动性。 该装置可以被配置并且可操作以执行自旋承载电流载流子的磁通的自旋操纵，以提供所述自旋承载电流的以下类型的偏离中的至少一种：自旋依赖折射​​，自旋相关反射和自旋依赖衍射 所述自旋载体载流子的运动方向的期望偏离角入射在所述至少一个不均匀区域上。 该装置还可以被配置和可操作以允许电流载流子从不均匀性区域的一侧的漫射区域发射到不均匀性区域的相反侧的弹道区域，以提供电流载流子在多个方向上的传播 具有这些方向的宽角度范围的弹道区域。