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    Pharmaceutically useful compounds
    82.
    发明授权
    Pharmaceutically useful compounds 有权
    药用有用化合物

    公开(公告)号：US07183440B2

    公开(公告)日：2007-02-27

    申请号：US11059086

    申请日：2005-02-07

    申请人： Stanley Michael Roberts ,  Maria Gabriella Santoro ,  Vasudev Jadhav ,  Alan Michael Happe ,  Jérôme Dauvergne

    发明人： Stanley Michael Roberts ,  Maria Gabriella Santoro ,  Vasudev Jadhav ,  Alan Michael Happe ,  Jérôme Dauvergne

    IPC分类号： C07C315/00 ,  C07C49/00 ,  A61K31/12 ,  A61K31/095

    CPC分类号： C07C323/59 ,  C07C45/673 ,  C07C49/647 ,  C07C49/653 ,  C07C49/657 ,  C07C49/753 ,  C07C205/45 ,  C07C225/20 ,  C07C233/32 ,  C07C233/76 ,  C07C271/24 ,  C07C271/36 ,  C07C271/56 ,  C07C271/66 ,  C07C311/20 ,  C07C311/53 ,  C07C323/43 ,  C07C2601/08 ,  C07C2601/10

    摘要： A compound of formula (I) or (II): wherein A is hydrogen or CR1R2; Y and Z are each, independently, hydrogen or a halogen; X is —NR4R5, or R7; R1 is hydrogen, or a substituted or unsubstituted alkyl or alkenyl group containing 1–4 carbon atoms; when X is —NR4R5, R2 is a substituted or unsubstituted alkyl, alkenyl, alkynyl, aryl, aralkyl aralkenyl, or aralkynyl group, that optionally includes at least one heteroatom in its carbon skeleton and contains 1–12 carbon atoms; when X is R7, R2 is an unsubstituted alkyl, alkenyl or alkynyl group, or a substituted or unsubstituted aryl, aralkyl aralkenyl, or aralkynyl group, that optionally includes at least one heteroatom in its carbon skeleton and contains 1–12 carbon atoms; R3 is a substituted or unsubstituted alkyl, alkenyl, alkynyl, aryl, aralkyl aralkenyl, or aralkynyl group, that optionally includes at least one heteroatom in its carbon skeleton and contains 1–12 carbon atoms; R4 is hydrogen, a substituted or unsubstituted alkyl, alkenyl, alkynyl, aryl, aralkyl aralkenyl, or aralkynyl group, that optionally includes at least one heteroatom in its carbon skeleton and contains 1–12 carbon atoms, —COOR8, or —COR8; R5 is hydrogen, or a substituted or unsubstituted alkyl or alkenyl group containing 1–5 carbon atoms; R7 is an unsubstituted alkyl, alkenyl, or alkynyl group, that contains 1–4 carbon atoms; and, R8 is an unsubstituted or halo-substituted alkyl, aryl, or aralkyl group, that contains 1–12 carbon atoms

    摘要翻译： 式（I）或（II）的化合物：其中A是氢或CR 1 R 2; Y和Z各自独立地为氢或卤素; X是-NR 4 R 5或R 7; R 1是氢或含有1-4个碳原子的取代或未取代的烷基或链烯基; 当X是-NR 4 R 5时，R 2是取代或未取代的烷基，烯基，炔基，芳基，芳烷基芳烯基或芳炔基 基团，其任选地在其碳骨架中包含至少一个杂原子并且含有1-12个碳原子; 当X是R 7时，R 2是未取代的烷基，烯基或炔基，或取代或未取代的芳基，芳烷基芳烯基或芳炔基，其任选地包括在 其碳骨架中至少有一个杂原子，含有1-12个碳原子; R 3是取代或未取代的烷基，烯基，炔基，芳基，芳烷基芳烯基或芳炔基，其任选地在其碳骨架中包含至少一个杂原子并含有1-12个碳原子; R 4是氢，取代或未取代的烷基，烯基，炔基，芳基，芳烷基芳烯基或芳炔基，其任选地在其碳骨架中包含至少一个杂原子并含有1-12个碳原子， -COOR 8或-COR 8; R 5是氢或含有1-5个碳原子的取代或未取代的烷基或链烯基; R 7是含有1-4个碳原子的未取代的烷基，烯基或炔基; 并且R 8是含有1-12个碳原子的未取代或卤素取代的烷基，芳基或芳烷基

    Use of allicin as preservative, as disinfectant, as antimicrobial or as biocidal agent
    84.
    发明申请
    Use of allicin as preservative, as disinfectant, as antimicrobial or as biocidal agent 审中-公开
    使用大蒜素作为防腐剂，作为消毒剂，作为抗微生物剂或杀生物剂

    公开(公告)号：US20070036875A1

    公开(公告)日：2007-02-15

    申请号：US10551235

    申请日：2004-03-29

    申请人： Norman Bennett ,  Peter Josling

    发明人： Norman Bennett ,  Peter Josling

    IPC分类号： A61K36/8962 ,  A61K31/095

    CPC分类号： C02F1/50 ,  A01N41/02 ,  A23K20/105 ,  A23K50/80 ,  A23L3/3535 ,  A61K31/255 ,  A61L2/0082 ,  A61L2/16 ,  Y02A40/818

    摘要： The present invention provides the use of allicin in (i) the treatment of leishmaniasis; (ii) as a disinfectant or biocida treatment of aquatic species; (iii) as an antimicrobial agent for animal feed; (iv) as a preservative agent in foodstuffs; (v) as a water disinfectant or biocide; (vi) as an antiparasitic treatment or antibacterial treatment for bees (apis); or (vii) in the preparation of a medicament for the treatment of Glycopeptide Intermediate Resistant Stapohylococcus Aureus.

