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公开(公告)号：US08072595B1
公开(公告)日：2011-12-06
申请号：US11873337
申请日：2007-10-16
申请人： Glenn Bastiaans , Steve Hankins , Jerald Alan Cole
发明人： Glenn Bastiaans , Steve Hankins , Jerald Alan Cole
IPC分类号： G01J3/44
CPC分类号： G01N21/7703 , G01J1/46 , G01J3/027 , G01J3/2889 , G01J3/44 , G01J3/4412 , G01J2003/1213 , G01N21/65 , G01N2021/1793
摘要： A time correlated single photon counting system having a programmable delay generator triggered by a laser fire event detector. The system may be used for chemical agent detection based on Rayleigh scattering using optical time domain reflectometry techniques. The system may also be used for Raman detection using frequency to time transformations.
摘要翻译： 具有由激光火灾事件检测器触发的可编程延迟发生器的时间相关单光子计数系统。 该系统可用于使用光时域反射测量技术的基于瑞利散射的化学试剂检测。 该系统也可以用于使用频率到时间变换的拉曼检测。
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2.发明申请Methods of Diagnosis and Treatment of M.Tuberculosis Infection and Reagents Therefor 审中-公开结核分枝杆菌感染及其试剂的诊断和治疗方法公开(公告)号：US20090011426A1
公开(公告)日：2009-01-08
申请号：US11660851
申请日：2005-08-19
CPC分类号： C07K7/08 , A61K38/00 , C07K14/35 , G01N2333/35 , G01N2469/20
摘要： The present invention provides diagnostic, prognostic and therapeutic reagents for infection of an animal subject such as a human by M. tuberculosis, and conditions associated with such infections, such as, for example, tuberculosis. More particularly, the present invention provides a recombinant protein of M. tuberculosis designated “BSX” (SEQ ID NO: 1) and immunogenic epitopes thereof such as, for example, comprising SEQ ID NOS: 34, 25 and 45, that are useful in antibody-based diagnostic applications. The present invention also provides antibodies against BSX and its immunogenic peptides that are useful for antigen-based diagnostic and prognostic tests, and for therapy and vaccine formulations.
摘要翻译： 本发明提供了用于由结核分枝杆菌感染动物受试者例如人的诊断，预后和治疗试剂，以及与这种感染例如结核病相关的病症。 更具体地，本发明提供了称为“BSX”（SEQ ID NO：1）的结核分枝杆菌重组蛋白及其免疫原性表位，例如包含SEQ ID NO：34,25和45，其可用于 基于抗体的诊断应用。 本发明还提供针对BSX及其免疫原性肽的抗体，其可用于基于抗原的诊断和预后测试以及治疗和疫苗制剂。
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3.发明申请公开(公告)号：US20080045240A1
公开(公告)日：2008-02-21
申请号：US11877985
申请日：2007-10-24
申请人： Alan Cole , Sastry Duri , Vineet Gupta , Jonathan Munson , David Wood
发明人： Alan Cole , Sastry Duri , Vineet Gupta , Jonathan Munson , David Wood
IPC分类号： H04Q7/22
摘要： Techniques are presented for identifying mobile devices within a coverage legion of a wireless station Positions for mobile devices, if any, within the coverage region are determined. It is then determined whether the positions are within one or more defined areas, called “notification areas” herein. Additionally, selected mobile devices within notification areas are sent messages. The selected mobile devices ale selected via certain criteria, including, for instance, campaign specifications and subscriber information A message can be sent to a mobile device if the subscriber corresponding to the mobile device has indicated an acceptance of a category of notifications for the message and for the publisher who is publishing the notifications. The category could be traffic conditions and the publisher could be a Department of transportation having responsibility for a particular freeway. These are two examples of multiple criteria for selecting mobile devices to which messages could be sent.
