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公开(公告)号：US20220238320A1
公开(公告)日：2022-07-28
申请号：US17717505
申请日：2022-04-11
申请人： Micromass UK Limited
发明人： John Brian Hoyes , Boris Kozlov
摘要： A Time of Flight mass analyser is disclosed comprising: at least one ion mirror 34 for reflecting ions; an ion detector 36 arranged for detecting the reflected ions; a first pulsed ion accelerator 30 for accelerating an ion packet in a first dimension (Y-dimension) towards the ion detector 36 so that the ion packet spatially converges in the first dimension as it travels to the detector 36; and a pulsed orthogonal accelerator 32 for orthogonally accelerating the ion packet in a second, orthogonal dimension (X-dimension) into one of said at least one ion mirrors 34.
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公开(公告)号：US10741376B2
公开(公告)日：2020-08-11
申请号：US15570537
申请日：2016-04-29
摘要： A method of time-of-flight mass spectrometry is disclosed comprising: providing two ion mirrors (42) that are spaced apart in a first dimension (X-dimension) and that are each elongated in a second dimension (Z-dimension) orthogonal to the first dimension; introducing packets of ions (47) into the space between the mirrors using an ion introduction mechanism (43) such that the ions repeatedly oscillate in the first dimension (X-dimension) between the mirrors (42) as they drift through said space in the second dimension (Z-dimension); oscillating the ions in a third dimension (Y-dimension) orthogonal to both the first and second dimensions as the ions drift through said space in the second dimension (Z-dimension); and receiving the ions in or on an ion receiving mechanism (44) after the ions have oscillated multiple times in the first dimension (X-dimension); wherein at least part of the ion introduction mechanism (43) and/or at least part of the ion receiving mechanism (44) is arranged between the mirrors (42).
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3.发明授权公开(公告)号：US10586691B2
公开(公告)日：2020-03-10
申请号：US15035965
申请日：2014-11-11
申请人： Micromass UK Limited
摘要： A method of mass spectrometry is disclosed comprising separating precursor ions using an ion mobility separator such that different precursor ions have different drift times through the on mobility separator; mass filtering said separated precursor ions with a mass filter, wherein the mass to charge ratios of the precursor ions transmitted by the mass filter vary as a function of the drift times of the precursor ions through the ion mobility separator; performing a first mode of operation comprising fragmenting the separated and mass filtered precursor ions in a fragmentation device to form fragment ions; urging the fragment ions through the fragmentation device such that fragment ions derived from different precursor ions that have been separated by the ion mobility separator are maintained spatially separated from each other as they are urged through the fragmentation device; and detecting the fragment ions. The method enables precursor ions to be associated with their related fragment ions more accurately.
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公开(公告)号：US20180330936A1
公开(公告)日：2018-11-15
申请号：US15776585
申请日：2016-11-16
CPC分类号： H01J49/405 , H01J49/0004 , H01J49/062 , H01J49/067 , H01J49/10 , H01J49/406
摘要： A time-of-flight mass spectrometer is disclosed comprising ion optics that map an array of ions at an ion source array (71) to a corresponding array of positions on a position sensitive ion detector (79). The ion optics include at least one gridless ion mirror (76) for reflecting ions, which may compensate for various aberrations and allows the spectrometer to have relatively high mass and spatial resolutions.
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公开(公告)号：US09728391B2
公开(公告)日：2017-08-08
申请号：US14401683
申请日：2013-05-16
申请人： Micromass UK Limited
CPC分类号： H01J49/401 , G01N2223/506 , H01J49/0031 , H01J49/405 , H01J49/406 , H01J49/408
摘要： A Time of Flight mass analyzer is disclosed comprising an annular ion guide having a longitudinal axis and comprising a first annular ion guide section and a second annular ion guide section. Ions are introduced into the first annular ion guide section so that the ions form substantially stable circular orbits within the first annular ion guide section about the longitudinal axis. An ion detector is disposed within the annular ion guide. Ions are orthogonally accelerated in a first axial direction from the first annular ion guide section into the second annular ion guide section. An axial DC potential is maintained along at least a portion of the second annular ion guide section so that the ions are reflected in a second axial direction which is substantially opposed to the first axial direction. The ions undergo multiple axial passes through the second annular ion guide section before being detected by the ion detector.
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公开(公告)号：US20160293391A1
公开(公告)日：2016-10-06
申请号：US15035965
申请日：2014-11-11
申请人： Micromass UK Limited
CPC分类号： H01J49/0031 , G01N27/622 , H01J49/0045 , H01J49/421
摘要： A method of mass spectrometry is disclosed comprising separating precursor ions using an ion mobility separator such that different precursor ions have different drift times through the on mobility separator; mass filtering said separated precursor ions with a mass filter, wherein the mass to charge ratios of the precursor ions transmitted by the mass filter vary as a function of the drift times of the precursor ions through the ion mobility separator; performing a first mode of operation comprising fragmenting the separated and mass filtered precursor ions in a fragmentation device to form fragment ions; urging the fragment ions through the fragmentation device such that fragment ions derived from different precursor ions that have been separated by the ion mobility separator are maintained spatially separated from each other as they are urged through the fragmentation device; and detecting the fragment ions. The method enables precursor ions to be associated with their related fragment ions more accurately.
