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96 条记录 (耗时 0.036 秒)

    Pallet changing system for a machine tool
    1.
    发明授权
    Pallet changing system for a machine tool 有权

    公开(公告)号：US10723570B2

    公开(公告)日：2020-07-28

    申请号：US15962855

    申请日：2018-04-25

    申请人： FIDIA S.p.A.

    发明人： Giuseppe Morfino ,  Giacomo Bene

    IPC分类号： B65G65/00 ,  B23Q7/14 ,  B65G1/04 ,  B23Q1/52

    摘要： The pallet changing system comprises a pallet deposition and pick-up station and a pallet loading and unloading station, horizontally spaced from one another along a first horizontal direction (A-A), as well as a pallet handling unit. The pallet handling unit includes: horizontal guide means extending along the first horizontal direction (A-A) between the pallet deposition and pick-up station and the pallet loading and unloading station; a pair of motorized uprights, which are jointly movable in a controlled manner in the first horizontal direction (A-A) between the pallet deposition and pick-up station and the pallet loading and unloading station, each upright being provided with a respective motorized lifting carriage vertically movable in a controlled manner, each lifting carriage being provided with a pair of gripping devices which are horizontally spaced from one another and selectively or jointly controllable to engage a corresponding end of a pallet (P) so as to allow rotation of the pallet (P) about a first horizontal axis; a pair of motorized auxiliary carriages, which are jointly movable in the first horizontal direction (A-A) between the pallet deposition and pick-up station and the pallet loading and unloading station, and are provided each with a gripping device arranged to engage a corresponding end of the pallet (P) facing the pallet deposition and pick-up station, so as to allow rotation of the pallet (P) about the first horizontal axis; and a motorized transporting carriage which is arranged to transport, in a vertical attitude, the pallet (P) with the workpiece (WP) connected thereto, and is movable between the pallet loading and unloading station and a working area (SW) of the machine tool (MT) in a second horizontal direction (B-B) forming an angle with respect to the first horizontal direction (A-A).

    Sulfated lyso-ganglioside derivatives
    3.
    发明授权
    Sulfated lyso-ganglioside derivatives 失效
    硫酸溶解性神经节苷脂衍生物

    公开(公告)号：US5795869A

    公开(公告)日：1998-08-18

    申请号：US530267

    申请日：1995-11-02

    申请人： Aurelio Romeo ,  Gunter Kirschner ,  Carlo Chizzolini ,  Hari Manev ,  Laura Facci

    发明人： Aurelio Romeo ,  Gunter Kirschner ,  Carlo Chizzolini ,  Hari Manev ,  Laura Facci

    IPC分类号： C07H15/10 ,  A61K31/70 ,  C07H15/00

    CPC分类号： C07H15/10

    摘要： Semisynthetic analogues of gangliosides selected from the group consisting of N-sulfo-, N-hydrocarbyl-sulfonyl- and N-hydrocarbyloxy-sulfonyl-N,N'-dilyso-gangliosides and the N'-acyl derivatives thereof, N'-sulfo-, N'-hydrocarbylsulfonyl- and N'-hydrocarbyloxy-sulfonyl-N,N'-dilyso-gangliosides and the N-acyl derivatives thereof, N,N'-di or polysulfo-N,N'-di- or poly-lyso-gangliosides, N,N'-di- or polyhydrocarbylsulfonyl-N,N'-di- or poly-lyso-gangliosides and N,N'-di- or polyhydrocarbyloxy-N,N'-di- or poly-lyso-gangliosides, and functional derivatives thereof, and salts of these compounds, have protective activity against neurotoxicity induced by excitatory amino acids and are foreseen to be used in therapy in the nervous system and in modulating of the expression of determinants such as CD.sub.4 on the surface of human cells in the immune system.

    摘要翻译： PCT No.PCT / US94 / 01966 Sec。 371日期：1995年11月2日 102（e）1995年11月2日日期PCT 1994年3月4日PCT公布。 出版物WO94 / 20516 PCT 日期1994年9月15日选自N-磺基 - ，N-烃基 - 磺酰基 - 和N-烃氧基 - 磺酰基-N，N'-二甘氨酸神经节苷脂及其N'-酰基衍生物的神经节苷脂的合成类似物， N' - 磺基 - ，N'-烃基磺酰基 - 和N'-烃氧基 - 磺酰基-N，N'-二甘氨酸神经节苷脂及其N-酰基衍生物，N，N'-二或多磺基-N，N'-二 - 或多溶解神经节苷脂，N，N'-二 - 或多烃基磺酰基-N，N'-二 - 或多赖氨酸神经节苷脂和N，N'-二 - 或多羟基氧基-N，N'-二 - 或 多元神经节苷脂及其功能衍生物和这些化合物的盐具有对兴奋性氨基酸诱导的神经毒性的保护作用，并且预期用于神经系统的治疗和调节诸如CD4 在免疫系统中的人类细胞表面。

    Method of using low molecular weight hyaluronic acid for stimulating bone formation
    4.
    发明授权
    Method of using low molecular weight hyaluronic acid for stimulating bone formation 失效
    使用低分子量透明质酸刺激骨形成的方法

    公开(公告)号：US5646129A

    公开(公告)日：1997-07-08

    申请号：US318804

    申请日：1995-01-17

    申请人： Lanfranco Callegaro ,  Aurelio Romeo

    发明人： Lanfranco Callegaro ,  Aurelio Romeo

    IPC分类号： C08B37/08 ,  A61K31/715 ,  A61K31/728 ,  A61P19/08 ,  A61P43/00

    CPC分类号： C08B37/0072

    摘要： The present invention is drawn to hyaluronic acid fractions having molecular weights in the range of from about 20,000 to about 60,000 daltons, wherein these hyaluronic acid fractions possess osteoinductive activity. The present invention further includes pharmaceutical compositions comprising such hyaluronic acid fractions to be used in the treatment of various types of bone disorders, as well as methods of treating such disorders using the pharmaceutical compositions.

