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公开(公告)号：US08470373B2
公开(公告)日：2013-06-25
申请号：US13120408
申请日：2009-09-07
IPC分类号： A61K9/1694
CPC分类号： A61K9/14 , A61K9/0056 , A61K9/0095 , A61K9/2013 , A61K9/209 , A61K9/4858 , A61K31/05 , A61K31/16 , A61K31/164 , A61K31/352 , Y02A50/40 , A61K2300/00
摘要： The present invention relates to a composition for pharmaceutical or veterinary use, comprising palmitoylethanolamide. In particular, the present invention relates to a pharmaceutical composition for human or veterinary use, containing a therapeutically efficient amount of palmitoylethanolamide in the ultra-micronized form, wherein more than 90% by weight of palmitoylethanolamide has particle sizes lower than 6 microns, together with pharmaceutically acceptable excipients.
摘要翻译： 本发明涉及用于药物或兽医用途的组合物，其包含棕榈酰乙醇酰胺。 特别地，本发明涉及一种用于人或兽用药物的药物组合物，其含有超微粉化形式的治疗有效量的棕榈酰乙醇酰胺，其中超过90重量％的棕榈酰乙醇酰胺具有小于6微米的粒度，以及 药学上可接受的赋形剂。
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2.发明申请PHARMACOLOGICAL PREPARATION FOR TOPICAL USE CONTAINING N-PALMITOYL-VANILLAMIDE 有权含有N-棕榈酰 - 丹宁的局部使用药理学准备公开(公告)号：US20120115808A1
公开(公告)日：2012-05-10
申请号：US13291294
申请日：2011-11-08
申请人： Francesco DELLA VALLE , Luciano De Petrocellis , Sabatino Maione , Vincenzo Di Marzo , Maria Federica Della Valle
发明人： Francesco DELLA VALLE , Luciano De Petrocellis , Sabatino Maione , Vincenzo Di Marzo , Maria Federica Della Valle
IPC分类号： A61K31/165 , A61K31/728 , A61P29/00 , A61K31/201
CPC分类号： A61K31/165 , A61K9/0014 , A61K9/0031 , A61K9/0034 , A61K9/0048 , A61K9/006 , A61K9/0095 , A61K9/06 , A61K9/7038 , A61K31/07 , A61K31/194 , A61K31/728 , A61K45/06 , A61K2300/00
摘要： The present invention relates to topical preparations containing N-palmitoyl-vanillamide having hyperalgesic activity. In particular, the invention relates to N-palmitoyl-vanillamide for use in the treatment of pathologies selected from: post-herpetic neuralgia, neuralgia of trigeminus, occipital neuralgia, dental neuralgia, glottopharyngeal neuralgia, uremic neuralgia, diabetic neuralgia, headache of different origin, neuropathic itch, neurogenic itch, uremic itch, vulvodinia, vulvar vestibulitis, ano-rectal pain and itch, balano-preputial pain and itch, painful urogenital disorders of dogs and cats, psoriasis-associated pruritus and pain, itching skin diseases (e.g. atopic dermatitis) in the human and veterinary field, muscular pain, pain of the tendon, osteoarthritis associated pain in humans, dogs and cats; painful eye diseases in the human and veterinary field, inflammatory pathologies of the oral cavity in the human and veterinary field.
摘要翻译： 本发明涉及具有过敏反应活性的N-棕榈酰 - 香草酰胺的局部制剂。 特别地，本发明涉及用于治疗选自以下的病理学的N-棕榈酰基 - 香草酰胺：疱疹后神经痛，三叉神经痛神经痛，枕骨神经痛，牙齿神经痛，咽喉神经痛，尿毒症神经痛，糖尿病性神经痛，不同来源的头痛 ，神经性瘙痒，神经源性瘙痒，尿毒症瘙痒，外阴阴道炎，外阴前庭炎，直肠疼痛和瘙痒，巴拉阴性疼痛和瘙痒，狗和猫的疼痛性泌尿生殖器疾病，牛皮癣相关性瘙痒和疼痛，瘙痒性皮肤病 人类和兽医领域的肌肉炎，肌肉疼痛，肌腱疼痛，人类，狗和猫中的骨关节炎相关疼痛; 人类和兽医领域的痛苦的眼睛疾病，人类和兽医领域的口腔炎症病理。
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3.发明申请Pharmaceutical Composition for the Treatment of Pathologies Caused by the General Response of the Immune System 审中-公开用于治疗由免疫系统的一般反应引起的病理学的药物组合物公开(公告)号：US20110288037A1
公开(公告)日：2011-11-24
申请号：US13196964
申请日：2011-08-03
申请人： Francesco Della Valle , Maria Federica Della Valle , Gabriele Marcolongo , Gianpiero Ravagnan , Vincenzo Di Marzo
发明人： Francesco Della Valle , Maria Federica Della Valle , Gabriele Marcolongo , Gianpiero Ravagnan , Vincenzo Di Marzo
IPC分类号： A61K31/16 , A61P37/00 , A61P37/08 , A61P17/00 , A61P27/02 , A61P25/00 , A61P17/06 , A61P29/00 , A61P19/04 , A61P13/08 , A61P9/10 , A61P25/02 , A61P15/00 , A61P31/12 , A61P1/00 , A61P1/04 , A61K31/7034
CPC分类号： A61K31/7032 , A61K31/05 , A61K31/16 , A61K31/194 , A61K2300/00
摘要： The present invention relates to a pharmaceutical composition consisting of amides of mono- and di-carboxylic acids and hydroxystilbenes, and may be used for the treatment of pathologies caused, sustained and/or characterised by an abnormal general response of the immune system, in both humans and animals.
