公开(公告)号：US20110002888A1

公开(公告)日：2011-01-06

申请号：US12793658

申请日：2010-06-03

申请人： Craig A. Rosen ,  Adam Bell ,  Paul A. Moore ,  Yanggu Shi ,  David Lafleur ,  Jason B. Bock ,  Michael W. Laird ,  William A. Haseltine ,  Douglas B. Woods ,  Mani Subramanian

发明人： Craig A. Rosen ,  Adam Bell ,  Paul A. Moore ,  Yanggu Shi ,  David Lafleur ,  Jason B. Bock ,  Michael W. Laird ,  William A. Haseltine ,  Douglas B. Woods ,  Mani Subramanian

IPC分类号： A61K38/21 ,  C07K14/76 ,  A61K38/38 ,  C07H21/00 ,  C12N15/63 ,  C12N5/10 ,  A61K38/46 ,  A61K38/18 ,  A61K38/22 ,  A61K39/395 ,  A61K38/43 ,  C12N9/96 ,  A61K39/12 ,  A61K38/30 ,  A61P35/00 ,  A61P3/04 ,  A61P3/10 ,  A61P3/00 ,  A61P37/02 ,  A61P9/08 ,  A61P9/00 ,  A61P9/04 ,  A61P1/16 ,  A61P25/30 ,  A61P31/12 ,  A61P9/12

CPC分类号： C07K14/58 ,  C07K14/765 ,  C07K2319/01

摘要： The present invention encompasses albumin fusion proteins. Nucleic acid molecules encoding the albumin fusion proteins of the invention are also encompassed by the invention, as are vectors containing these nucleic acids, host cells transformed with these nucleic acids vectors, and methods of making the albumin fusion proteins of the invention and using these nucleic acids, vectors, and/or host cells. Additionally the present invention encompasses pharmaceutical compositions comprising albumin fusion proteins and methods of treating, preventing, or ameliorating diseases, disorders or conditions using albumin fusion proteins of the invention.

公开(公告)号：US20080194481A1

公开(公告)日：2008-08-14

申请号：US11932823

申请日：2007-10-31

申请人： Craig A. Rosen ,  Adam Bell ,  Paul A. Moore ,  Yanggu Shi ,  David LaFleur ,  Jason B. Bock ,  Michael W. Laird ,  William A. Haseltine ,  Douglas B. Woods ,  Mani Subramanian

发明人： Craig A. Rosen ,  Adam Bell ,  Paul A. Moore ,  Yanggu Shi ,  David LaFleur ,  Jason B. Bock ,  Michael W. Laird ,  William A. Haseltine ,  Douglas B. Woods ,  Mani Subramanian

IPC分类号： A61K38/00 ,  C07K14/00 ,  C12N15/11 ,  C12N15/00 ,  C12N5/06 ,  A61P9/00 ,  A61P1/00 ,  A61P25/00 ,  C12N1/00 ,  C12N1/20 ,  C12P21/04

CPC分类号： C07K14/58 ,  C07K14/765 ,  C07K2319/01

摘要： The present invention encompasses albumin fusion proteins. Nucleic acid molecules encoding the albumin fusion proteins of the invention are also encompassed by the invention, as are vectors containing these nucleic acids, host cells transformed with these nucleic acids vectors, and methods of making the albumin fusion proteins of the invention and using these nucleic acids, vectors, and/or host cells. Additionally the present invention encompasses pharmaceutical compositions comprising albumin fusion proteins and methods of treating, preventing, or ameliorating diseases, disorders or conditions using albumin fusion proteins of the invention.

公开(公告)号：US20100291033A1

公开(公告)日：2010-11-18

申请号：US12793652

申请日：2010-06-03

申请人： Craig A. ROSEN ,  Adam Bell ,  Paul A. Moore ,  Yanggu Shi ,  David W. LaFleur ,  Jason B. Bock ,  Michael W. Laird ,  William A. Haseltine ,  Douglas B. Woods ,  Mani Subramanian

发明人： Craig A. ROSEN ,  Adam Bell ,  Paul A. Moore ,  Yanggu Shi ,  David W. LaFleur ,  Jason B. Bock ,  Michael W. Laird ,  William A. Haseltine ,  Douglas B. Woods ,  Mani Subramanian

IPC分类号： A61K38/38 ,  C07K14/76 ,  A61K38/21 ,  C07H21/04 ,  A61P31/18 ,  A61P35/00 ,  A61P31/12 ,  A61P9/12 ,  A61P9/04 ,  A61P35/02 ,  A61P31/04 ,  A61P3/10 ,  C12N5/10 ,  C12N1/19 ,  C12N1/21

CPC分类号： C07K14/765 ,  A61K38/38 ,  A61K47/643 ,  C07K2319/31

摘要： The present invention encompasses albumin fusion proteins. Nucleic acid molecules encoding the albumin fusion proteins of the invention are also encompassed by the invention, as are vectors containing these nucleic acids, host cells transformed with these nucleic acids vectors, and methods of making the albumin fusion proteins of the invention and using these nucleic acids, vectors, and/or host cells. Additionally the present invention encompasses pharmaceutical compositions comprising albumin fusion proteins and methods of treating, preventing, or ameliorating diseases, disorders or conditions using albumin fusion proteins of the invention.

