公开(公告)号：US5223227A

公开(公告)日：1993-06-29

申请号：US703203

申请日：1991-05-20

申请人： Leon Zuckerman

发明人： Leon Zuckerman

IPC分类号： G01N11/16 ,  G01N33/49 ,  G01N33/86

CPC分类号： G01N33/86 ,  G01N11/162 ,  G01N33/4905

摘要： An instrument for measuring the coagulation characteristics of whole blood samples is provided with disposable parts for contacting the blood. The pin has a blood-compatible plastic sleeve surrounding a metal stem which weights the pin assembly so it sinks into the blood sample. The metal stem also engages into the pin suspension apparatus of the instrument. A blood-compatible plastic cup receives the blood sample to be tested, and is surrounded by a metal collar to transfer heat to the cup for the time required for a test. The plastic surfaces which contact the blood sample are slightly roughened, to a matte finish, to improve adhesion so as to approximate the results obtained with stainless steel pins and cups.

摘要翻译： 用于测量全血样品的凝血特性的仪器设置有用于接触血液的一次性部件。 引脚具有围绕金属杆的血液兼容的塑料套筒，其对销组件进行加重，使其沉入血液样品中。 金属杆也接合到仪器的销悬挂装置中。 血液相容的塑料杯接收待测试的血液样品，并且被金属环围绕以将热量传递到杯子，以达到测试所需的时间。 与血液样品接触的塑料表面稍微粗糙，无光泽，以提高粘合性，以接近不锈钢针和杯所获得的结果。

公开(公告)号：US07179652B2

公开(公告)日：2007-02-20

申请号：US10384345

申请日：2003-03-07

申请人： Eli Cohen ,  Roslyn Cohen ,  Roger Carroll

发明人： Eli Cohen ,  Roslyn Cohen ,  Roger Carroll

IPC分类号： G01N33/86

CPC分类号： G01N11/162 ,  G01N11/167 ,  G01N33/86 ,  G01N2800/52

摘要： A hemostasis analyzer, such as the Thrombelastograph® (TEG®) hemostasis analyzer is utilized to measure continuously in real time, the hemostasis process from the initial fibrin formation, through platelet-fibrin interaction and lysis to generate blood hemostasis parameters. The measured blood hemostasis parameters permit evaluation of platelet inhibition therapy.

摘要翻译： 止血分析仪，如Thrombelastograph（T）（TEG））止血分析仪用于实时连续测量，从初始纤维蛋白形成，血小板 - 纤维蛋白相互作用和裂解产生血液止血参数的止血过程。 测量的血液止血参数允许评估血小板抑制治疗。

公开(公告)号：US20010053552A1

公开(公告)日：2001-12-20

申请号：US09845222

申请日：2001-04-30

申请人： Haemoscope Corporation

发明人： Eli Cohen ,  Peter R. Delmenico ,  Gabriel Raviv ,  William R. George ,  John A. Lake

IPC分类号： G01N033/49

CPC分类号： G01N11/162 ,  G01N11/167 ,  G01N33/4905

摘要： A method and apparatus are provided for measuring hemostasis. The apparatus includes a torque sensing column having a torque sensing element and a drive ring disposed around a body of the column and in registration with the column so as to allow rotation of the drive ring around a longitudinal axis of the column. The apparatus further includes a first guide shaft rigidly secured to the drive ring, the guide shaft extending parallel to the longitudinal axis of the column and a cup holder movably attached to the guide shaft, allowing the cup holder to move parallel to the longitudinal axis of the column. The apparatus also includes a sample cup adapted to engage the cup holder on a outer surface and the torque sensing element of the torque sensing column on an inner surface.

