-
公开(公告)号：US07357044B2
公开(公告)日：2008-04-15
申请号：US11126824
申请日：2005-05-11
Applicant: Richard Sleeman , John George Luke , Samantha Ollerton
Inventor： Richard Sleeman , John George Luke , Samantha Ollerton
IPC: G01N1/00
CPC classification number: G01N1/2214 , G01N1/02 , G01N2001/024 , G01N2001/028
Abstract: A sample collection device for use with a chemical analyzer, the device comprising a sample collecting assembly having at least one sampling medium and a sample desorbing assembly arranged to receive the sampling medium therein, the sample collecting assembly and sample desorbing assembly being movable with respect to one another between a sample collecting configuration in which the sampling medium is substantially exposed and a sample desorbing configuration in which the sampling medium is substantially housed within the sample desorbing assembly.
Abstract translation: 一种与化学分析仪一起使用的样品收集装置，该装置包括具有至少一个采样介质的样品采集组件和布置成在其中接收采样介质的样品解吸组件，样品收集组件和样品解吸组件可相对于 采样介质基本上暴露在样本收集结构和样品解吸结构之间，其中采样介质基本上容纳在样品解吸组件内。
-
公开(公告)号：US5604642A
公开(公告)日：1997-02-18
申请号：US376588
申请日：1995-01-20
Applicant: Czeslaw Deminet , George Luke
Inventor： Czeslaw Deminet , George Luke
Abstract: The invention provides method and apparatus for making light-weight honeycomb mirrors by assembling fused quartz ribs in a honeycomb pattern so that rib ends are proximate other rib ends to form rib junctions. A laser beam is then directed at the rib junctions to weld the rib ends together to form a honeycomb structure having a plurality of rib-defined cells or modules therein. Fused quartz plates of matching size are then positioned across the so-formed rib cells and welded by directing a high powered laser beam at the edges of the plates and adjacent ribs to weld the plates to the rib cells of the honeycomb structure and define a honeycomb mirror blank. The surface of the plates of, e.g. fused quartz, are then ground and polished to a mirror finish and a reflective coating added, to complete the light-weight honeycomb mirror by the method and apparatus of the invention.
Abstract translation: 本发明提供了通过将蜂窝图案中的熔融石英肋组装成使得肋端靠近其他肋端而形成肋结的方法和装置来制造轻质蜂窝镜。 然后激光束被引导到肋结处以将肋端部焊接在一起，以形成在其中具有多个肋限定单元或模块的蜂窝结构。 然后将匹配尺寸的熔融石英板定位在穿过如此形成的肋细胞并且通过在板和相邻肋的边缘处引导高功率激光束来焊接，以将板焊接到蜂窝结构的肋细胞并且限定蜂窝 镜子空白。 板的表面，例如。 熔融石英，然后研磨抛光成镜面，并加入反射涂层，以通过本发明的方法和设备完成轻质蜂窝镜。
-
3.发明申请公开(公告)号：US20070208048A1
公开(公告)日：2007-09-06
申请号：US11680865
申请日：2007-03-01
Applicant: George Luke , George Maynard , Scott Mitchell , Andrew Thurkauf , Linghong Xie , LuYan Zhang , Suoming Zhang , He Zhao , Bertrand Chenard , Yang Gao , Bingsong Han , Xiao He
Inventor： George Luke , George Maynard , Scott Mitchell , Andrew Thurkauf , Linghong Xie , LuYan Zhang , Suoming Zhang , He Zhao , Bertrand Chenard , Yang Gao , Bingsong Han , Xiao He
IPC: A61K31/505 , A61K31/415 , A61K31/44 , A61K31/50
CPC classification number: C07D233/64 , A61K31/4164 , C07D233/68 , C07D235/02 , C07D235/30 , C07D237/12 , C07D401/04 , C07D401/12 , C07D403/06 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/04 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14
Abstract: The invention provides Aryl substituted imidazoles, pyrazoles, pyridizines and related compounds of the Formula where the ring system represented by is a 5 membered heteroaryl ring system, in which x is 0, A is chosen from carbon and heteroatoms nitrogen, oxygen, and sulfur, and E and G are independently carbon or nitrogen provided that the 5 membered heteroaryl ring system does not contain more than 3 heteroatoms or more than 1 oxygen or sulfur atom, or a 6 membered heteroaryl ring system, in which x is 1, A, B, E, and G are independently chosen from carbon and nitrogen, provided that the 6 membered heteroaryl ring system does not contain more than 3 nitrogen atoms. The remaining variables, Ar1, Ar2, R, R1, R2, R3, R4, R5, R6, y and z are defined herein Such compounds are ligands of C5a receptors. Preferred compounds of the invention act bind to C5a receptors with high affinity and exhibit neutral antagonist or inverse agonist activity at C5a receptors. This invention also relates to pharmaceutical compositions comprising such compounds. It further relates to the use of such compounds in treating a variety of inflammatory and immune system disorders.