    摘要翻译： 本发明提供大蒜素在（i）利什曼病治疗中的用途; （ii）作为水生物种的消毒剂或生物杀虫剂处理; （iii）作为动物饲料的抗微生物剂; （iv）作为食品中的防腐剂; （v）作为水消毒剂或杀生物剂; （vi）作为蜜蜂（apis）的抗寄生虫治疗或抗菌治疗; 或（vii）在制备用于治疗糖肽中等抗性金黄色葡萄球菌的药物中的用途。

    Treatment and prevention of inflammatory disease and mitochondrial dysfunction with high dose selenium
    85.
    发明申请
    Treatment and prevention of inflammatory disease and mitochondrial dysfunction with high dose selenium 审中-公开
    用高剂量硒治疗和预防炎性疾病和线粒体功能障碍

    公开(公告)号：US20070026090A1

    公开(公告)日：2007-02-01

    申请号：US10570789

    申请日：2004-07-29

    申请人： Oren Tirosh ,  Ram Reifen

    发明人： Oren Tirosh ,  Ram Reifen

    IPC分类号： A61K33/04 ,  A61K38/05 ,  A61K31/198 ,  A61K31/195 ,  A61K31/095

    CPC分类号： A61K31/095 ,  A61K31/195 ,  A61K31/198 ,  A61K31/41 ,  A61K33/04 ,  Y02A50/414

    摘要： The present invention is of a method for reducing activity of inflammatory immune cells by exposure to selenium. Particularly, the invention relates to a method of short-term, high dose dietary selenium supplementation for treating a subject having an inflammatory disease, particularly inflammatory bowel disease (IBD). An article of manufacture comprising a pharmaceutical composition providing a therapeutic selenium unit dosage suitable for the method of the present invention is also provided.

    摘要翻译： 本发明是通过暴露于硒来降低炎症免疫细胞的活性的方法。 特别地，本发明涉及用于治疗具有炎性疾病，特别是炎症性肠病（IBD）的受试者的短期高剂量膳食硒补充方法。 还提供了包含提供适用于本发明方法的治疗性硒单位剂量的药物组合物的制品。

    3-methoxybenzyl thiourea derivatives and improved lipid compositions containing same
    86.
    发明授权
    3-methoxybenzyl thiourea derivatives and improved lipid compositions containing same 有权
    3-甲氧基苄基硫脲衍生物和包含其的改进的脂质组合物

    公开(公告)号：US07169815B2

    公开(公告)日：2007-01-30

    申请号：US10426122

    申请日：2003-04-29

    申请人： Thomas P. Abbott ,  Alan Wohlman

    发明人： Thomas P. Abbott ,  Alan Wohlman

    IPC分类号： A61K31/095 ,  A61K45/00

    CPC分类号： A61K8/46 ,  A61K2800/522 ,  A61Q5/00 ,  A61Q17/00 ,  A61Q17/04 ,  A61Q19/00 ,  B05D3/007 ,  B05D3/12 ,  C11B5/0042

    摘要： 1-(3-methoxybenzyl)-3-substituted thiourea antioxidant compounds and improved lipids compositions which are supplemented with amounts of such antioxidant compounds effective for augmenting oxidative stability of the base lipid are provided. Also provided are methods for enhancing the oxidative stability of a lipid comprising supplementing a base lipid in need of enhanced oxidative stability with at least one 1-(3-methoxybenzyl)-3-substituted thiourea compound of the present invention.

    摘要翻译： 提供1-（3-甲氧基苄基）-3-取代的硫脲抗氧化剂化合物和改进的脂质组合物，其补充了一些有效增强基础脂质的氧化稳定性的抗氧化剂化合物。 还提供了用于增强脂质的氧化稳定性的方法，其包括用至少一种本发明的1-（3-甲氧基苄基）-3-取代的硫脲化合物补充需要增强的氧化稳定性的基础脂质。

    Methods for treating allergy
    88.
    发明申请
    Methods for treating allergy 审中-公开
    治疗过敏的方法

    公开(公告)号：US20050143473A1

    公开(公告)日：2005-06-30

    申请号：US11015362

    申请日：2004-12-17

    申请人： Gary Wong ,  Francis Chi

    发明人： Gary Wong ,  Francis Chi

    IPC分类号： A61K31/095 ,  A61K31/13

    CPC分类号： A61K31/095 ,  A61K31/13

    摘要： The subject invention provides materials and methods for treating allergy in animals. In a preferred embodiment, the invention provides methods for alleviating an animal's hypersensitive response to allergens, including, without limitation, migraine, asthma, allergic rhinitis, digestive disturbances, coeliac disease, conjunctivitis, urticaria, eczema, drowsiness, hyperactivity (in children), tinnitus, recurrent sinusitis and ear infections. Specifically exemplified herein is the use of a cysteamine compound to reduce the hypersensitive response in animals to allergens. In a preferred embodiment, oral administration of cysteamine hydrochloride to an animal diagnosed with an allergy can substantially reduce the animal's reaction to the allergen.

    摘要翻译： 本发明提供了用于治疗动物过敏的材料和方法。 在优选的实施方案中，本发明提供了减轻动物对变应原的过敏反应的方法，包括但不限于偏头痛，哮喘，过敏性鼻炎，消化系统紊乱，乳糜泻，结膜炎，荨麻疹，湿疹，嗜睡，多动症（儿童） 耳鸣，复发性鼻窦炎和耳部感染。 本文具体示例是使用半胱胺化合物来减少动物对过敏原的过敏反应。 在优选的实施方案中，将半胱胺盐酸盐口服给予诊断为过敏的动物可以显着降低动物对变应原的反应。