摘要翻译： 提供了一种用于测量止血的方法和装置。 该装置包括具有转矩检测元件的转矩感测柱和设置在柱体上并与柱对准的驱动环，以便允许驱动环围绕柱的纵向轴线旋转。 该装置还包括刚性地固定到驱动环的第一引导轴，平行于柱的纵向轴线延伸的引导轴和可移动地连接到引导轴的杯架，允许杯架平行于纵向轴线 列。 该装置还包括适于在外表面上接合杯架的样品杯和内表面上的转矩感测塔的转矩感测元件。

公开(公告)号：US20070092405A1

公开(公告)日：2007-04-26

申请号：US11425818

申请日：2006-06-22

申请人： Hans Kautzky

发明人： Hans Kautzky

IPC分类号： G01N33/00

CPC分类号： G01N11/167 ,  G01N33/49

摘要： A method and device for blood hemostasis analysis is disclosed. A blood sample is displaced to reach a resonant state. The resonant frequency of the blood sample is determined before, during and after a hemostasis process. The changes in the resonant frequency of the blood sample are indicative of the hemostasis characteristics of the blood sample.

摘要翻译： 公开了一种用于血液止血分析的方法和装置。 血液样本被移位以达到共振状态。 在止血过程之前，之中和之后确定血液样品的共振频率。 血液样本的共振频率的变化表示血液样本的止血特征。

公开(公告)号：US06890299B2

公开(公告)日：2005-05-10

申请号：US10409479

申请日：2003-04-08

申请人： Eli Cohen ,  Irene Navickas

发明人： Eli Cohen ,  Irene Navickas

IPC分类号： G01N33/49 ,  G01N33/86 ,  A61B5/00

CPC分类号： G01N33/86 ,  G01N33/4905 ,  G06F19/00

摘要： A method and apparatus for monitoring hemostasis in a connection with a recipient of an artificial surface device provide a multi-phase monitoring protocol. In a first, pre- and intra-operative phase, hemostasis of the recipient is monitored relative to preventing clot formation to achieve artificial surface patency. In a second, post operative phase hemostasis of the recipient is monitored relative to bringing about clot formation to achieve vascular recovery. In a third, stabilizing intensive care phase hemostasis of the recipient is monitored relative to balancing hemostasis toward an anti-coagulation bias. In a fourth, maintenance phase hemostasis is monitored relative to maintaining balanced hemostasis.

摘要翻译： 用于监测与人造表面装置的接收者相关联的止血的方法和装置提供了多相监测协议。 在第一个术前和术中阶段，监测接受者的止血，以防止凝块形成以实现人造表面通畅。 在一秒钟内，相对于引起血块形成来监测接受者的手术后止血以实现血管恢复。 第三，稳定性重症监护期，接受者的止血相对于抵抗抗凝血偏倚的平衡止血情况进行监测。 第四，相对于维持平衡止血来监测维持期止血。

公开(公告)号：US20080038828A1

公开(公告)日：2008-02-14

申请号：US11753071

申请日：2007-05-24

申请人： Eli Cohen ,  Roslyn Cohen

发明人： Eli Cohen ,  Roslyn Cohen

IPC分类号： G01N33/86

CPC分类号： G01N33/86 ,  G01N2800/52 ,  G06F19/00

摘要： A hemostasis analyzer, such as the Thrombelastograph® (TEG®) hemostasis analyzer is utilized to measure continuously in real time, the hemostasis process from the initial fibrin formation, through platelet-fibrin interaction and lysis to generate blood hemostasis parameters. The measured blood hemostasis parameters permit evaluation of hemostasis therapies including anticoagulation therapies such as direct thrombin inhibition therapies.

摘要翻译： 止血分析仪，如Thrombelastograph（T）（TEG））止血分析仪用于实时连续测量，从初始纤维蛋白形成，血小板 - 纤维蛋白相互作用和裂解产生血液止血参数的止血过程。 测量的血液止血参数允许评估止血疗法，包括抗凝治疗如直接凝血酶抑制治疗。

公开(公告)号：US20070184508A1

公开(公告)日：2007-08-09

申请号：US11608174

申请日：2006-12-07

申请人： Eli Cohen ,  Roslyn Cohen

发明人： Eli Cohen ,  Roslyn Cohen

IPC分类号： C12Q1/60

CPC分类号： G01N33/86 ,  C12Q1/56

摘要： A hemostasis analyzer, such as the Thrombelastograph® (TEG®) hemostasis analyzer is utilized to measure continuously in real time, the hemostasis process from the initial fibrin formation, through platelet-fibrin interaction and lysis to generate blood hemostasis parameters. The measured blood hemostasis parameters permit evaluation of a patient hemostasis condition.

