公开(公告)号：US20030102437A1

公开(公告)日：2003-06-05

申请号：US09505910

申请日：2000-02-17

Inventor： Paul C. Goodley ,  Jean-Luc Truche

IPC: H01J049/00

CPC classification number: H01J49/167 ,  H01J49/0018

Abstract: A source of ions for an analyzer includes a reservoir for containing a liquid and a channel having a first end opening into the reservoir. A nozzle element adjacent a second end of the channel includes a plurality of tips for producing individual droplets from the liquid. The plurality of tips reduces the likelihood that individual droplets will coalesce, increases the overall flow of material or analyte to the mass spectrometer and provides a level of redundancy in the delivery of liquid for producing droplets. The tips also may produce a higher current output and greater signal from the system, as well. With micro-miniaturization, the individual droplets are relatively small, thereby increasing the likelihood that ions would be ejected from the droplet surfaces under the influence of an electric field. Multiple nozzle elements can be used to more selectively deliver fluid droplets to the analyzer, or to increase the overall flow rate of droplets from the reservoir. The tips may have a volcano or truncated cone shape for the desired fluid delivery, electrostatic effects and manufacture ability.

Abstract translation: 用于分析器的离子源包括用于容纳液体的储存器和具有通向储存器的第一端开口的通道。 与通道的第二端相邻的喷嘴元件包括用于从液体产生单个液滴的多个尖端。 多个提示降低了单个液滴聚结的可能性，将材料或分析物的总体流量增加到质谱仪，并且在用于产生液滴的液体输送中提供了一定程度的冗余度。 尖端也可能产生更高的电流输出和来自系统的更大的信号。 通过微小型化，单个液滴相对较小，从而增加离子在电场影响下从液滴表面喷出的可能性。 可以使用多个喷嘴元件来更有选择地将流体液滴输送到分析器，或者增加来自储存器的液滴的总体流速。 尖端可以具有用于期望的流体输送，静电效应和制造能力的火山形或截锥形。

公开(公告)号：US20020185595A1

公开(公告)日：2002-12-12

申请号：US09860727

申请日：2001-05-18

Inventor： Richard D. Smith ,  Taeman Kim ,  Harold R. Udseth

IPC: H01J049/00 ,  B01D059/44

CPC classification number: H01J49/0404 ,  H01J49/066 ,  H01J49/165

Abstract: A multi-capillary inlet to focus ions and other charged particles generated at or near atmospheric pressure into a relatively low pressure region, which allows increased conductance of ions and other charged particles. The multi-capillary inlet is juxtaposed between an ion source and the interior of an instrument maintained at near atmospheric pressure, it finds particular advantages when deployed to improve the ion transmission between an electrospray ionization source and the first vacuum stage of a mass spectrometer, and finds its greatest advantages when deployed in conjunction with an electrodynamic (RF) ion funnel deployed within the interior of the mass spectrometer, particularly an ion funnel equipped with a jet disturber.

Abstract translation: 将多个毛细管入口聚焦在大气压下或接近大气压下产生的离子和其他带电粒子到相对较低的压力区域，这样可以增加离子和其他带电粒子的电导率。 多毛细管入口与离子源和维持在接近大气压的仪器的内部并置，当部署以改善电喷雾离子源和质谱仪的第一真空级之间的离子传递时，它具有特别的优点，以及 与部署在质谱仪内部的电动（RF）离子漏斗配合使用时，具有最大的优势，特别是配备有喷射干燥器的离子漏斗。

公开(公告)号：US20020172619A1

公开(公告)日：2002-11-21

申请号：US10157958

申请日：2002-05-31

Inventor： James E. Moon ,  Timothy J. Davis ,  Gregory J. Galvin ,  Gary A. Schultz ,  Thomas N. Corso ,  Stephen Lowes

IPC: G01N023/06 ,  H01J049/00

CPC classification number: G01N30/6095 ,  G01N30/7266 ,  G01N2030/6013 ,  H01J49/0018 ,  H01J49/167 ,  Y10T436/24 ,  Y10T436/2575

