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公开(公告)号：US5149425A
公开(公告)日：1992-09-22
申请号：US679801
申请日：1991-04-03
申请人： M. Abdul Mazid
发明人： M. Abdul Mazid
CPC分类号： A61M1/3679 , B01J20/14 , B01J20/261 , B01J20/262 , B01J20/264 , B01J20/265 , B01J20/267 , B01J20/28004 , B01J20/28033 , B01J20/28078 , B01J20/286 , B01J20/3064 , B01J20/3204 , B01J20/3219 , B01J20/3229 , B01J20/3257 , B01J20/327 , B01J20/3272 , B01J20/3274 , B01J20/3276 , B01J20/3282 , B01J2220/54 , G01N2030/525 , G01N2030/567 , G01N2030/8813 , G01N30/02
摘要： A method of coating chromatographic particulate supports to provide a biocompatible outer layer of synthetic membrane-type film which prevents the release of fines but permits the adsorption of components to an affinity ligand is described. The matrix is provided with a membrane-type coating, which prevents leaching of fines, with a pore size of at least 20 angstroms. The coating is applied to a solid particulate under conditions where an integral membrane coat will be formed. It may also be necessary to control the size and number of pores of the membranes by treating a suspension of the solid support in a solvent which contains 0.1-1% of the support weight of a biocompatible polymer along with 0.5-5% of the weight of said polymer of a dissolved compatible pore-controlling component. The solvent is then removed from the suspension and the membrane-coated material used in extracorporeal treatment of body fluids or in other chromatographic techniques. The coating process can be conducted before or after the particulate support is functionalized and/or derivatized.
摘要翻译： 描述了涂覆色谱颗粒载体以提供合成膜型膜的生物相容性外层的方法，其防止细粒释放，但允许将组分吸附到亲和配体上。 该基质设置有膜型涂层，其防止细孔浸出至少20埃的细孔。 在将形成整体膜涂层的条件下将涂层施加到固体颗粒上。 也可能需要通过将固体支持物的悬浮液处理在包含生物相容性聚合物的0.1-1％的载体重量的溶剂中以及0.5-5％的重量来控制膜的孔的尺寸和数量 的溶解的相容孔控制组分的所述聚合物。 然后将溶剂从悬浮液中除去，并将膜包被的材料用于体液的体外治疗或其他色谱技术。 涂覆方法可以在颗粒载体官能化和/或衍生化之前或之后进行。
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公开(公告)号：US5059535A
公开(公告)日：1991-10-22
申请号：US336932
申请日：1989-04-12
申请人： M. Abdul Mazid , Mohammed A. Kashem
发明人： M. Abdul Mazid , Mohammed A. Kashem
IPC分类号： C12N9/10
CPC分类号： C12N9/1081 , Y10S435/803 , Y10S435/815
摘要： Specific sialyl transferases (ST) are important enzymes in the manufacture of carbohydrate moieties useful for pharmacological purposes and for diagnostic and clinical procedures. The invention offers simplified methods to isolate highly specific forms of these ST enzymes by taking advantage of the affinity of the ST for its acceptor substrate in the presence of the sialyl-CMP analogs, such as CDP. Specifically exemplified are isolation of the alpha 2,3-ST, specific for Le.sup.c or LacNAc, and alpha 2,6-ST specific for LacNAc.
摘要翻译： 特定的唾液酸转移酶（ST）是制造用于药理目的和诊断和临床程序的碳水化合物部分的重要酶。 本发明提供简化的方法，通过在唾液酸-CPC类似物如CDP的存在下利用ST对其受体底物的亲和力来分离这些ST酶的高度特异性形式。 具体示例是分离对于Lec或LacNAc特异性的α2-3-ST，对LacNAc特异性的是α-2,6-ST。
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3.发明授权Synthesis of 2-amino-2-deoxyglycoses and 2-amino-2-deoxyglycosides from glycals 失效合成2-氨基-2-脱氧糖苷和2-氨基-2-脱氧糖苷
公开(公告)号：US4362720A
公开(公告)日：1982-12-07
申请号：US77012
申请日：1979-09-19
CPC分类号： C07H13/08 , C07H15/04 , C07H3/06 , C07H5/06 , Y10S530/816
摘要： O-acetylated glycals react with ceric ammonium nitrate in the presence of sodium azide to provide, in good yield, O-acetylated 2-azido-2-deoxy glycosyl nitrates. These nitrates can be used to prepare 2-amino-2-deoxy sugars, such as D-galactosamine and lactosamine. The O-acetylated 2-azido-2-deoxy glycosyl nitrates can alternately be converted to O-acetylated 2-azido-2-deoxy glycosyl halides which are useful in the preparation of O-acetylated 2-azido-2-deoxy glycosides, which in turn can be reduced to 2-amino-2-deoxy glycosides. Of particular interest are the syntheses of 2-amino-2-deoxy glycosides which correspond to the terminal units of the antigenic determinant for the human A blood group. Attachment of these glycosides to a solid support provides immunoabsorbents which efficiently and preferentially absorb anti-A antibodies from blood plasma.
