利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

33 条记录 (耗时 0.022 秒)

    Naphthyridine derivatives having inhibitory activity against HIV integrase
    1.
    发明授权
    Naphthyridine derivatives having inhibitory activity against HIV integrase 有权
    对HIV整合酶具有抑制活性的萘吡啶衍生物

    公开(公告)号：US07919623B2

    公开(公告)日：2011-04-05

    申请号：US10587857

    申请日：2005-02-02

    申请人： Teruhiko Taishi ,  Yukio Tada

    发明人： Teruhiko Taishi ,  Yukio Tada

    IPC分类号： C07D471/02

    CPC分类号： C07D471/04

    摘要： A compound having HIV Integrase Inhibitory activity of the formula: (wherein: R1 is optionally substituted aralkyl; R2 and R3 are each independently hydrogen, optionally substituted alkyl, optionally substituted amino, optionally substituted alkenyl or optionally substituted alkoxy (provided that each substituent for “optionally substituted” is a noncyclic group); R4 is hydrogen, optionally substituted carboxy, optionally substituted formylamino, optionally substituted carbamoyl, optionally substituted amino (provided that a substituent on amino in “optionally substituted formylamino”, “optionally substituted carbamoyl” and “optionally substituted amino” may form an optionally-substituted N-atom containing heterocyclic ring together with an adjacent N atom), optionally substituted alkyl, optionally substituted alkenyl, optionally substituted aryl, or optionally substituted heteroaryl) or a salt thereof.

    摘要翻译： 具有下式的HIV整合酶抑制活性的化合物：其中：R 1为任选取代的芳烷基; R 2和R 3各自独立地为氢，任选取代的烷基，任选取代的氨基，任选取代的烯基或任选取代的烷氧基（条件是每个取代基为“ 任选取代的“是非环基团）; R 4是氢，任选取代的羧基，任选取代的甲酰氨基，任选取代的氨基甲酰基，任选取代的氨基（条件是在”任选取代的甲酰氨基“中的氨基上的取代基，”任选取代的氨基甲酰基“ 取代的氨基“可以与相邻的N原子一起形成任选取代的含有N原子的杂环，任选取代的烷基，任选取代的烯基，任选取代的芳基或任选取代的杂芳基）或其盐。

    Biphenyl derived thiamides as calpain inhibitors
    3.
    发明授权
    Biphenyl derived thiamides as calpain inhibitors 失效
    联苯衍生的thiamides作为钙蛋白酶抑制剂

    公开(公告)号：US07476754B2

    公开(公告)日：2009-01-13

    申请号：US11579737

    申请日：2005-05-06

    申请人： Bernardo Herradon Garcia ,  Mercedes Alonso Giner ,  Esperanza Benito Cano ,  Antonio Chana Lopez ,  Ana Montero Aguado

    发明人： Bernardo Herradon Garcia ,  Mercedes Alonso Giner ,  Esperanza Benito Cano ,  Antonio Chana Lopez ,  Ana Montero Aguado

    IPC分类号： C07C205/00 ,  C07C69/76 ,  C07C327/00 ,  C07C321/00 ,  C07C235/00 ,  C07C315/00 ,  C07C63/33

    CPC分类号： C07D209/18 ,  C07C327/48

    摘要： The present invention relates to compounds derived from biphenyl with activity as calpain inhibitors. One compound of the present invention is a 2,2′-disubstituted biphenyl, where the substituents in the 2 and 2′ positions of the biphenyl skeleton are chains containing structures related to amino acids, including fragments of aminocarbonylic compounds where at least one of the substituents in said 2- or 2′-positions is bonded to the biphenyl skeleton via a thiocarbonyl group, forming compounds with thioamide functionality. The present invention also encompasses any of the conformational isomers (atropisomers) of said compound of formula I. The compounds of formula I have application in the preventive or therapeutic treatment of a degenerative disease.

    摘要翻译： 本发明涉及具有活性作为钙蛋白酶抑制剂的联苯衍生物。 本发明的一种化合物是2,2'-二取代的联苯，其中联苯骨架的2和2'位的取代基是含有与氨基酸相关的结构的链，包括氨基羰基化合物的片段，其中至少一个 所述2-或2'-位的取代基通过硫代羰基与联苯骨架结合，形成具有硫酰胺官能团的化合物。 本发明还包括式I化合物的任何构象异构体（阻转异构体）。式I化合物可用于预防或治疗退行性疾病。

    Ni-base directionally solidified superalloy and Ni-base single crystal superalloy
    4.
    发明授权
    Ni-base directionally solidified superalloy and Ni-base single crystal superalloy 有权
    镍基定向凝固超合金和Ni基单晶超合金

