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公开(公告)号：US12239744B2
公开(公告)日：2025-03-04
申请号：US17722357
申请日：2022-04-17
Applicant: 3-D Matrix, Ltd.
Inventor： Eun Seok Gil , Elton Aleksi , Noriaki Matsuda
IPC: A61K9/00 , A61K9/08 , A61K9/51 , A61K31/713 , A61K47/42 , A61K31/7105 , A61K45/06
Abstract: Disclosed herein are surfactant peptide nanostructures wherein the peptides have repeating hydrophobic amino acids in an integer equal to or less than four. The peptide nanostructures are useful for therapeutic applications, including for delivery of drugs and siRNA.
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公开(公告)号：US20250020668A1
公开(公告)日：2025-01-16
申请号：US18814981
申请日：2024-08-26
Applicant: 3-D Matrix, Ltd.
Inventor： Hideki MATSUI , Atsushi FUJIMURA
Abstract: The present invention relates to a method, a kit, etc., for predicting the response of a BNCT using a BSH-related medicine-containing boron preparation and a BPA-containing boron preparation, the method and kit being characterized by examining the expression of CD44, a translation-related factor and/or LAT1 in cancer cells of a sample. When the expression of the CD44 or translation-related factor in the cancer cells of the sample is high, it can be predicted that the BNCT using the BSH-related medicine-containing boron preparation is likely to be responsive. When the expression of the LAT1 in the cancer cells of the sample is high, it can be predicted that the BNCT using the BPA-containing boron preparation is likely to be responsive.
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公开(公告)号：US12006085B2
公开(公告)日：2024-06-11
申请号：US17832612
申请日：2022-06-04
Applicant: 3-D Matrix, Ltd.
Inventor： Masahiro Nohara , Yuya Hasegawa
IPC: C07K1/34 , B65B3/00 , B65B55/04 , B65B55/12 , B65B63/00 , C07K1/36 , C07K7/08 , A61K38/00 , C07K5/103 , C07K5/11
CPC classification number: B65B55/12 , B65B3/003 , B65B55/04 , B65B63/00 , C07K1/34 , C07K1/36 , C07K7/08 , A61K38/00 , C07K5/101 , C07K5/1019
Abstract: The enclosed disclosure describes, among other things, a method including the steps of a first deaerating step in which a mixture comprising peptides is deaerated by lowering the pressure, filtering the mixture through a sterilizing filter; and a second deaerating step, in which the filtrate is deaerated by vibration and lowering the pressure.
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公开(公告)号：US11801281B2
公开(公告)日：2023-10-31
申请号：US17568026
申请日：2022-01-04
Applicant: 3-D Matrix, Ltd.
Inventor： Kentaro Takamura , Satoshi Gojo , Satoru Kobayashi
IPC: A61K38/10 , C07K7/08 , A61K38/16 , A61L31/14 , A61L31/04 , A61K31/7004 , A61K31/7016 , A61K38/08 , C07K7/06
CPC classification number: A61K38/10 , A61K31/7004 , A61K31/7016 , A61K38/08 , A61K38/16 , A61L31/047 , A61L31/148 , C07K7/06 , C07K7/08 , A61L2400/04 , A61L2430/36
Abstract: There is provided a bioabsorbable peptide tissue occluding agent that can be applied to large mammals including humans, the peptide tissue occluding agent being obtained by artificial synthesis to avoid concerns of infection by viruses and the like.
The tissue occluding agent contains a peptide, wherein the peptide is an amphiphilic peptide having 8-200 amino acid residues with the hydrophilic amino acids and hydrophobic amino acids alternately bonded, and is a self-assembling peptide exhibiting a β-structure in aqueous solution in the presence of physiological pH and/or a cation.-
公开(公告)号：US11738113B2
公开(公告)日：2023-08-29
申请号：US17981445
申请日：2022-11-06
Applicant: 3-D Matrix, Ltd.
