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1.发明授权
公开(公告)号：US5650164A
公开(公告)日：1997-07-22
申请号：US209626
申请日：1994-03-14
CPC分类号： C12N5/0629 , A61F2/105 , A61L27/60 , C12N5/0062 , C12N5/0068 , A61K35/12 , C12N2533/70 , C12N2533/80 , C12N2539/10 , Y10T428/24273
摘要： The invention relates to biocompatible membranes constructed of materials of natural, synthetic or semisynthetic origin, and having a thickness of between 10 and 500 .mu., characterised by containing an ordered series of holes of a constant size between 10 and 1000 .mu., separated from each other by a constant distance of between 50 and 1000 .mu., and obtained by perforation by mechanical, thermal laser or ultraviolet radiation means, they being suitable for use as a support for the in vitro growth of epithelial cells, the invention also relating to the artificial skin obtained thereby and its use in grafts.
摘要翻译： 本发明涉及由天然，合成或半合成来源的材料构成的生物相容性膜，其厚度为10至500微米，其特征在于包含彼此分离的10至1000微米的恒定尺寸的有序系列的孔 通过50至1000微米之间的恒定距离，并且通过机械，热激光或紫外线辐射手段穿孔获得，它们适合用作上皮细胞的体外生长的载体，本发明还涉及人造皮肤 由此获得并在移植中的应用。
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2.发明授权Biocompatible perforated membranes, processes for their preparation, their use as a support in the in vitro growth of epithelial cells, the artificial skin obtained in this manner, and its use in skin grafts 失效生物相容性穿孔膜，其制备方法，它们作为上皮细胞体外生长中的载体的用途，以这种方式获得的人造皮肤及其在皮肤移植物中的用途
公开(公告)号：US5326356A
公开(公告)日：1994-07-05
申请号：US19818
申请日：1993-02-16
IPC分类号： A61L27/00 , A61F2/10 , A61K35/12 , A61L27/60 , C12N5/00 , C12N5/071 , A61F2/02 , A61F2/54 , A61F13/00
CPC分类号： C12N5/0629 , A61F2/105 , A61L27/60 , C12N5/0062 , C12N5/0068 , A61K35/12 , C12N2533/70 , C12N2533/80 , C12N2539/10 , Y10T428/24273
摘要： It is provided biocompatible membranes constructed of materials of natural, synthetic or semisynthetic origin, and having a thickness of between 10 and 500.mu., characterised by containing an ordered series of holes of a constant size between 10 and 1000.mu., separated from each other by a constant distance of between 50 and 1000.mu., and obtained by perforation by mechanical, thermal laser or ultraviolet radiation means, they being suitable for use as a support for the in vitro growth of epithelial cells. Artificial skins obtained thereby and its use in grafts are also provided.
摘要翻译： 提供由天然，合成或半合成来源的材料构成的生物相容性膜，其厚度为10至500微米，其特征在于含有10至1000微米之间的恒定尺寸的有序系列的孔，彼此分开通过 通过机械，热激光或紫外线辐射手段穿孔获得50至1000微米的恒定距离，它们适合用作上皮细胞体外生长的载体。 还提供了由此获得的人造皮肤及其在移植物中的用途。
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公开(公告)号：US5709877A
公开(公告)日：1998-01-20
申请号：US476569
申请日：1995-06-07
IPC分类号： A61K9/70 , A61K9/06 , A61L15/22 , A61L15/28 , A61L15/44 , C08L5/04 , C08L5/08 , A61K47/36 , A61L15/64
CPC分类号： C08L5/08 , A61L15/225 , A61L15/28 , A61L15/44 , C08L5/04 , A61L2300/00 , Y10S424/13 , Y10S514/944
摘要： This invention provides new gels in the form of highly hydrated self-supporting film, comprising one or more alkaline alginates, an alkaline earth alginate, a polyalcohol and a natural, synthetic or semisynthetic polymer of hydrophilic nature, and their preparation process. These polysaccharide-matrix gels in highly hydrated self-supporting film form are suitable for use as covering and protection materials for cutaneous lesions and/or pathologies in that they are obtainable in self-supporting form in the desired thickness, are transparent, flexible, have good mechanical characteristics, are adaptable to the lesion surface without strongly adhering to it, and are permeable to gas but are impermeable to liquids and bacteria; one or more pharmacologically active substances can also be incorporated in the gel.
