公开(公告)号：US10882898B2

公开(公告)日：2021-01-05

申请号：US16273753

申请日：2019-02-12

申请人： Gilead Sciences, Inc.

发明人： Mini Balakrishnan ,  Brian A. Carr ,  John Corbin ,  Craig S. Pace ,  Nathan D. Thomsen ,  Xue Zhang

IPC分类号： C07K16/10 ,  C07H21/00 ,  A61K39/00

摘要： The present invention provides novel anti-HIV antibodies with improved therapeutic properties, related pharmaceutical compositions, and methods of use thereof.

公开(公告)号：US20200377544A1

公开(公告)日：2020-12-03

申请号：US16634994

申请日：2018-08-31

申请人： THE JOHNS HOPKINS UNIVERSITY

发明人： David H. Gracias ,  Thao D. Nguyen ,  ChangKyu Yoon ,  Rebecca B. Schulman ,  Angelo Cangialosi ,  Ruohong Shi

IPC分类号： C07H21/00 ,  G03F7/20

摘要： Described are a combinatorial library of DNA molecules that can induce shape changes within specific regions of hydrogels up to centimeter scales. The DNA molecules include polymerizing hairpins, terminating hairpins, reversal strands, and crosslink nucleic acid sequences.

公开(公告)号：US20200369703A1

公开(公告)日：2020-11-26

申请号：US16756855

申请日：2017-12-26

申请人： GUANGZHOU RIBOBIO CO., LTD.

发明人： Biliang ZHANG ,  Wei WANG

IPC分类号： C07H15/04 ,  C12N15/113 ,  C07H21/00

摘要： The present disclosure falls within the field of biomedical technology, and in particular relates to modified oligonucleatides and a compound that can be used for synthesizing same and a method for modifying oligonucleotides. The present disclosure also relates to the use of the modified oligonucleotides for preventing and/or treating diseases associated with the liver in a subject.

公开(公告)号：US20200339982A1

公开(公告)日：2020-10-29

申请号：US15733307

申请日：2018-12-21

申请人： Roche Innovation Center Copenhagen A/S

发明人： Konrad BLEICHER ,  Henrik Frydenlund HANSEN ,  Troels KOCH ,  Jesper WORM ,  Adrian SCHAEUBLIN ,  Erik FUNDER ,  Joerg DUSCHMALÉ ,  Lars JOENSON ,  Meiling LI ,  Martina Brigitte DUSCHMALÉ ,  Yong WU ,  Xi SHU

IPC分类号： C12N15/11 ,  C07H21/00 ,  C07H1/00

摘要： The present invention relates to an oligonucleotide comprising at least one phosphorodithioate internucleoside linkage of formula (I) (I) as defined in the description and in the claim. The oligonucleotide of the invention can be used as a medicament.

公开(公告)号：US20200339633A1

公开(公告)日：2020-10-29

申请号：US16889495

申请日：2020-06-01

申请人： Ventana Medical Systems, Inc.

发明人： Rui Hong ,  Aoune Barhoumi

IPC分类号： C07K14/00 ,  C07H21/00

摘要： The present disclosure is directed to conjugates of a specific binding entity and an oligomer, i.e. [Specific Binding Entity]-[Oligomer]n, wherein n is an integer ranging from 1 to 12, and where the Oligomer includes, in some embodiments, a PNA sequence having at least one substituent at a gamma carbon position. In some embodiments, the substituent at the gamma carbon position, e.g. an amino acid, a peptide, a miniPEG, or a polymer, includes at least one reporter moiety.

公开(公告)号：US20200325167A1

公开(公告)日：2020-10-15

申请号：US16916887

申请日：2020-06-30

申请人： Illumina Cambridge Limited

发明人： Xiaohai LIU ,  John MILTON ,  Silke RUEDIGER ,  Xiaolin WU

IPC分类号： C07H19/04 ,  C12Q1/6874 ,  C07H21/04 ,  C07H19/06 ,  C07H19/10 ,  C07H19/16 ,  C07H19/20 ,  C07H21/00 ,  C12Q1/6869 ,  C07H19/14

摘要： The invention provides a nucleotide or nucleoside having a base attached to a detectable label via a cleavable linker, characterised in that the cleavable linker contains a moiety selected from the group comprising: Formula (I) (wherein X is selected from the group comprising O, S, NH and NQ wherein Q is a C1-10 substituted or unsubstituted alkyl group, Y is selected from the group comprising O, S, NH and N(allyl), T is hydrogen or a C1-10 substituted or unsubstituted alkyl group and * indicates where the moiety is connected to the remainder of the nucleotide or nucleoside).

