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公开(公告)号：US20240342286A1
公开(公告)日：2024-10-17
申请号：US18669670
申请日：2024-05-21
CPC分类号： A61K41/0057 , C07F5/022 , C07F7/0814
摘要： Near-infrared (NIR) absorbing photosensitizers for imaging and treatment of cancer in a photodynamic therapy (PDT) are provided. Specifically, the NIR photosensitizers are mitochondria targeted and water-soluble, and used as a cytotoxic drug in a photodynamic therapy of the cancer. The NIR photosensitizers are activated with wavelengths of light, wherein the light penetrates through a body not just a skin. Hence the NIR photosensitizers aim to transform PDT from being a specialized treatment to a generally applicable one. PDT is almost completely non-invasive compared to current treatment methods.
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公开(公告)号：US11832052B2
公开(公告)日：2023-11-28
申请号：US17638211
申请日：2020-08-28
CPC分类号： H04R1/406 , H04R3/005 , H04R2201/401
摘要： A spherically steerable microphone array structure is provided. The spherically steerable microphone array structure uses pressure and acoustic particle velocity signals obtained from sensors positioned co-planarly on a circular arc. The spherically steerable microphone array structure allows a calculation of all spatial partial derivatives of a sound field up to a given order. The spatial partial derivatives are used to obtain a spherical harmonic decomposition of a recorded sound field. Spherical harmonic decomposition coefficients are used in a spherically direction-invariant acoustic mode beamforming.
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公开(公告)号：US20210252152A1
公开(公告)日：2021-08-19
申请号：US16973435
申请日：2018-06-25
摘要： Near-infrared (NIR) absorbing photosensitizers for imaging and treatment of cancer in a photodynamic therapy (PDT) are provided. Specifically, the NIR photosensitizers are mitochondria targeted and water-soluble, and used as a cytotoxic drug in a photodynamic therapy of the cancer. The NIR photosensitizers are activated with wavelengths of light, wherein the light penetrates through a body not just a skin. Hence the NIR photosensitizers aim to transform PDT from being a specialized treatment to a generally applicable one. PDT is almost completely non-invasive compared to current treatment methods.
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公开(公告)号：US12091658B2
公开(公告)日：2024-09-17
申请号：US17276186
申请日：2019-09-23
发明人： Pinar Calik , Burcu Gunduz Ergun
CPC分类号： C12N15/102 , C07K14/39 , C12N1/14 , C12N15/815 , C12R2001/72 , C12R2001/78 , C12R2001/84 , C12R2001/88
摘要： Pichia pastoris alcohol dehydrogenase 2 (ADH2) promoter variants include at least one of the specified modifications on wild-type Pichia pastoris ADH2 promoter (SEQ ID NO: 1). The modification includes one of the following mutations: integration of a Cat8 transcription factor binding site (TFBS), particularly integration of SEQ ID NO: 3 or other gene sequences that show at least 80% similarity with this sequence, at any positions within nucleotides a) 647 to 660; b) 739 to 752; c) 1 to 948; and d) mutations specified with SEQ ID NO: 2 within nucleotides 15 to 848 separately and combinations thereof.
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公开(公告)号：US11889264B2
公开(公告)日：2024-01-30
申请号：US17604441
申请日：2019-04-18
发明人： Baris Bayram , Asaf Behzat Sahin , Ilker Oguz , Goktug Cihan Ozmen , Ekin Muharrem Karaca , Do{hacek over (g)}a Buse Cavdir
IPC分类号： H04R23/00
CPC分类号： H04R23/008 , H04R2201/003
摘要： A fiber optic MEMS microphone featuring an electrically deflectable MEMS membrane via a conversion of an optical energy propagating in an optical fiber cable to an electrical energy with a photodiode chip. The fiber optic MEMS microphone includes a MEMS device, the photodiode chip, a voltage, a power adjustable laser beam and a light.