摘要翻译： O-乙酰化的甘氨酸在叠氮化钠存在下与硝酸铈铵反应，以高产率提供O-乙酰化的2-叠氮基-2-脱氧糖基硝酸盐。 这些硝酸盐可用于制备2-氨基-2-脱氧糖，如D-半乳糖胺和乳糖胺。 O-乙酰化的2-叠氮基-2-脱氧糖基硝酸盐可以替代地转化成O-乙酰化的2-叠氮基-2-脱氧糖基卤化物，其可用于制备O-乙酰化的2-叠氮基-2-脱氧糖苷，其中 又可以还原成2-氨基-2-脱氧糖苷。 特别感兴趣的是对应于人A血型的抗原决定簇的末端单元的2-氨基-2-脱氧糖苷的合成。 将这些糖苷连接到固体支持物上提供有效和优先地从血浆吸收抗-A抗体的免疫吸收剂。
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4.发明授权Synthesis of 2-amino-2-deoxyglycoses and 2-amino-2-deoxyglycosides from glycals 失效合成2-氨基-2-脱氧糖苷和2-氨基-2-脱氧糖苷
公开(公告)号：US4308376A
公开(公告)日：1981-12-29
申请号：US77014
申请日：1979-09-19
IPC分类号： C07D309/30 , A61K31/7028 , A61K31/715 , A61K39/00 , A61P37/00 , C07H3/06 , C07H5/02 , C07H5/04 , C07H5/06 , C07H13/06 , C07H13/08 , C07H15/04 , G01N33/53 , C07H11/02
摘要： O-acetylated glycals react with ceric ammonium nitrate in the presence of sodium azide to provide, in good yield, O-acetylated 2-azido-2-deoxy glycosyl nitrates. These nitrates can be used to prepare 2-amino-2-deoxy sugars, such as D-galactosamine and lactosamine. The O-acetylated 2-azido-2-deoxy glycosyl nitrates can alternately be converted to O-acetylated 2-azido-2-deoxy glycosyl halides which are useful in the preparation of O-acetylated 2-azido-2-deoxy glycosides, which in turn can be reduced to 2-amino-2-deoxy glycosides. Of particular interest are the syntheses of 2-amino-2-deoxy glycosides which correspond to the terminal units of the antigenic determinant for the human A blood group. Attachment of these glycosides to a solid support provides immunoabsorbents which efficiently and preferentially absorb anti-A antibodies from blood plasma.
摘要翻译： O-乙酰化的甘氨酸在叠氮化钠存在下与硝酸铈铵反应，以高产率提供O-乙酰化的2-叠氮基-2-脱氧糖基硝酸盐。 这些硝酸盐可用于制备2-氨基-2-脱氧糖，如D-半乳糖胺和乳糖胺。 O-乙酰化的2-叠氮基-2-脱氧糖基硝酸盐可以替代地转化成O-乙酰化的2-叠氮基-2-脱氧糖基卤化物，其可用于制备O-乙酰化的2-叠氮基-2-脱氧糖苷，其中 又可以还原成2-氨基-2-脱氧糖苷。 特别感兴趣的是对应于人A血型的抗原决定簇的末端单元的2-氨基-2-脱氧糖苷的合成。 将这些糖苷连接到固体支持物上提供有效和优先地从血浆吸收抗-A抗体的免疫吸收剂。
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公开(公告)号：US5032505A
公开(公告)日：1991-07-16
申请号：US274069
申请日：1988-11-21
申请人： James M. Pierce , Ole Hindsgaul
发明人： James M. Pierce , Ole Hindsgaul
IPC分类号： C12N9/99 , A61K31/70 , A61K31/7028 , A61P35/00 , A61P43/00 , C07H15/04 , C07H15/18 , C12Q1/48
CPC分类号： C07H15/18 , A61K31/70 , C07H15/04 , Y10S436/813
摘要： Synthetic glycosaminosyl transferase-V acceptors and inhibitors are disclosed. Minimal trisaccharide inhibitors and acceptors specific for GnT-V, which is associated with the ability of cells to metastasize are useful, in diagnosis and treatment of conditions characterized by metastatic cells.
