公开(公告)号：US08865179B2

公开(公告)日：2014-10-21

申请号：US12011303

申请日：2008-01-26

Applicant: Swey-Shen Alex Chen

Inventor： Swey-Shen Alex Chen

IPC: A61K39/00 ,  G01N33/68 ,  C07K16/42 ,  C07K14/705

CPC classification number: G01N33/6845 ,  C07K14/70503 ,  C07K16/00 ,  C07K16/4291 ,  C07K2317/50 ,  C07K2317/622 ,  C07K2317/64 ,  C07K2318/00 ,  C07K2318/10 ,  C07K2319/00 ,  C07K2319/60 ,  G01N33/6878 ,  Y10S424/805 ,  Y10S424/81

Abstract: A method is disclosed wherein an antigenic B-cell epitope is discovered by in vitro transcription and translation of pre-determined sequence on thermostable protein scaffolds detected by antibodies to a native protein. Immune reactivities of IgE B-cell epitopes from pre-determined IgE sequences from the constant region, engaged in binding to high affinity IgE Fc receptors, placed in a loop of green fluorescent protein (GFP) were shown immuno-reactive with anti-IgE. Moreover, the antigenic B-cell epitope can be further optimized by molecular evolution, selected by conformer antibody and receptor on solid phase via ribosome display. Alternatively, a random aptameric antigenic sequence inserted into a loop of the protein scaffold, mimicking a pre-determined sequence of a native protein, can be selected by solid phase conformer antibody and receptor via ribosome display. High affinity binding of B-cell epitopes selected from the random aptameric library with antibodies to native pre-determined B-cell epitope of a native protein can be optimized by molecular evolution with error-prone RT-PCR by ribosome display.

Abstract translation: 公开了一种方法，其中通过抗体对天然蛋白质检测到的耐热蛋白质支架上的预定序列的体外转录和翻译来发现抗原性B细胞表位。 IgE B细胞表位的免疫反应性与来自固定区域的预定IgE序列的免疫反应性（参与与高亲和性IgE Fc受体的结合）置于绿色荧光蛋白（GFP）的环中，显示出与抗IgE的免疫反应性。 此外，可以通过分子进化进一步优化抗原性B细胞表位，通过构象异构体抗体和通过核糖体展示的固相受体选择。 或者，可以通过固相构象异构体抗体和受体通过核糖体显示来选择插入到蛋白质支架的环中的模拟预先确定的天然蛋白质序列的随机适体抗原序列。 选择随机适体文库的B细胞表位与天然蛋白质天然预先确定的B细胞表位的抗体的高亲和力结合可以通过分子进化来优化，通过核糖体显示出现易发生的RT-PCR。

公开(公告)号：US20090150897A1

公开(公告)日：2009-06-11

申请号：US12372612

申请日：2009-02-17

Applicant: Alex Chen ,  Angqin Bai ,  Theodore Timothy Harris, JR.

Inventor： Alex Chen ,  Angqin Bai ,  Theodore Timothy Harris, JR.

IPC: G06F9/46 ,  G06F9/50

CPC classification number: G06F9/5011 ,  G06F9/524

Abstract: Provided are a system and program for managing operation requests using different resources. In one embodiment, a first queue is provided for operations which utilize a first resource of a first and second resource. A second queue is provided for operations which utilize the second resource. An operation is queued on the first queue until the first resource is acquired. The first resource is released if the second resource is not also acquired. The operation is queued on the second queue when the first resource is acquired but the second resource is not. In addition, the first resource is released until the operation acquires both the first resource and the second resource.

Abstract translation: 提供了一种用于使用不同资源来管理操作请求的系统和程序。 在一个实施例中，为使用第一和第二资源的第一资源的操作提供第一队列。 为使用第二资源的操作提供第二队列。 操作在第一个队列中排队，直到获取第一个资源。 如果没有获得第二个资源，则第一个资源被释放。 当获取第一个资源但第二个资源没有时，操作在第二个队列中排队。 此外，第一资源被释放，直到操作获取第一资源和第二资源。

公开(公告)号：US07512948B2

公开(公告)日：2009-03-31

申请号：US10719070

申请日：2003-11-20

Applicant: Alex Chen ,  Angqin Bai ,  Theodore Timothy Harris, Jr.

