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    Skin depigmenting compositions comprising adapalene and at least one depigmenting active agent
    6.
    发明申请
    Skin depigmenting compositions comprising adapalene and at least one depigmenting active agent 审中-公开
    皮肤脱色组合物，其包含阿达帕林和至少一种脱色素活性剂

    公开(公告)号：US20050163731A1

    公开(公告)日：2005-07-28

    申请号：US11042519

    申请日：2005-01-26

    申请人： Isabelle Pelisson ,  Andre Jomard

    发明人： Isabelle Pelisson ,  Andre Jomard

    IPC分类号： A61K8/34 ,  A61K8/67 ,  A61K31/19 ,  A61K38/00 ,  A61Q19/02 ,  A61K7/42 ,  A61K7/135

    CPC分类号： A61K8/347 ,  A61K8/671 ,  A61Q19/02

    摘要： Topically applicable skin depigmenting compositions, suited for treatment of such hyperpigmentary disorders as melasma and chloasma, contain a thus effective amount of at least one skin depigmenting active agent, for example hydroquinone or 4-hydroxyanisole, in admixture with a depigmentation-accelerating amount of adapalene (6-[3-(1-adamantyl)-4-methoxyphenyl]-2-napthanoic acid), and optionally with at least one sunscreen, formulated into a topically applicable, physiologically acceptable medium therefor.

    摘要翻译： 适用于治疗黑斑病和黄褐斑等色素沉着过度症状的局部适用的皮肤色素沉着组合物含有如此有效量的至少一种皮肤脱色活性剂，例如氢醌或4-羟基苯甲醚，与褪色促进量的阿达帕林 （6- [3-（1-金刚烷基）-4-甲氧基苯基] -2-萘酸）和任选地与至少一种防晒剂一起配制成局部适用的生理学上可接受的培养基。

    Process for identifying RAR-receptor-antagonist compounds
    7.
    发明授权
    Process for identifying RAR-receptor-antagonist compounds 失效
    鉴定RAR受体拮抗剂化合物的方法

    公开(公告)号：US5827500A

    公开(公告)日：1998-10-27

    申请号：US665814

    申请日：1996-06-19

    申请人： Michel Demarchez ,  Andre Jomard

    发明人： Michel Demarchez ,  Andre Jomard

    IPC分类号： A61K49/00 ,  G01N31/00 ,  A61K31/19 ,  A61K31/59

    CPC分类号： A61K49/0006

    摘要： The present invention relates to a process for identifying RAR-antagonist molecules, characterized in that it comprises the following steps: (i) a sufficient amount of an RAR-agonist molecule is applied topically to a part of the skin of a mammal, (ii) a molecule capable of having an RAR-antagonist activity is administered systemically or topically to this same mammal, or to this same part of the skin of the mammal, before, during or after step (i), and (iii) the response on that part of the skin of the mammal thus treated is evaluated.

    摘要翻译： 本发明涉及一种鉴定RAR拮抗剂分子的方法，其特征在于其包括以下步骤：（i）将足量的RAR-激动剂分子局部施用于哺乳动物皮肤的一部分，（ii） ）在步骤（i）之前，期间或之后，对该相同的哺乳动物或哺乳动物的该皮肤的该部分皮肤系统地或局部地施用能够具有RAR-拮抗剂活性的分子，和（iii）对 评价这样处理的哺乳动物的皮肤部分。

    Process for identifying RXR-receptor-agonist compounds
    8.
    发明授权
    Process for identifying RXR-receptor-agonist compounds 失效
    识别RXR-受体 - 激动剂化合物的方法

    公开(公告)号：US5696104A

    公开(公告)日：1997-12-09

    申请号：US665866

    申请日：1996-06-19

    申请人： Michel Demarchez ,  Andre Jomard

    发明人： Michel Demarchez ,  Andre Jomard

    IPC分类号： A61K49/00 ,  A61K31/59 ,  A61K31/19 ,  A61K31/20

    CPC分类号： A61K49/0006

    摘要： The present invention relates to a process for identifying RXR-agonist molecules, characterized in that it comprises the following steps: (i) a sufficient amount of a compound which is an active ligand for at least one receptor of the super-family of steroidal/thyroidal receptors, other than an RXR-receptor-specific ligand, and which can heterodimerize with the RXRs, is applied topically to a part of the skin of a mammal, (ii) a molecule capable of having an RXR-agonist activity is administered systemically or topically to this same mammal, or to this same part of the skin of the mammal, before, during or after step (i), and (iii) the response on that part of the skin of the mammal thus treated is evaluated.

    摘要翻译： 本发明涉及一种鉴定RXR激动剂分子的方法，其特征在于其包括以下步骤：（i）足量的化合物，其为甾体/超氧化物歧化酶超家族的至少一种受体的活性配体， 不同于RXR受体特异性配体的甲状腺受体，可与RXR异源二聚化，局部应用于哺乳动物皮肤的一部分，（ii）能够具有RXR-激动剂活性的分子被全身施用 或局部给予该相同的哺乳动物，或在步骤（i）之前，期间或之后的哺乳动物皮肤的相同部分，和（iii）评估对该治疗的哺乳动物的该部分皮肤的反应。