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4.发明授权Gels in the form of highly hydrated self-supporting film, the process for their preparation, and their use in the therapy of cutaneous lesions and/or pathologies 失效高度水合的自支撑膜形式的凝胶，其制备方法及其在治疗皮肤病变和/或病理学中的应用
公开(公告)号：US5523093A
公开(公告)日：1996-06-04
申请号：US707790
申请日：1991-05-30
IPC分类号： A61K9/70 , A61K9/06 , A61L15/22 , A61L15/28 , A61L15/44 , C08L5/04 , C08L5/08 , A61K47/36 , A61L15/64
CPC分类号： C08L5/08 , A61L15/225 , A61L15/28 , A61L15/44 , C08L5/04 , A61L2300/00 , Y10S424/13 , Y10S514/944
摘要： This invention provides new gels in the form of highly hydrated self-supporting film, comprising one or more alkaline alginates, an alkaline earth alginate, a polyalcohol and a natural, synthetic or semisynthetic polymer of hydrophilic nature, and their preparation process. These polysaccharide-matrix gels in highly hydrated self-supporting film form are suitable for use as covering and protection materials for cutaneous lesions and/or pathologies in that they are obtainable in self-supporting form in the desired thickness, are transparent, flexible, have good mechanical characteristics, are adaptable to the lesion surface without strongly adhering to it, and are permeable to gas but are impermeable to liquids and bacteria; one or more pharmacologically active substances can also be incorporated in the gel.
摘要翻译： 本发明提供了高度水合的自支撑膜形式的新凝胶，其包含一种或多种亲水性的碱性藻酸盐，碱土金藻酸盐，多元醇和天然的，合成的或半合成的聚合物及其制备方法。 这些高度水合的自支撑膜形式的多糖基质凝胶适合用作皮肤损伤和/或病变的覆盖和保护材料，因为它们可以以所需厚度的自支撑形式获得，是透明的，柔性的，具有 良好的机械特性，适应于病变表面而不强烈粘附在其上，并且可渗透气体，但不渗透液体和细菌; 一种或多种药理活性物质也可以掺入凝胶中。
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5.发明授权
公开(公告)号：US5618561A
公开(公告)日：1997-04-08
申请号：US488049
申请日：1995-06-07
CPC分类号： C08L5/08 , A61L15/225 , A61L15/28 , A61L15/44 , C08L5/04 , A61L2300/00 , Y10S424/13 , Y10S514/944
摘要： This invention provides new gels in the form of highly hydrated self-supporting film, comprising one or more alkaline alginates, an alkaline earth alginate, a polyalcohol and a hyaluronic acid or a derivative thereof, and their preparation process. These polysaccharide-matrix gels in highly hydrated self-supporting film form are suitable for use as covering and protection materials for cutaneous lesions and/or pathologies in that they are obtainable in self-supporting form in the desired thickness, are transparent, flexible, have good mechanical characteristics, are adaptable to the lesion surface without strongly adhering to it, and are permeable to gas but are impermeable to liquids and bacteria; one or more pharmacologically active substances can also be incorporated in the gel.
摘要翻译： 本发明提供了具有高度水合的自支撑膜形式的新凝胶，其制备方法包括一种或多种碱性藻酸盐，碱土藻酸盐，多元醇和透明质酸或其衍生物。 这些高度水合的自支撑膜形式的多糖基质凝胶适合用作皮肤损伤和/或病变的覆盖和保护材料，因为它们可以以所需厚度的自支撑形式获得，是透明的，柔性的，具有 良好的机械特性，适应于病变表面而不强烈粘附在其上，并且可渗透气体，但不渗透液体和细菌; 一种或多种药理活性物质也可以掺入凝胶中。
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6.发明授权Biocompatible perforated membranes, processes for their preparation, their use as a support in the in vitro growth of epithelial cells, the artificial skin obtained in this manner, and its use in skin grafts 失效生物相容性穿孔膜，其制备方法，它们作为上皮细胞体外生长中的载体的用途，以这种方式获得的人造皮肤及其在皮肤移植物中的用途
公开(公告)号：US5658331A
公开(公告)日：1997-08-19
申请号：US478541
申请日：1995-06-07
CPC分类号： C12N5/0629 , A61F2/105 , A61L27/60 , C12N5/0062 , C12N5/0068 , A61K35/12 , C12N2533/70 , C12N2533/80 , C12N2539/10 , Y10T428/24273
摘要： The invention relates to biocompatible membranes constructed of materials of natural, synthetic or semisynthetic origin, and having a thickness of between 10 and 500.mu., characterized by containing an ordered series of holes of a constant size between 10 and 1000.mu., separated from each other by a constant distance of between 50 and 1000.mu., and obtained by perforation by mechanical, thermal laser or ultraviolet radiation means, they being suitable for use as a support for the in vitro growth of epithelial cells, the invention also relating to the artificial skin obtained thereby and its use in grafts.