Inventor： Alex Chen ,  Angqin Bai ,  Theodore Timothy Harris, Jr.

IPC: G06F9/46 ,  G06F11/00

CPC classification number: G06F9/5011 ,  G06F9/524

Abstract: Provided is a method, system and program for managing operation requests using different resources. In one embodiment, a first queue is provided for operations which utilize a first resource of a first and second resource. A second queue is provided for operations which utilize the second resource. An operation is queued on the first queue until the first resource is acquired. The first resource is released if the second resource is not also acquired. The operation is queued on the second queue when the first resource is acquired but the second resource is not. In addition, the first resource is released until the operation acquires both the first resource and the second resource.

Abstract translation: 提供了一种用于使用不同资源来管理操作请求的方法，系统和程序。 在一个实施例中，为使用第一和第二资源的第一资源的操作提供第一队列。 为使用第二资源的操作提供第二队列。 操作在第一个队列中排队，直到获取第一个资源。 如果没有获得第二个资源，则第一个资源被释放。 当获取第一个资源但第二个资源没有时，操作在第二个队列中排队。 此外，第一资源被释放，直到操作获取第一资源和第二资源。

公开(公告)号：US20060287528A1

公开(公告)日：2006-12-21

申请号：US10569566

申请日：2004-08-27

Applicant: Robert Wenslow ,  Joseph Armstrong ,  Alex Chen ,  Stephen Cypes ,  Russell Ferlita ,  Karl Hansen ,  Christopher Lindemann ,  Evangelia Spartalis

Inventor： Robert Wenslow ,  Joseph Armstrong ,  Alex Chen ,  Stephen Cypes ,  Russell Ferlita ,  Karl Hansen ,  Christopher Lindemann ,  Evangelia Spartalis

IPC: C07D487/04

CPC classification number: C07D487/04

Abstract: The present invention relates to crystalline anhydrate polymorphs of the dihydrogenphosphate salt of (2R)4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-α]pyrazin-7(8H) yl]-1-(2,4,5-trifluorophenyl)butan-2-amine as well as a process for their preparation, pharmaceutical compositions containing these novel forms, and methods of use of the novel forms and pharmaceutical compositions for the treatment of diabetes, obesity, and high blood pressure. The invention also concerns novel crystalline solvates of the dihydrogenphosphate salt of (2R)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]tria-zolo [4,3-α]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine as well as a crystalline desolvated polymorph and their use for the preparation of the anhydrate polymorphs of the present invention.

Abstract translation: 本发明涉及（2R）-4-氧代-4- [3-（三氟甲基）-5,6-二氢[1,2,4]三唑并[4,3-a]吡嗪的磷酸二氢盐的晶体无水物多晶型物 -7（8H）基] -1-（2,4,5-三氟苯基）丁-2-胺以及它们的制备方法，含有这些新形式的药物组合物，以及新型形式和药物的使用方法 用于治疗糖尿病，肥胖和高血压的组合物。 本发明还涉及（2R）-4-氧代-4- [3-（三氟甲基）-5,6-二氢[1,2,4]三唑并[4,3-a]的磷酸二氢盐的新结晶溶剂合物 ]吡嗪-7（8H） - 基] -1-（2,4,5-三氟苯基）丁-2-胺以及晶体脱溶化多晶型物及其用于制备本发明的无水物多晶型物的用途。

公开(公告)号：US20060115425A1

公开(公告)日：2006-06-01

申请号：US10559228

申请日：2004-06-25

Applicant: H. Donald Burns ,  Alex Chen ,  Raymond Gibson ,  Mark Goulet ,  William Hagmann ,  Terence Hamill ,  James Jewell ,  Linus Lin ,  Ping Liu ,  Andrey Peresypkin

Inventor： H. Donald Burns ,  Alex Chen ,  Raymond Gibson ,  Mark Goulet ,  William Hagmann ,  Terence Hamill ,  James Jewell ,  Linus Lin ,  Ping Liu ,  Andrey Peresypkin

IPC: A61K51/00 ,  C07D213/70

CPC classification number: C07D213/64 ,  A61K51/0406 ,  A61K51/0455 ,  A61K51/0459 ,  C07D239/34

Abstract: The present invention relates to particular radiolabeled Cannabinoid-1 (CB1) receptor modulators, and methods of using these modulators for labeling and diagnostic imaging of Cannabinoid-1 receptors in mammals, particularly humans. In addition, intermediates useful for the synthesis of the radiolabeled Cannabinoid-1 receptor modulators are also disclosed, as well as the processes for synthesizing the radiolabeled Cannabinoid-1 receptor modulators. Still further, formulations of the radiolabeled Cannabinoid-1 receptor compounds are described.

