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26 条记录 (耗时 0.013 秒)

    Thermal regulation catheter system
    1.
    发明授权
    Thermal regulation catheter system 有权

    公开(公告)号：US11419656B2

    公开(公告)日：2022-08-23

    申请号：US14678393

    申请日：2015-04-03

    申请人： CPSI Holdings LLC

    发明人： John M. Baust ,  Jennie F. McKain ,  Anthony T. Robilotto ,  Joshua T. Smith

    IPC分类号： A61B18/02 ,  A61B18/00

    摘要： A thermal regulation catheter system and method of use are disclosed, for moderating the temperature and other parameters of tissue surrounding a target tissue for an ablation procedure, or for performing a thermal treatment procedure. In an embodiment, the device includes a catheter having a shaft with a fluid supply line and a fluid return line disposed therein, and an inflatable heat exchange vessel at a distal end of the shaft. The fluid supply line supplies fluid to inflate the heat exchange vessel, and the fluid return line conducts fluid away from the heat exchange vessel.

    DEPLOYABLE ASSEMBLY SLEEVE FOR ABLATION PROBE WITH DEPLOYABLE SENSORS
    2.
    发明申请
    DEPLOYABLE ASSEMBLY SLEEVE FOR ABLATION PROBE WITH DEPLOYABLE SENSORS 有权

    公开(公告)号：US20220061902A1

    公开(公告)日：2022-03-03

    申请号：US17523377

    申请日：2021-11-10

    申请人： CPSI HOLDINGS LLC

    发明人： Marie Molnar-Hammond ,  John M. Baust

    IPC分类号： A61B18/02 ,  A61B18/14

    摘要： The present disclosure relates to a deployable assembly sleeve including a longitudinal body including a lumen, with the longitudinal body having a proximal end and a distal end; and at least one deployable assembly disposed upon the longitudinal body, the deployable assembly including a flexible and substantially rigid deployment member, and at least one sensor affixed to a distal end of the deployment member; and a control mechanism for controlling deployment in a distal direction and retraction in a proximal direction of the deployable assembly.

    System for heating and cooling samples
    3.
    发明授权
    System for heating and cooling samples 有权

    公开(公告)号：US10196598B2

    公开(公告)日：2019-02-05

    申请号：US14876087

    申请日：2015-10-06

    申请人： CPSI Holdings LLC

    发明人： John M. Baust ,  Joshua T. Smith ,  William Corwin ,  Kristi Snyder ,  Anthony T. Robilotto

    IPC分类号： C12M1/34 ,  B01L1/00 ,  B01L7/00 ,  C12M1/02 ,  C12M1/36

    摘要： A system for heating or cooling a sample is disclosed, which includes an insulated chamber; at least one of a heater or a cooling pad disposed within the chamber; and at least one compliant, fluid filled pillow. The at least one compliant, fluid-filled pillow is disposed in the chamber and adjacent to the at least one thermal device while being heated or cooled to a desired temperature by the heater or the cooling pad, and upon reaching the desired temperature, the at least one compliant, fluid filled pillow substantially conforms to a container containing the sample.

    PRESSURIZED SUB-COOLED CRYOGENIC SYSTEM AND METHOD OF USE
    5.
    发明申请
    PRESSURIZED SUB-COOLED CRYOGENIC SYSTEM AND METHOD OF USE 有权

    公开(公告)号：US20220205589A1

    公开(公告)日：2022-06-30

    申请号：US17655369

    申请日：2022-03-18

    申请人： CPSI Holdings LLC

    发明人： John M. Baust ,  Joshua T. Smith ,  Anthony T. Robilotto ,  Jennie F. McKain

    IPC分类号： F17C1/00 ,  F17C5/02 ,  F17C3/00 ,  A61B18/02

    摘要： A method of generating a pressurized, sub-cooled mixed-phase cryogen is disclosed, including providing a cryogenic system including a reservoir containing a liquid cryogen; and a heat exchange coil immersed in the liquid cryogen, the heat exchange coil having an input end and an output end not immersed in the liquid cryogen; introducing a pressurized gas cryogen to the input end of the heat exchange coil; cooling the pressurized gas cryogen within the heat exchange coil; and collecting the pressurized gas cryogen at an output end of the heat exchange coil.

