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公开(公告)号：US12276592B2
公开(公告)日：2025-04-15
申请号：US17341998
申请日：2021-06-08
Applicant: Particle Measuring Systems, Inc.
Inventor： Daniel Rodier
IPC: G01N15/1434 , G01N15/0205
Abstract: Particle detection systems and methods are disclosed. In one embodiment, a particle detection system comprises an incident beam light source that emits an incident beam, a particle interrogation zone disposed in the path of the incident beam, a photodetector disposed to detect the incident beam after passing through the particle interrogation zone, a pump beam light source for emitting a pump beam, the pump beam being targeted at the particle interrogation zone, wherein the incident beam, the pump beam, and photodetector are arranged such that the photodetector is configured to detect a combination of light from the incident beam, scattered light due to incident beam scattering in the particle interrogation zone, and scattered light due to pump beam scattering in the particle interrogation zone.
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公开(公告)号：US11892462B2
公开(公告)日：2024-02-06
申请号：US17151899
申请日：2021-01-19
Applicant: Particle Measuring Systems, Inc. , Pharma Integration SRL
Inventor： Giovanni Scialò , Davide Recchia , Claudio Bechini
CPC classification number: G01N35/0099 , B01L3/502 , B25J9/0009 , B25J11/00 , C12M23/22 , C12M37/00 , C12Q1/04 , G01N1/2208 , G01N1/2273 , B01L2200/0689 , B01L2300/04 , B01L2300/168
Abstract: Devices and methods for sampling, detecting and/or characterizing particles, for example, via collection, growth and analysis of viable biological particles such as microorganisms. Devices and methods of the invention include particle samplers and impactors including a sampling head comprising one or more intake apertures, a selectively removable cover, an impactor base connected to the sampling head, and one or more magnets fixed to the sampling head, the selectively removable cover and/or the impactor base. The one or more magnets allow for robotic manipulation of the impactor devices.
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公开(公告)号：US11781965B2
公开(公告)日：2023-10-10
申请号：US16652653
申请日：2018-10-25
Applicant: PARTICLE MEASURING SYSTEMS, INC.
Inventor： Nir Karasikov , Ori Weinstein , Shoam Shwartz , Mehran Vahdani Moghaddam , Uri Dubin
CPC classification number: G01N15/1434 , G01N15/1459 , G01N2015/1075 , G01N2015/1486 , G01N2015/1493
Abstract: An optical system for particle size and concentration analysis, includes: at least one laser that produces an illuminating beam; a focusing lens that focuses the illuminating beam on particles that move relative to the illuminating beam at known or pre-defined angles to the illuminating beam through the focal region of the focusing lens; and at least two forward-looking detectors, that detect interactions of particles with the illuminating beam in the focal region of the focusing lens. The focusing lens is a cylindrical lens that forms a focal region that is: (i) narrow in the direction of relative motion between the particles and the illuminating beam, and (ii) wide in a direction perpendicular to a plane defined by an optical axis of the system and the direction of relative motion between the particles and the illuminating beam. Each of the two forward-looking detectors is comprised of two segmented linear arrays of detectors.
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公开(公告)号：US20230009668A1
公开(公告)日：2023-01-12
申请号：US17848751
申请日：2022-06-24
Applicant: PARTICLE MEASURING SYSTEMS, INC.
Inventor： Giovanni SCIALÒ , Davide RECCHIA
IPC: G01N1/22 , G01N33/497
Abstract: Disclosed is a liquid impinger, for example a liquid impinger, particularly a disposable liquid impinger. The liquid impinger comprises, for example, at least one nozzle positioned in the interior and attached to the bottom portion. In some aspects, the liquid impinger comprises a polymeric material. Also disclosed are methods of making the liquid impinger comprising, for example, forming at least two components, assembling the at least two components into the liquid impinger, filling the liquid impinger with liquid, and exposing the filled liquid impinger to radiation for sterilization prior to use. Also disclosed are methods of using the liquid impinger, for example, by transporting a gas comprising analytes through the liquid impinger and transferring at least a portion of the analytes from the gas into the liquid contained therein. The method further comprises, for example, after transferring analytes form the gas into the liquid, incubating and/or detecting at least a portion of the analytes in the liquid without removing the liquid from the liquid impinger.