Abstract translation: 本发明涉及特定的放射性标记的大麻素-1（CB1）受体调节剂，以及使用这些调节剂用于哺乳动物，特别是人类中大麻素-1受体的标记和诊断成像的方法。 此外，还公开了可用于合成放射性标记的大麻素-1受体调节剂的中间体，以及合成放射性标记的大麻素-1受体调节剂的方法。 此外，描述了放射性标记的大麻素-1受体化合物的制剂。

公开(公告)号：US20050114573A1

公开(公告)日：2005-05-26

申请号：US10719484

申请日：2003-11-20

Applicant: Alex Chen ,  James Chen ,  Olympia Gluck ,  Theodore Harris ,  Minh-Ngoc Huynh ,  Gabriel Walder

Inventor： Alex Chen ,  James Chen ,  Olympia Gluck ,  Theodore Harris ,  Minh-Ngoc Huynh ,  Gabriel Walder

IPC: G06F3/06 ,  H04L12/24 ,  H04L29/06 ,  G06F13/12

CPC classification number: G06F3/0607 ,  G06F3/0605 ,  G06F3/0635 ,  G06F3/065

Abstract: A method to provide information from a first information storage and retrieval system to a second information storage and retrieval system. Applicants' method provides a first information storage and retrieval system, where that first information storage and retrieval system comprises (N) PPRC adapters and information, and provides a second information storage and retrieval system. The method generates and saves an Established Path Bitmap which recites each of the (N) PPRC adapters, and generates an Available Path Bitmap. If a PPRC adapter is in communication with the secondary information storage and retrieval system, then the method adds that adapter to the Available Path Bitmap. The Established Path Bitmap and the Available Path Bitmap are used for subsequent PPRC operations.

Abstract translation: 一种从第一信息存储和检索系统向第二信息存储和检索系统提供信息的方法。 申请人的方法提供了第一信息存储和检索系统，其中第一信息存储和检索系统包括（N）个PPRC适配器和信息，并提供第二信息存储和检索系统。 该方法生成并保存了一个已建立的路径位图，该位图会记录（N）个PPRC适配器中的每一个，并生成可用的路径位图。 如果PPRC适配器与辅助信息存储和检索系统通信，则该方法将该适配器添加到可用路径位图。 建立路径位图和可用路径位图用于后续的PPRC操作。

公开(公告)号：US20210121986A1

公开(公告)日：2021-04-29

申请号：US16660817

申请日：2019-10-23

Applicant: Alex Chen

Inventor： Alex Chen

IPC: B23K26/364 ,  B23K26/12 ,  B23K26/08 ,  B23K26/10 ,  B23K26/16 ,  B23K26/352

Abstract: The invention discloses a laser engraving machine, comprising a casing, a processing platform, a laser engraving head, a laser emitter, and a red light projector, the platform is disposed in the casing, and has a lateral moving trajectory and a longitudinal moving trajectory; the longitudinal trajectory is disposed on one side of the platform, the lateral trajectory is spanned thereon; one end of the lateral trajectory is connected with the longitudinal trajectory, the other is engaged with the platform side; the head is disposed on the lateral trajectory and can move along it. The invention has reasonable structure and convenient use. By adding a working panel, the device can process hard and soft material products, meeting more requirements; by changing the external fan to the built-in fan and smoke exhaust chamber, the installation is simple, the exhaust effect is better, while the proportion of damage during transportation is reduced.

公开(公告)号：US08443371B2

公开(公告)日：2013-05-14

申请号：US12372612

申请日：2009-02-17

Applicant: Alex Chen ,  Angqin Bai ,  Theodore Timothy Harris, Jr.