    Method of molecular stress control
    7.
    发明授权
    Method of molecular stress control 有权

    公开(公告)号：US10336984B2

    公开(公告)日：2019-07-02

    申请号：US14819960

    申请日：2015-08-06

    申请人： CPSI Holdings LLC

    发明人： John M. Baust ,  John G. Baust ,  William L. Corwin ,  Robert G. Van Buskirk

    IPC分类号： C12N5/00 ,  A61K31/05 ,  A61K31/07 ,  A61K31/34 ,  A61K31/355 ,  A61K31/47 ,  A61K31/593 ,  G01N33/50 ,  C12N5/0735 ,  C12N5/074

    摘要： A novel class of agents has been identified to serve as cell-guard agents and/or target-specific supplements to increase cell quality and yield, as well as select for target cell populations. Several additive agents (both natural and synthetic) have been identified, including Vitamin D3, NAC, resveratrol, salubrinal, AKT, and tunicamycin (among others) that hold promise for application in cell models. In one embodiment, hypothermic stress regimes are utilized. In another embodiment, normothermic conditions are utilized while other stressors are tested in the processing. The methods of maintaining mass cell cultures and/or selecting out particular cell populations for further research and clinical use represents an important step in therapeutic discovery.

    TISSUE ENGINEERED MODEL
    10.
    发明申请
    TISSUE ENGINEERED MODEL 有权
    组织工程模型

    公开(公告)号：US20140273063A1

    公开(公告)日：2014-09-18

    申请号：US14206533

    申请日：2014-03-12

    申请人： CPSI HOLDINGS LLC

    发明人： John G. BAUST ,  Joshua T. SMITH ,  Kimberly L. SANTUCCI ,  Kristi K. SNYDER ,  Anthony T. ROBILOTTO ,  Robert G. VAN BUSKIRK ,  John M. BAUST ,  William L. CORWIN ,  Jennie F. MCKAIN

    IPC分类号： G01N33/50

    CPC分类号： C12M21/08 ,  C12M25/06 ,  C12M25/14 ,  C12M27/00 ,  C12M29/00 ,  C12N5/0062 ,  C12N5/0068 ,  C12N5/0697 ,  C12N2537/00 ,  G01N33/5008 ,  G01N33/5017

    摘要： A tissue engineered model (TEM) structure, an apparatus and method for making a TEM structure, and methods of using a TEM structure are disclosed. In an embodiment, the TEM structure includes at least one TEM segment. Each TEM segment includes a frame defining a bounded area, the frame having a height, a first edge, and a second edge opposite the first edge, each of the first edge and the second edge defining a perimeter of the bounded area, and the height defining a distance between the first edge and the second edge; a membrane affixed to the first edge about a perimeter of the frame; and a solidified gel and cell matrix disposed within the bounded area within the frame, wherein the solidified gel and cell matrix substantially fills a volume defined by the bounded area and the height of the frame.

    摘要翻译： 公开了一种组织工程模型（TEM）结构，用于制造TEM结构的装置和方法，以及使用TEM结构的方法。 在一个实施例中，TEM结构包括至少一个TEM段。 每个TEM段包括限定有界区域的框架，框架具有高度，第一边缘和与第一边缘相对的第二边缘，第一边缘和第二边缘中的每一个限定有界区域的周边，并且高度 限定所述第一边缘和所述第二边缘之间的距离; 围绕所述框架的周边固定到所述第一边缘的膜; 以及设置在框架内的有界区域内的凝固凝胶和细胞基质，其中凝固的凝胶和细胞基质基本上填充由界限区域和框架的高度限定的体积。