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    Cryotreatment pellet
    2.
    发明授权
    Cryotreatment pellet 有权
    冷冻沉淀

    公开(公告)号：US08747397B2

    公开(公告)日：2014-06-10

    申请号：US13683140

    申请日：2012-11-21

    申请人： CPSI Holdings LLC

    发明人： John M. Baust ,  John G. Baust ,  Anthony T. Robilotto ,  Kristi K. Snyder ,  Robert G. Van Buskirk

    IPC分类号： A61B18/02

    CPC分类号： A61B18/02 ,  A61B2018/0212 ,  A61K9/0024 ,  A61K9/145 ,  A61K31/00 ,  A61K31/282 ,  A61K31/337 ,  A61K31/513 ,  A61K31/59 ,  A61K31/7048 ,  A61K45/06 ,  A61M5/44 ,  A61M37/0069 ,  A61M2205/3606

    摘要： The resorbable cryoprobe device and process is a novel approach for treating localized disease allowing for the precise combined application of freezing temperatures and cytotoxic or cryosensitizing agents within a self-contained matrix/package for optimized tissue destruction. The cryopellet is comprised of a list of components including a source of cryogen to produce the sub-zero temperatures, a porous matrix to contain the cytotoxic agent, cytotoxic agent, and a delivery packet. Data presented herein demonstrates the efficacy of this approach in destroying cancerous tissue. For example, the application of freezing temperatures to −10° C. results in approximately 15% cell death, while exposure to cytotoxic agents such as TRAIL produces minimal cell death. The utilization of the cryopellet approach results in a synergistic effect yielding complete cell death at the same temperature. The innovation behind the resorbable probe application includes the strategic combination of agents to activate intrinsic or extrinsic cell death responses (including apoptosis and necrosis), unique packaging of the cryogen and cytotoxic agent, and a unique delivery system. The resorbable cryoprobe technology will assist directly in the treatment of cancer, as well as will likely lead to broader application for disease treatment.

    摘要翻译： 可再吸收的冷冻探针装置和方法是用于治疗局部疾病的新方法，其允许在自包含的基质/包装内精确地联合应用冷冻温度和细胞毒性或冷冻敏化剂以优化组织破坏。 冷冻条由包括产生低于零温度的冷冻源的组分的列表组成，含有细胞毒剂，细胞毒性剂和递送包的多孔基质。 本文提供的数据显示了这种方法在破坏癌组织中的功效。 例如，将冻结温度施加到-10℃导致约15％的细胞死亡，而暴露于细胞毒性剂如TRAIL的细胞会导致最小的细胞死亡。 cryopellet方法的利用导致在相同温度下产生完全细胞死亡的协同效应。 可再吸收探针应用的创新包括激活内在或外在细胞死亡反应（包括细胞凋亡和坏死），冷冻剂和细胞毒性剂的独特包装以及独特的递送系统的药剂的战略组合。 可再吸收的冷冻探针技术将有助于直接治疗癌症，并可能导致更广泛的疾病治疗应用。

    CRYO-MEDICAL INJECTION DEVICE AND METHOD OF USE
    4.
    发明申请
    CRYO-MEDICAL INJECTION DEVICE AND METHOD OF USE 有权
    CRYO医疗注射装置及其使用方法

    公开(公告)号：US20130079761A1

    公开(公告)日：2013-03-28

    申请号：US13683140

    申请日：2012-11-21

    申请人： CPSI HOLDINGS LLC

    发明人： John M. Baust ,  John G. Baust ,  Anthony T. Robilotto ,  Kristi K. Snyder ,  Robert G. Van Buskirk

    IPC分类号： A61B18/02

    CPC分类号： A61B18/02 ,  A61B2018/0212 ,  A61K9/0024 ,  A61K9/145 ,  A61K31/00 ,  A61K31/282 ,  A61K31/337 ,  A61K31/513 ,  A61K31/59 ,  A61K31/7048 ,  A61K45/06 ,  A61M5/44 ,  A61M37/0069 ,  A61M2205/3606

    摘要： The resorbable cryoprobe device and process is a novel approach for treating localized disease allowing for the precise combined application of freezing temperatures and cytotoxic or cryosensitizing agents within a self-contained matrix/package for optimized tissue destruction. The cryopellet is comprised of a list of components including a source of cryogen to produce the sub-zero temperatures, a porous matrix to contain the cytotoxic agent, cytotoxic agent, and a delivery packet. Data presented herein demonstrates the efficacy of this approach in destroying cancerous tissue. For example, the application of freezing temperatures to −10° C. results in approximately 15% cell death, while exposure to cytotoxic agents such as TRAIL produces minimal cell death. The utilization of the cryopellet approach results in a synergistic effect yielding complete cell death at the same temperature. The innovation behind the resorbable probe application includes the strategic combination of agents to activate intrinsic or extrinsic cell death responses (including apoptosis and necrosis), unique packaging of the cryogen and cytotoxic agent, and a unique delivery system. The resorbable cryoprobe technology will assist directly in the treatment of cancer, as well as will likely lead to broader application for disease treatment.

