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公开(公告)号：US20180093986A1
公开(公告)日：2018-04-05
申请号：US15783510
申请日：2017-10-13
发明人： Magdalene M. Moran , Christopher Fanger , Jayhong A. Chong , Colleen McNamara , Xiaoguang Zhen , Josh Mandel-Brehm
IPC分类号： C07D473/08 , C07D239/22 , C07K14/705 , A61K31/555 , A61K31/522 , A61K31/513 , A61K31/505
CPC分类号： C07D473/08 , A61K31/505 , A61K31/513 , A61K31/522 , A61K31/555 , C07D239/22 , C07K14/705
摘要： The present application relates to compounds and methods for treating pain, incontinence and other conditions.
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公开(公告)号：US09969736B2
公开(公告)日：2018-05-15
申请号：US15622838
申请日：2017-06-14
IPC分类号： C07D473/04 , C07D487/04 , C07D487/12 , C07D473/06
CPC分类号： C07D473/04 , C07D473/06 , C07D487/04 , C07D487/12
摘要： Compounds, compositions and methods are described for inhibiting the TRPC5 ion channel and disorders related to TRPC5.
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公开(公告)号：US09505756B2
公开(公告)日：2016-11-29
申请号：US14616100
申请日：2015-02-06
发明人： Xinyuan Wu , Spencer David Kimball , Ping Chen , Ding Zhou , Shaoping Peng
IPC分类号： C07D239/70 , C07D487/04 , C07D471/04 , A61K31/519
CPC分类号： C07D471/04 , A61K31/519 , C07D239/70
摘要： Compounds and compositions for treating disorders related to TRPA1 are described herein.
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![Pyrido[3,4-d]pyrimidine-2,4(1H,3H)-dione derivatives](/abs-image/US/2016/09/13/US09440973B2/abs.jpg.150x150.jpg)
公开(公告)号：US09440973B2
公开(公告)日：2016-09-13
申请号：US14822232
申请日：2015-08-10
IPC分类号： A61K31/519 , C07D471/04
CPC分类号： C07D471/04 , A61K31/519
摘要： This invention relates to novel Pyrido[3,4-d]pyrimidine-2,4(1H,3H)-dione derivatives of Formula (I): and their use as TRPC5 modulators, pharmaceutical compositions containing the same, and methods of using the same as agents for the treatment of TRPC5 receptor mediated disorders or conditions. R1, R2, R3 and R4 have meanings given in the description.
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5.发明授权Compounds and compositions for treating chemical warfare agent-induced injuries 有权用于治疗化学战剂诱发的伤害的化合物和组合物公开(公告)号：US09260431B2
公开(公告)日：2016-02-16
申请号：US14198050
申请日：2014-03-05
申请人： Jayhong A. Chong
发明人： Jayhong A. Chong
IPC分类号： C07D473/30 , C07D487/04 , A61K31/4188 , A61K31/519 , A61K9/00 , C07D471/04
CPC分类号： A61K31/522 , A61K9/0014 , A61K9/0019 , A61K9/0048 , A61K9/0053 , A61K31/4188 , A61K31/4985 , A61K31/519 , C07D471/04 , C07D473/30 , C07D487/04
摘要： Compounds and compositions for treating injuries caused by exposure to chemical warfare agents are described herein.
摘要翻译： 本文描述了用于治疗由化学战剂引起的伤害的化合物和组合物。
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公开(公告)号：US20150335622A1
公开(公告)日：2015-11-26
申请号：US14579881
申请日：2014-12-22
IPC分类号： A61K31/4245 , A61F6/04
CPC分类号： C07D271/08 , A61F6/04 , A61K31/4245 , C07D413/14
摘要： The invention provides novel compositions and compounds that inhibit CatSper channel activity, that preferentially inhibits sperm hyperactivity over sperm motility, or both. The compounds of the invention are useful as contraceptive agents that may be adminstered to males, females, or concurrently to both sexual partners. The invention further provides methods of conducting drug discovery business and of conducting a reproductive medicine business. The invention also provides methods of identifying compounds that modulate sperm hypermotility.