摘要翻译： 本发明包括白蛋白融合蛋白。 编码本发明的白蛋白融合蛋白的核酸分子也包括在本发明中，载体含有这些核酸，用这些核酸载体转化的宿主细胞，以及制备本发明的白蛋白融合蛋白并使用这些核酸的方法 酸，载体和/或宿主细胞。 另外，本发明包括包含白蛋白融合蛋白的药物组合物以及使用本发明的白蛋白融合蛋白来治疗，预防或改善疾病，病症或病症的方法。

公开(公告)号：US20080004206A1

公开(公告)日：2008-01-03

申请号：US11495624

申请日：2006-07-31

申请人： Craig Rosen ,  Adam Bell ,  Paul Moore ,  Yanggu Shi ,  David LaFleur ,  Jason Bock ,  Michael Laird ,  William Haseltine ,  Douglas Woods ,  Mani Subramanian

发明人： Craig Rosen ,  Adam Bell ,  Paul Moore ,  Yanggu Shi ,  David LaFleur ,  Jason Bock ,  Michael Laird ,  William Haseltine ,  Douglas Woods ,  Mani Subramanian

IPC分类号： A61K38/38 ,  C07H21/04 ,  C07K14/76 ,  C12N15/00 ,  C12N5/00

CPC分类号： C07K14/765 ,  A61K38/38 ,  A61K47/643 ,  C07K2319/31

摘要： The present invention encompasses albumin fusion proteins. Nucleic acid molecules encoding the albumin fusion proteins of the invention are also encompassed by the invention, as are vectors containing these nucleic acids, host cells transformed with these nucleic acids vectors, and methods of making the albumin fusion proteins of the invention and using these nucleic acids, vectors, and/or host cells. Additionally the present invention encompasses pharmaceutical compositions comprising albumin fusion proteins and methods of treating, preventing, or ameliorating diseases, disorders or conditions using albumin fusion proteins of the invention.

公开(公告)号：US20090029914A1

公开(公告)日：2009-01-29

申请号：US11759843

申请日：2007-06-07

申请人： Craig A. Rosen ,  Adam Bell ,  David W. LaFleur ,  Douglas B. Woods ,  Ping Feng ,  Rodger G. Smith ,  Baiqin Teng

发明人： Craig A. Rosen ,  Adam Bell ,  David W. LaFleur ,  Douglas B. Woods ,  Ping Feng ,  Rodger G. Smith ,  Baiqin Teng

IPC分类号： A61K38/00 ,  C07K14/00 ,  C07K1/00 ,  C12N15/11 ,  C12N15/00 ,  C12N5/06 ,  A61P43/00

CPC分类号： C12N9/96 ,  A61K38/00 ,  C07K14/765 ,  C07K2319/00 ,  C12N15/62

摘要： The present invention encompasses albumin fusion proteins. Nucleic acid molecules encoding the albumin fusion proteins of the invention are also encompassed by the invention, as are vectors containing these nucleic acids, host cells transformed with these nucleic acids vectors, and methods of making the albumin fusion proteins of the invention and using these nucleic acids, vectors, and/or host cells. Additionally the present invention encompasses pharmaceutical compositions comprising albumin fusion proteins and methods of treating, preventing, or ameliorating diseases, disorders or conditions using albumin fusion proteins of the invention.

摘要翻译： 本发明包括白蛋白融合蛋白。 编码本发明的白蛋白融合蛋白的核酸分子也包括在本发明中，载体含有这些核酸，用这些核酸载体转化的宿主细胞，以及制备本发明的白蛋白融合蛋白并使用这些核酸的方法 酸，载体和/或宿主细胞。 另外，本发明包括包含白蛋白融合蛋白的药物组合物以及使用本发明的白蛋白融合蛋白来治疗，预防或改善疾病，病症或病症的方法。

公开(公告)号：US20070048282A1

公开(公告)日：2007-03-01

申请号：US11500314

申请日：2006-08-08

申请人： Craig Rosen ,  William Haseltine ,  Paul Moore ,  Jason Bock ,  Adam Bell ,  Yanggu Shi ,  David LaFleur