    摘要翻译： 可再吸收的冷冻探针装置和方法是用于治疗局部疾病的新方法，其允许在自包含的基质/包装内精确地联合应用冷冻温度和细胞毒性或冷冻敏化剂以优化组织破坏。 冷冻条由包括产生低于零温度的冷冻源的组分的列表组成，含有细胞毒剂，细胞毒性剂和递送包的多孔基质。 本文提供的数据显示了这种方法在破坏癌组织中的功效。 例如，将冻结温度施加到-10℃导致约15％的细胞死亡，而暴露于细胞毒性剂如TRAIL的细胞会导致最小的细胞死亡。 cryopellet方法的利用导致在相同温度下产生完全细胞死亡的协同效应。 可再吸收探针应用的创新包括激活内在或外在细胞死亡反应（包括细胞凋亡和坏死），冷冻剂和细胞毒性剂的独特包装以及独特的递送系统的药剂的战略组合。 可再吸收的冷冻探针技术将有助于直接治疗癌症，并可能导致更广泛的疾病治疗应用。

    Thermal regulation catheter system
    5.
    发明授权
    Thermal regulation catheter system 有权

    公开(公告)号：US11419656B2

    公开(公告)日：2022-08-23

    申请号：US14678393

    申请日：2015-04-03

    申请人： CPSI Holdings LLC

    发明人： John M. Baust ,  Jennie F. McKain ,  Anthony T. Robilotto ,  Joshua T. Smith

    IPC分类号： A61B18/02 ,  A61B18/00

    摘要： A thermal regulation catheter system and method of use are disclosed, for moderating the temperature and other parameters of tissue surrounding a target tissue for an ablation procedure, or for performing a thermal treatment procedure. In an embodiment, the device includes a catheter having a shaft with a fluid supply line and a fluid return line disposed therein, and an inflatable heat exchange vessel at a distal end of the shaft. The fluid supply line supplies fluid to inflate the heat exchange vessel, and the fluid return line conducts fluid away from the heat exchange vessel.

    System for heating and cooling samples
    6.
    发明授权
    System for heating and cooling samples 有权

    公开(公告)号：US10196598B2

    公开(公告)日：2019-02-05

    申请号：US14876087

    申请日：2015-10-06

    申请人： CPSI Holdings LLC

    发明人： John M. Baust ,  Joshua T. Smith ,  William Corwin ,  Kristi Snyder ,  Anthony T. Robilotto

    IPC分类号： C12M1/34 ,  B01L1/00 ,  B01L7/00 ,  C12M1/02 ,  C12M1/36

    摘要： A system for heating or cooling a sample is disclosed, which includes an insulated chamber; at least one of a heater or a cooling pad disposed within the chamber; and at least one compliant, fluid filled pillow. The at least one compliant, fluid-filled pillow is disposed in the chamber and adjacent to the at least one thermal device while being heated or cooled to a desired temperature by the heater or the cooling pad, and upon reaching the desired temperature, the at least one compliant, fluid filled pillow substantially conforms to a container containing the sample.

    PRESSURIZED SUB-COOLED CRYOGENIC SYSTEM AND METHOD OF USE
    8.
    发明申请
    PRESSURIZED SUB-COOLED CRYOGENIC SYSTEM AND METHOD OF USE 审中-公开

    公开(公告)号：US20180340654A1

    公开(公告)日：2018-11-29

    申请号：US16042411

    申请日：2018-07-23

    申请人： CPSI Holdings LLC

    发明人： John M. Baust ,  Joshua T. Smith ,  Anthony T. Robilotto ,  Jennie F. McKain

    IPC分类号： F17C1/00 ,  F17C5/02

    摘要： A cryogenic system as well as a method of generating a pressurized, sub-cooled mixed-phase cryogen and a method of delivering such a cryogen to a cryoprobe are disclosed. In an embodiment, the cryogenic system includes a reservoir containing a liquid cryogen and a sub-cooling coil immersed in the liquid cryogen. The cryogen is supplied to the sub-cooling coil and is cooled under pressure to produce a pressurized mixed phase cryogen within the sub-cooling coil. This pressurized mixed phase cryogen is provided via supply line to a cryo-device for use.

