公开(公告)号：US12030869B2

公开(公告)日：2024-07-09

申请号：US17989237

申请日：2022-11-17

Applicant: Assembly Biosciences, Inc.

Inventor： Simon Nicolas Haydar ,  Leping Li ,  Mark G. Bures ,  Roopa Rai ,  Lynne Bannen ,  Michael Walker

IPC: C07D231/38 ,  A61P31/20 ,  C07D401/08 ,  C07D403/04 ,  C07D403/08 ,  C07D403/10 ,  C07D403/12 ,  C07D405/04 ,  C07D413/04 ,  C07D413/08 ,  C07D417/08

CPC classification number: C07D403/08 ,  A61P31/20 ,  C07D231/38 ,  C07D401/08 ,  C07D403/04 ,  C07D403/10 ,  C07D403/12 ,  C07D405/04 ,  C07D413/04 ,  C07D413/08 ,  C07D417/08

Abstract: The present disclosure provides, in part, 5-membered heteroaryl carboxamide compounds, and pharmaceutical compositions thereof, useful for disruption of HBV core protein assembly, and methods of treating Hepatitis B (HBV) infection.

公开(公告)号：US20230295096A1

公开(公告)日：2023-09-21

申请号：US17920546

申请日：2021-04-21

Applicant: ASSEMBLY BIOSCIENCES, INC.

Inventor： Simon Nicolas HAYDAR ,  Thilo HECKRODT ,  Michael WALKER ,  Min ZHONG

IPC: C07D231/38 ,  C07D401/08 ,  C07D417/08 ,  C07D403/08 ,  C07D413/08 ,  C07D405/12 ,  C07D401/12 ,  C07D453/02 ,  C07D409/12 ,  C07D413/04 ,  C07D417/14 ,  C07D403/04 ,  C07D417/04 ,  C07D405/14 ,  C07D401/14 ,  C07D403/14 ,  A61P31/20

CPC classification number: C07D231/38 ,  A61P31/20 ,  C07D401/08 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D403/08 ,  C07D403/14 ,  C07D405/12 ,  C07D405/14 ,  C07D409/12 ,  C07D413/04 ,  C07D413/08 ,  C07D417/04 ,  C07D417/08 ,  C07D417/14 ,  C07D453/02

Abstract: The present disclosure provides, in part, pyrazole carboxamide compounds, and pharmaceutical compositions thereof, useful for disruption of HBV core protein assembly, and methods of treating Hepatitis B (HBV) infection.

公开(公告)号：US20230183213A1

公开(公告)日：2023-06-15

申请号：US17920544

申请日：2021-04-21

Applicant: ASSEMBLY BIOSCIENCES, INC.

Inventor： Thilo HECKRODT ,  Michael WALKER ,  Min ZHONG

IPC: C07D403/08 ,  C07D233/90 ,  C07D401/08 ,  C07D487/04 ,  C07D263/34 ,  C07D277/56 ,  C07D471/04 ,  C07D498/04 ,  A61P31/20

CPC classification number: C07D403/08 ,  C07D233/90 ,  C07D401/08 ,  C07D487/04 ,  C07D263/34 ,  C07D277/56 ,  C07D471/04 ,  C07D498/04 ,  A61P31/20 ,  C07B2200/05

Abstract: The present disclosure provides, in part, 5-membered heteroaryl carboxamide compounds, and pharmaceutical compositions thereof, useful for disruption of HBV core protein assembly, and methods of treating Hepatitis B (HBV) infection.

公开(公告)号：US20210380577A1

公开(公告)日：2021-12-09

申请号：US17149485

申请日：2021-01-14

Applicant: Assembly Biosciences, Inc.

Inventor： Leping Li ,  Lee D. Arnold ,  Sreenivasa Reddy

IPC: C07D417/12 ,  C07C231/10 ,  C07C231/12 ,  C07C315/02 ,  C07C315/04 ,  C07C319/14 ,  C07C319/20

Abstract: The present disclosure provides, in part, a process for preparing compounds (I) having allosteric effector properties against Hepatitis B virus Cp.

公开(公告)号：US11078170B2

公开(公告)日：2021-08-03

申请号：US16490223

申请日：2018-03-01

Applicant: Assembly Biosciences, Inc.

Inventor： William W. Turner, Jr. ,  Leping Li ,  Simon Nicolas Haydar ,  Mark G. Bures ,  Roopa Rai ,  Samson Francis ,  Lee D. Arnold

IPC: C07D285/16 ,  A61P31/20 ,  C07D417/04 ,  C07D417/10 ,  C07D417/14

Abstract: The present disclosure provides, in part, cyclic sulfamide compounds, and pharmaceutical compositions thereof, useful as modulators of Hepatitis B (HBV) core protein, and methods of treating Hepatitis B (HBV) infection.