Abstract translation: 本发明提供芳基取代的咪唑，吡唑，吡啶并且其中由其表示的环系是5元杂芳基环系的相关化合物，其中x为0，A选自碳和杂原子氮，氧和硫， 并且E和G独立地为碳或氮，条件是5元杂芳基环系不包含多于3个杂原子或多于1个氧或硫原子，或6元杂芳基环系，其中x为1，A，B E和G独立地选自碳和氮，条件是6元杂芳基环系不含3个以上的氮原子。 其余的变量Ar 1，R 2，R 1，R 1，R 2，R 2， 3，R 4，R 5，R 6，y和z在本文中定义。这些化合物是C5a受体的配体。 本发明优选的化合物作用以高亲和力结合C5a受体，在C5a受体上表现出中性拮抗剂或反向激动剂活性。 本发明还涉及包含这些化合物的药物组合物。 它还涉及这些化合物在治疗各种炎性和免疫系统疾病中的应用。
-
公开(公告)号：US20060142301A1
公开(公告)日：2006-06-29
申请号：US11100355
申请日：2005-04-06
Applicant: Alan Hutchison , Bertrand Chenard , James Tarrant , Guiying Li , Manuka Ghosh , George Luke , John Peterson , Wallace Pringle , Mary-Margaret O'Donnell , Kyungae Lee , Linda Gustavson , Dario Doller
Inventor： Alan Hutchison , Bertrand Chenard , James Tarrant , Guiying Li , Manuka Ghosh , George Luke , John Peterson , Wallace Pringle , Mary-Margaret O'Donnell , Kyungae Lee , Linda Gustavson , Dario Doller
IPC: A61K31/496 , A61K31/497 , C07D403/02
CPC classification number: C07D213/74 , C07D213/82 , C07D471/04 , C07D487/04 , C07D487/08
Abstract: Compounds of Formula I are provided, in which variables are as described herein: Such compounds may be used to modulate MCH binding to MCH receptors in vivo or in vitro, and are particularly useful in the treatment of a variety of metabolic, feeding and sexual disorders in humans, domesticated companion animals and livestock animals. Pharmaceutical compositions and methods for treating such disorders are provided, as are methods for using such ligands for detecting MCH receptors (e.g., receptor localization studies).
Abstract translation: 提供了式I化合物，其中变量如本文所述：这样的化合物可用于在体内或体外调节MCH与MCH受体的结合，并且特别可用于治疗各种代谢，进食和性障碍 在人类，驯养的伴侣动物和家畜中。 还提供了用于治疗这种病症的药物组合物和方法，以及使用这些配体检测MCH受体的方法（例如受体定位研究）。
-
公开(公告)号：US3950948A
公开(公告)日：1976-04-20
申请号：US505845
申请日：1974-09-13
Applicant: William George Luke
Inventor： William George Luke
Abstract: Hydraulic control apparatus for automatic remote control of a hydraulic actuating ram. The apparatus has a double-acting slave cylinder connectable hydraulically to an actuating ram, and a double-acting master cylinder the piston of which is mechanically connected to the piston of the slave cylinder, the master cylinder being operable by hydraulic pressure supplied via a pilot-operated valve arranged automatically to reverse the stroke of the master ram at limits set according to the desired stroke of the actuating ram. The control apparatus may be used for controlling actuating rams which effect reciprocating pivotal movement about one or more axes of a water jet monitor.