    Tissue engineered model
    9.
    发明授权
    Tissue engineered model 有权
    组织工程模型

    公开(公告)号：US09213025B2

    公开(公告)日：2015-12-15

    申请号：US14206533

    申请日：2014-03-12

    申请人： CPSI HOLDINGS LLC

    发明人： John G. Baust ,  Joshua T. Smith ,  Kimberly L. Santucci ,  Kristi K. Snyder ,  Anthony T. Robilotto ,  Robert G. Van Buskirk ,  John M. Baust ,  William L. Corwin ,  Jennie F. McKain

    IPC分类号： C12N5/00 ,  G01N33/50

    CPC分类号： C12M21/08 ,  C12M25/06 ,  C12M25/14 ,  C12M27/00 ,  C12M29/00 ,  C12N5/0062 ,  C12N5/0068 ,  C12N5/0697 ,  C12N2537/00 ,  G01N33/5008 ,  G01N33/5017

    摘要： A tissue engineered model (TEM) structure, an apparatus and method for making a TEM structure, and methods of using a TEM structure are disclosed. In an embodiment, the TEM structure includes at least one TEM segment. Each TEM segment includes a frame defining a bounded area, the frame having a height, a first edge, and a second edge opposite the first edge, each of the first edge and the second edge defining a perimeter of the bounded area, and the height defining a distance between the first edge and the second edge; a membrane affixed to the first edge about a perimeter of the frame; and a solidified gel and cell matrix disposed within the bounded area within the frame, wherein the solidified gel and cell matrix substantially fills a volume defined by the bounded area and the height of the frame.

    摘要翻译： 公开了一种组织工程模型（TEM）结构，用于制造TEM结构的装置和方法，以及使用TEM结构的方法。 在一个实施例中，TEM结构包括至少一个TEM段。 每个TEM段包括限定有界区域的框架，框架具有高度，第一边缘和与第一边缘相对的第二边缘，第一边缘和第二边缘中的每一个限定有界区域的周边，并且高度 限定所述第一边缘和所述第二边缘之间的距离; 围绕所述框架的周边固定到所述第一边缘的膜; 以及设置在框架内的有界区域内的凝固凝胶和细胞基质，其中凝固的凝胶和细胞基质基本上填充由界限区域和框架的高度限定的体积。

    PRESSURIZED SUB-COOLED CRYOGENIC SYSTEM AND METHOD OF USE
    10.
    发明申请
    PRESSURIZED SUB-COOLED CRYOGENIC SYSTEM AND METHOD OF USE 审中-公开
    加压副冷却低温系统及其使用方法

    公开(公告)号：US20150300569A1

    公开(公告)日：2015-10-22

    申请号：US14687449

    申请日：2015-04-15

    申请人： CPSI Holdings LLC

    发明人： John M. Baust ,  Joshua T. Smith ,  Anthony T. Robilotto ,  Jennie F. McKain

    IPC分类号： F17C1/00 ,  F17C5/02

    CPC分类号： F17C1/00 ,  F17C5/02

    摘要： A cryogenic system as well as a method of generating a pressurized, sub-cooled mixed-phase cryogen and a method of delivering such a cryogen to a cryoprobe are disclosed. In an embodiment, the cryogenic system includes a reservoir containing a liquid cryogen and a sub-cooling coil immersed in the liquid cryogen. The cryogen is supplied to the sub-cooling coil and is cooled under pressure to produce a pressurized mixed phase cryogen within the sub-cooling coil. This pressurized mixed phase cryogen is provided via supply line to a cryo-device for use.

    摘要翻译： 公开了一种低温系统以及产生加压的亚冷却混合相制冷剂的方法和将这种冷冻剂递送到冷冻探针的方法。 在一个实施例中，低温系统包括容纳液体冷冻剂和浸没在液体冷冻剂中的次级冷却盘管的储存器。 将冷冻剂供给到副冷却盘管，并在压力下冷却，以在副冷却盘管内产生加压混合相制冷剂。 该加压混合相制冷剂通过供应管线提供给冷冻装置以供使用。