Abstract: An electrospray device, a liquid chromatography device and an electrospray-liquid chromatography system are disclosed. The electrospray device comprises a substrate defining a channel between an entrance orifice on an injection surface and an exit orifice on an ejection surface, a nozzle defined by a portion recessed from the ejection surface surrounding the exit orifice, and an electrode for application of an electric potential to the substrate to optimize and generate an electrospray; and, optionally, additional electrode(s) to further modify the electrospray. The liquid chromatography device comprises a separation substrate defining an introduction channel between an entrance orifice and a reservoir and a separation channel between the reservoir and an exit orifice, the separation channel being populated with separation posts perpendicular to the fluid flow; a cover substrate bonded to the separation substrate to enclose the reservoir and the separation channel adjacent the cover substrate; and, optionally, electrode(s) for application of a electric potential to the fluid. The exit orifice of the liquid chromatography device may be homogeneously interfaced with the entrance orifice of the electrospray device to form an integrated single system. An array of multiple systems may be fabricated in a single monolithic chip for rapid sequential fluid processing and generation of electrospray for subsequent analysis, such as by positioning the exit orifices of the electrospray devices near the sampling orifice of a mass spectrometer.

公开(公告)号：US20020166960A1

公开(公告)日：2002-11-14

申请号：US10086304

申请日：2002-02-28

Inventor： Peter P. Pronko ,  Paul A. Vanrompay ,  Zhiyu Zhang

IPC: H01J049/00

CPC classification number: B01D59/44

Abstract: Methods for separating isotopes or chemical species of an element and causing enrichment of a desired isotope or chemical species of an element utilizing laser ablation plasmas to modify or fabricate a material containing such isotopes or chemical species are provided. This invention may be used for a wide variety of materials which contain elements having different isotopes or chemical species.

Abstract translation: 提供用于分离元素的同位素或化学物质并引起利用激光烧蚀等离子体来改善或制造含有这种同位素或化学物质的材料的元素的期望同位素或化学物质的富集的方法。 本发明可以用于含有具有不同同位素或化学物质的元素的各种材料。

公开(公告)号：US20020125426A1

公开(公告)日：2002-09-12

申请号：US10139241

申请日：2002-05-07

Inventor： Atsumu Hirabayashi ,  Minoru Sakairi ,  Yasuaki Takada ,  Hideaki Koizumi ,  Kaoru Umemura

IPC: B01D059/44 ,  H01J049/00 ,  G01N027/26 ,  G01N027/447

CPC classification number: H01J49/045

Abstract: An ion source includes a body having a gas passage and an orifice. A capillary is inserted into the gas passage so that a tip portion of the capillary extends into the orifice. A gas supplier supplies a gas into the gas passage to form a gas flow through the gas passage along the capillary and through the orifice past a tip of the capillary so that the gas flow sprays a sample solution flowing through the capillary from the tip of the capillary. A flow controller regulates a pressure of the gas in the gas passage to adjust a characteristic value F/S to a predetermined value, where F is a flow rate of the gas flow at standard conditions (20null C., 1 atmosphere), and S is a difference between a cross section of the orifice and a cross section of the tip portion of the capillary in the orifice.

Abstract translation: 离子源包括具有气体通道和孔的主体。 毛细管插入到气体通道中，使得毛细管的尖端部分延伸到孔中。 气体供应商将气体供应到气体通道中以形成沿着毛细管的气体通道的气流，并且通过孔经过毛细管的尖端，使得气流从其中的尖端喷射流过毛细管的样品溶液 毛细管。 流量控制器调节气体通道中的气体的压力，以将特征值F / S调节到预定值，其中F是在标准条件（20℃，1个大气压）下气流的流量，以及 S是孔口的截面与孔口中的毛细管的尖端部分的横截面之间的差异。

公开(公告)号：US20020104962A1

公开(公告)日：2002-08-08

申请号：US10048488

申请日：2002-02-12

Inventor： Minoru Danno ,  Hideo Yamakoshi ,  Mitsuo Koshi

IPC: H01J049/00

CPC classification number: H01J49/40 ,  G01N27/622 ,  G01N33/0049 ,  H01J49/162

Abstract: A vacuum ultraviolet ray generating unit (5) which generates vacuum ultraviolet rays used for ionizing a sample gas Gs in an ionization chamber (1) and a mass spectrometry unit (6) which accelerates the sample gas Gsi ionized by vacuum ultraviolet rays so as to measure the flight time of the accelerated substance.

