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    Modified release drug powder composition comprising gastro-retentive RAFT forming systems having trigger pulse drug release
    1.
    发明授权
    Modified release drug powder composition comprising gastro-retentive RAFT forming systems having trigger pulse drug release 有权

    公开(公告)号：US11337919B2

    公开(公告)日：2022-05-24

    申请号：US16955377

    申请日：2018-12-18

    Applicant: Tris Pharma, Inc.

    Inventor： Paras Rameshlal Jain ,  Sachin Vasant Chaudhari

    IPC: A61K9/00 ,  A61K31/00 ,  A61K47/58 ,  A61K9/16 ,  A61K45/06

    Abstract: An orally administrable drug powder composition which forms a gastro-retentive RAFT having at least two trigger pulses is provided. The composition contains, at a minimum, (a) at least one drug in an immediate release pulse release form; (b) at least one drug in a delayed trigger release form; (c) at least one non-toxic gas generating agent and (d) a RAFT system, wherein following oral ingestion, the composition provides a self-assembling gastro-retentive RAFT having entrapped therein, the at least one drug of (a) and (b) and the gas generated in situ by the non-toxic gas generating agent, thereby providing a floating gastro-retentive RAFT having a dual pulse system wherein at least the second pulse is a trigger pulse and which retains the at least one drug in the stomach for at least about 3 hours, provided that the composition does not include a gamma hydroxybutyrate and its salts, hydrates, tautomers, or solvates, or complexes thereof.

    Compositions comprising AAV expressing dual antibody constructs and uses thereof
    3.
    发明授权
    Compositions comprising AAV expressing dual antibody constructs and uses thereof 有权

    公开(公告)号：US10138295B2

    公开(公告)日：2018-11-27

    申请号：US15310555

    申请日：2015-05-13

    Applicant: The Trustees of the University of Pennsylvania

    Inventor： James M. Wilson ,  Anna Tretiakova

    IPC: A61K48/00 ,  C12N7/00 ,  C12Q1/68 ,  A61K38/00 ,  C07K16/00 ,  C07K16/10 ,  C12N15/86 ,  A61K39/00

    Abstract: A recombinant adeno-associated virus (AAV) having an AAV capsid and packaged therein a heterologous nucleic acid which expresses two functional antibody constructs in a cell is described. Also described are antibodies comprising a heavy chain and a light chain from a heterologous antibody. In one embodiment, the antibodies are co-expressed from a vector containing: a first expression cassette which encodes at least a first open reading frame (ORF) for a first immunoglobulin under the control of regulatory control sequences which direct expression thereof; and a second expression cassette which comprises a second ORF, a linker, and a third ORF under the control of regulatory control sequences which direct expression thereof, wherein the second and third ORF encode for a second and third immunoglobulin construct. The vector co-expressing these two antibody constructs is in one embodiment an AAV, in which the 5′ and 3′ ITRs flank the expression cassettes and regulatory sequences.

    Movable guide for transmission device
    6.
    发明授权
    Movable guide for transmission device 失效
    传动装置可动导轨

    公开(公告)号：US07137916B2

    公开(公告)日：2006-11-21

    申请号：US10718958

    申请日：2003-11-21

    Applicant: Junya Kurohata ,  Atsushi Kumakura

    Inventor： Junya Kurohata ,  Atsushi Kumakura

    IPC: F16H7/08 ,  F16H7/18

    CPC classification number: F16H7/18 ,  F16H2007/0872

    Abstract: In a pivoting guide for a traveling transmission chain, composed of a synthetic resin body having a shoe and a slotted reinforcement, and a plate fitting into the slot, the plate has a mounting hole received on a boss formed on the guide body and coaxial with a mounting hole on the guide body which receives a pivot shaft. This structure facilitates assembly and mounting because the plate is securely attached to the guide body before the assembly is mounted. The plate does not contact the pivot shaft, and therefore full advantage is taken of the self-lubricating property of the synthetic resin. The boss may be elongated so that the length of the mounting hole of the guide body is greater than the width of the shoe so that wear in of the guide body due to biased loads is dispersed, and the useful life of the guide is extended.

