公开(公告)号：US07371350B2

公开(公告)日：2008-05-13

申请号：US10479820

申请日：2002-06-07

申请人： David Jones ,  Amanda Jayne Crudace ,  Peter Alan Hutchinson

发明人： David Jones ,  Amanda Jayne Crudace ,  Peter Alan Hutchinson

IPC分类号： A62B7/08

CPC分类号： A62B21/00

摘要： An oxygen generator comprising an oxygen generating unit including: (a) a chlorate oxygen generating candle for generating oxygen when ignited; and (b) an ignition device for igniting the candle to initiate oxygen generation from the candle. The candle is arranged during operation to sustain propagation of a plurality of burn fronts therethrough, the fronts propagating in different directions.

摘要翻译： 一种氧气发生器，包括氧气发生单元，包括：（a）用于在点燃时产生氧气的氯酸盐氧气发生蜡烛; 和（b）用于点燃蜡烛以引发蜡烛产生氧气的点火装置。 在操作期间布置蜡烛以维持多个燃烧锋面的传播通过其中，前沿沿不同方向传播。

公开(公告)号：US06723730B2

公开(公告)日：2004-04-20

申请号：US09910442

申请日：2001-07-20

申请人： Rajagopal Bakthavatchalam ,  Alan Hutchinson ,  Robert W. DeSimone ,  Kevin J. Hodgetts ,  James E. Krause ,  Geoffrey G. White

发明人： Rajagopal Bakthavatchalam ,  Alan Hutchinson ,  Robert W. DeSimone ,  Kevin J. Hodgetts ,  James E. Krause ,  Geoffrey G. White

IPC分类号： C07D295192

CPC分类号： C07D213/74 ,  C07D213/75 ,  C07D217/22 ,  C07D241/20 ,  C07D405/12 ,  C07D417/12

摘要： Disclosed are diaryl piperazines and related compounds of the following Formula: wherein the variables are as defined in the specification. These compounds are selective modulators of capsaicin receptors, including human capsaicin receptors, that are, therefore, useful in the treatment of a chronic and acute pain conditions, itch and urinary incontinence. Methods of treatment of such disorders and well as packaged pharmaceutical compositions are also provided. Compounds of the invention are also useful as probes for the localization of capsaicin receptors and as standards in assays for capsaicin receptor binding and capsaicin receptor mediated cation conductance. Methods of using the compounds in receptor localization studies are given.

摘要翻译： 公开了下式的二芳基哌嗪和相关化合物：其中变量如说明书中所定义。 这些化合物是辣椒素受体的选择性调节剂，包括人类辣椒素受体，因此可用于治疗慢性和急性疼痛病症，瘙痒和尿失禁。 还提供了治疗这种疾病以及包装的药物组合物的方法。 本发明的化合物也可用作辣椒素受体定位的探针，也可用作辣椒素受体结合和辣椒素受体介导的阳离子电导测定中的标准。 给出了在受体定位研究中使用化合物的方法。

公开(公告)号：US06310212B1

公开(公告)日：2001-10-30

申请号：US09535825

申请日：2000-03-28

申请人： Jun Yuan ,  Alan Hutchinson

发明人： Jun Yuan ,  Alan Hutchinson

IPC分类号： A61K3155

CPC分类号： C07D401/04 ,  C07D487/04

摘要： Disclosed are compounds of the Formula I where R1, R2, R3, R4, X, Y1, and Y2 are defined herein. These compounds bind with high affinity to GABAA receptors. Also disclosed are pharmaceutical compositions comprising these compounds, and methods of treating patients suffering from certain central nervous system and peripheral diseases or disorders with these pharmaceutical compositions. This invention also relates to the use of such compounds in combination with one or more other CNS agents to potentiate the effects of the other CNS agents. The compounds of this invention are also useful as probes for the localization of GABAA receptors.