Inventor： Marika G. Rioult , Eun Seok Gil , Elton Aleksi , Naoki Yamamoto
CPC classification number: A61L27/227 , A61L2/0035 , A61L2/081 , A61L2/26 , C07K7/08 , C12N5/0068 , A61K38/00
Abstract: Gamma ray and e-beam irradiation provided efficient sterilization of certain self-assembling peptides (including RADA16 in solution) without substantial degradation of the major peptide, while, e.g., another self-assembly peptide, QLEL12 was significantly degraded following irradiation. Irradiation sterilization enhances the rheological property of, for example, RADA16 hydrogel once applied to tissue at a physiological pH. The rheological property increase can result in higher efficacy in a variety of biomedical applications.
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Patent Agency Ranking
公开(公告)号：US20230241157A1
公开(公告)日：2023-08-03
申请号：US18166973
申请日：2023-02-09
Applicant: 3-D MATRIX, LTD.
Inventor： Eun Seok Gil , Elton Aleksi , Naoki Yamamoto
CPC classification number: A61K38/10 , A61P19/04 , A61K9/06 , A61K9/08 , A61K38/39 , A61K47/02 , A61K45/06
Abstract: Provided herein are ionic self-assembling peptides, pharmaceutical compositions comprising the peptides, and methods of using and making the same.
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公开(公告)号：US20230149598A1
公开(公告)日：2023-05-18
申请号：US17981445
申请日：2022-11-06
Applicant: 3-D Matrix, Ltd.
Inventor： Marika G. Rioult , Eun Seok Gil , Elton Aleksi , Naoki Yamamoto
CPC classification number: A61L27/227 , C12N5/0068 , C07K7/08 , A61L2/081 , A61L2/26 , A61L2/0035 , A61K38/00
Abstract: Gamma ray and e-beam irradiation provided efficient sterilization of certain self-assembling peptides (including RADA16 in solution) without substantial degradation of the major peptide, while, e.g., another self-assembly peptide, QLEL12 was significantly degraded following irradiation. Irradiation sterilization enhances the rheological property of, for example, RADA16 hydrogel once applied to tissue at a physiological pH. The rheological property increase can result in higher efficacy in a variety of biomedical applications.
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公开(公告)号：US20220258900A9
公开(公告)日：2022-08-18
申请号：US16948353
申请日：2020-09-15
Applicant: 3-D Matrix, Ltd.
Inventor： Masahiro Nohara , Yuya Hasegawa
Abstract: The enclosed disclosure describes, among other things, a method including the steps of a first deaerating step in which a mixture comprising peptides is deaerated by lowering the pressure, filtering the mixture through a sterilizing filter; and a second deaerating step, in which the filtrate is deaerated by vibration and lowering the pressure.
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公开(公告)号：US11260072B2
公开(公告)日：2022-03-01
申请号：US16501468
申请日：2019-04-04
Applicant: 3-D Matrix, Ltd.
Inventor： Takahiro Ochiya , Tomohiro Fujiwara
IPC: A61K31/7105 , A61K31/282 , A61P35/00 , A61K31/7115 , A61K45/06
Abstract: Provided are methods and compositions useful in the diagnosis, treatment, and monitoring of osteosarcoma. Antisense to certain microRNA (miRNA) found to be associated with cancer stem cells (CSCs) or tumor-initiating cells (TICs) of osteosarcoma are useful to suppress tumor growth and metastasis, and prolong survival. Antisense oligonucleotides to miR-133a are synergistic in combination with standard chemotherapy such as cisplatin in the treatment of osteosarcoma.
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公开(公告)号：US20210024236A1
公开(公告)日：2021-01-28
申请号：US16948353
申请日：2020-09-15
Applicant: 3-D Matrix, Ltd.
Inventor： Masahiro Nohara , Yuya Hasegawa
Abstract: The enclosed disclosure describes, among other things, a method including the steps of a first deaerating step in which a mixture comprising peptides is deaerated by lowering the pressure, filtering the mixture through a sterilizing filter; and a second deaerating step, in which the filtrate is deaerated by vibration and lowering the pressure.
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