摘要翻译： 本发明涉及由单羧酸和二羧酸和羟基茋的酰胺组成的药物组合物，可用于治疗由免疫系统的异常一般反应引起，持续和/或表征的病理学 人类和动物。
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4.发明授权Covalent derivatives of alkanolamides of monocarboxylic and dicarboxylic acids functionally active on the CB2 cannabinoid receptor 有权单羧酸和二羧酸的链烷醇酰胺的共价衍生物在CB2大麻素受体上功能活性公开(公告)号：US06864285B1
公开(公告)日：2005-03-08
申请号：US10030061
申请日：1999-07-07
IPC分类号： A61P43/00 , C07C233/18 , C07C235/74 , C07C271/12 , C07C271/22 , C07D295/088 , C07D307/20 , A61K43/00 , C07C233/00
CPC分类号： C07D295/088 , C07C233/18 , C07C235/74 , C07C271/12 , C07C271/22 , C07D307/20
摘要： The present invention relates to novel covalent derivatives of alkanolamides of monocarboxylic and dicarboxylic acids with aminoalcohols of general formula (I) which can usefully be used as agonists of the CB2 cannabinoid receptor and hence as drugs active in pathological conditions which can be controlled by stimulation and/or costimulation of this receptor
摘要翻译： 本发明涉及一元羧酸和二羧酸的链烷醇酰胺与通式（I）的氨基醇的新型共价衍生物，其可有效地用作CB2大麻素受体的激动剂，因此作为在病理状态下活性的药物，其可以通过刺激和 /或共刺激该受体
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5.发明授权Highly bioadhesive and mucoadhesive compositions containing polyvinyl alcohol, polycarbophil and biopolymer for the treatment of skin conditions and as vehicles for active ingredients 失效含有聚乙烯醇，聚卡波非和生物聚合物的高度生物粘附和粘膜粘附组合物，用于治疗皮肤病症和作为活性成分的载体
公开(公告)号：US5876744A
公开(公告)日：1999-03-02
申请号：US776537
申请日：1997-04-22
IPC分类号： A61K8/73 , A61K8/81 , A61K9/00 , A61K47/10 , A61K47/32 , A61K47/36 , A61Q11/00 , A61Q19/00 , A61F13/00
CPC分类号： A61Q19/007 , A61K8/732 , A61K8/733 , A61K8/735 , A61K8/8129 , A61K9/0014 , A61K9/006 , A61Q11/00 , A61Q19/00 , A61K47/10 , A61K47/32 , A61K47/36 , A61K9/0034 , A61K9/0048
摘要： Compositions having high bioadhesion, mucoadhesion and visoelasticity, containing mixtures of synthetic polymers, such as polyvinyl alcohol and Polycarbophil, and of biopolymers, such as alginic acid, hyaluronic acid and dermatan sulfate, useful in the treatment of skin and mucosal tissues dryness and dehydration, and suitables as vehicles for active ingredients in percutaneous absorption.
摘要翻译： PCT No.PCT / EP95 / 02999第 371日期1997年04月22日 102（e）1997年4月22日PCT PCT 1995年7月28日PCT公布。 第WO96 / 03973号公报 日期1996年2月15日具有高生物粘附性，粘膜粘附性和粘弹性的组合物，其包含合成聚合物如聚乙烯醇和聚卡波非的混合物，以及可用于治疗皮肤和粘膜的生物聚合物，例如海藻酸，透明质酸和硫酸皮肤素 组织干燥和脱水，以及适合作为经皮吸收的活性成分的载体。
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6.发明授权Biotin amides able to control glucidic metabolisms under dysmetabolic conditions and relative therapeutical compositions 失效生物素酰胺能够在异常代谢条件和相对治疗组合物下控制糖代谢
公开(公告)号：US5814650A
公开(公告)日：1998-09-29
申请号：US825458
申请日：1997-03-28
IPC分类号： C07D495/04 , C07D519/00 , A61K31/415
CPC分类号： C07D495/04
摘要： Described herein are biotin amides which are able to control glucidic metabolism under dysmetabolic conditions and relative therapeutical compositions for the treatment of insulin-independent diabetes, insulin-dependent diabetes and relative complicating diseases, such as peripheral neuropathies and other associated chronic invalidating disorders.