摘要翻译： 呈现用于识别无线站的覆盖范围内的移动设备的技术确定覆盖区域内的移动设备（如果有的话）的位置。 然后确定位置是否在一个或多个限定区域内，这里称为“通知区域”。 此外，通知区域内的所选移动设备是发送消息。 所选择的移动设备通过特定标准选择，包括例如活动规范和用户信息。如果与移动设备相对应的用户已经表示接受消息的类别的通知，则消息可以被发送到移动设备，以及 对于发布通知的发布者。 该类别可能是交通条件，出版商可能是运输部门，负责特定的高速公路。 这些是用于选择可以发送消息的移动设备的多个标准的两个示例。
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公开(公告)号：US20070188318A1
公开(公告)日：2007-08-16
申请号：US11354496
申请日：2006-02-15
申请人： Alan Cole , Jeffrey Elliott , Holger Maier , Paul Moskowitz , Amadeus Podvratnik
发明人： Alan Cole , Jeffrey Elliott , Holger Maier , Paul Moskowitz , Amadeus Podvratnik
CPC分类号： G08B13/14 , G06Q10/08 , G07C9/00103 , G07C9/00111 , G08B13/2417 , G08B13/2462
摘要： The invention provides an approach for automatic and dynamic mapping of zone boundaries for position-determination systems. The system of the present invention utilizes beacons (“position determining devices”) to identify the boundaries and limits of device area coverage (“zone”) for tracking objects with a position-determination system. Beacons, used both to identify zone boundaries and to tag assets to be tracked, are distributed within the zone. The beacon locations are then detected and displayed in the visualization application. Three or more beacons may be linked together, either manually or automatically, to establish a detection zone. Using beacons to establish detection zone boundaries eliminates guesswork and its associated errors, and produces a zone boundary that is actually valid. In an improvement over present systems, greater accuracy is assured using zone-defining beacons, because if a beacon is unintentionally placed in an area unavailable to the position-determination system, that beacon will not appear in the visualization application display, and thus will not be available to create an incorrect zone representation.
摘要翻译： 本发明提供了一种用于位置确定系统的区域边界的自动和动态映射的方法。 本发明的系统使用信标（“位置确定装置”）来识别用于通过位置确定系统跟踪对象的设备区域覆盖（“区域”）的边界和限制。 用于识别区域边界和标记要跟踪的资产的信标分布在区域内。 然后在可视化应用中检测并显示信标位置。 三个或更多个信标可以手动或自动地链接在一起，以建立检测区域。 使用信标建立检测区域边界消除了猜测及其相关错误，并产生实际有效的区域边界。 在对现有系统的改进中，使用区域定义信标确保更高的精度，因为如果信标被无意地放置在位置确定系统不可用的区域中，则该信标将不会出现在可视化应用程序显示中，因此不会 可用于创建不正确的区域表示。
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公开(公告)号：US07205159B2
公开(公告)日：2007-04-17
申请号：US10487052
申请日：2002-08-20
IPC分类号： G01N33/543
CPC分类号： B01L3/5023 , B01L2200/0642 , B01L2300/0825 , B01L2300/16 , B01L2400/0406 , B01L2400/0633 , G01N33/54306 , G01N33/54366 , Y02A50/58 , Y10S435/81 , Y10S435/973 , Y10S436/81
摘要： A method and apparatus for use in a flow through assay process is disclosed. The method is characterised by a “pre-incubation step” in which the sample which is to be analysed, (typically for the presence of a particular protein), and a detection analyte (typically an antibody bound to colloidal gold or a fluorescent tag) which is known to bind to the particular protein may bind together for a desired period of time. This pre incubation step occurs before the mixture of sample and detection analyte come into contact with a capture analyte bound to a membrane. The provision of the pre-incubation step has the effect of both improving the sensitivity of the assay and reducing the volume of sample required for an assay. An apparatus for carrying out the method is disclosed defining a pre-incubation chamber for receiving the sample and detection analyte having a base defined by a membrane and a second membrane to which a capture analyte is bound. In one version the pre-incubation chamber is supported above the second membrane in one position but can be pushed into contact with the membrane carrying the capture analyte thus permitting fluid transfer from the incubation chamber through the capture membrane. In another version the membrane at the base of the incubation chamber is hydrophobic and its underside contacts the capture membrane and when a wetting agent is applied to the contents of the pre-incubation chamber fluid transfer occurs.