Inventor： Alex Chen ,  Angqin Bai ,  Theodore Timothy Harris, Jr.

IPC: G06F9/46

CPC classification number: G06F9/5011 ,  G06F9/524

Abstract: Provided are a system and program for managing operation requests using different resources. In one embodiment, a first queue is provided for operations which utilize a first resource of a first and second resource. A second queue is provided for operations which utilize the second resource. An operation is queued on the first queue until the first resource is acquired. The first resource is released if the second resource is not also acquired. The operation is queued on the second queue when the first resource is acquired but the second resource is not. In addition, the first resource is released until the operation acquires both the first resource and the second resource.

Abstract translation: 提供了一种用于使用不同资源来管理操作请求的系统和程序。 在一个实施例中，为使用第一和第二资源的第一资源的操作提供第一队列。 为使用第二资源的操作提供第二队列。 操作在第一个队列中排队，直到获取第一个资源。 如果没有获得第二个资源，则第一个资源被释放。 当获取第一个资源但第二个资源没有时，操作在第二个队列中排队。 此外，第一资源被释放，直到操作获取第一资源和第二资源。

公开(公告)号：US08240145B2

公开(公告)日：2012-08-14

申请号：US12391433

申请日：2009-02-24

Applicant: Gerald Dyck ,  John Czepak ,  Francesco Michele Caldarella ,  Dayao Alex Chen ,  Stig Ingemar Bratt

Inventor： Gerald Dyck ,  John Czepak ,  Francesco Michele Caldarella ,  Dayao Alex Chen ,  Stig Ingemar Bratt

IPC: F16H39/08 ,  F16H61/423

CPC classification number: F16H61/423 ,  F16H39/08 ,  F16H61/433 ,  F16H2039/005

Abstract: A hydrostatic assembly includes a pump having a yoke and an associated rotating group. The pump yoke has a bucket portion and an arm portion. At least one fluid passage extends through the pump yoke. The hydrostatic assembly also includes a motor having a yoke and an associated rotating group. The motor yoke also has a bucket portion and an arm portion. At least one fluid passage extends through the motor yoke. The arm portion of the pump yoke and the arm portion of the motor yoke have associated coupling portions for fluidly coupling the pump yoke to the motor yoke so that the at least one fluid passage in the pump yoke is in direct fluid communication with the at least one fluid passage in the motor yoke.

Abstract translation: 静压组件包括具有轭和相关联的旋转组的泵。 泵轭具有铲斗部分和臂部分。 至少一个流体通道延伸穿过泵轭。 静压组件还包括具有轭和相关联的旋转组的电动机。 马达轭也具有铲斗部分和臂部分。 至少一个流体通道延伸穿过马达轭。 泵轭的臂部分和电动机轭的臂部分具有相关联的联接部分，用于将泵轭流体耦合到电动机轭，使得泵轭中的至少一个流体通道与至少一个 电机轭中的一个流体通道。

公开(公告)号：US07916052B2

公开(公告)日：2011-03-29

申请号：US12501866

申请日：2009-07-13

Applicant: Alex Chen-Chu Yeh ,  Gerald Lothair Fudge

Inventor： Alex Chen-Chu Yeh ,  Gerald Lothair Fudge

IPC: H03M1/00

CPC classification number: H03M1/109 ,  H03M1/1245

Abstract: A system for characterizing a compressed sensing apparatus is described which broadly includes a random vector generator for generating an input vector, a waveform generator in communication with the random vector generator for converting the input vector into an analog signal, a compressed sensing apparatus in communication with the digital-to-analog converter for determining a digital bit stream from the analog signal, a serial-to-parallel converter for converting the digital bit stream into an input vector; and an electronic processor in communication with the random number generator and the serial-to-parallel converter configured for determining a compressed sensing matrix.

Abstract translation: 描述用于表征压缩感测装置的系统，其广泛地包括用于产生输入矢量的随机矢量发生器，与随机矢量发生器通信的波形发生器，用于将输入矢量转换为模拟信号;压缩感测装置，与 用于从模拟信号确定数字比特流的数模转换器，用于将数字比特流转换为输入向量的串并转换器; 以及与所述随机数发生器和串行到并行转换器通信的电子处理器，其被配置用于确定压缩的感测矩阵。