公开(公告)号：US20200318109A1

公开(公告)日：2020-10-08

申请号：US16812233

申请日：2020-03-06

申请人： Roche Innovation Center Copenhagen A/S

发明人： Dennis Jul Hansen ,  Joerg Hoernschemeyer ,  Jacob Ravn ,  Christoph Rosenbohm

IPC分类号： C12N15/11 ,  C07H21/00 ,  C07H1/00 ,  C12N15/113

摘要： Recent advancements in LNA oligonucleotides include the use of amine linkers to link an LNA antisense oligonucleotide to a conjugate group. For example please see WO2014/I 18267. The present invention originates from the identification of a problem when de-protecting LNA oligonucleotides which comprise an aliphatic amine group and DMF protected LNA G nucleoside, which results in the production of a +28 Da impurity. This problem is solved by using acyl protection groups on the exocyclic nitrogen of the LNA-G residue, rather than the standard DMF protection group.

公开(公告)号：US10793865B2

公开(公告)日：2020-10-06

申请号：US16421839

申请日：2019-05-24

申请人： The Government of the United States of America, as represented by the Secretary of the Navy

发明人： Daniel A. Phillips ,  Sarah M. Glaven

IPC分类号： C07H21/00 ,  C07H21/02 ,  A61K39/00 ,  C12N15/74 ,  C07K14/195

摘要： A prokaryotic protein appearing to have a Bin/Amphiphysin/Rvs (BAR) domain, previously known in eukaryotes, has been identified. Expression of this protein causes formation of outer membrane extensions.

公开(公告)号：US10788452B2

公开(公告)日：2020-09-29

申请号：US15719198

申请日：2017-09-28

申请人： General Automation Lab Technologies, Inc.

发明人： Peter Christey ,  Alexander Hallock

IPC分类号： C12Q1/68 ,  C12Q1/6888 ,  C07H21/00 ,  G01N27/00 ,  G01N27/447 ,  G01N33/569 ,  C12Q1/06 ,  C12M1/04 ,  C12M1/32 ,  C12Q1/6853 ,  B01L3/00 ,  C12Q1/6816 ,  C12Q1/689 ,  B01L3/02

摘要： A method is provided for analyzing a sample including a population of biological entities using at least one microfabricated device. A plurality of the microwells on the microfabricated device are each uniquely indexed, and loaded with a sample such that at least some microwells each include more than one cell of a biological entity. The microfabricated device was incubated at predetermined conditions, and a selected genetic material of the cells of the biological entities obtained from the incubation is amplified to obtaining amplicons. An aggregate of the amplicons are sequenced obtain sequencing data, based on which and the indexing of the microwells, an identification of the biological entities present in each of the plurality of microwells is obtained. Such identification can then be used to determine a relationship between different types of biological entities in the sample.

公开(公告)号：US10781445B2

公开(公告)日：2020-09-22

申请号：US15528769

申请日：2016-03-10

申请人： Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.

发明人： Rotem Karni

IPC分类号： C12N15/113 ,  C12N15/115 ,  C07H21/00

摘要： An isolated oligonucleotide comprising ribonucleotides is disclosed. The oligonucleotide comprises a nucleic acid sequence which encodes at least one copy of a splicing-factor binding site. The oligonucleotide is no more than 150 bases and may be devoid of a sequence that allows hybridization thereof to cellular RNA under physiological conditions. The oligonucleotide inhibits overall cellular splicing activity of a specific splicing factor. Pharmaceutical compositions comprising the oligonucleotide and uses thereof are further disclosed.