摘要翻译： 公开了一种质谱法，其包括使用离子迁移率分离器分离前体离子，使得不同的前体离子通过上迁移分离器具有不同的漂移时间; 用质量过滤器对所分离的前体离子进行质量过滤，其中由质量过滤器传输的前体离子的质荷比随着前体离子通过离子迁移分离器的漂移时间的变化而变化; 执行第一操作模式，包括在分离装置中分离和质量过滤的前体离子碎裂以形成碎片离子; 促使碎片离子通过碎裂装置，使得衍生自已被离子迁移率分离器分离的不同前体离子的碎片离子保持空间上彼此分离，因为它们通过破碎装置被推动; 并检测碎片离子。 该方法使前体离子更准确地与其相关的片段离子相关联。
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公开(公告)号：US20160274059A1
公开(公告)日：2016-09-22
申请号：US15035919
申请日：2014-11-11
申请人： MICROMASS UK LIMITED
摘要： A method of mass spectrometry is disclosed comprising isolating a group of different ions derived from chemical compounds in the same class, wherein the different ions have different mass to charge ratios and ion mobilities. The step of isolating comprises temporally separating the ions according to their ion mobility in an ion mobility separator; and mass filtering the ions according to mass to charge ratio with a mass filter. The mass to charge ratios transmitted by the mass filter are varied as a function of time such that said different ions derived from chemical compounds in the same class are transmitted by the mass filter and other ions are not transmitted by the mass filter.
摘要翻译： 公开了一种质谱方法，其包括分离衍生自同一类别中的化合物的一组不同离子，其中不同的离子具有不同的质荷比和离子迁移率。 分离步骤包括在离子迁移分离器中根据其离子迁移率暂时分离离子; 并根据质量与质量过滤器的质荷比质量过滤离子。 由质量过滤器传输的质荷比随着时间的变化而变化，使得衍生自同一级别的化合物的所述不同离子通过质量过滤器传输，而其它离子不被质量过滤器传输。
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公开(公告)号：US20160035548A1
公开(公告)日：2016-02-04
申请号：US14774756
申请日：2014-03-10
申请人： MICROMASS UK LIMITED
发明人： Jeffery Mark Brown , Kevin Giles , Martin Raymond Green , John Brian Hoyes , Christopher Jones , Michael Raymond Morris , Steven Derek Pringle , Keith Richardson , Farnoush Salarzaei , Jason Lee Wildgoose
IPC分类号： H01J49/00
CPC分类号： H01J49/005 , G01N27/622 , H01J49/0031 , H01J49/0045 , H01J49/0072
摘要： A method of mass spectrometry is disclosed comprising:performing a survey scan of a plurality of different types of parent or precursor ions, wherein said survey scan comprises analysing the ion mobilities of the ions and mass analysing the ions;determining the charge states of parent or precursor ions analysed in the survey scan based on their determined combinations of ion mobility and mass to charge ratio;selecting a parent or precursor ion for fragmentation or reaction; andfragmenting or reacting said selected ion, wherein the fragmentation or reaction conditions are selected from a plurality of different fragmentation or reaction conditions based upon the determined charge state of the selected ion.
摘要翻译： 公开了一种质谱方法，包括：对多种不同类型的母体或前体离子进行测量扫描，其中所述测量扫描包括分析离子的离子迁移率和大量分析离子; 基于它们确定的离子迁移率和质荷比的组合来确定在测量扫描中分析的母体或前体离子的电荷状态; 选择母体或前体离子进行碎裂或反应; 并且使所述选择的离子断裂或反应，其中基于所选离子的确定的电荷状态，所述断裂或反应条件选自多个不同的断裂或反应条件。
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公开(公告)号：US08884220B2
公开(公告)日：2014-11-11
申请号：US14348130
申请日：2012-09-28
申请人： Micromass UK Limited
CPC分类号： H01J49/025 , H01J49/0031 , H01J49/40
摘要： An ion detector for a Time of Flight mass spectrometer is disclosed comprising a single Microchannel Plate 1 which is arranged to receive ions 2 and output electrons 3. The electrons 3 are directed onto an array of photodiodes 4 which directly detects the electrons 3. The output from each photodiode 4 is connected to a separate Time to Digital Converter provided on an ASIC 5.
摘要翻译： 公开了一种用于飞行时间质谱仪的离子检测器，其包括单个微通道板1，其被布置成接收离子2并输出电子3.电子3被引导到直接检测电子的光电二极管阵列4上。输出 从每个光电二极管4连接到在ASIC 5上提供的单独的时间到数字转换器。
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公开(公告)号：US20140264008A1
公开(公告)日：2014-09-18
申请号：US14291274
申请日：2014-05-30
申请人： Micromass UK Limited
发明人： John Brian Hoyes
IPC分类号： H01J49/36
CPC分类号： H01J49/36 , H01J49/0031 , H01J49/4235
摘要： A mass analyser is provided comprising a plurality of electrodes having apertures through which ions are transmitted. A plurality of pseudo-potential corrugations are created along the axis of the mass analyser. The amplitude or depth of the pseudo-potential corrugations is inversely proportional to the mass to charge ratio of an ion. Transient DC voltages are applied to the electrodes in order to urge ions along the length of the mass analyser. The amplitude of the transient DC voltages applied to the electrodes is increased with time and ions are caused to be emitted from the mass analyser in reverse order of their mass to charge ratio. Two AC or RF voltages are applied to the electrodes. The first AC or RF voltage is arranged to provide optimal pseudo-potential corrugations whilst the second AC or RF voltage is arranged to provide optimal radial confinement of ions within the mass analyser.
摘要翻译： 提供质量分析器，其包括具有孔的多个电极，离子通过该孔具有孔。 沿着质量分析器的轴线产生多个伪电位波纹。 伪电位波纹的振幅或深度与离子的质荷比成反比。 将瞬态DC电压施加到电极，以沿着质量分析器的长度推动离子。 施加到电极的瞬态DC电压的幅度随时间增加，并且使离子从质量分析器以其质荷比的相反顺序发射。 两个AC或RF电压施加到电极。 第一AC或RF电压被布置成提供最佳伪电位波纹，而第二AC或RF电压被布置成在质量分析器内提供离子的最佳径向约束。
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