公开(公告)号：US20180134674A1

公开(公告)日：2018-05-17

申请号：US15814322

申请日：2017-11-15

Applicant: ABIDE THERAPEUTICS, INC.

Inventor： Cheryl A. GRICE ,  Daniel J. BUZARD ,  Michael B. SHAGHAFI

IPC: C07D295/195

CPC classification number: C07D295/195 ,  C07D295/205

Abstract: Provided herein are piperazine carbamates and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful as modulators of MAGL. Furthermore, the subject compounds and compositions are useful for the treatment of pain.

公开(公告)号：US20170327500A1

公开(公告)日：2017-11-16

申请号：US15593239

申请日：2017-05-11

Applicant: Abide Therapeutics, Inc.

Inventor： Justin S. CISAR ,  Cheryl A. GRICE ,  Todd K. JONES ,  Olivia D. WEBER ,  Daniel J. BUZARD ,  Michael B. SHAGHAFI

IPC: C07D471/10 ,  C07D519/00

CPC classification number: C07D471/10 ,  C07D519/00

Abstract: Provided herein are spirocycle compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful as modulators of MAGL and/or ABHD6. Furthermore, the subject compounds and compositions are useful for the treatment of pain.

公开(公告)号：US20190352273A1

公开(公告)日：2019-11-21

申请号：US16412212

申请日：2019-05-14

Applicant: Abide Therapeutics, Inc.

Inventor： Cheryl A. GRICE ,  Daniel J. BUZARD ,  Michael B. SHAGHAFI

IPC: C07D295/185 ,  C07D305/08 ,  C07D263/32 ,  C07D241/12 ,  C07D213/55

Abstract: Provided herein are piperazine carbamates and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful as modulators of MAGL. Furthermore, the subject compounds and compositions are useful for the treatment of pain.

公开(公告)号：US20190256494A1

公开(公告)日：2019-08-22

申请号：US15777198

申请日：2016-11-18

Applicant: Abide Therapeutics, Inc.

Inventor： Olivia D. WEBER ,  Michael B. SHAGHAFI ,  Cheryl A. GRICE ,  Todd K. JONES

IPC: C07D401/14 ,  A61P25/04 ,  C07D487/10 ,  C07D413/14 ,  C07D491/08

Abstract: Provided herein are pyrazole compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful as modulators of MAGL and/or ABHD6. Furthermore, the subject compounds and compositions are useful for the treatment of, for example, pain.

公开(公告)号：US20190202801A1

公开(公告)日：2019-07-04

申请号：US16334335

申请日：2017-09-18

Applicant: ABIDE THERAPEUTICS, INC.

Inventor： Cheryl A. GRICE ,  Daniel J. BUZARD ,  Michael B. SHAGHAFI ,  Olivia D. WEBER

IPC: C07D401/10 ,  C07D403/10 ,  C07D413/10 ,  C07D403/14 ,  C07D405/10 ,  C07D471/06 ,  C07D241/04 ,  A61P23/00 ,  A61P29/00 ,  A61P1/00 ,  A61P25/28

CPC classification number: C07D401/10 ,  A61K45/06 ,  A61P1/00 ,  A61P23/00 ,  A61P25/28 ,  A61P29/00 ,  C07D205/04 ,  C07D207/09 ,  C07D207/16 ,  C07D211/26 ,  C07D211/58 ,  C07D211/60 ,  C07D211/62 ,  C07D231/12 ,  C07D241/04 ,  C07D265/30 ,  C07D295/205 ,  C07D309/08 ,  C07D333/38 ,  C07D333/40 ,  C07D401/04 ,  C07D403/10 ,  C07D403/14 ,  C07D405/10 ,  C07D413/10 ,  C07D471/06 ,  C07D471/10 ,  C07D487/04 ,  C07D487/08 ,  C07D487/10

Abstract: Provided herein are piperazine carbamates and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful as modulators of MAGL and/or ABHD6. Furthermore, the subject compounds and compositions are useful for the treatment of pain.