摘要翻译： 公开了式I的化合物，其中R 1，R 2，R 3，R 4，X，Y 1和Y 2在本文中定义。 这些化合物以高亲和力结合GABA A受体。 还公开了包含这些化合物的药物组合物，以及用这些药物组合物治疗患有某些中枢神经系统和外周疾病或病症的患者的方法。 本发明还涉及这样的化合物与一种或多种其它CNS剂组合用于增强其它CNS剂的作用的用途。 本发明的化合物也可用作GABA A受体定位的探针。

公开(公告)号：US20060009456A1

公开(公告)日：2006-01-12

申请号：US11154986

申请日：2005-06-16

申请人： Alan Hutchinson ,  Bertrand Chenard ,  Guiying Li ,  Manuka Ghosh ,  James Tarrant ,  Taeyoung Yoon ,  George Luke ,  Kyungae Lee ,  Mary-Margaret O'Donnell ,  Wallace Pringle ,  John Peterson ,  Kevin Hodgetts ,  Cheryl Steenstra ,  Dario Doller

发明人： Alan Hutchinson ,  Bertrand Chenard ,  Guiying Li ,  Manuka Ghosh ,  James Tarrant ,  Taeyoung Yoon ,  George Luke ,  Kyungae Lee ,  Mary-Margaret O'Donnell ,  Wallace Pringle ,  John Peterson ,  Kevin Hodgetts ,  Cheryl Steenstra ,  Dario Doller

IPC分类号： A61K31/498 ,  A61K31/497 ,  A61K31/496 ,  C07D403/02 ,  C07D487/04

CPC分类号： C07D295/073 ,  C07D207/08 ,  C07D207/12 ,  C07D207/26 ,  C07D207/38 ,  C07D211/18 ,  C07D211/34 ,  C07D211/38 ,  C07D211/42 ,  C07D211/46 ,  C07D211/52 ,  C07D211/74 ,  C07D213/64 ,  C07D213/74 ,  C07D213/82 ,  C07D231/12 ,  C07D233/54 ,  C07D233/56 ,  C07D249/04 ,  C07D249/08 ,  C07D257/04 ,  C07D261/08 ,  C07D275/02 ,  C07D295/088 ,  C07D295/096 ,  C07D295/192 ,  C07D307/20 ,  C07D307/79 ,  C07D307/82 ,  C07D309/06 ,  C07D309/12 ,  C07D311/14 ,  C07D401/12 ,  C07D471/04 ,  C07D471/08 ,  C07D487/04 ,  C07D487/08

摘要： Aryl-substituted piperazine derivatives are provided. Such compounds may be used to modulate MCH receptor activity in vivo or in vitro, and are particularly useful in the treatment of a variety of metabolic, feeding and sexual disorders in humans, domesticated companion animals and livestock animals. Pharmaceutical compositions and methods for treating such disorders are provided, as are methods for using such ligands for detecting MCH receptors (e.g., receptor localization studies).

摘要翻译： 提供了芳基取代的哌嗪衍生物。 这样的化合物可用于在体内或体外调节MCH受体活性，并且特别可用于治疗人，驯养伴侣动物和家畜中的各种代谢，喂养和性障碍。 还提供了用于治疗这种病症的药物组合物和方法，以及使用这些配体检测MCH受体的方法（例如受体定位研究）。

公开(公告)号：US06511987B1

公开(公告)日：2003-01-28

申请号：US09709887

申请日：2000-11-10

申请人： Jun Yuan ,  Pamela Albaugh ,  Kenneth Shaw ,  Alan Hutchinson

发明人： Jun Yuan ,  Pamela Albaugh ,  Kenneth Shaw ,  Alan Hutchinson

IPC分类号： C07D47104

CPC分类号： C07D217/26 ,  C07D237/30 ,  C07D471/04 ,  C07D487/04 ,  C07D519/00 ,  G01N2333/70571

摘要： Disclosed are compounds of the formula: and the pharmaceutically acceptable salts thereof, wherein W, Q, X, X1, Y and Z are as defined herein. These compounds bind with high selectivity and/or high affinity to the benzodiazepine site of GABAA receptors and are therefore useful in the treatment of central nervous system (CNS) diseases and as probes for the localization of GABAA receptors in tissue samples. Also disclosed are intermediates useful in the preparation of these compounds.

