HMGI proteins in cancer
    6.
    发明授权
    HMGI proteins in cancer 失效
    HMGI蛋白在癌症

    公开(公告)号:US06171779B2

    公开(公告)日:2001-01-09

    申请号:US08679529

    申请日:1996-07-12

    IPC分类号: C12Q100

    摘要: The present invention pertains to a method for detecting HMGI-C or HMGI(Y) as a diagnostic marker for benign or malignant tumors using a probe for a sample from a patient that recognizes HMGI-C or HMGI(Y). The method comprises the steps of (a) contacting HMGI-C or HMGI(Y) from a sample from a patient with a probe which binds to HMGI-C or HMGI(Y); and (b) analyzing for HMGI-C or HMGI(Y) by detecting levels of the probe bound to the HMGI-C or HMGI(Y). The presence of HMGI-C or HMGI(Y) in the sample is positive for a benign or malignant tumor. The present invention also pertains to a method for detecting antibodies to HMGI-C or HMGI(Y) as a diagnostic marker for benign or malignant tumors. The present invention further pertains to a method for treating benign and malignant tumors in a patient by blocking the biological activity of HMGI-C or HMGI(Y). The present invention also pertains to a method for treating obesity in a patient by blocking the biological activity of HMGI-C or HMGI(Y).

    摘要翻译: 本发明涉及使用来自识别HMGI-C或HMGI(Y)的患者的样品的探针来检测HMGI-C或HMGI(Y)作为良性或恶性肿瘤的诊断标记物的方法。 该方法包括以下步骤:(a)将来自患者的样品的HMGI-C或HMGI(Y)与结合HMGI-C或HMGI(Y)的探针接触; 和(b)通过检测与HMGI-C或HMGI(Y)结合的探针的水平来分析HMGI-C或HMGI(Y)。 样品中HMGI-C或HMGI(Y)的存在对于良性或恶性肿瘤是阳性的。 本发明还涉及用于检测HMGI-C或HMGI(Y)的抗体作为良性或恶性肿瘤的诊断标记物的方法。 本发明还涉及通过阻断HMGI-C或HMGI(Y)的生物学活性来治疗患者的良性和恶性肿瘤的方法。 本发明还涉及通过阻断HMGI-C或HMGI(Y)的生物学活性来治疗患者肥胖的方法。