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    BIGUANIDE COMPOUND AND USE THEREOF
    2.
    发明申请
    BIGUANIDE COMPOUND AND USE THEREOF 审中-公开

    公开(公告)号：US20180044283A1

    公开(公告)日：2018-02-15

    申请号：US15527621

    申请日：2015-11-20

    申请人： ImmunoMet Therapeutics Inc.

    发明人： Hong Woo KIM ,  Jae Kap JEONG ,  Ji Sun LEE ,  Hye Jin HEO ,  Hong Bum LEE ,  Ji Ae KOOK ,  Sung Wuk KIM

    IPC分类号： C07C279/26 ,  C07D211/10

    CPC分类号： C07C279/26 ,  A61K31/155 ,  A61P35/00 ,  C07D211/10 ,  C07D211/34

    摘要： The present invention relates to a guanidine compound and a use thereof, and more specifically, to a guanidine derivative showing excellent effects of inhibiting cancer cell proliferation, cancer metastasis, and cancer recurrence; a preparation method thereof; and a pharmaceutical composition containing the same as an active ingredient. Compared to existing drugs, the guanidine derivative according to the present invention shows excellent effects of inhibiting cancer cell proliferation, cancer metastasis, and cancer recurrence even with small doses, and may thus be effectively used in preventing or treating various cancers such as uterine cancer, breast cancer, stomach cancer, brain cancer, rectal cancer, colorectal cancer, lung cancer, skin cancer, blood cancer, liver cancer, etc., inhibiting cancer cell proliferation and cancer metastasis.

    Biguanide compound and use thereof
    4.
    发明授权
    Biguanide compound and use thereof 有权

    公开(公告)号：US11572341B2

    公开(公告)日：2023-02-07

    申请号：US16820860

    申请日：2020-03-17

    申请人： ImmunoMet Therapeutics Inc.

    发明人： Hong Woo Kim ,  Jae Kap Jeong ,  Ji Sun Lee ,  Hye Jin Heo ,  Hong Bum Lee ,  Ji Ae Kook ,  Sung Wuk Kim

    IPC分类号： C07C279/26 ,  C07D211/10 ,  C07D211/34 ,  A61K31/155 ,  A61P35/00

    摘要： The present invention relates to a guanidine compound and a use thereof, and more specifically, to a guanidine derivative showing excellent effects of inhibiting cancer cell proliferation, cancer metastasis, and cancer recurrence; a preparation method thereof; and a pharmaceutical composition containing the same as an active ingredient. Compared to existing drugs, the guanidine derivative according to the present invention shows excellent effects of inhibiting cancer cell proliferation, cancer metastasis, and cancer recurrence even with small doses, and may thus be effectively used in preventing or treating various cancers such as uterine cancer, breast cancer, stomach cancer, brain cancer, rectal cancer, colorectal cancer, lung cancer, skin cancer, blood cancer, liver cancer, etc., inhibiting cancer cell proliferation and cancer metastasis.

    N1-cyclic amine-N5-substituted biguanide derivatives, methods of preparing the same and pharmaceutical composition comprising the same
    8.
    发明授权
    N1-cyclic amine-N5-substituted biguanide derivatives, methods of preparing the same and pharmaceutical composition comprising the same 有权
    N 1 - 环胺-N 5取代双胍衍生物，其制备方法和包含其的药物组合物

    公开(公告)号：US09321742B2

    公开(公告)日：2016-04-26

    申请号：US14237546

    申请日：2012-08-08

    申请人： Sung Wuk Kim ,  Chang Hee Min ,  Se Hwan Park ,  Duck Kim ,  Ji Sun Lee ,  Yong Eun Kim ,  Ju Hoon Oh

    发明人： Sung Wuk Kim ,  Chang Hee Min ,  Se Hwan Park ,  Duck Kim ,  Ji Sun Lee ,  Yong Eun Kim ,  Ju Hoon Oh

    IPC分类号： C07C279/26 ,  C07C29/16 ,  C07D205/04 ,  C07D213/40 ,  C07D295/215 ,  C07D333/20 ,  C07D307/52

    CPC分类号： C07D295/215 ,  C07D205/04 ,  C07D213/40 ,  C07D307/52 ,  C07D333/20

    摘要： A N1-cyclic amine-N5-substituted biguanide derivative of Formula 1 or a pharmaceutically acceptable salt thereof, a method of manufacturing the same, and a pharmaceutical composition including the biguanide derivative or the pharmaceutically acceptable salt thereof as an active ingredient are provided. The biguanide derivatives have an effect of inhibiting cancer cell proliferation and also exhibit anticancer activity including inhibition of cancer metastasis and cancer recurrence, because they are effective in activating AMPK, which is associated with the control of energy metabolism, even when administered in a small dose compared with conventional drugs. Also, the biguanide derivatives are highly effective at lowering blood glucose and lipid concentration by AMPK activation, thus they may be effectively used to treat diabetes mellitus, obesity, hyperlipemia, hypercholesterolemia, fatty liver, coronary artery disease, osteoporosis, polycystic ovary syndrome and metabolic syndrome.

    摘要翻译： 提供式1的N 1 - 环胺-N 5 - 取代双胍衍生物或其药学上可接受的盐，其制备方法和包含双胍衍生物或其药学上可接受的盐作为活性成分的药物组合物。 双胍衍生物具有抑制癌细胞增殖的作用，并且还表现出抗肿瘤活性，包括抑制癌症转移和癌症复发，因为即使以小剂量施用也能有效地激活与能量代谢控制有关的AMPK 与常规药物相比。 此外，双胍衍生物通过AMPK活化降低血糖和脂质浓度高度有效，因此可有效用于治疗糖尿病，肥胖症，高脂血症，高胆固醇血症，脂肪肝，冠状动脉疾病，骨质疏松症，多囊卵巢综合征和代谢 综合征