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公开(公告)号：US11764323B2
公开(公告)日：2023-09-19
申请号：US17416538
申请日：2019-10-25
发明人： Tunay Tansel , Rasit Turan
IPC分类号： H01L31/103 , H01L31/0224 , H01L31/0236 , H01L31/0288 , H01L31/18
CPC分类号： H01L31/103 , H01L31/0288 , H01L31/02363 , H01L31/022408 , H01L31/1804
摘要： A semiconductor photodiode which functions in a wide band range up to medium wave infrared and far wavelengths in addition to visible region and near infrared includes: a light absorber region in micro structure which can provide light absorbance upon being roughened by laser; a first electrical lower contact coated with metal materials such as aluminium (Al), silver (Ag); a silicon which consists of crystalline silicon (c-Si); a second electrical lower contact which is coated with metal materials such as aluminium (Al), silver (Ag); a chalcogen doped hyper-filled silicone region which is obtained as a result of doping by pulse laser to the silicone region implanted by chalcogen elements; and upper electrical contact parts which are coated generally in the thickness range of 10 nm-1000 nm by using two-layered alloys with aluminium (Al)—(Al)-silver (Ag), two-layered alloys with titanium (Ti)-gold (Au), three-layered alloys with Ti-Platinum(Pt)—Au—Ag or three-layered alloys with Ti-lead(Pb)—Ag.
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公开(公告)号：US20230229726A1
公开(公告)日：2023-07-20
申请号：US17767949
申请日：2020-10-08
CPC分类号： G06F17/11 , G06F17/16 , G06F17/141 , G06F30/23 , G06F2119/14
摘要： A modal superposition method using a response dependent non-linear mode concept for a vibration analysis of non-linear engineering structures is provided. The modal superposition method is provided to find steady state response of non-linear systems in frequency domain. The modal superposition method is used in many mechanical structures, especially in design of aerospace and automotive structures, defense industry platforms, steam and gas turbines and mechanical structures containing non-linear forces such as gas turbine engines and jet engines.
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公开(公告)号：US20220337944A1
公开(公告)日：2022-10-20
申请号：US17638211
申请日：2020-08-28
摘要： A spherically steerable microphone array structure is provided. The spherically steerable microphone array structure uses pressure and acoustic particle velocity signals obtained from sensors positioned co-planarly on a circular arc. The spherically steerable microphone array structure allows a calculation of all spatial partial derivatives of a sound field up to a given order. The spatial partial derivatives are used to obtain a spherical harmonic decomposition of a recorded sound field. Spherical harmonic decomposition coefficients are used in a spherically direction-invariant acoustic mode beamforming.
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9.发明授权公开(公告)号：US11451174B2
公开(公告)日：2022-09-20
申请号：US17272676
申请日：2019-10-02
发明人： Ilker Sahin , Ozan Keysan
摘要： A method for reducing a total operational load of a method of a model predictive control-by conducting simplifications based on specific observations, in order to drive alternating current motors by using the method of the MPC with a two-level voltage source inverter. The method includes the steps of determining at which one of the predefined sectors a resultant of stator currents is present, determining a motor mode, reducing seven estimation vectors to four estimation vectors and calculating a cost function or reducing seven estimation vectors to five estimation vectors and calculating the cost function.
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公开(公告)号：US11482239B2
公开(公告)日：2022-10-25
申请号：US17270075
申请日：2019-09-16
IPC分类号： G10L21/028 , G10L21/0272 , G10L21/0216
摘要： A method is provided for acoustic source direction of arrival estimation and acoustic source separation, via spatial weighting of the dictionary based display of the steered response function calculated for a certain number of directions from spherical harmonic decomposition coefficients obtained from microphone array recordings of the sound field. The usage of spatial band limited functions of plane waves to represent more complex directional maps of the sound field constitutes the algorithm. These functions are calculated for pre-defined directions on an analysis surface (such as a sphere). The directions of arrival of sound sources are calculated with the same method in order to group source estimates to localize sound sources. Thereby, directions of arrival can be obtained from the recordings of the sound sources captured by means of a microphone array and following this, sound sources can be separated by using this direction information or predetermined source arrival directions.
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