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131 条记录 (耗时 0.015 秒)

    3-[(Chlorophenylsulfonyl)methyl]-1,2,4-oxadiazole-5-carboxylic acid derivatives
    85.
    发明授权
    3-[(Chlorophenylsulfonyl)methyl]-1,2,4-oxadiazole-5-carboxylic acid derivatives 失效
    3- {8（氯苯基磺酰基）甲基{9 -1,2,4-恶二唑-5-羧酸衍生物

    公开(公告)号：US4148801A

    公开(公告)日：1979-04-10

    申请号：US921293

    申请日：1978-07-03

    申请人： Arthur A. Santilli ,  Robert L. Morris

    发明人： Arthur A. Santilli ,  Robert L. Morris

    IPC分类号： C07C259/14 ,  C07D271/06

    CPC分类号： C07D271/06 ,  C07C259/14

    摘要： Disclosed herein are 3-[(chlorophenylsulfonyl)methyl]-1,2,4-oxadiazole-5-carboxylic acid derivatives and 3-[(chlorophenylsulfonyl)ethyl]-1,2,4-oxadiazole-5-carboxylic acid derivatives exhibiting antihypertensive or antiviral activity and having the following formula: ##STR1## wherein: X = 1 or 2; andZ is --OR, --OH, --OK, --ONa, --NHOH, --NHNH.sub.2, --NHNHCOCO.sub.2 R, or --NHNHSO.sub.2 R; andR is --CH.sub.3, --CH.sub.2 CH.sub.3, --CH.sub.2 CH.sub.2 CH.sub.3 or --CH(CH.sub.3).sub.2.

    摘要翻译： 本文公开了表现出抗高血压的3 - [（氯苯基磺酰基）甲基] -1,2,4-恶二唑-5-羧酸衍生物和3 - [（氯苯基磺酰基）乙基] -1,2,4-恶二唑-5-羧酸衍生物 或抗病毒活性，并具有以下分子式：其中：

    Acetamidoxime compounds
    87.
    发明授权
    Acetamidoxime compounds 失效
    乙酰肟化合物

    公开(公告)号：US4041072A

    公开(公告)日：1977-08-09

    申请号：US668061

    申请日：1976-03-18

    申请人： Claude P. Fauran ,  Guy R. Bourgery ,  Claude J. Gouret

    发明人： Claude P. Fauran ,  Guy R. Bourgery ,  Claude J. Gouret

    IPC分类号： A61K31/165 ,  A61K31/15 ,  C07C251/32 ,  C07C259/14 ,  C07C103/28 ,  C07C103/365 ,  C07C103/76

    CPC分类号： C07C259/14

    摘要： Compounds having the formula ##STR1## wherein R is hydrogen, or chlorine, or alkyl having one to 4 carbons, or alkoxy having one to 3 carbons, and R.sub.1 is hydrogen, or ##STR2## or --CONH--R.sub.3, wherein R.sub.2 is hydrogen, or chlorine, or nitro, or alkoxy having no more than 3 carbons, or trifluoromethyl, and R.sub.3 is alkyl having one to 4 carbons, or cycloalkyl having no more than 6 carbons, or phenyl.The compounds are prepared by reacting R-substituted cyano-2 acetanilides with hydroxylamine to obtain compounds in which R.sub.1 is hydrogen, and then reacting with acid chlorides containing R.sub.2 or isocyanates containing R.sub.3. The compounds possess psychtropic properties.

    摘要翻译： 具有式“IMAGE”的化合物，其中R是氢或氯，具有1至4个碳的烷基或具有1至3个碳原子的烷氧基，R 1是氢，或者R 3是-CONH-R 3，其中R 2是氢 或氯或硝基，或不多于3个碳原子的烷氧基，或三氟甲基，R3是具有1-4个碳原子的烷基，或不多于6个碳的烷基或苯基。

    Oxadiazole and oxadiazoline derivatives
    88.
    发明授权
    Oxadiazole and oxadiazoline derivatives 失效
    恶二唑和恶二唑啉衍生物

    公开(公告)号：US4012377A

    公开(公告)日：1977-03-15

    申请号：US556324

    申请日：1975-03-07

    申请人： John Anthony Claisse ,  Gordon Ian Gregory ,  William Kingston Warburton

    发明人： John Anthony Claisse ,  Gordon Ian Gregory ,  William Kingston Warburton

    IPC分类号： C07C45/74 ,  C07C47/24 ,  C07C259/14 ,  C07D271/06 ,  C07D271/07 ,  C07D333/24 ,  C07D333/28

    CPC分类号： C07D271/06 ,  C07C259/14 ,  C07C317/00 ,  C07C323/00 ,  C07C45/74 ,  C07C47/24 ,  C07D271/07 ,  C07D333/24 ,  C07D333/28

    摘要： There are described new compounds of formula ##STR1## in which E is selected from the group consisting of residues of formula ##STR2## in which R" is selected from the group consisting of amino, vinyl, allyl, ethynyl, C.sub.1 -C.sub.5 alkyl, C.sub.1 -C.sub.5 alkoxy, or C.sub.1 -C.sub.5 alkylthio or a C.sub.1 -C.sub.5 alkyl group susbstituted by at least one halogen atom; and hydrogen; in which R.sup.1 and R.sup.2 are each selected from the group consisting of hydrogen, halogen, methyl and ethyl; and R' is selected from substituted phenyl when R" is other than hydrogen, and phenyl, thienyl and substituted phenyl and thienyl when R" is hydrogen.The compounds are useful in the control of parasites.Certain of the compounds have antimicrobial properties.

    摘要翻译： 描述了新的式“IMAGE”化合物，其中E选自由下式组成的组：IMAGE＆gt;＆lt; IMAGE＆gt;其中R“选自氨基，乙烯基，烯丙基，乙炔基， C 1 -C 5烷基，C 1 -C 5烷氧基或C 1 -C 5烷硫基或被至少一个卤素原子取代的C 1 -C 5烷基; 和氢; 其中R 1和R 2各自选自氢，卤素，甲基和乙基; 当R“不是氢时，R'选自取代的苯基，当R”是氢时，R'选自苯基，噻吩基和取代的苯基和噻吩基。

    Substituted phenylthioamidines
    89.
    发明授权
    Substituted phenylthioamidines 失效
    取代苯硫酰脒

    公开(公告)号：US3933912A

    公开(公告)日：1976-01-20

    申请号：US486705

    申请日：1974-07-08

    申请人： Earl R. Bockstahler

    发明人： Earl R. Bockstahler

    IPC分类号： C07C259/14 ,  C07C123/00

    CPC分类号： C07C259/14

    摘要： Substituted phenylthioamidine compounds such as 2-(4-chlorophenylthio)acetamidine; 2-(4-chlorophenylthio)-acetamidoxime; and their pharmaceutically acceptable salts are prepared by the reaction of a substituted phenylthioacetonitrile with hydroxylamine hydrochloride or with methanol followed by ammonium chloride. The compounds have antimicrobial activity and also inhibit ADP-induced aggregation of blood platelets.

    摘要翻译： 取代的苯基硫代脒化合物如2-（4-氯苯硫基）乙脒; 2-（4-氯苯硫基） - 乙酰胺肟; 其药学上可接受的盐通过取代的苯基硫代乙腈与羟胺盐酸盐或甲醇反应，随后用氯化铵反应来制备。 该化合物具有抗微生物活性，也抑制ADP诱导的血小板聚集。