公开(公告)号：US20210060090A1

公开(公告)日：2021-03-04

申请号：US17006430

申请日：2020-08-28

Applicant: Assembly Biosciences, Inc.

Inventor： Peyman Akbari ,  Ali Akin ,  Rounak Feigelman ,  Wayne Herber ,  Jason Hudak ,  Jun Ma ,  Jackie Papkoff ,  Lauren Wong

IPC: A61K35/741 ,  A61K9/19 ,  A61K9/00 ,  A61P1/00 ,  A61K9/16 ,  A61P17/06 ,  A23L33/135 ,  A23K10/18

Abstract: The disclosure relates generally to bacterial strains of the genus Christensenella, e.g., Christensenella sp. P152-H6d bacterial strains, and compositions comprising such bacterial strains. The disclosure further relates to methods of using such bacterial strains and compositions for preventing or treating a disorder, e.g., an inflammatory disorder, a gastrointestinal disorder, a metabolic disorder, and/or dysbiosis.

公开(公告)号：US10392379B2

公开(公告)日：2019-08-27

申请号：US15760343

申请日：2016-09-15

Applicant: Assembly Biosciences, Inc. ,  INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION

Inventor： William Turner ,  Lee Daniel Arnold ,  Hans Maag ,  Mark Bures

IPC: C07D243/38 ,  C07D267/20 ,  C07D281/16 ,  C07D401/12 ,  C07D403/12 ,  C07D417/12 ,  C07D417/14 ,  C07D453/02 ,  C07D471/04 ,  A61K45/06 ,  A61P31/20 ,  C07D413/12

Abstract: The present disclosure provides, in part, compounds having allosteric effector properties against Hepatitis B virus Cp. Also provided herein are methods of treating viral infections, such as hepatitis B, comprising administering to a patient in need thereof a disclosed compound.

公开(公告)号：US20180258084A1

公开(公告)日：2018-09-13

申请号：US15760284

申请日：2016-09-15

Applicant: Assembly Biosciences, Inc. ,  INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION

Inventor： William Turner ,  Lee Daniel Arnold ,  Hans Maag ,  Leping Li ,  Mark Bures ,  Simon Haydar ,  Samson Francis

IPC: C07D417/12 ,  C07D417/14 ,  C07D453/02 ,  C07D471/04

CPC classification number: C07D417/12 ,  A61K45/06 ,  A61P31/20 ,  C07D243/38 ,  C07D267/20 ,  C07D281/16 ,  C07D401/12 ,  C07D403/12 ,  C07D413/12 ,  C07D417/14 ,  C07D453/02 ,  C07D471/04

Abstract: The present disclosure provides, in part, compounds having allosteric effector properties against Hepatitis B virus Cp. Also provided herein are methods of treating viral infections, such as hepatitis B, comprising administering to a patient in need thereof a disclosed compound.

公开(公告)号：US10987360B2

公开(公告)日：2021-04-27

申请号：US16333788

申请日：2017-09-14

Applicant: Assembly Biosciences, Inc.

Inventor： William W. Turner, Jr. ,  Lee D. Arnold ,  Leping Li ,  Mark G. Bures ,  Simon Nicolas Haydar ,  Hans Maag ,  Lynne Bannen

IPC: C07D417/12 ,  C07D487/04 ,  C07D513/04 ,  A61K31/55 ,  A61K31/5513 ,  A61P31/12 ,  A61K31/554 ,  A61P31/20 ,  A61K31/426 ,  A61K31/427 ,  A61K31/454 ,  C07D277/28 ,  C07D281/14 ,  C07D417/04

Abstract: The present disclosure provides, in part, compounds having allosteric effector properties against Hepatitis B virus Cp. Also provided herein are methods of treating viral infections, such as hepatitis B, comprising administering to a patient in need thereof a disclosed compound of formula:

公开(公告)号：US20200002325A1

公开(公告)日：2020-01-02

申请号：US16493614

申请日：2018-03-13

Applicant: Assembly Biosciences, Inc.

Inventor： Leping Li ,  Lee D. Arnold ,  Sreenivasa Reddy

IPC: C07D417/12 ,  C07C231/10 ,  C07C231/12 ,  C07C319/14 ,  C07C315/02 ,  C07C315/04 ,  C07C319/20

Abstract: The present disclosure provides, in part, a process for preparing compounds (I) having allosteric effector properties against Hepatitis B virus Cp.