公开(公告)号：US07514463B2

公开(公告)日：2009-04-07

申请号：US10922747

申请日：2004-08-20

申请人： Gunda I. Georg ,  Joseph S. Tash ,  Ramappa Chakrasali ,  Sudhakar Rao Jakkaraj

发明人： Gunda I. Georg ,  Joseph S. Tash ,  Ramappa Chakrasali ,  Sudhakar Rao Jakkaraj

IPC分类号： A61K31/416 ,  C07D231/56

CPC分类号： C07D231/56 ,  C07D471/04

摘要： Novel compounds useful for inhibiting spermatogenesis and cancer treatment, and in particular as inhibitors of heat shock proteins and/or elongation factor 1 alpha.

摘要翻译： 用于抑制精子发生和癌症治疗的新型化合物，特别是作为热休克蛋白和/或延伸因子1α的抑制剂。

公开(公告)号：US12127876B2

公开(公告)日：2024-10-29

申请号：US17284758

申请日：2019-10-11

申请人： University of Kansas

发明人： Sandra A. Billinger ,  Eric D. Vidoni

IPC分类号： A61B8/08 ,  A61B8/00 ,  A61B8/06

CPC分类号： A61B8/0816 ,  A61B8/06 ,  A61B8/4227 ,  A61B8/488 ,  A61B8/5223

摘要： A method of evaluating a cerebrovascular health of a patient includes causing a patient to exercise for an exercise duration at an exercise intensity, collecting cerebrovascular information from the patient during the exercise duration, collecting cardiovascular information from the patient during the exercise duration, correlating the cerebrovascular information to the cardiovascular information to create a correlated cerebrovascular curve, and determining a cerebrovascular health and viability for cerebrovascular therapy.

公开(公告)号：US20240342179A1

公开(公告)日：2024-10-17

申请号：US18635508

申请日：2024-04-15

申请人： University of Kansas

发明人： Andrew K. Godwin ,  Frank John Schoenen ,  Anuradha Roy ,  Benjamin Gibbs ,  Rebecca Wates

IPC分类号： A61K31/519 ,  A61K31/198 ,  A61K31/433 ,  A61K31/4436 ,  A61K31/506 ,  A61K31/517 ,  A61K38/17 ,  A61P35/00 ,  C12N15/113

CPC分类号： A61K31/519 ,  A61K31/198 ,  A61K31/433 ,  A61K31/4436 ,  A61K31/506 ,  A61K31/517 ,  A61K38/1709 ,  A61P35/00 ,  C12N15/113 ,  C12N2310/14

摘要： A method of inhibiting KIF15 can include administering a compound to the KIF15 to inhibit biological functionality of KIF15. The compound includes a structure of Formula 1. R1 and R2 are each independently a non-hydrogen substituent, such that the compound inhibits biological functionality of KIF15, or a stereoisomeric form or a mixture of stereoisomeric forms, or pharmaceutically acceptable salts of the compound. The compound is administered to the KIF15 to inhibit KIF15 from interacting with TPX2 so as to inhibit or disrupt a protein-protein interaction therebetween. The administering of the compound can be to a subject having the KIF15, which is administered in a therapeutically effective amount to treat a disease or disorder associated with KIF15 interacting with TPX2, such as treating a cancer or neoplasm.

公开(公告)号：US12120959B2

公开(公告)日：2024-10-15

申请号：US17045262

申请日：2019-04-02

申请人： UNIVERSITY OF KANSAS ,  EVOKE MEDICAL, LLC

发明人： Elizabeth Annamaria Friis ,  Ember Krech ,  Eileen Cadel ,  Bonnie Reinsch ,  Leighton Lapierre

IPC分类号： H10N30/50 ,  H10N30/30 ,  H10N30/853 ,  H10N30/857 ,  A61N1/05

CPC分类号： H10N30/50 ,  H10N30/30 ,  H10N30/8536 ,  H10N30/8554 ,  H10N30/857 ,  A61N1/0551

摘要： The present application relates to stacked piezoelectric energy harvesters that include compliant layers between piezoelectric layers. The energy harvesters are useful in various structures and devices, including tissue-stimulating implants, such as spinal fusion implants. The present application also relates to methods of increasing the power output of a piezoelectric energy harvester through the inclusion of compliant layers.

公开(公告)号：US20240316056A1

公开(公告)日：2024-09-26

申请号：US18735506

申请日：2024-06-06

申请人： The United States of America,as represented by the Secretary,Department of Health and Human Services ,  University of Kansas ,  Northwestern University

发明人： Udo Rudloff ,  Serguei Kozlov ,  Juan Jose Marugan ,  Sui Huang ,  Samarjit Patnaik ,  John C. Braisted ,  Noel T. Southall ,  Marc Ferrer ,  Christopher Dextras ,  John Haslam ,  Michael Baltezor

IPC分类号： A61K31/519 ,  A61K31/7068 ,  A61K45/06 ,  A61K47/12 ,  A61P35/04

CPC分类号： A61K31/519 ,  A61K31/7068 ,  A61K45/06 ,  A61K47/12 ,  A61P35/04

摘要： Disclosed are pharmaceutical formulations comprising a compound of formula (I):




in which R1, R2, R3, and R4 are as described herein, or a pharmaceutically acceptable salt thereof. Also provided are methods for treating pancreatic adenocarcinoma comprising administration of a compound of formula (I), or a pharmaceutically acceptable salt thereof, and methods of detecting the change in expression levels of one or both of FoxA1 and FoxO6 in a pancreatic adenocarcinoma tumor sample from a mammal, wherein the mammal has been administered a compound of formula (I), or a pharmaceutically acceptable salt thereof.