摘要翻译： 本文描述了生物素酰胺，其能够在代谢紊乱条件下控制糖代谢，并且用于治疗不依赖胰岛素的糖尿病，胰岛素依赖性糖尿病和相对并发疾病如周围神经病和其它相关的慢性无效疾病的相对治疗组合物。
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7.发明授权
公开(公告)号：US5650164A
公开(公告)日：1997-07-22
申请号：US209626
申请日：1994-03-14
CPC分类号： C12N5/0629 , A61F2/105 , A61L27/60 , C12N5/0062 , C12N5/0068 , A61K35/12 , C12N2533/70 , C12N2533/80 , C12N2539/10 , Y10T428/24273
摘要： The invention relates to biocompatible membranes constructed of materials of natural, synthetic or semisynthetic origin, and having a thickness of between 10 and 500 .mu., characterised by containing an ordered series of holes of a constant size between 10 and 1000 .mu., separated from each other by a constant distance of between 50 and 1000 .mu., and obtained by perforation by mechanical, thermal laser or ultraviolet radiation means, they being suitable for use as a support for the in vitro growth of epithelial cells, the invention also relating to the artificial skin obtained thereby and its use in grafts.
摘要翻译： 本发明涉及由天然，合成或半合成来源的材料构成的生物相容性膜，其厚度为10至500微米，其特征在于包含彼此分离的10至1000微米的恒定尺寸的有序系列的孔 通过50至1000微米之间的恒定距离，并且通过机械，热激光或紫外线辐射手段穿孔获得，它们适合用作上皮细胞的体外生长的载体，本发明还涉及人造皮肤 由此获得并在移植中的应用。
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公开(公告)号：US5332809A
公开(公告)日：1994-07-26
申请号：US833517
申请日：1992-02-11
IPC分类号： A23L1/30 , A61K8/40 , A61K8/41 , A61K8/49 , A61K8/64 , A61K8/72 , A61K8/73 , A61K8/96 , A61L15/28 , A61L31/00 , C08B37/00 , C07H13/02
CPC分类号： C08B37/006
摘要： The present invention is directed to total and partial esters of gellan in which the esterifying alcohol component is derived from aliphatic, araliphatic, cycloaliphatic or heterocyclic alcohols, and salts of said partial esters with inorganic or organic bases, and compositions containing the same.
摘要翻译： 本发明涉及结构甘醇的全部和部分酯，其中酯化醇组分衍生自脂族，芳脂族，脂环族或杂环醇，所述偏酯与无机或有机碱的盐，以及含有它们的组合物。
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公开(公告)号：US5147861A
公开(公告)日：1992-09-15
申请号：US761511
申请日：1991-09-18
CPC分类号： A61K9/0014 , A61K47/36 , A61K47/4823 , A61K8/733 , A61K9/0019 , A61L17/10 , A61L27/20 , A61Q19/00 , C08B37/0084 , Y10S514/912
摘要： Total esters of alginic acid with aliphatic and araliphatic alcohols possess important bioplastic and pharmaceutical qualities and are useful in various fields including the sanitary and surgical fields.
摘要翻译： 藻酸与脂肪族和芳脂肪醇的总酯具有重要的生物塑料和药物特性，可用于包括卫生和外科领域在内的各个领域。
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公开(公告)号：US4897381A
公开(公告)日：1990-01-30
申请号：US209490
申请日：1988-06-21
IPC分类号： A61K31/16 , A61K31/165 , A61K31/195 , A61K31/435 , A61K31/4406 , A61K31/4409 , A61K31/455 , A61K31/48 , A61K31/52 , A61K31/522 , A61K31/66 , A61K31/675 , A61K31/70 , A61K31/7028 , A61P25/08 , A61P25/20 , A61P25/24 , A61P25/26 , A61P43/00 , C07C231/02 , C07C233/18 , C07C233/71 , C07C235/48 , C07C235/52 , C07C237/08 , C07C237/12 , C07D213/81 , C07D213/82 , C07D457/06 , C07D473/08 , C07F9/09 , C07F9/10 , C07F9/113 , C07F9/58 , C07H15/04 , C07H15/10 , C07H15/18 , C07H15/26
CPC分类号： C07D213/81 , C07D213/82 , C07D457/06 , C07D473/08 , C07F9/091 , C07F9/10 , C07F9/113 , C07F9/588 , C07H15/10 , C07H15/18 , C07H15/26
摘要： Organic amide compounds of the formula ##STR1## wherein R.sub.1 --CO is a residue of a carboxylic acid with the proviso that the carboxylic acid is not a natural fatty acid normally bound to nitrogen of nitrogenous lipids, R.sub.2 is a hydrogen atom, a C.sub.1-7 alkyl group, or a C.sub.4-7 cycloalkyl group, and R.sub.3-N is a residue of a nitrogenous lipid. The compounds are useful in increasing or stimulating the in vivo biological activity of in vitro biologically active carboxylic acids.
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