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公开(公告)号：US11540248B2
公开(公告)日：2022-12-27
申请号：US17087906
申请日：2020-11-03
Inventor： Giovanni Scialò , Davide Recchia , Claudio Bechini
Abstract: A mobile monitoring device for monitoring controlled contamination areas may include a motorized mobile structure, a sampling unit, and a central management and control unit. The motorized mobile structure is configured to move within an area to be monitored. The sampling unit is positioned on said mobile structure, and configured to perform sampling operations of air and/or surfaces of said area and obtain sampling data. The central management and control unit is operatively connected to the mobile structure and to said sampling unit. The mobile structure may be controlled by the central unit to reach predefined points of the area to be monitored. The sampling unit may be selectively activated and/or deactivated by said central unit in correspondence with said predefined starting points of said sampling operations.
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Patent Agency Ranking
公开(公告)号：US20220397510A1
公开(公告)日：2022-12-15
申请号：US17839565
申请日：2022-06-14
Applicant: PARTICLE MEASURING SYSTEMS, INC.
Inventor： Edward YATES , Cary HERTERT , Brian A. KNOLLENBERG
Abstract: Disclosed is a method for detecting and/or growing particles, comprising controlling the surface area exposed to the saturator region by monitoring at least one of a depth of the working liquid on the saturator surface, the surface area exposed to the saturator region, or a volume of the working liquid on the saturator surface. Also disclosed is an apparatus or system for detecting and/or growing particles, comprising a fluidics system configured to control the surface area exposed to the saturator region by monitoring at least one of a depth of the working liquid on the saturator surface, the surface area exposed to the saturator region, or a volume of the working liquid on the saturator surface. Certain aspects do not employ one or more porous structures for vapor generation, nor a separate carrier fluid flow or inlet comprising a carrier fluid and vaporized working liquid for combining with the sample flow in the saturator region.
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7.发明授权公开(公告)号：US11255760B2
公开(公告)日：2022-02-22
申请号：US16678687
申请日：2019-11-08
Applicant: Particle Measuring Systems, Inc.
Inventor： Giovanni Scialo , Davide Recchia
Abstract: Provided herein are systems and methods allowing for automated sampling and/or analysis of controlled environments, for example, to determine the presence, quantity, size, concentration, viability, species or characteristics of particles within the environment. The described systems and methods may utilize robotics or automation or remove some or all of the collection or analysis steps that are traditionally performed by human operators. The methods and systems described herein are versatile and may be used with known particle sampling and analysis techniques and particle detection devices including, for example, optical particle counters, impingers and impactors.
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公开(公告)号：US11250684B2
公开(公告)日：2022-02-15
申请号：US17224599
申请日：2021-04-07
Applicant: Particle Measuring Systems, Inc.
Inventor： Scott MacLaughlin , Matt Michaelis , Brian A. Knollenberg
Abstract: The invention generally provides devices and methods for particle detection for minimizing human-caused contamination in manufacturing environments requiring low levels of microbes, such as cleanroom environments for electronics manufacturing and aseptic environments for manufacturing pharmaceutical and biological products, such as sterile medicinal products. Methods of the invention may incorporate wirelessly transmitting an alarm signal from a particle detector to a remote device, replicating a graphical user interface of the particle detector on an electronic display of the remote device, and passing one or more user instructions from the remote device to the particle detector via the replicate graphical interface of the remote device.
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公开(公告)号：US11181455B2
公开(公告)日：2021-11-23
申请号：US16678968
申请日：2019-11-08
Applicant: Particle Measuring Systems, Inc.
Inventor： Thomas A. Bates , Matt Michaelis , Brett Haley
Abstract: Provided are particle analyzers and related methods for verifying calibration status of the particle analyzer. The method includes the steps of providing an optical particle analyzer and modulating a power applied to a source of EMR. The method includes the steps of, in response to the modulating step, inducing a detector signal waveform and analyzing the detector signal waveform to determine a value of at least one diagnostic parameter associated with one or more of the source of EMR, an optical assembly, a chamber, a detector, and an optical collection system of the optical particle analyzer. The method includes the step of determining a calibration status of the optical particle analyzer based on the one or more determined values of the at least one diagnostic parameter.
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公开(公告)号：US20210295670A1
公开(公告)日：2021-09-23
申请号：US17224599
申请日：2021-04-07
Applicant: Particle Measuring Systems, Inc.
Inventor： Scott MacLAUGHLIN , Matt MICHAELIS
Abstract: The invention generally provides devices and methods for particle detection for minimizing human-caused contamination in manufacturing environments requiring low levels of microbes, such as cleanroom environments for electronics manufacturing and aseptic environments for manufacturing pharmaceutical and biological products, such as sterile medicinal products. Methods of the invention may incorporate wirelessly transmitting an alarm signal from a particle detector to a remote device, replicating a graphical user interface of the particle detector on an electronic display of the remote device, and passing one or more user instructions from the remote device to the particle detector via the replicate graphical interface of the remote device.
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