公开(公告)号：US12070342B2

公开(公告)日：2024-08-27

申请号：US17399626

申请日：2021-08-11

申请人： University of Kansas

发明人： Holly Hull

IPC分类号： A61B6/04

CPC分类号： A61B6/0421 ,  A61B2503/04

摘要： A medical imaging support includes a substantially flat radiotransparent platform, a plurality of radiotransparent flaps, and closure mechanisms. The platform has a longitudinal direction between a top edge and a bottom edge. The plurality of sets of radiotransparent flaps have a first set of the radiotransparent flaps positioned closer to the top edge in the longitudinal direction than the second set of radiotransparent flaps, and at least one set of flaps includes a first flap and a second flap where the first flap is fixed to the platform proximate a first side edge and the second flap is fixed to the platform proximate a second side edge. The closure mechanisms are positioned on the first flap or second flap of each set of radiotransparent flaps, wherein the closure mechanism selectively fixes the first flap to the second flap of each set of radiotransparent flaps.

公开(公告)号：US20240261532A1

公开(公告)日：2024-08-08

申请号：US18566926

申请日：2022-06-03

申请人： UNIVERSITY OF KANSAS

发明人： Christopher TACCA ,  Barbara A. Kerr

IPC分类号： A61M21/00 ,  A61B5/00 ,  A61B5/16 ,  A61B5/375 ,  G06T19/00

CPC分类号： A61M21/00 ,  A61B5/0006 ,  A61B5/0022 ,  A61B5/165 ,  A61B5/375 ,  A61B5/6803 ,  A61B5/744 ,  A61B5/7465 ,  G06T19/00 ,  G06T2219/024

摘要： A remote psychotherapy system includes an environment. A patient selects a patient avatar. The patient provides input for a provider avatar, which may be influenced by one or more Jungian archetypes. The patient wears a virtual reality simulator having a head mounted device. The virtual reality simulator includes a sensor that collects biofeedback information. The biofeedback information is used to determine state information about the patient, such as an emotional state of the user. The state information and/or the biofeedback information is transmitted to the provider and presented to the provider in a graphical user interface (GUI) on a provider virtual reality device.

公开(公告)号：US12049683B2

公开(公告)日：2024-07-30

申请号：US17287258

申请日：2019-10-22

申请人： University of Kansas

发明人： Mark Brandon Shiflett ,  David Richard Corbin ,  Ankit Verma

IPC分类号： C22B7/00 ,  C22B26/12 ,  H01M10/54

CPC分类号： C22B7/008 ,  C22B7/007 ,  C22B26/12 ,  H01M10/54

摘要： Methods for recovering metals from metal-containing materials are provided. The metal-containing material comprises either Co and Li (e.g., an electrode material from a spent lithium ion battery) or Fe and Al (e.g., bauxite). The metal-containing material is exposed to a leaching solution comprising ammonium hydrogen oxalate, oxalic acid, or both, to provide a solid composed of either cobalt oxalate or iron oxalate, and a solution of either lithium oxalate or aluminum oxalate. The solid is processed to provide either cobalt oxide or iron oxide; the solution is processed to provide either a lithium precipitate or an aluminum precipitate, and a filtrate comprising an oxalate; and the filtrate comprising the oxalate is processed to recover ammonium hydrogen oxalate, oxalic acid, or both. The method further comprises repeating the digestion step with the recovered ammonium hydrogen oxalate, the recovered oxalic acid, or both.

公开(公告)号：US12029460B2

公开(公告)日：2024-07-09

申请号：US17484736

申请日：2021-09-24

申请人： University of Kansas

发明人： Terence Edward McIff ,  Edward Bruce Toby

IPC分类号： A61B17/86 ,  A61B17/064 ,  A61B17/68 ,  A61B17/00 ,  A61B17/17

CPC分类号： A61B17/8685 ,  A61B17/0642 ,  A61B17/68 ,  A61B17/869 ,  A61B2017/00004 ,  A61B17/064 ,  A61B2017/0641 ,  A61B2017/0645 ,  A61B17/1782

摘要： Embodiments of the present invention relate to systems, methods, and apparatus for immobilizing and/or securing bone portions. Particularly, at least one embodiment involves a compact anti-rotation device that can secure adjacent bones and/or bone portions in a manner that prevents or limits relative rotational movement thereof.

公开(公告)号：US20240175666A1

公开(公告)日：2024-05-30

申请号：US18396605

申请日：2023-12-26

申请人： University of Kansas

发明人： Ronald Martin Barrett ,  Lauren Nicole Schumacher

IPC分类号： F42B14/06 ,  B64D1/04 ,  F42B10/30 ,  F42B10/64 ,  F42B14/08

CPC分类号： F42B14/061 ,  B64D1/04 ,  F42B10/30 ,  F42B10/64 ,  F42B14/08

摘要： An aeromechanically stable sabot system that includes a center of gravity that is placed forward of an aerodynamic center of the aeromechanically stable sabot system when in steady-state flight. By placing the center of gravity forwards of the aerodynamic center, the sabot system exhibits positive longitudinal and directional stability. To illustrate, the sabot system and/or portions thereof will return to stable flight after being disturbed in pitch (vertically or about a transverse horizontal axis) or yaw (side to side or about a vertical axis) when traveling horizontally.