摘要翻译： 公开了下式的化合物及其药学上可接受的盐，其中W，Q，X，X 1，Y和Z如本文所定义。 这些化合物以高选择性和/或高亲和力结合GABA A受体的苯并二氮杂位点，因此可用于治疗中枢神经系统（CNS）疾病和作为组织样品中GABA A受体定位的探针。 还公开了可用于制备这些化合物的中间体。

公开(公告)号：US20090086469A1

公开(公告)日：2009-04-02

申请号：US11906385

申请日：2007-10-01

申请人： Timothy Alan Hutchinson ,  Robert Colantuono ,  Michael McKee

发明人： Timothy Alan Hutchinson ,  Robert Colantuono ,  Michael McKee

IPC分类号： F21V33/00

CPC分类号： G02B6/0001 ,  H01R13/502 ,  H01R13/631 ,  H01R13/7172 ,  H01R13/7175 ,  H01R24/62 ,  H01R2107/00

摘要： An electrical connector including a connector subassembly having a front mating portion and a waveguide disposed around the front mating portion of the connector subassembly. The waveguide may alternatively be disposed near the front mating portion of the connector subassembly and an illumination device is provided at the side portion of the connector subassembly adjacent to the waveguide for coupling light emanating therefrom onto a portion of the waveguide which in turn conducts the light to illuminate at least a front end of the waveguide. The connector subassembly may further cooperate with a bezel having a frame and an opening. The frame retains the connector subassembly in position with the front mating portion of connector subassembly extending to the opening. The waveguide is then configured to have a front portion disposed between a rim portion of the opening and the front mating portion of the connector subassembly.

摘要翻译： 一种电连接器，包括具有前配合部分和布置在连接器子组件的前配合部分周围的波导的连接器子组件。 波导可以可选地设置在连接器子组件的前配合部分附近，并且照明装置设置在与波导相邻的连接器子组件的侧部，用于将从其发射的光耦合到波导的一部分上，该部分又导通光 以至少照亮波导的前端。 连接器子组件还可以与具有框架和开口的边框配合。 框架将连接器子组件保持就位，其中连接器子组件的前配合部分延伸到开口。 然后将波导配置成具有设置在开口的边缘部分和连接器子组件的前配合部分之间的前部分。

公开(公告)号：US07744231B2

公开(公告)日：2010-06-29

申请号：US11906385

申请日：2007-10-01

申请人： Timothy Alan Hutchinson ,  Robert Colantuono ,  Michael McKee

发明人： Timothy Alan Hutchinson ,  Robert Colantuono ,  Michael McKee

IPC分类号： F21V33/00

CPC分类号： G02B6/0001 ,  H01R13/502 ,  H01R13/631 ,  H01R13/7172 ,  H01R13/7175 ,  H01R24/62 ,  H01R2107/00

摘要： An electrical connector including a connector subassembly having a front mating portion and a waveguide disposed around the front mating portion of the connector subassembly. The waveguide may alternatively be disposed near the front mating portion of the connector subassembly and an illumination device is provided at the side portion of the connector subassembly adjacent to the waveguide for coupling light emanating therefrom onto a portion of the waveguide which in turn conducts the light to illuminate at least a front end of the waveguide. The connector subassembly may further cooperate with a bezel having a frame and an opening. The frame retains the connector subassembly in position with the front mating portion of connector subassembly extending to the opening. The waveguide is then configured to have a front portion disposed between a rim portion of the opening and the front mating portion of the connector subassembly.

摘要翻译： 一种电连接器，包括具有前配合部分和布置在连接器子组件的前配合部分周围的波导的连接器子组件。 波导可以可选地设置在连接器子组件的前配合部分附近，并且照明装置设置在与波导相邻的连接器子组件的侧部，用于将从其发射的光耦合到波导的一部分上，该部分又导通光 以至少照亮波导的前端。 连接器子组件还可以与具有框架和开口的边框配合。 框架将连接器子组件保持就位，其中连接器子组件的前配合部分延伸到开口。 然后将波导配置成具有设置在开口的边缘部分和连接器子组件的前配合部分之间的前部分。