    Abstract translation: 在由具有鞋和合成树脂制的行走传动链的枢转引导件中，该合成树脂本体具有鞋和开槽的加强件以及与该槽相配合的板，该板具有安装孔，该安装孔容纳在形成于引导体上的凸台上， 引导体上的安装孔，该安装孔容纳枢转轴。 这种结构便于组装和安装，因为在安装组件之前，板被牢固地附接到引导体。 板不接触枢轴，因此充分利用合成树脂的自润滑性能。 凸台可以是细长的，使得引导体的安装孔的长度大于鞋的宽度，使得由于偏置的负载引起的引导体的磨损被分散，并且引导件的使用寿命延长。

    Method for providing a chrome finish on a substrate
    8.
    发明授权
    Method for providing a chrome finish on a substrate 有权
    在基材上提供镀铬处理的方法

    公开(公告)号：US07132130B1

    公开(公告)日：2006-11-07

    申请号：US11134106

    申请日：2005-05-20

    Applicant: Terence J. Kloss

    Inventor： Terence J. Kloss

    IPC: B05D3/00 ,  C23C14/00 ,  C23C14/06

    CPC classification number: C23C14/14 ,  C23C14/024 ,  Y10T428/12736

    Abstract: An environmentally-friendly process for applying a chrome finish on a substrate is provided. The chrome finish comprises a thin film of aluminum and chromium deposited onto the substrate by physical vapor deposition (PVD) techniques. The thin layer can consist of three separately deposited metallic layers including a chromium layer sandwiched between a pair of aluminum layers or can consist of a single, simultaneously co-deposited layer of aluminum and chromium in a ratio of 10% to 70% by weight chromium and 30% to 90% aluminum. The structure of a coated substrate is also disclosed.

    Abstract translation: 提供了一种在基板上施加铬涂层的环保工艺。 镀铬处理包括通过物理气相沉积（PVD）技术沉积到衬底上的铝和铬的薄膜。 薄层可以由三个分开沉积的金属层组成，包括夹在一对铝层之间的铬层，或者可以由10％至70％重量的铬的单一同时共沉积的铝和铬层组成 和30％至90％的铝。 还公开了涂覆的基底的结构。

    Roller chain
    9.
    发明授权
    Roller chain 有权
    滚子链

    公开(公告)号：US07121969B2

    公开(公告)日：2006-10-17

    申请号：US10723869

    申请日：2003-11-26

    Applicant: Arimasa Kaga ,  Kazuhiko Shimaya

    Inventor： Arimasa Kaga ,  Kazuhiko Shimaya

    IPC: F16G13/06 ,  F16G13/02

    CPC classification number: F16G13/06

    Abstract: In a roller chain, the outside diameters D of the rollers and the outside diameters d of the pins extending through bushings on which the rollers are disposed satisfy the relationships 0.72P≦D≦0.79P and 0.40P≦d≦0.44P where P is the pitch of the roller chain. The height H of the inner plates of the chain satisfies the relationship 0.96P≦H. The elongation ratio of the chain is significantly reduced, and improvements in breaking strength of the pin and in the rotational fatigue of the chain are realized. Consequently wear resistance, strength, and endurance of the chain are significantly improved, making the chain suitable for use as a timing chain in an engine that rotates at high speed.

    Abstract translation: 在滚子链中，滚子的外径D和延伸穿过其上布置的套管的销的外径d满足关系0.72P <= D <= 0.79P和0.40P <= d <= 0.44 P其中P是滚子链的间距。 链条内板的高度H满足0.96P <= H的关系。 链的伸长率显着降低，并且实现了销的断裂强度和链的旋转疲劳的提高。 因此，链条的耐磨性，强度和耐久性得到显着提高，使链条适用于在高速旋转的发动机中的正时链条。

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