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公开(公告)号：US3595999A
公开(公告)日：1971-07-27
申请号：US3595999D
申请日：1968-12-09
申请人： MARTIN ALAN COLE
发明人： COLE MARTIN ALAN
CPC分类号： H04M1/658 , H04M11/045
摘要： An automatic telephone alarm apparatus for transmitting simulated dialing pulses to a switched telephone network and prerecorded voice messages to the selected telephone instrument. Message groups are stored on multitrack magnetic tape and are played back using a standard audio tape cartridge playback unit. The specific track to be played back is determined by the presence of one or more external stimuli. The selection of a specific message group from the plurality of groups recorded on a single tape track is determined by a combination of the presence of one or more external stimuli and a detection circuit responsive to a specific recorded audio tone header which precedes each message. The occurrence of an external signal initiates the switching of the telephone line from a telephone instrument to the system''s output, transmission of the recorded simulated selection pulses to the telephone network, and transmission of the recorded message to the selected telephone instrument.
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公开(公告)号：US08067246B2
公开(公告)日：2011-11-29
申请号：US12874675
申请日：2010-09-02
IPC分类号： G01N33/543
CPC分类号： B01L3/5023 , B01L2200/0642 , B01L2300/0825 , B01L2300/16 , B01L2400/0406 , B01L2400/0633 , G01N33/54306 , G01N33/54366 , Y02A50/58 , Y10S435/81 , Y10S435/973 , Y10S436/807 , Y10S436/81
摘要： A method and apparatus for use in a flow through assay process is disclosed. The method is characterised by a “pre-incubation step” in which the sample which is to be analyzed (typically for the presence of a particular protein), and a detection analyte (typically one or more antibodies bound to colloidal gold or a fluorescent tag) which is known to bind to the particular protein may bind together for a desired period of time. This pre-incubation step occurs before the mixture of sample and detection analyte come into contact with a capture analyte bound to a membrane. The provision of the pre-incubation step has the effect of both improving the sensitivity of the assay and reducing the volume of sample required for an assay. An apparatus for carrying out the method is disclosed defining a pre-incubation chamber for receiving the sample and detection analyte having a base defined by a membrane and a second membrane to which a capture analyte is bound. In one version the pre-incubation chamber is supported above the second membrane in one position but can be pushed into contact with the membrane carrying the capture analyte thus o permitting fluid transfer from the incubation chamber through the capture membrane. In another version the membrane at the base of the incubation chamber is hydrophobic and its underside contacts the capture membrane and when a wetting agent is applied to the contents of the pre-incubation chamber fluid transfer occurs.
摘要翻译： 公开了一种用于流过测定过程的方法和装置。 该方法的特征在于“预孵育步骤”，其中待分析的样品（通常为特定蛋白质的存在）和检测分析物（通常为结合胶体金或荧光标记的一种或多种抗体 ）已知结合特定蛋白质可以结合在一起所需的时间段。 此预孵育步骤在样品和检测分析物的混合物与结合到膜的捕获分析物接触之前发生。 提供预孵育步骤具有提高测定的灵敏度并降低测定所需样品的体积的效果。 公开了一种用于实施该方法的装置，其限定用于接收样品的预孵育室和具有由膜和第二膜限定的基底的检测分析物，捕获分析物与该第二膜结合。 在一个版本中，预孵育室在一个位置上被支撑在第二膜上方，但是可以被推入与携带捕获分析物的膜接触，从而允许流体通过捕获膜从孵育室转移。 在另一个版本中，孵育室底部的膜是疏水性的并且其下侧接触捕获膜，并且当将润湿剂施加到预孵育室的内容物时，发生流体转移。
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8.发明申请Method and system for multi-currency escrow service for web-based transactions 有权用于基于Web的交易的多币种托管服务的方法和系统公开(公告)号：US20090138398A1
公开(公告)日：2009-05-28
申请号：US12289381
申请日：2008-10-27
申请人： Alan Cole , Deborah Bennett , Hachadur Hashasian
发明人： Alan Cole , Deborah Bennett , Hachadur Hashasian
IPC分类号： G06Q40/00
CPC分类号： G06Q30/06 , G06Q20/02 , G06Q20/023 , G06Q20/04 , G06Q20/10 , G06Q20/102 , G06Q20/108 , G06Q20/12 , G06Q20/381 , G06Q30/00 , G06Q40/00 , G06Q40/025 , G06Q40/04
摘要： A method and system for escrow service for web-based transactions, such as multi-currency web-based transactions, is web-accessible and accepts registrations from exchanges and/or portal partners. The completion of registration and transactions is allowed to entitled users who access the system via the web. The system maintains an internal banking engine to act as a deal manager, messaging service and accounts sub-ledger and escrows funds entrusted to it. The transaction process is composed of a number of transaction statuses, and reporting of those statuses to users is accomplished online and via web query. The system provides local currency/multi-currency capability and supports several methods of payment, such as credit cards, authorized Automated Clearing House (ACH) or equivalent direct debit/credit and wire transfer payments, and all funds movements are electronic. The system supports transaction level detail through its banking engine accounts; funds movements from its currency accounts, and escrows funds to currency based escrow accounts. Buyers completing goods/services inspections after delivery initiate settlements.