    公开(公告)号：US07473326B2

    公开(公告)日：2009-01-06

    申请号：US10509427

    申请日：2003-03-27

    申请人： Toshiharu Kobayashi ,  Yutaka Koizumi ,  Tadaharu Yokokawa ,  Hiroshi Harada ,  Yasuhiro Aoki ,  Shouju Masaki

    发明人： Toshiharu Kobayashi ,  Yutaka Koizumi ,  Tadaharu Yokokawa ,  Hiroshi Harada ,  Yasuhiro Aoki ,  Shouju Masaki

    IPC分类号： C22C19/07

    CPC分类号： C22C19/057

    摘要： A Ni-base directionally solidified superalloy and a Ni-base single-crystal superalloy, which have superior creep strength at a high temperature, consists essentially of from 5.0 percent by weight to 7.0 percent by weight of Al, from 4.0 percent by weight to 16.0 percent by weight of Ta+Nb+Ti, from 1.0 percent by weight to 4.5 percent by weight of Mo, from 4.0 percent by weight to 8.0 percent by weight of W, from 3.0 percent by weight to 8.0 percent by weight of Re, 2.0 percent by weight or less of Hf, 10.0 percent by weight or less of Cr, 15.0 percent by weight or less of Co, from 1.0 percent by weight to 4.0 percent by weight of Ru, 0.2 percent by weight or less of C, 0.03 percent by weight or less of B, and Ni and inescapable impurities as a balance. The superalloys can be used for a turbine blade, a turbine vane and the like of a jet engine, an industrial gas turbine and the like.

    摘要翻译： 在高温下具有优异的蠕变强度的Ni基方向固化超合金和Ni基单晶超合金基本上由5.0重量％至7.0重量％的Al组成，4.0重量％至16.0重量％ Ta + Nb + Ti的重量％，1.0重量％〜4.5重量％的Mo，4.0重量％〜8.0重量％的W，3.0重量％〜8.0重量％的Re 2.0 重量％以下的Hf，10.0重量％以下的Cr，15.0重量％以下的Co，1.0重量％〜4.0重量％的Ru，0.2重量％以下的C，0.03重量％ 以下的B，Ni和不可避免的杂质作为平衡。 超级合金可以用于喷气发动机，工业燃气轮机等的涡轮叶片，涡轮叶片等。

    Method of expressing foreign gene in kidney
    5.
    发明授权
    Method of expressing foreign gene in kidney 失效
    在肾脏中表达外源基因的方法

    公开(公告)号：US07381709B2

    公开(公告)日：2008-06-03

    申请号：US10478537

    申请日：2002-05-24

    申请人： Hiroki Maruyama ,  Jun-ichi Miyazaki

    发明人： Hiroki Maruyama ,  Jun-ichi Miyazaki

    IPC分类号： A61K48/00 ,  C12N15/00

    CPC分类号： C07K14/505 ,  A61K48/005 ,  A61K48/0075

    摘要： The invention of this application provides a method of expressing a gene, which comprises transferring a plasmid vector recombined with an exogenous gene into the kidney by administration via the renal vein so that the exogenous gene is expressed mainly in renal interstitial fibroblasts. The method of this invention can transfer the exogenous gene into the kidneys safely and efficiently and express the transgene over a long period of time.

    摘要翻译： 本申请的发明提供了表达基因的方法，其包括通过经由肾静脉给药将与外源基因重组的质粒载体转移到肾中，使得外源基因主要在肾间质成纤维细胞中表达。 本发明的方法可以将外源基因安全有效地转运到肾脏中，并在长时间内表达转基因。

    Data recording apparatus
    7.
    发明授权
    Data recording apparatus 有权
    数据记录装置

    公开(公告)号：US08676026B2

    公开(公告)日：2014-03-18

    申请号：US13338614

    申请日：2011-12-28

    申请人： Naoki Fujimoto ,  Hiroyuki Awano ,  Kengo Yasumura ,  Keigo Sato

    发明人： Naoki Fujimoto ,  Hiroyuki Awano ,  Kengo Yasumura ,  Keigo Sato

    IPC分类号： H04N5/77 ,  H04N5/917

    CPC分类号： H04N5/772 ,  G11B27/322 ,  H04N9/7921 ,  H04N9/8205

    摘要： A data recording apparatus includes an acquisition unit configured to acquire a first type data and a second type data, and a recording unit configured to record the first type data or the second type data acquired by the acquisition unit in a recording medium. The recording unit refers to a first pointer which indicates a logical position regarding the first type data in the recording medium to determine a position to start recording the first type data based on the logical position indicated by the first pointer. The recording unit refers to a second pointer which indicates a logical position regarding the second type data in the recording medium to determine a position to start recording the second type data based on the logical position indicated by the second pointer.