Abstract translation: 液压控制装置，用于自动遥控液压驱动柱塞。 该装置具有液压连接到致动柱塞的双作用从动缸，以及其活塞机械地连接到从动缸的活塞的双作用主缸，主缸通过经由驾驶员提供的液压被操作 自动配置的阀门根据驱动压头的所需行程设定的极限，自动排除主压头的行程。 控制装置可用于控制致动柱塞，其实现围绕水射流监视器的一个或多个轴线的往复运动。
-
Patent Agency Ranking
公开(公告)号：US20060025425A1
公开(公告)日：2006-02-02
申请号：US11179458
申请日：2005-07-12
Applicant: Guiying Li , Pamela Albaugh , Kevin Currie , Guolin Cai , Linda Gustavson , Kyungae Lee , Alan Hutchison , George Maynard , Jun Yuan , Ling Xie , Manuka Ghosh , Nian Liu , George Luke , Scott Mitchell , Martin Allen , Spiros Liras
Inventor： Guiying Li , Pamela Albaugh , Kevin Currie , Guolin Cai , Linda Gustavson , Kyungae Lee , Alan Hutchison , George Maynard , Jun Yuan , Ling Xie , Manuka Ghosh , Nian Liu , George Luke , Scott Mitchell , Martin Allen , Spiros Liras
IPC: A61K31/506 , A61K31/4745 , A61K31/427 , A61K31/4184 , C07D471/02 , C07D403/02 , C07D417/02 , C07D413/02
CPC classification number: C07D401/04 , C07D233/20 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/06 , C07D413/14 , C07D417/04 , C07D417/06 , C07D417/14 , C07D471/04 , C07D473/00 , C07D491/08 , C07D491/10
Abstract: This invention relates to benzimidazoles, pyridylimidazoles and related bicyclic heteroaryl compounds, all of which may be described by of Formula I The invention is particularly related to such compounds that bind with high selectivity and high affinity to the benzodiazepine site of GABAA receptors. This invention also relates to pharmaceutical compositions comprising such compounds and to the use of such compounds in treatment of certain central nervous system (CNS) diseases. Novel processes for preparing compounds of Formula I are disclosed. This invention also relates to the use of benzimidazoles, pyridylimidazoles and related bicyclic heteroaryl compounds of Formula I in combination with one or more other CNS agents to potentiate the effects of the other CNS agents. Additionally this invention relates to the use such compounds as probes for the localization of GABAA receptors in tissue sections.
Abstract translation: 本发明涉及苯并咪唑，吡啶基咪唑和相关双环杂芳基化合物，所有这些可以由式I描述。本发明特别涉及以高选择性和高亲和力结合GABA A的苯并二氮杂部位的化合物， / SUB>受体。 本发明还涉及包含这些化合物的药物组合物以及这些化合物在治疗某些中枢神经系统（CNS）疾病中的用途。 公开了制备式I化合物的新方法。 本发明还涉及式I的苯并咪唑，吡啶基咪唑和相关的双环杂芳基化合物与一种或多种其它CNS剂的组合用于增强其它CNS剂的作用。 此外，本发明涉及使用这些化合物作为组织切片中GABA A A受体定位的探针。
-
公开(公告)号：US07669487B2
公开(公告)日：2010-03-02
申请号：US11100019
申请日：2005-04-05
Applicant: John George Luke , Richard Sleeman
Inventor： John George Luke , Richard Sleeman
IPC: G01N1/22
CPC classification number: H01J49/04 , G01N1/2214 , G01N2001/007 , G01N2001/022 , G01N2001/2241
Abstract: A desorber for use with a chemical ionisation mass spectrometer comprises a body portion that has a cavity formed therein, the cavity being arranged to receive a sample collector, the sample collector being preferably carried by a holding device that can be slid in and out of the cavity. The body portion includes an air intake passage in communication with the cavity and at least one heating element arranged to heat air drawn through the air intake passage into the cavity.
Abstract translation: 与化学电离质谱仪一起使用的解吸器包括其中形成有腔的主体部分，空腔布置成接收样品收集器，样品收集器优选地由保持装置携带，该保持装置可以滑入和移出 腔。 主体部分包括与空腔连通的进气通道和布置成将通过进气通道吸入的空气加热到空腔中的至少一个加热元件。
-
公开(公告)号：US20070249616A1
公开(公告)日：2007-10-25
申请号：US11763926
申请日：2007-06-15
Applicant: Alan Hutchison , Bertrand Chenard , James Tarrant , Guiying Li , Manuka Ghosh , George Luke , John Peterson , Wallace Pringle , Mary-Margaret O'Donnell , Kyungae Lee , Linda Gustavson , Dario Doller
Inventor： Alan Hutchison , Bertrand Chenard , James Tarrant , Guiying Li , Manuka Ghosh , George Luke , John Peterson , Wallace Pringle , Mary-Margaret O'Donnell , Kyungae Lee , Linda Gustavson , Dario Doller
IPC: A61K31/496 , A61K31/498 , A61P3/04
CPC classification number: C07D213/74 , C07D213/82 , C07D471/04 , C07D487/04 , C07D487/08
Abstract: Compounds of Formula I are provided, in which variables are as described herein: Such compounds may be used to modulate MCH binding to MCH receptors in vivo or in vitro, and are particularly useful in the treatment of a variety of metabolic, feeding and sexual disorders in humans, domesticated companion animals and livestock animals. Pharmaceutical compositions and methods for treating such disorders are provided, as are methods for using such ligands for detecting MCH receptors (e.g., receptor localization studies).
