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公开(公告)号：US20170152323A1
公开(公告)日：2017-06-01
申请号：US14997849
申请日：2016-01-18
Applicant: Immunwork Inc.
Inventor： Tse-Wen Chang , Jou-Han Chen , Hsing-Mao Chu
IPC: C07K16/46 , C07K16/28 , C07K14/705 , C07K16/18 , C07K16/24
CPC classification number: A61K47/6803 , A61K31/397 , A61K31/4545 , A61K31/4709 , A61K31/4745 , A61K31/537 , A61K31/739 , A61K47/58 , A61K47/60 , A61K47/61 , A61K47/64 , A61K47/6801 , A61K47/6843 , A61K47/6845 , A61K47/6849 , A61K47/6851 , A61K47/6883 , A61K51/065 , A61K51/088 , A61K2039/505 , C07K14/485 , C07K14/655 , C07K14/705 , C07K14/70578 , C07K14/7151 , C07K16/18 , C07K16/22 , C07K16/241 , C07K16/244 , C07K16/2803 , C07K16/2809 , C07K16/2818 , C07K16/2863 , C07K16/2875 , C07K16/2887 , C07K16/32 , C07K16/468 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/524 , C07K2317/526 , C07K2317/55 , C07K2317/622 , C07K2317/64 , C07K2317/71 , C07K2317/73 , C07K2317/732 , C07K2317/76 , C07K2317/94 , C07K2319/30 , C07K2319/32 , C07K2319/33
Abstract: The present disclosure provides various molecular constructs having a targeting element and an effector element. Methods for treating various diseases using such molecular constructs are also disclosed.
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公开(公告)号：US20160340435A1
公开(公告)日：2016-11-24
申请号：US15159862
申请日：2016-05-20
Applicant: Immunwork Inc.
Inventor： Tse-Wen CHANG , Hsing-Mao CHU , Wei-Ting TIAN
IPC: C07K16/28 , C07K14/565 , C07K16/12 , C07K16/18 , C07K16/10
CPC classification number: C07K16/283 , A61K31/137 , A61K47/60 , A61K47/64 , A61K47/65 , A61K47/6849 , A61K47/6883 , C07K7/08 , C07K14/001 , C07K14/565 , C07K16/1027 , C07K16/1203 , C07K16/18 , C07K16/2839 , C07K16/2881 , C07K17/02 , C07K17/06 , C07K2317/31 , C07K2317/35 , C07K2317/55 , C07K2317/622 , C07K2317/64 , C07K2317/76 , C07K2319/33 , C07K2319/70 , C07K2319/74
Abstract: The present disclosure provides various molecular constructs having a targeting element and an effector element. Methods for treating various diseases using such molecular constructs are also disclosed.
Abstract translation: 本公开提供具有靶向元件和效应子元件的各种分子构建体。 还公开了使用这种分子构建体治疗各种疾病的方法。
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3.发明授权公开(公告)号：US11203614B2
公开(公告)日：2021-12-21
申请号：US16830249
申请日：2020-03-25
Applicant: Immunwork Inc.
Inventor： Tse-Wen Chang , Hsing-Mao Chu , Wei-Ting Tian , Yueh-Hsiang Yu
Abstract: Disclosed herein are composite polypeptide. According to various embodiments, the composite polypeptide includes a parent polypeptide and a metal binding motif capable of forming a complex with a metal cation. The composite polypeptide may be conjugated with a linker unit having a plurality of functional elements to form a multi-functional molecular construct. Alternatively, multiple composite polypeptides may be conjugated to a linker unit to form a molecular construct, or a polypeptide bundle. Linker units suitable for conjugating with the composite polypeptide having the metal binding motif are also disclosed.
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公开(公告)号：US10202455B2
公开(公告)日：2019-02-12
申请号：US15159834
申请日：2016-05-20
Applicant: Immunwork Inc.