    摘要翻译： 数据记录装置包括获取单元，被配置为获取第一类型数据和第二类型数据，以及记录单元，被配置为将由获取单元获取的第一类型数据或第二类型数据记录在记录介质中。 记录单元是指第一指针，其指示关于记录介质中的第一类型数据的逻辑位置，以基于由第一指针指示的逻辑位置来确定开始记录第一类型数据的位置。 记录单元是指第二指示器，其指示关于记录介质中的第二类型数据的逻辑位置，以基于由第二指示符指示的逻辑位置来确定开始记录第二类型数据的位置。

    Wiper apparatus control method and wiper control system
    8.
    发明授权
    Wiper apparatus control method and wiper control system 有权
    刮水器控制方法和刮水器控制系统

    公开(公告)号：US08044614B2

    公开(公告)日：2011-10-25

    申请号：US12292086

    申请日：2008-11-12

    申请人： Toshiyuki Amagasa ,  Taku Suzuki ,  Takashi Kondo ,  Toru Namiki

    发明人： Toshiyuki Amagasa ,  Taku Suzuki ,  Takashi Kondo ,  Toru Namiki

    IPC分类号： B60S1/08

    CPC分类号： B60S1/0814

    摘要： A wiper apparatus includes: a wiper blade driven by a motor; and a wiper blade driven by a motor. The motors are drive-controlled by control microcomputers, respectively. The control microcomputers are connected to each other through a communication line. While exchanging position information of the wiper blades through the communication line, the control microcomputers synchronously drive the motors on the basis of a position relationship between both of the wiper blades. In the case where a communication abnormality occurs when the position relationship between the wiper blades is in a normal state, the wiper blade is stopped after reaching a lower turning position. In the case where the communication abnormality occurs in a state where the position relationship between the blades is inverted, the blade is stopped after reaching an upper turning position.

    摘要翻译： 刮水器装置包括：由马达驱动的刮水片; 以及由马达驱动的刮水片。 电机分别由控制微型计算机驱动控制。 控制微型计算机通过通信线路相互连接。 在通过通信线交换刮水片的位置信息的同时，控制微型计算机基于两个刮水片之间的位置关系来同步地驱动马达。 当刮水片之间的位置关系处于正常状态时发生通信异常的情况下，刮水片在到达下转动位置之后停止。 在使叶片的位置关系反转的状态下发生通信异常的情况下，叶片在达到上部转动位置后停止。

    Piezoelectric resonator, method of manufacturing piezoelectric resonator, and filter, duplexer, and communication device using piezoelectric resonator
    9.
    发明授权
    Piezoelectric resonator, method of manufacturing piezoelectric resonator, and filter, duplexer, and communication device using piezoelectric resonator 失效
    压电谐振器，制造压电谐振器的方法以及使用压电谐振器的滤波器，双工器和通信装置

    公开(公告)号：US07477115B2

    公开(公告)日：2009-01-13

    申请号：US11488148

    申请日：2006-07-18

    申请人： Hiroshi Nakatsuka ,  Keiji Onishi ,  Hiroyuki Nakamura ,  Takehiko Yamakawa ,  Hiroshi Yamaguchi

    发明人： Hiroshi Nakatsuka ,  Keiji Onishi ,  Hiroyuki Nakamura ,  Takehiko Yamakawa ,  Hiroshi Yamaguchi

    IPC分类号： H03H9/72 ,  H03H9/64 ,  H03H9/15

    CPC分类号： H03H3/04 ,  H03H9/0211 ,  H03H9/173 ,  Y10T29/42

    摘要： A piezoeletric resonator includes: a substrate; a lower electrode formed on or above the substrate; a piezoeletric body formed on or above the lower electrode; an upper electrode formed on or above the piezoeletric body; and a cavity under a vibrating portion formed by the lower electrode, the piezoeletric body, and the upper electrode. Where a resonant frequency of vibration with a thickness of the vibrating portion being a half of a wavelength is taken as fr, an average of ultrasonic velocity in a material forming the cavity is taken as Vc, and a value determined based on the resonant frequency fr and the average of ultrasonic velocity Vc is taken as λc (=Vc/fr), a depth of the cavity is set so as to be equal to or larger than n×λc/2−λc/8 and equal to or smaller than n×λc/2+λc/8.

    摘要翻译： 压电谐振器包括：基板; 形成在基板上或上方的下电极; 形成在下电极上或上的压电体; 形成在压电体上或上的上电极; 以及由下电极，压电体和上电极形成的振动部下的空腔。 其中振动部分的厚度为波长的一半的振动的共振频率为fr，将形成空腔的材料中的超声速度的平均值作为Vc，并且基于谐振频率fr确定的值 超声波速度Vc的平均值为lambdac（= Vc / fr），空腔的深度设定为等于或大于n×lambdac / 2-lambdac / 8且等于或小于nxlambdac / 2 + lambdac / 8。