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公开(公告)号：US11104727B2
公开(公告)日：2021-08-31
申请号：US15768183
申请日：2016-10-13
发明人： Toshihiro Tsukui , Miyuki Kageyama , Masahiro Kato , Rieko Suzuki
IPC分类号： C07K16/24 , G01N33/53 , A61P37/06 , G01N33/577 , A61K39/00 , C12N5/10 , A61P17/00 , C12N15/09 , C12N15/85
摘要： Provided are an anti-canine TARC antibody for use in the treatment and diagnosis of canine atopic dermatitis, and a method for treating or diagnosing canine atopic dermatitis using the same.
An anti-canine TARC monoclonal antibody binding to canine TARC, comprising a heavy chain variable region consisting of the amino acid sequence shown in SEQ ID NO: 2 and a light chain variable region consisting of the amino acid sequence shown in SEQ ID NO: 4, or a functional fragment thereof binding to canine TARC.-
公开(公告)号：US10428112B2
公开(公告)日：2019-10-01
申请号：US15317693
申请日：2015-06-11
发明人： Kenichi Masuda , Yasuyuki Ishii , Toshihiro Tsukui
摘要： The present invention provides a synthetic peptide capable of inducing an antibody to an autoantigen, and specifically, provides: a multiplexed same type-antigenic peptide having a dendritic core and B-cell recognition peptides, wherein the multiplexed same type-antigenic peptide comprises 4 to 8 B-cell recognition peptides of the same type that are bound to the terminal ends of the dendritic core directly or via a spacer, and each B-cell recognition peptide is bound to the terminal end of the dendritic core directly or via a spacer; an antibody production-inducing agent having the peptides; and a method for producing the peptide.
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公开(公告)号：US20170158764A1
公开(公告)日：2017-06-08
申请号：US15320412
申请日：2015-07-08
发明人： Takuya MIZUNO , Kazuha SHOSU
IPC分类号： C07K16/28
CPC分类号： C07K16/2803 , A61K39/395 , C07K16/2818 , C07K16/2827 , C07K2317/20 , C07K2317/34 , C07K2317/76 , C12N15/09
摘要： The object of the present invention is to provide an anti-canine PD-1 antibody or an anti-canine PD-L1 antibody, an agent for inhibiting binding between a canine PD-1 and a canine PD-L1 containing such an antibody, a method for inhibiting binding between a canine PD-1 and a canine PD-L1 comprising using such an antibody, and a gene encoding such an antibody. An anti-canine PD-1 antibody that specifically binds to a canine PD-1 consisting of the amino acid sequence set forth in SEQ ID NO: 1 and an anti-canine PD-L1 antibody that specifically binds to a canine PD-L1 consisting of the amino acid sequence set forth in SEQ ID NO: 6 are produced. An agent for inhibiting binding between a canine PD-1 and a canine PD-L1 containing such an antibody is also produced.
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4.发明申请ANTI-DOG IgE MONOCLONAL ANTIBODY, AND LIGHT-CHAIN VARIABLE REGION AND HEAVY-CHAIN VARIABLE REGION OF ANTI-DOG IgE MONOCLONAL ANTIBODY 有权抗IgE单克隆抗体，抗链可变区和抗链IgE单克隆抗体的重链可变区公开(公告)号：US20160272728A1
公开(公告)日：2016-09-22
申请号：US14778452
申请日：2014-03-17
申请人： Kazusa DNA Research Institute , Animal Allergy Clinical Laboratories Inc. , Nippon Zenyaku Kogyo Co., Ltd.