摘要翻译： 止血分析仪，如Thrombelastograph（T）（TEG））止血分析仪用于实时连续测量，从初始纤维蛋白形成，血小板 - 纤维蛋白相互作用和裂解产生血液止血参数的止血过程。 测量的血液止血参数允许评估患者止血状况。

公开(公告)号：US20070059840A1

公开(公告)日：2007-03-15

申请号：US11383567

申请日：2006-05-16

申请人： Eli Cohen ,  Vincent Contini ,  Peter Delmenico ,  Matthew Fleming ,  Thomas Haubert ,  Gabriel Raviv ,  Ronnie Raviv ,  Mark Wilson

发明人： Eli Cohen ,  Vincent Contini ,  Peter Delmenico ,  Matthew Fleming ,  Thomas Haubert ,  Gabriel Raviv ,  Ronnie Raviv ,  Mark Wilson

IPC分类号： G01N33/86

CPC分类号： G01N33/4905 ,  G01N2011/147

摘要： Apparatus for measuring hemostasis includes a container for holding a sample to be tested and a bobber configured to be buoyantly suspended on the sample. A magnet is secured to the bobber. A drive assembly is coupled to the container for driving the container in an oscillating motion. A magnetic field generator is disposed adjacent the container and configured to generate a magnetic field in the vicinity of the magnet. A magnetic field strength detector is disposed adjacent the container, and the magnetic field strength detector is configured to sense changes in the magnetic field as a result of movement of the bobber and magnet responsive to the oscillating motion of the container and clotting of the sample.

摘要翻译： 用于测量止血的装置包括用于保持待测试样品的容器和构造成悬浮在样品上的浮子。 磁铁固定在浮子上。 驱动组件联接到容器以便以振荡运动来驱动容器。 磁场发生器设置在容器附近并被配置为在磁体附近产生磁场。 磁场强度检测器设置在容器附近，并且磁场强度检测器被配置为响应于容器的振荡运动和样品凝结而感测到浮子和磁体的移动而导致的磁场变化。

公开(公告)号：US07524670B2

公开(公告)日：2009-04-28

申请号：US10634553

申请日：2003-08-05

申请人： Eli Cohen ,  Roslyn Cohen ,  Roger C. Carroll

发明人： Eli Cohen ,  Roslyn Cohen ,  Roger C. Carroll

IPC分类号： C12M1/34

CPC分类号： C12Q1/56

摘要： A hemostasis analyzer, such as the Thrombelastograph® (TEG®) hemostasis analyzer is utilized to measure continuously in real time, the hemostasis process from the initial fibrin formation, through platelet-fibrin interaction and lysis to generate blood hemostasis parameters. The measured blood hemostasis parameters permit determination of heparin-induced thrombocytopenia II complex (HiT II).

摘要翻译： 止血分析仪，如Thrombelastograph（T）（TEG））止血分析仪用于实时连续测量，从初始纤维蛋白形成，血小板 - 纤维蛋白相互作用和裂解产生血液止血参数的止血过程。 测量的血液止血参数允许测定肝素诱导的血小板减少II复合物（HiT II）。

公开(公告)号：US20070237677A1

公开(公告)日：2007-10-11

申请号：US11756801

申请日：2007-06-01

申请人： Hans Kautzky

发明人： Hans Kautzky

IPC分类号： B01L11/00

CPC分类号： G01N33/4905 ,  B01L3/508 ,  B01L2300/024 ,  B01L2300/0663 ,  B01L2300/0809

摘要： A method and device for blood hemostasis analysis is disclosed. A blood sample is displaced to reach a resonant state. The resonant frequency of the blood sample is determined before, during and after a hemostasis process. The changes in the resonant frequency of the blood sample are indicative of the hemostasis characteristics of the blood sample.

摘要翻译： 公开了一种用于血液止血分析的方法和装置。 血液样本被移位以达到共振状态。 在止血过程之前，之中和之后确定血液样品的共振频率。 血液样本的共振频率的变化表示血液样本的止血特征。