Abstract translation: 提供了式I化合物，其中变量如本文所述：这样的化合物可用于在体内或体外调节MCH与MCH受体的结合，并且特别可用于治疗各种代谢，进食和性障碍 在人类，驯养的伴侣动物和家畜中。 还提供了用于治疗这种病症的药物组合物和方法，以及使用这些配体检测MCH受体的方法（例如受体定位研究）。
-
公开(公告)号：US07275636B2
公开(公告)日：2007-10-02
申请号：US11098982
申请日：2005-04-05
Applicant: John George Luke , Richard Sleeman
Inventor： John George Luke , Richard Sleeman
IPC: B65G29/00
CPC classification number: B65H5/062 , B65H2404/144 , B65H2701/193 , G01N1/2214 , G01N2001/007 , G01N2001/022 , G01N2035/00039
Abstract: A transport roller suspension mechanism for supporting at least one transport roller of a sample transport mechanism for introducing a substantially planar sample carrier to a chemical analysis device, the transport roller mechanism comprising: a suspension block arranged to be pivotally connected to a fixed portion of the sample transport mechanism and being arranged to rotatably receive one end of a transport roller shaft; and a biasing member arranged to be resiliently urged against the suspension block.
Abstract translation: 一种输送辊悬挂机构，用于支撑用于将基本上平面的样品载体引导到化学分析装置的样品输送机构的至少一个输送辊，所述输送辊机构包括：悬挂块，其布置成枢转地连接到所述固定部分 样品传送机构，并且布置成可旋转地容纳传送辊轴的一端; 以及偏置构件，其被布置成弹性地推靠在所述悬架上。
-
公开(公告)号：US20060009456A1
公开(公告)日：2006-01-12
申请号：US11154986
申请日：2005-06-16
Applicant: Alan Hutchinson , Bertrand Chenard , Guiying Li , Manuka Ghosh , James Tarrant , Taeyoung Yoon , George Luke , Kyungae Lee , Mary-Margaret O'Donnell , Wallace Pringle , John Peterson , Kevin Hodgetts , Cheryl Steenstra , Dario Doller
Inventor： Alan Hutchinson , Bertrand Chenard , Guiying Li , Manuka Ghosh , James Tarrant , Taeyoung Yoon , George Luke , Kyungae Lee , Mary-Margaret O'Donnell , Wallace Pringle , John Peterson , Kevin Hodgetts , Cheryl Steenstra , Dario Doller
IPC: A61K31/498 , A61K31/497 , A61K31/496 , C07D403/02 , C07D487/04
CPC classification number: C07D295/073 , C07D207/08 , C07D207/12 , C07D207/26 , C07D207/38 , C07D211/18 , C07D211/34 , C07D211/38 , C07D211/42 , C07D211/46 , C07D211/52 , C07D211/74 , C07D213/64 , C07D213/74 , C07D213/82 , C07D231/12 , C07D233/54 , C07D233/56 , C07D249/04 , C07D249/08 , C07D257/04 , C07D261/08 , C07D275/02 , C07D295/088 , C07D295/096 , C07D295/192 , C07D307/20 , C07D307/79 , C07D307/82 , C07D309/06 , C07D309/12 , C07D311/14 , C07D401/12 , C07D471/04 , C07D471/08 , C07D487/04 , C07D487/08
Abstract: Aryl-substituted piperazine derivatives are provided. Such compounds may be used to modulate MCH receptor activity in vivo or in vitro, and are particularly useful in the treatment of a variety of metabolic, feeding and sexual disorders in humans, domesticated companion animals and livestock animals. Pharmaceutical compositions and methods for treating such disorders are provided, as are methods for using such ligands for detecting MCH receptors (e.g., receptor localization studies).
Abstract translation: 提供了芳基取代的哌嗪衍生物。 这样的化合物可用于在体内或体外调节MCH受体活性，并且特别可用于治疗人，驯养伴侣动物和家畜中的各种代谢，喂养和性障碍。 还提供了用于治疗这种病症的药物组合物和方法，以及使用这些配体检测MCH受体的方法（例如受体定位研究）。
-
-
-
-
-
-
-
-
-
Search Results
13
records
(took 0.03 seconds)