摘要翻译： 公开了合成的糖基糖基转移酶-V受体和抑制剂。 与细胞转移能力相关的GnT-V特异性的最小三糖抑制剂和受体可用于诊断和治疗以转移细胞为特征的病症。
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公开(公告)号：US4855126A
公开(公告)日：1989-08-08
申请号：US86360
申请日：1987-08-17
IPC分类号： A61K39/00 , C07H3/06 , C07H15/04 , G01N33/569 , G01N33/574
CPC分类号： C07H15/04 , A61K39/0011 , C07H3/06 , G01N33/56972 , G01N33/57469 , A61K2039/6081
摘要： Processes are provided for the synthesis of the human T-antigenic determinant 2-acetamido-2-deoxy-3-O-(.beta.-D-galactopyranosyl)-.alpha.-D-galactopyranoside containing an .alpha.-O-glycosidically linked bridging arm O--(CH.sub.2).sub.n COR. The determinant is coupled to carrier molecules to form artificial T-antigens, and to insoluble supports to form T-immunoadsorbents. The artificial T-antigen is shown to elicit a delayed type hypersensitivity reaction as a diagnostic for the presence of cancer in humans.
摘要翻译： 提供的方法用于合成含有α-O-糖苷键连接的桥连臂O-端基的人T-抗原决定簇2-乙酰氨基-2-脱氧-3-O-（β-D-吡喃半乳糖基）-α-D-吡喃半乳糖苷， （CH2）nCOR。 该决定簇与载体分子偶联以形成人造T抗原，并与不溶性载体偶联以形成T-免疫吸附剂。 显示人造T抗原引起延迟型超敏反应作为人类癌症存在的诊断。
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公开(公告)号：US4767845A
公开(公告)日：1988-08-30
申请号：US86357
申请日：1987-08-17
IPC分类号： A61K39/00 , C07H3/06 , C07H15/04 , G01N33/569 , G01N33/574 , C07H15/00 , C07H15/06
CPC分类号： C07H15/04 , A61K39/0011 , C07H3/06 , G01N33/56972 , G01N33/57469 , A61K2039/6081
摘要： Processes are provided for the synthesis of the human T-antigenic determinant 2-acetamido-2-deoxy-3-O-(.beta.-D-galactopyranosyl)-.alpha.-D-galactopyranoside containing an .alpha.-O-glycosidically linked bridging arm O--(CH.sub.2).sub.n COR. The determinant is coupled to carrier molecules to form artificial T-antigens, and to insoluble supports to form T-immunoadsorbents. The artifical T-antigen is shown to elicit a delayed type hypersensitivity reaction as a diagnostic for the presence of cancer in humans.