摘要翻译： 用于基于Web的交易（例如多货币基于网络的交易）的托管服务的方法和系统是可访问的，并接受来自交易所和/或门户合作伙伴的注册。 注册和交易的完成被允许授权通过网络访问系统的用户。 该系统维护一个内部银行引擎，作为交易经理，短信服务和帐户分类帐，并托管委托给它的资金。 交易过程由多个交易状态组成，用户的状态报告是通过网络查询完成的。 该系统提供本地货币/多币种能力，并支持多种付款方式，如信用卡，授权自动清算所（ACH）或同等的直接付款/信用和电汇付款，所有资金流动均为电子支付。 该系统通过其银行引擎账户支持交易级细节; 资金流动来自其货币账户，并将资金托管到货币代管帐户。 交货后完成商品/服务检验的买家开始定居。
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公开(公告)号：US4002814A
公开(公告)日：1977-01-11
申请号：US557378
申请日：1975-03-11
IPC分类号： C08F4/00 , C08F4/42 , C08F210/16 , C08F4/02 , C08F10/02
CPC分类号： C08F210/16
摘要： Ethylene is copolymerized with one or more mono .alpha.-olefins, especially butene and/or hexene, using as catayst a Group IVA metal hydrocarbyl compound supported on particulate alumina, the purity ratio (i.e. the molar ratio of Group IVA metal to Group I to III metal) of the said compound being at least 100/1 and, preferably, 500/1. By using these very pure compounds, especially in the case of zirconium tetrabenzyl, the incorporation of co-monomer in the copolymer product may be enhanced.
摘要翻译： 乙烯与一种或多种单α-烯烃，特别是丁烯和/或己烯共聚，使用负载在颗粒氧化铝上的IVA族金属烃基化合物，其纯度比（即IVA族金属与I族至III族的摩尔比 金属）为至少100/1，优选为500/1。 通过使用这些非常纯的化合物，特别是在四苄基锆的情况下，可以增加在共聚物产物中引入共聚单体。
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公开(公告)号：US08338858B1
公开(公告)日：2012-12-25
申请号：US13310652
申请日：2011-12-02
申请人： Glenn Bastiaans , Steve Hankins , Jerald Alan Cole
发明人： Glenn Bastiaans , Steve Hankins , Jerald Alan Cole
IPC分类号： H01L31/107
CPC分类号： G01N21/7703 , G01J1/46 , G01J3/027 , G01J3/2889 , G01J3/44 , G01J3/4412 , G01J2003/1213 , G01N21/65 , G01N2021/1793
摘要： A time correlated single photon counting system having a programmable delay generator triggered by a laser fire event detector. The system may be used for chemical agent detection based on Rayleigh scattering using optical time domain reflectometry techniques. The system may also be used for Raman detection using frequency to time transformations.
摘要翻译： 具有由激光火灾事件检测器触发的可编程延迟发生器的时间相关单光子计数系统。 该系统可用于使用光时域反射测量技术的基于瑞利散射的化学试剂检测。 该系统也可以用于使用频率到时间变换的拉曼检测。
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