摘要翻译： 本发明涉及由天然，合成或半合成来源的材料构成的生物相容性膜，其厚度为10至500微米，其特征在于包含彼此分离的10至1000微米的恒定尺寸的有序系列的孔 通过50至1000微米之间的恒定距离，并且通过机械，热激光或紫外线辐射手段穿孔获得，它们适合用作上皮细胞的体外生长的载体，本发明还涉及人造皮肤 由此获得并在移植中的应用。
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7.发明授权
公开(公告)号：US5550249A
公开(公告)日：1996-08-27
申请号：US200545
申请日：1994-02-22
IPC分类号： C07D495/04 , A61K31/38
CPC分类号： C07D495/04
摘要： Salts of biotin are described with alkanolamines and the respective water soluble therapeutical compositions, suitable to be orally, parenterally and topically administered.The compositions above are particularly suitable for the treatment of the vitamin H deficiency, having a dermatologic manifestation, for the treatment of the insufficiency in multiple carboxylase enzymes, for the treatment of dermatologic phatologies, like the seborrheal dermatitis in the newborn, and for the treatment of diabetic neuropathies.
摘要翻译： 用链烷醇胺和各自的水溶性治疗组合物描述生物素的盐，其适合于口服，胃肠外和局部施用。 上述组合物特别适用于治疗具有皮肤病学表现的维生素H缺乏症，用于治疗多种羧化酶的不足，用于治疗皮肤病学类，如新生儿的脂溢性皮炎和治疗 的糖尿病神经病变。
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公开(公告)号：US5424294A
公开(公告)日：1995-06-13
申请号：US138184
申请日：1993-10-20
CPC分类号： C07H15/10
摘要： N-acyl-N,N'-di-lysogangliosides, N'-acyl-N,N'-di-lysogangliosides and N,N'-diacyl-N,N'-di-lysogangliosides, in which the acyl groups are derived from an organic acid of the aliphatic, aromatic, araliphatic, alicyclic or heterocyclic series and in which at least one of the two acyl groups is not aliphatic, and their preparation are disclosed. Also disclosed is the preparation of the esters, inner esters, amides and hydroxy peracylates of these compounds and salts thereof. These compounds are useful in the treatment of pathologies of the central and peripheral nervous systems.
摘要翻译： N-酰基-N，N'-二溶菌索双胞苷，N'-酰基-N，N'-二溶菌索双胍和N，N'-二酰基-N，N'-二赖藻糖苷，其中酰基衍生 来自脂族，芳族，芳脂族，脂环族或杂环系列的有机酸，其中两个酰基中的至少一个不是脂族的，并且其公开。 还公开了这些化合物的酯，内酯，酰胺和羟基过酰基化物及其盐的制备。 这些化合物可用于治疗中枢和周围神经系统的病理。
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9.发明授权
公开(公告)号：US4736024A
公开(公告)日：1988-04-05
申请号：US847632
申请日：1986-04-03
IPC分类号： A61K9/00 , A61K20060101 , A61K9/06 , A61K9/08 , A61K31/05 , A61K31/16 , A61K31/195 , A61K31/22 , A61K31/27 , A61K31/335 , A61K31/34 , A61K31/40 , A61K31/415 , A61K31/46 , A61K31/495 , A61K31/505 , A61K31/51 , A61K31/52 , A61K31/57 , A61K31/635 , A61K31/70 , A61K31/715 , A61K38/00 , A61K38/18 , A61K38/22 , A61K45/00 , A61K45/06 , A61K45/08 , A61K47/00 , A61K47/36 , A61K47/48 , A61P17/00 , A61P25/02 , A61P29/00 , A61P31/04 , A61P31/12 , A61P35/00 , A61P43/00 , C01F20060101 , C08B37/08 , F17C1/02
CPC分类号： A61K31/715 , A61K38/1808 , A61K45/06 , A61K47/36 , A61K47/4823 , A61K9/0048 , C08B37/0072
摘要： Pharmaceutical preparations for topical administration containing a pharmacologically active substance together with hyaluronic acid or a molecular weight fraction thereof. The hyaluronic acid may be in the form of the free acid or may be a salt with an alkali or alkaline earth metal, magnesium, aluminum or ammonium, or in the form of a salt with one or more pharmacologically active substances.
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公开(公告)号：US06407072B1
公开(公告)日：2002-06-18
申请号：US08268730
申请日：1994-06-30
IPC分类号： A61K3170
CPC分类号： C07H15/10
摘要： Novel N-acyl-lysogangliosides obtained from gangliosides by deacyation of the ceramide group, wherein the acyl group is derived from an aliphatic acid having from 2 to 24 carbon atoms, substituted by one or more polar groups. The N-acyl-lysogangliosides of the invention exhibit an inhibiting action on protein-kinase C activation and, thus, can be utilized in therapies for various pathologies of the nervous system.
摘要翻译： 通过神经酰胺基去酰化从神经节苷脂获得的新型N-酰基 - 溶血杆菌二糖苷，其中酰基衍生自具有2至24个碳原子的脂族酸，被一个或多个极性基团取代。 本发明的N-酰基 - 溶血杆菌二糖苷对蛋白激酶C活化具有抑制作用，因此可用于神经系统各种病理学的治疗。
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