-
公开(公告)号:US08871953B2
公开(公告)日:2014-10-28
申请号:US12990442
申请日:2010-03-23
申请人: Andrea Castellin , Clark Ferrari , Marco Galvagni
发明人: Andrea Castellin , Clark Ferrari , Marco Galvagni
IPC分类号: C07D313/12 , C07D313/06
CPC分类号: C07D313/12
摘要: The present invention relates to a novel process for the preparation of olopatadine hydrochloride starting from an advanced intermediate.
摘要翻译: 本发明涉及从高级中间体开始制备盐酸奥洛他定的新方法。
-
公开(公告)号:US09315470B2
公开(公告)日:2016-04-19
申请号:US14395703
申请日:2014-02-11
发明人: Ottorino De Lucchi , Stefano Tartaggia , Clark Ferrari , Marco Galvagni , Marta Pontini , Stefano Fogal , Riccardo Motterle , Rosa Maria Moreno , Alex Comely
IPC分类号: C07D239/42 , C07F7/18 , C07D317/30 , C07D215/14 , C07D209/24 , C07D413/12 , C07D419/12
CPC分类号: C07F7/1804 , B01J27/13 , B01J31/122 , B01J2231/543 , C07D209/12 , C07D209/24 , C07D213/30 , C07D215/14 , C07D239/42 , C07D317/30 , C07D413/12 , C07D419/12 , C07F7/188 , C07F7/1892
摘要: Object of the present invention is an improved process for the preparation of key intermediates for the synthesis of statins.
摘要翻译: 本发明的目的是制备用于合成他汀类药物的关键中间体的改进方法。
-
3.
公开(公告)号:US09169236B2
公开(公告)日:2015-10-27
申请号:US14624997
申请日:2015-02-18
发明人: Francesco Fontana , Alfredo Paio
IPC分类号: C07D405/04 , C07D405/14
CPC分类号: C07D405/04 , C07C309/30 , C07D405/14
摘要: The present invention refers to a new efficient process for the synthesis of the active pharmaceutical ingredient Lapatinib and salts thereof. In particular, the present synthesis is carried out employing new intermediates in which the amine function is protected by a group cleavable in basic milieu that provides a higher overall yield of the synthesis process.
-
-