发明人： Osamu OHARA , Takahiro NAGASE , Yoshihiro YAMAGUCHI , Reiko OHARA , Kenichi MASUDA , Toshihiro TSUKUI
IPC分类号： C07K16/42 , G01N33/68 , G01N33/577 , C12N15/85
CPC分类号： C07K16/4291 , A01K2217/052 , A01K2227/706 , A01K2267/01 , C07K2317/14 , C07K2317/52 , C07K2317/54 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/624 , C07K2317/626 , C07K2319/21 , C12N15/8509 , C12N2015/8518 , G01N33/577 , G01N33/6854
摘要： Problem to be Solved: The present invention is intended to provide a polynucleotide encoding the light-chain variable region and the heavy-chain variable region of an anti-dog IgE antibody; and an anti-dog IgE antibody containing these variable regions.Solution: The present invention is DNA encoding a heavy-chain variable region consisting of the amino acid sequence represented by SEQ ID NO: 2 or 6 and DNA encoding a light-chain variable region consisting of the amino acid sequence represented by SEQ ID NO: 4 or 8, and an anti-dog IgE monoclonal antibody which binds to dog IgE, containing these variable regions or a functional fragment thereof which binds to dog IgE.
摘要翻译： 解决方案：本发明是编码由SEQ ID NO：2或6所示的氨基酸序列组成的重链可变区的DNA和编码由SEQ ID NO：2或6所示氨基酸序列组成的轻链可变区的DNA。 4或8，以及结合狗IgE的抗狗IgE单克隆抗体，其含有这些可变区或其与狗IgE结合的功能片段。
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公开(公告)号：US08460926B2
公开(公告)日：2013-06-11
申请号：US12084655
申请日：2006-11-17
申请人： Naoto Yamashiro , Kohichi Saze , Osamu Ohneda , Masumi Nagano
发明人： Naoto Yamashiro , Kohichi Saze , Osamu Ohneda , Masumi Nagano
CPC分类号： A01N1/02 , A01N1/0221
摘要： To provide an aqueous solution for cell preservation which is free of a natural animal-derived component such as a basal medium or serum. An aqueous preservation solution showing a high cell survival rate was obtained by removing a natural animal-derived component such as a basal medium or serum and controlling other components and their concentrations.
摘要翻译： 提供不含天然动物衍生成分如基础培养基或血清的细胞保存用水溶液。 通过除去天然动物衍生成分如基础培养基或血清并控制其它成分及其浓度，获得显示高细胞存活率的水性保存溶液。
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公开(公告)号：US20130034731A1
公开(公告)日：2013-02-07
申请号：US13516114
申请日：2010-12-17
申请人： Shizuo Akira , Ken Ishii , Cevayir Coban , Toshihiro Tsukui , Yoshikatsu Igari , Keiichi Ohata
发明人： Shizuo Akira , Ken Ishii , Cevayir Coban , Toshihiro Tsukui , Yoshikatsu Igari , Keiichi Ohata
CPC分类号： A61K39/39 , A61K39/015 , A61K39/35 , A61K2039/543 , A61K2039/55505 , A61K2039/55511 , A61K2039/55561 , Y02A50/39 , Y02A50/407 , Y02A50/466 , Y02A50/484 , Y10T428/2982
摘要： The present invention is directed to providing a method for preparing a vaccine adjuvant composition containing β-hematin and a vaccine adjuvant composition obtained by the preparation method. The present invention is directed to a vaccine adjuvant composition containing a β-hematin crystal having an average particle size of 20 to 500 nm.
摘要翻译： 本发明涉及提供一种制备含有本发明的疫苗佐剂组合物的方法和通过该制备方法获得的疫苗佐剂组合物。 本发明涉及一种含有平均粒度为20〜500nm的白蛋白晶体的疫苗佐剂组合物。
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公开(公告)号：US20090142830A1
公开(公告)日：2009-06-04
申请号：US12084655
申请日：2006-11-17
申请人： Naoto Yamashiro , Kohichi Saze , Osamu Ohneda , Masumi Nagano
发明人： Naoto Yamashiro , Kohichi Saze , Osamu Ohneda , Masumi Nagano
IPC分类号： C12N5/08
CPC分类号： A01N1/02 , A01N1/0221
摘要： To provide an aqueous solution for cell preservation which is free of a natural animal-derived component such as a basal medium or serum. An aqueous preservation solution showing a high cell survival rate was obtained by removing a natural animal-derived component such as a basal medium or serum and controlling other components and their concentrations.