Abstract translation: 一种真空紫外线发生单元（5），其产生用于电离室（1）中的样品气体Gs的离子化的真空紫外线和质量分析单元（6），其加速由真空紫外线离子化的样品气体Gsi，从而 测量加速物质的飞行时间。

公开(公告)号：US20020079442A1

公开(公告)日：2002-06-27

申请号：US09971119

申请日：2001-10-04

Inventor： David P. Fries ,  Robert Timothy Short ,  Robert H. Byrne

IPC: H01J049/00

CPC classification number: H01J49/0022 ,  H01J49/0431

Abstract: A portable mass spectrometer for underwater use includes a watertight case having an inlet and means for transforming an analyte gas molecule from a solution phase into a gas phase positioned within the case. Means for directing a fluid to the transforming means from the inlet and means for analyzing the gas-phase analyte molecule to determine an identity thereof are also positioned within the case.

公开(公告)号：US20020063207A1

公开(公告)日：2002-05-30

申请号：US09930227

申请日：2001-08-16

Inventor： Robert Harold Bateman ,  Kevin Giles

IPC: H01J049/00

CPC classification number: H01J49/065

Abstract: A mass spectrometer is disclosed comprising an ion guide 15 which spans two or more vacuum chambers 18,19. The ion guide 15 comprises a plurality of electrodes having apertures. Preferably, one of the electrodes 8 may also form the differential pumping aperture which separates two vacuum chambers 18,19.

Abstract translation: 公开了一种质谱仪，其包括跨越两个或更多个真空室18,19的离子导向器15。 离子导向器15包括具有孔的多个电极。 优选地，电极8中的一个还可以形成分离两个真空室18,19的差分泵浦孔。

公开(公告)号：US20020063206A1

公开(公告)日：2002-05-30

申请号：US09876122

申请日：2001-06-08

Inventor： Robert Harold Bateman ,  John Brian Hoyes ,  Edward James Clayton

IPC: H01J049/00

CPC classification number: H01J49/0045

Abstract: A method is disclosed of identifying parent ions by matching daughter ions found to be produced at substantially the same time that the parent ions elute from a mixture. Ions emitted from an ion source are incident upon a collision cell which alternately and repeatedly switches between a first mode wherein the ions are substantially fragmented to produce daughter ions and a second mode wherein the ions are not substantially fragmented. Mass spectra are taken in both modes, and at the end of an experimental run parent and daughter ions are recognized by comparing the mass spectra obtained in the two different modes. Daughter ions are matched to particular parent ions on the basis of the closeness of fit of their elution times, and this enables parent ions to then be identified.

Abstract translation: 公开了一种通过匹配发现在母体离子从混合物中洗脱出的基本上同时产生的子离子来鉴定亲本离子的方法。 从离子源发射的离子入射到碰撞单元上，该碰撞单元在离子基本上分裂以产生子离子的第一模式之间交替重复地切换，而第二模式其中离子基本上不分段。 在两种模式下都采用质谱，在实验运行结束时，通过比较两种不同模式中获得的质谱来识别母体和子离子。 基于其洗脱时间的拟合程度，子离子与特定的母体离子相匹配，这使母体离子能够被识别。

公开(公告)号：US20020053637A1

公开(公告)日：2002-05-09

申请号：US10006625

申请日：2001-11-30

Applicant: Cygnus, Inc.

Inventor： Thomas E. Conn ,  Russell Ford ,  Pravin L. Soni ,  Michael J. Tierney ,  Prema Vijayakumar

IPC: H01J049/00

CPC classification number: A61B5/1486

Abstract: The invention relates generally to consumable components of a device used for continually or continuously measuring the concentration of target chemical analytes present in a biological system. More particularly, the invention relates to collection assemblies, laminate structures, and autosensor assemblies, which are used in connection with a transdermal sampling device. In one aspect, the invention includes autosensor assemblies which include laminate structures, electrode assemblies, and support trays. One important application of the invention involves an autosensor assembly for use in a blood glucose monitoring device.