    摘要翻译： PCT No.PCT / EP93 / 00932 Sec。 371日期1995年1月17日 102（e）日期1995年1月17日PCT 1993年4月16日PCT公布。 出版物WO93 / 20827 日期：1993年10月28日本发明涉及分子量在约20,000至约60,000道尔顿范围内的透明质酸部分，其中这些透明质酸部分具有骨诱导活性。 本发明还包括药物组合物，其包含用于治疗各种类型的骨骼疾病的这种透明质酸组分，以及使用该药物组合物治疗此类病症的方法。

    Preparation of highly hydrated self-supporting hyaluronic acid containing films
    5.
    发明授权
    Preparation of highly hydrated self-supporting hyaluronic acid containing films 失效
    高水合自支撑透明质酸含膜的制备

    公开(公告)号：US5618561A

    公开(公告)日：1997-04-08

    申请号：US488049

    申请日：1995-06-07

    申请人： Francesco Della Valle ,  Alessandro Rastrelli ,  Gabriella Calderini ,  Aurelio Romeo

    发明人： Francesco Della Valle ,  Alessandro Rastrelli ,  Gabriella Calderini ,  Aurelio Romeo

    IPC分类号： A61K9/70 ,  A61K9/06 ,  A61L15/22 ,  A61L15/28 ,  A61L15/44 ,  C08L5/04 ,  C08L5/08 ,  D01F9/04

    CPC分类号： C08L5/08 ,  A61L15/225 ,  A61L15/28 ,  A61L15/44 ,  C08L5/04 ,  A61L2300/00 ,  Y10S424/13 ,  Y10S514/944

    摘要： This invention provides new gels in the form of highly hydrated self-supporting film, comprising one or more alkaline alginates, an alkaline earth alginate, a polyalcohol and a hyaluronic acid or a derivative thereof, and their preparation process. These polysaccharide-matrix gels in highly hydrated self-supporting film form are suitable for use as covering and protection materials for cutaneous lesions and/or pathologies in that they are obtainable in self-supporting form in the desired thickness, are transparent, flexible, have good mechanical characteristics, are adaptable to the lesion surface without strongly adhering to it, and are permeable to gas but are impermeable to liquids and bacteria; one or more pharmacologically active substances can also be incorporated in the gel.

    摘要翻译： 本发明提供了具有高度水合的自支撑膜形式的新凝胶，其制备方法包括一种或多种碱性藻酸盐，碱土藻酸盐，多元醇和透明质酸或其衍生物。 这些高度水合的自支撑膜形式的多糖基质凝胶适合用作皮肤损伤和/或病变的覆盖和保护材料，因为它们可以以所需厚度的自支撑形式获得，是透明的，柔性的，具有 良好的机械特性，适应于病变表面而不强烈粘附在其上，并且可渗透气体，但不渗透液体和细菌; 一种或多种药理活性物质也可以掺入凝胶中。

    Analgesic and nootropic drugs
    6.
    发明授权
    Analgesic and nootropic drugs 失效
    止痛药和益智药

    公开(公告)号：US5583142A

    公开(公告)日：1996-12-10

    申请号：US369761

    申请日：1995-01-06

    申请人： Alessandro Bartolini ,  Carla Ghelardini ,  Alberto Giotti ,  Fulvio Gualtieri ,  Serena Scapecchi ,  Gino Toffano

    发明人： Alessandro Bartolini ,  Carla Ghelardini ,  Alberto Giotti ,  Fulvio Gualtieri ,  Serena Scapecchi ,  Gino Toffano

    IPC分类号： A61K31/46 ,  A61P25/02 ,  C07D451/04 ,  C07D451/10 ,  A61K31/44 ,  C07D451/02

    CPC分类号： C07D451/04 ,  C07D451/10

    摘要： Compounds of general formula: ##STR1## where: Ar=phenyl or beta-naphtyl, or aromatic heterocyclic 6-membered ring containing one or two nitrogen atoms;R.sub.1 =one or more substituents of the Ar nucleus, preferably in para position, and selected out of the group consisting of H, CH.sub.3, CH.sub.2 --CH--(CH.sub.3).sub.2, O--CH.sub.3, Cl, F, Br, CF.sub.3, NH.sub.2, S--CH.sub.3, CN, NO.sub.2 R.sub.2 =H, CH.sub.3, C.sub.2 H.sub.5, CH(CH.sub.3).sub.2 ;R.sub.3 = ##STR2## Where R.sub.4 =H, CH.sub.3, C.sub.2 H.sub.5 R.sub.5 =H, CH.sub.3X=none O, S, NH, NCH.sub.3, --CH=CH--, --C.ident.C--Y=O, NH,both in the racemic Form and in the isomeric enantiomeric forms,which produce a nootropic effect, i.e. memory enhancement and learning facilitation, as well as an analgesic effect.

    摘要翻译： 通式为：其中：Ar =苯基或β-萘基，或含有一个或两个氮原子的芳香杂环六元环; R1 = Ar核的一个或多个取代基，优选在对位，选自H，CH 3，CH 2 -CH-（CH 3）2，O-CH 3，Cl，F，Br，CF 3，NH 2 ，S-CH 3，CN，NO 2 R 2 = H，CH 3，C 2 H 5，CH（CH 3）2; R3 = 其中R4 = H，CH3，C2H5 R5 = H，CH3 X =无O，S，NH，NCH 3，-CH = CH-，-C = CY = O，NH，均以外消旋形式和 在异构体对映异构体形式中，其产生向异性作用，即记忆增强和学习促进作用以及止痛作用。