摘要翻译： 提供的方法用于合成含有α-O-糖苷键连接的桥连臂O-端基的人T-抗原决定簇2-乙酰氨基-2-脱氧-3-O-（β-D-吡喃半乳糖基）-α-D-吡喃半乳糖苷， （CH2）nCOR。 该决定簇与载体分子偶联以形成人造T抗原，并与不溶性载体偶联以形成T-免疫吸附剂。 人造T型抗原被证明引起延迟型超敏反应作为人类癌症存在的诊断。
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8.发明授权Synthesis of 2-amino-2-deoxyglycoses and 2-amino-2-deoxyglycosides from glycals 失效合成2-氨基-2-脱氧糖苷和2-氨基-2-脱氧糖苷
公开(公告)号：US4195174A
公开(公告)日：1980-03-25
申请号：US894366
申请日：1978-04-07
IPC分类号： C07D309/30 , A61K31/7028 , A61K31/715 , A61K39/00 , A61P37/00 , C07H3/06 , C07H5/02 , C07H5/04 , C07H5/06 , C07H13/06 , C07H13/08 , C07H15/04 , G01N33/53 , C07H11/02
摘要： O-acetylated glycals react with ceric ammonium nitrate in the presence of sodium azide to provide, in good yield, O-acetylated 2-azido-2-deoxy glycosyl nitrates. These nitrates can be used to prepare 2-amino-2-deoxy sugars, such as D-galactosamine and lactosamine. The O-acetylated 2-azido-2-deoxy glycosyl nitrates can alternately be converted to O-acetylated 2-azido-2-deoxy glycosyl halides which are useful in the preparation of O-acetylated 2-azido-2-deoxy glycosides, which in turn can be reduced to 2-amino-2-deoxy glycosides. Of particular interest are the syntheses of 2-amino-2-deoxy glycosides which correspond to the terminal units of the antigenic determinant for the human A blood group. Attachment of these glycosides to a solid support provides immunoabsorbents which efficiently and preferentially absorb anti-A antibodies from blood plasma.
摘要翻译： O-乙酰化的甘氨酸在叠氮化钠存在下与硝酸铈铵反应，以高产率提供O-乙酰化的2-叠氮基-2-脱氧糖基硝酸盐。 这些硝酸盐可用于制备2-氨基-2-脱氧糖，如D-半乳糖胺和乳糖胺。 O-乙酰化的2-叠氮基-2-脱氧糖基硝酸盐可以替代地转化成O-乙酰化的2-叠氮基-2-脱氧糖基卤化物，其可用于制备O-乙酰化的2-叠氮基-2-脱氧糖苷，其中 又可以还原成2-氨基-2-脱氧糖苷。 特别感兴趣的是对应于人A血型的抗原决定簇的末端单元的2-氨基-2-脱氧糖苷的合成。 将这些糖苷连接到固体支持物上提供有效和优先地从血浆吸收抗-A抗体的免疫吸收剂。
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公开(公告)号：US5240601A
公开(公告)日：1993-08-31
申请号：US270950
申请日：1988-11-09
申请人： M. Abdul Mazid
发明人： M. Abdul Mazid
IPC分类号： A61M1/36 , B01D15/00 , B01D15/08 , B01J20/26 , B01J20/281 , B01J20/286 , B01J20/32 , G01N30/02 , G01N30/52 , G01N30/56 , G01N30/88
CPC分类号： B01J20/327 , A61M1/3679 , B01J20/286 , B01J20/3204 , B01J20/3219 , B01J20/3242 , B01J20/3248 , B01J20/3268 , B01J20/3272 , B01J20/3274 , G01N2030/525 , G01N2030/567 , G01N2030/8813 , G01N2030/8822 , G01N30/02
摘要： A method of coating chromatographic particulate supports to provide a biocompatible outer layer of synthetic membrane-type film which prevents the release of fines but permits the adsorption of components to an affinity ligand is described. The matrix is provided with a membrane-type coating, which prevents leaching of fines, with a pore size of at least 20 angstroms. The coating is applied to a solid particulate under conditions where an integral membrane coat will be formed. It may also be necessary to control the size and number of pores of the membranes by treating a suspension of the solid support in a solvent which contains 0.1-1% of the support weight of a biocompatible polymer along with 0.5-5% of the weight of said polymer of a dissolved compatible pore-controlling component. The solvent is then removed from the suspension and the membrane-coated material used in extracorporeal treatment of body fluids or in other chromatographic techniques. The coating process can be conducted before or after the particulate support is functionalized and/or derivatized.
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公开(公告)号：US5206356A
公开(公告)日：1993-04-27
申请号：US730227
申请日：1991-07-15
申请人： James M. Pierce , Ole Hindsgaul
发明人： James M. Pierce , Ole Hindsgaul
摘要： Synthetic glycosaminosyl transferase-V acceptors and inhibitors are disclosed. Minimal trisaccharide inhibitors and acceptors specific for GnT-V, which is associated with the ability of cells to metastasize are useful, in diagnosis and treatment of conditions characterized by metastatic cells.
摘要翻译： 公开了合成的糖基糖基转移酶-V受体和抑制剂。 与细胞转移能力相关的GnT-V特异性的最小三糖抑制剂和受体可用于诊断和治疗以转移细胞为特征的病症。
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