Inventor： Tse-Wen Chang , Hsing-Mao Chu
IPC: A61K39/395 , A61K39/00 , G01N33/53 , C07K14/00 , C07K14/475 , C07K14/48 , A61K38/18 , C07K16/00 , C12P21/08 , A61K49/00 , A61K49/16 , C07K16/28 , C07K16/10 , C07K14/565 , C07K16/18 , A61K31/137 , C07K7/08 , C07K16/12 , C07K17/06 , C07K17/02 , A61K47/65 , A61K47/60 , A61K47/64 , A61K47/68
Abstract: The present disclosure provides various molecular constructs having a targeting element and an effector element. Methods for treating various diseases using such molecular constructs are also disclosed.
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公开(公告)号：US20180055946A1
公开(公告)日：2018-03-01
申请号：US15693503
申请日：2017-09-01
Applicant: Immunwork Inc.
Inventor： Tse-Wen CHANG , Hsing-Mao CHU
CPC classification number: A61K47/65 , A61K47/60 , C07K5/1008 , C07K5/1013 , C07K7/06 , C08G65/32
Abstract: Disclosed herein are linker units comprising a center core, a plurality of linking arms, and optionally, a coupling arm. According to the embodiments of the present disclosure, the present linker units further comprises a targeting element and an effector element. Also disclosed herein are methods for treating various diseases using such linker units.
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Patent Agency Ranking
公开(公告)号：US20170056519A1
公开(公告)日：2017-03-02
申请号：US15212305
申请日：2016-07-18
Applicant: Immunwork Inc.
Inventor： Tse-Wen Chang , Hsing-Mao Chu , Wei-Ting Tian
IPC: A61K47/48 , A61K31/397 , C07K16/18 , A61K31/4709
CPC classification number: A61K47/6803 , A61K31/397 , A61K31/4545 , A61K31/4709 , A61K31/4745 , A61K31/537 , A61K31/739 , A61K47/58 , A61K47/60 , A61K47/61 , A61K47/64 , A61K47/6801 , A61K47/6843 , A61K47/6845 , A61K47/6849 , A61K47/6851 , A61K47/6883 , A61K51/065 , A61K51/088 , A61K2039/505 , C07K14/485 , C07K14/655 , C07K14/705 , C07K14/70578 , C07K14/7151 , C07K16/18 , C07K16/22 , C07K16/241 , C07K16/244 , C07K16/2803 , C07K16/2809 , C07K16/2818 , C07K16/2863 , C07K16/2875 , C07K16/2887 , C07K16/32 , C07K16/468 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/524 , C07K2317/526 , C07K2317/55 , C07K2317/622 , C07K2317/64 , C07K2317/71 , C07K2317/73 , C07K2317/732 , C07K2317/76 , C07K2317/94 , C07K2319/30 , C07K2319/32 , C07K2319/33
Abstract: The present disclosure provides various molecular constructs having a targeting element and an effector element. Methods for treating various diseases using such molecular constructs are also disclosed.
Abstract translation: 本公开提供具有靶向元件和效应子元件的各种分子构建体。 还公开了使用这种分子构建体治疗各种疾病的方法。
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7.发明申请Molecular constructs with targeting and effector moieties for treating central nervous system diseases 审中-公开具有用于治疗中枢神经系统疾病的靶向和效应部分的分子构建体公开(公告)号：US20160339115A1
公开(公告)日：2016-11-24
申请号：US15159834
申请日：2016-05-20
Applicant: Immunwork Inc.
Inventor： Tse-Wen CHANG , Hsing-Mao CHU
IPC: A61K47/48
CPC classification number: C07K16/283 , A61K31/137 , A61K47/60 , A61K47/64 , A61K47/65 , A61K47/6849 , A61K47/6883 , C07K7/08 , C07K14/001 , C07K14/565 , C07K16/1027 , C07K16/1203 , C07K16/18 , C07K16/2839 , C07K16/2881 , C07K17/02 , C07K17/06 , C07K2317/31 , C07K2317/35 , C07K2317/55 , C07K2317/622 , C07K2317/64 , C07K2317/76 , C07K2319/33 , C07K2319/70 , C07K2319/74
Abstract: The present disclosure provides various molecular constructs having a targeting element and an effector element. Methods for treating various diseases using such molecular constructs are also disclosed.