摘要翻译： 提供不含天然动物衍生成分如基础培养基或血清的细胞保存用水溶液。 通过除去天然动物衍生成分如基础培养基或血清并控制其它成分及其浓度，获得显示高细胞存活率的水性保存溶液。
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公开(公告)号：US10280223B2
公开(公告)日：2019-05-07
申请号：US15320412
申请日：2015-07-08
发明人： Takuya Mizuno , Kazuha Shosu
IPC分类号： C07K16/28 , A61K39/395 , C12N15/09
摘要： The object of the present invention is to provide an anti-canine PD-1 antibody or an anti-canine PD-L1 antibody, an agent for inhibiting binding between a canine PD-1 and a canine PD-L1 containing such an antibody, a method for inhibiting binding between a canine PD-1 and a canine PD-L1 comprising using such an antibody, and a gene encoding such an antibody. An anti-canine PD-1 antibody that specifically binds to a canine PD-1 consisting of the amino acid sequence set forth in SEQ ID NO: 1 and an anti-canine PD-L1 antibody that specifically binds to a canine PD-L1 consisting of the amino acid sequence set forth in SEQ ID NO: 6 are produced. An agent for inhibiting binding between a canine PD-1 and a canine PD-L1 containing such an antibody is also produced.
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公开(公告)号：US09056094B2
公开(公告)日：2015-06-16
申请号：US12740899
申请日：2008-10-31
申请人： Toshihiro Tsukui , Ken Ishii , Shizuo Akira , Cevayir Coban
发明人： Toshihiro Tsukui , Ken Ishii , Shizuo Akira , Cevayir Coban
CPC分类号： A61K39/39 , A61K9/0019 , A61K39/35 , A61K47/46 , A61K2039/55516
摘要： The present invention provides a vaccine adjuvant composition which is used in combination with an allergen vaccine, infection vaccine or tumor vaccine. The present invention specifically provides a vaccine adjuvant composition comprising hemozoin or β-hematin and being used in combination with an allergen vaccine, infection vaccine or tumor vaccine, and a vaccine composition comprising the vaccine adjuvant composition and an allergen vaccine, infection vaccine or tumor vaccine.
摘要翻译： 本发明提供了与变应原疫苗，感染疫苗或肿瘤疫苗组合使用的疫苗佐剂组合物。 本发明具体提供一种疫苗佐剂组合物，其包含血红素或重金属，并与变应原疫苗，感染疫苗或肿瘤疫苗组合使用，以及包含疫苗佐剂组合物和变应原疫苗，感染疫苗或肿瘤的疫苗组合物 疫苗。
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公开(公告)号：US20140080997A1
公开(公告)日：2014-03-20
申请号：US14052879
申请日：2013-10-14
IPC分类号： C07K14/435
CPC分类号： C07K14/43531 , A61K39/00 , A61K39/35 , G01N33/56905 , G01N33/6854
摘要： A safe and efficient recombinant mite allergen is provided as a therapeutic agent or a diagnostic agent for mite allergic diseases, which contains no anaphylaxis-inducing impurities. The following recombinant protein (a) or (b) is provided:(a) a protein comprising the amino acid sequence represented by SEQ ID NO: 2 or 35; or (b) a protein comprising an amino acid sequence derived from the amino acid sequence represented by SEQ ID NO: 2 or 35 by deletion, substitution, or addition of one or several amino acids and having mite allergen activity.
摘要翻译： 提供安全有效的重组螨变应原作为不含过敏反应性杂质的螨过敏性疾病的治疗剂或诊断剂。 提供以下重组蛋白（a）或（b）：（a）包含SEQ ID NO：2或35所示的氨基酸序列的蛋白质; 或（b）通过缺失，取代或添加一个或几个氨基酸并具有螨变应原活性的蛋白质，其包含由SEQ ID NO：2或35所示的氨基酸序列衍生的氨基酸序列。
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