发明人： Craig Rosen ,  William Haseltine ,  Paul Moore ,  Jason Bock ,  Adam Bell ,  Yanggu Shi ,  David LaFleur

IPC分类号： A61K38/21 ,  A61K38/38 ,  C12P21/04 ,  C12N15/00

CPC分类号： C07K14/765 ,  A61K38/00 ,  C07K2319/31 ,  C07K2319/35 ,  C12N15/62

摘要： The present invention encompasses albumin fusion proteins. Nucleic acid molecules encoding the albumin fusion proteins of the invention are also encompassed by the invention, as are vectors containing these nucleic acids, host cells transformed with these nucleic acids vectors, and methods of making the albumin fusion proteins of the invention and using these nucleic acids, vectors, and/or host cells. Additionally the present invention encompasses pharmaceutical compositions comprising albumin fusion proteins and methods of treating, preventing, or ameliorating diseases, disorders or conditions using albumin fusion proteins of the invention.

公开(公告)号：US07973139B2

公开(公告)日：2011-07-05

申请号：US11090847

申请日：2005-03-25

申请人： Adam Bell ,  Craig A. Rosen

发明人： Adam Bell ,  Craig A. Rosen

IPC分类号： C07K16/00 ,  C07K14/00 ,  C12N15/85 ,  C12N5/12 ,  A61K39/395

CPC分类号： C07K16/28 ,  A61K2039/505 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2317/76 ,  C07K2317/92

摘要： The present invention relates to antibodies and related molecules that specifically bind to the Nogo receptor (NogoR). Such antibodies have uses, for example, in the treatment of spinal cord injury, brain trauma, paralysis, degenerative nervous system diseases, and stroke. The invention also relates to nucleic acid molecules encoding anti-NogoR antibodies, vectors and host cells containing these nucleic acids, and methods for producing the same.

摘要翻译： 本发明涉及特异性结合Nogo受体（NogoR）的抗体和相关分子。 这样的抗体具有例如用于治疗脊髓损伤，脑损伤，麻痹，退行性神经系统疾病和中风的用途。 本发明还涉及编码抗NogoR抗体的核酸分子，含有这些核酸的载体和宿主细胞及其制备方法。

公开(公告)号：US20100319576A1

公开(公告)日：2010-12-23

申请号：US12818706

申请日：2010-06-18

申请人： Adam Bell ,  Mohamed Mohamed ,  Robert Zwick ,  James Blumenfeld

发明人： Adam Bell ,  Mohamed Mohamed ,  Robert Zwick ,  James Blumenfeld

IPC分类号： C09D101/12

CPC分类号： C08L1/02 ,  A61K8/731 ,  A61Q13/00 ,  C08L1/284

摘要： The present invention provides a process for optimizing the fragrance of a scented cellulosic.

摘要翻译： 本发明提供了一种用于优化香味纤维素的香味的方法。

公开(公告)号：US20050215770A1

公开(公告)日：2005-09-29

申请号：US11090847

申请日：2005-03-25

申请人： Adam Bell ,  Craig Rosen

发明人： Adam Bell ,  Craig Rosen

IPC分类号： A61K39/395 ,  C07K16/28

CPC分类号： C07K16/28 ,  A61K2039/505 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2317/76 ,  C07K2317/92

摘要： The present invention relates to antibodies and related molecules that specifically bind to the Nogo receptor (NogoR). Such antibodies have uses, for example, in the treatment of spinal cord injury, brain trauma, paralysis, degenerative nervous system diseases, and stroke. The invention also relates to nucleic acid molecules encoding anti-NogoR antibodies, vectors and host cells containing these nucleic acids, and methods for producing the same.

公开(公告)号：US20050028720A1

公开(公告)日：2005-02-10

申请号：US10634719

申请日：2003-08-05

申请人： Adam Bell ,  Anthony Saunders

发明人： Adam Bell ,  Anthony Saunders

IPC分类号： A01M29/06 ,  A01M29/12 ,  A01M29/16 ,  A01M29/00

CPC分类号： A01M29/06 ,  A01M29/12 ,  A01M29/16

摘要： A device carried by the human hiker that comprises a pop-up (preferably inflatable) figure that is large and may be rapidly deployed by the user. The figure is meant to scare away an attacking or aggressive animal such as a bear. The activation of the pop-up figure may be accompanied by noises and/or smells and/or projectiles and/or smoke.

摘要翻译： 由人类徒步旅行者携带的装置，其包括较大的弹出（优选可充气）图形，并且可由用户快速部署。 这个数字是为了吓唬一个攻击性或侵略性的动物，如熊。 弹出图形的激活可能伴随有噪音和/或气味和/或射弹和/或烟雾。