Abstract translation: 本公开提供具有靶向元件和效应子元件的各种分子构建体。 还公开了使用这种分子构建体治疗各种疾病的方法。
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8.发明申请Peptide core-based multi-arm linkers for treating central nervous system diseases 有权用于治疗中枢神经系统疾病的基于肽芯的多臂接头公开(公告)号：US20160339110A1
公开(公告)日：2016-11-24
申请号：US15159829
申请日：2016-05-20
Applicant: Immunwork Inc.
Inventor： Tse-Wen CHANG , Hsing-Mao CHU , Chien-Jen Lin , Chun-Yu Lin
CPC classification number: C07K16/283 , A61K31/137 , A61K47/60 , A61K47/64 , A61K47/65 , A61K47/6849 , A61K47/6883 , C07K7/08 , C07K14/001 , C07K14/565 , C07K16/1027 , C07K16/1203 , C07K16/18 , C07K16/2839 , C07K16/2881 , C07K17/02 , C07K17/06 , C07K2317/31 , C07K2317/35 , C07K2317/55 , C07K2317/622 , C07K2317/64 , C07K2317/76 , C07K2319/33 , C07K2319/70 , C07K2319/74
Abstract: The present disclosure provides various molecular constructs having a targeting element and an effector element. Methods for treating various diseases using such molecular constructs are also disclosed.
Abstract translation: 本公开提供具有靶向元件和效应子元件的各种分子构建体。 还公开了使用这种分子构建体治疗各种疾病的方法。
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公开(公告)号：US20160208021A1
公开(公告)日：2016-07-21
申请号：US14997827
申请日：2016-01-18
Applicant: Immunwork Inc.
Inventor： Tse-Wen Chang , Hsing-Mao Chu , Chun-Yu Lin
CPC classification number: A61K47/6803 , A61K31/397 , A61K31/4545 , A61K31/4709 , A61K31/4745 , A61K31/537 , A61K31/739 , A61K47/58 , A61K47/60 , A61K47/61 , A61K47/64 , A61K47/6801 , A61K47/6843 , A61K47/6845 , A61K47/6849 , A61K47/6851 , A61K47/6883 , A61K51/065 , A61K51/088 , A61K2039/505 , C07K14/485 , C07K14/655 , C07K14/705 , C07K14/70578 , C07K14/7151 , C07K16/18 , C07K16/22 , C07K16/241 , C07K16/244 , C07K16/2803 , C07K16/2809 , C07K16/2818 , C07K16/2863 , C07K16/2875 , C07K16/2887 , C07K16/32 , C07K16/468 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/524 , C07K2317/526 , C07K2317/55 , C07K2317/622 , C07K2317/64 , C07K2317/71 , C07K2317/73 , C07K2317/732 , C07K2317/76 , C07K2317/94 , C07K2319/30 , C07K2319/32 , C07K2319/33
Abstract: The present disclosure provides various molecular constructs having a targeting element and an effector element. Methods for treating various diseases using such molecular constructs are also disclosed.
Abstract translation: 本公开提供具有靶向元件和效应子元件的各种分子构建体。 还公开了使用这种分子构建体治疗各种疾病的方法。
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10.发明申请公开(公告)号：US20220064215A1
公开(公告)日：2022-03-03
申请号：US17496810
申请日：2021-10-08
Applicant: Immunwork Inc.
Inventor： Tse-Wen CHANG , Hsing-Mao CHU , Wei-Ting TIAN , Yueh-Hsiang YU
IPC: C07K7/06
Abstract: Disclosed herein are composite polypeptide. According to various embodiments, the composite polypeptide includes a parent polypeptide and a metal binding motif capable of forming a complex with a metal cation. The composite polypeptide may be conjugated with a linker unit having a plurality of functional elements to form a multi-functional molecular construct. Alternatively, multiple composite polypeptides may be conjugated to a linker unit to form a molecular construct, or a polypeptide bundle. Linker units suitable for conjugating with the composite polypeptide having the metal binding motif are also disclosed.
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