摘要翻译： 本发明提供抑制CatSper通道活性的新型组合物和化合物，其优先抑制精子活力超过精子活力或两者。 本发明的化合物可用作可被施用于男性，女性或并发给两性的避孕药。 本发明还提供了进行药物发现业务和进行生殖医学业务的方法。 本发明还提供鉴定调节精子超运动性的化合物的方法。
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公开(公告)号：US20150299225A1
公开(公告)日：2015-10-22
申请号：US14542089
申请日：2014-11-14
申请人： Jayhong A. Chong , Christopher Fanger , Glenn R. Larsen , William C. Lumma, JR. , Magdalene M. Moran , Amy Ripka , Dennis John Underwood , Manfred Weigele , Xiaoguang Zhen , Anu Mahadevan , Peter Meltzer
发明人： Jayhong A. Chong , Christopher Fanger , Glenn R. Larsen , William C. Lumma, JR. , Magdalene M. Moran , Amy Ripka , Dennis John Underwood , Manfred Weigele , Xiaoguang Zhen , Anu Mahadevan , Peter Meltzer
IPC分类号： C07D513/04 , A61K8/49 , A61K31/428 , A61K31/4709 , A61K31/55 , A61K31/498 , A61K31/538 , C07D215/08 , C07D223/16 , C07D277/70 , C07D417/12 , C07D401/12 , C07D413/12 , C07D409/14 , A61Q7/02 , A61K31/47
CPC分类号： C07D513/04 , A61K8/49 , A61K8/4906 , A61K8/4926 , A61K31/428 , A61K31/47 , A61K31/4709 , A61K31/498 , A61K31/538 , A61K31/55 , A61Q7/02 , C07D215/08 , C07D223/16 , C07D277/70 , C07D401/12 , C07D409/14 , C07D413/12 , C07D417/12
摘要： The present application relates to compounds and methods for treating pain and other conditions related to TRPV3.
摘要翻译： 本申请涉及用于治疗与TRPV3相关的疼痛和其它病症的化合物和方法。
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公开(公告)号：US09139573B2
公开(公告)日：2015-09-22
申请号：US14102020
申请日：2013-12-10
申请人： Jayhong A. Chong , Christopher Fanger , Magdalene M. Moran , Elisha Singer , Timothy Strassmaier , Howard Ng
发明人： Jayhong A. Chong , Christopher Fanger , Magdalene M. Moran , Elisha Singer , Timothy Strassmaier , Howard Ng
IPC分类号： A61K31/00 , A61K31/164 , A61K31/53 , C07D409/12 , A61K31/4184 , C07D235/30 , C07D251/16 , C07D251/46 , C07D251/52 , C07D263/58 , C07D405/14 , C07D409/06
CPC分类号： A61K31/423 , A61K31/00 , A61K31/164 , A61K31/4184 , A61K31/4196 , A61K31/53 , C07D235/30 , C07D251/16 , C07D251/46 , C07D251/52 , C07D263/58 , C07D405/14 , C07D409/06 , C07D409/12
摘要： Methods of treating a TRPC5 mediated disorder in a subject by administering an effective amount of a TRPC5 antagonist, such as a compound disclosed herein, are described.
摘要翻译： 描述了通过施用有效量的TRPC5拮抗剂（例如本文公开的化合物）来治疗受试者中TRPC5介导的病症的方法。
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公开(公告)号：US08916550B2
公开(公告)日：2014-12-23
申请号：US11600514
申请日：2006-11-15
申请人： Jayhong A. Chong , Christopher Fanger , Glenn R. Larsen , William C. Lumma, Jr. , Magdalene M. Moran , Amy Ripka , Dennis John Underwood , Manfred Weigele , Xiaoguang Zhen , Anu Mahadevan , Peter Meltzer
发明人： Jayhong A. Chong , Christopher Fanger , Glenn R. Larsen , William C. Lumma, Jr. , Magdalene M. Moran , Amy Ripka , Dennis John Underwood , Manfred Weigele , Xiaoguang Zhen , Anu Mahadevan , Peter Meltzer
IPC分类号： A61K31/55 , A61K31/47 , A61K31/40 , A61K31/165 , A61K31/428 , C07D417/12 , C07D513/04 , C07D401/12 , A61K31/4709
CPC分类号： C07D513/04 , A61K8/49 , A61K8/4906 , A61K8/4926 , A61K31/428 , A61K31/47 , A61K31/4709 , A61K31/498 , A61K31/538 , A61K31/55 , A61Q7/02 , C07D215/08 , C07D223/16 , C07D277/70 , C07D401/12 , C07D409/14 , C07D413/12 , C07D417/12
摘要： The present application relates to compounds and methods for treating pain and other conditions related to TRPV3.
摘要翻译： 本申请涉及用于治疗与TRPV3相关的疼痛和其它病症的化合物和方法。
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公开(公告)号：US20140275071A1
公开(公告)日：2014-09-18
申请号：US14210781
申请日：2014-03-14
IPC分类号： C07D473/04
CPC分类号： C07D473/04 , C07D473/06 , C07D487/04 , C07D487/12
摘要： Compounds, compositions and methods are described for inhibiting the TRPC5 ion channel and disorders related to TRPC5.
摘要翻译： 描述了抑制TRPC5离子通道和与TRPC5有关的紊乱的化合物，组合物和方法。
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