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1.发明申请公开(公告)号：US20140206760A1
公开(公告)日：2014-07-24
申请号：US14226132
申请日：2014-03-26
申请人： Christopher Kallus , Mark Broenstrup , Andreas Evers , Anja Globisch , Herman Schreuder , Michael Wagner
发明人： Christopher Kallus , Mark Broenstrup , Andreas Evers , Anja Globisch , Herman Schreuder , Michael Wagner
IPC分类号： C07D413/12 , C07D267/00 , C07D273/02 , C07D273/01
CPC分类号： C07D273/01 , A61K31/395 , C07D267/00 , C07D273/02 , C07D413/12 , C07D413/14
摘要： The invention relates to compounds of the formula (I) which are inhibitors of activated thrombin-activable fibrinolysis inhibitor. The compounds of the formula I are suitable for producing medicaments for prophylaxis, secondary prevention and treatment of one or more disorders associated with thromboses, embolisms, hypercoaguability or fibrotic changes.
摘要翻译： 本发明涉及作为活化凝血酶激活性纤维蛋白溶解抑制剂抑制剂的式（I）化合物。 式I的化合物适用于制备用于预防，二次预防和治疗与血栓形成，栓塞，高渗透性或纤维变性相关的一种或多种病症的药物。
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公开(公告)号：US08580777B2
公开(公告)日：2013-11-12
申请号：US12996460
申请日：2009-05-22
申请人： Christopher Kallus , Mark Broenstrup , Andreas Evers , Anja Globisch , Herman Schreuder , Michael Wagner
发明人： Christopher Kallus , Mark Broenstrup , Andreas Evers , Anja Globisch , Herman Schreuder , Michael Wagner
IPC分类号： C07D413/14 , C07D273/01 , A61K31/553 , A61P7/00
CPC分类号： C07D273/01 , A61K31/395 , C07D267/00 , C07D273/02 , C07D413/12 , C07D413/14
摘要： The invention relates to compounds of the formula (I) which are inhibitors of activated thrombin-activable fibrinolysis inhibitor. The compounds of the formula I are suitable for producing medicaments for prophylaxis, secondary prevention and treatment of one or more disorders associated with thromboses, embolisms, hypercoagulability or fibrotic changes.
摘要翻译： 本发明涉及作为活化凝血酶激活性纤维蛋白溶解抑制剂抑制剂的式（I）化合物。 式I的化合物适用于制备用于预防，二次预防和治疗与血栓形成，栓塞，高凝状态或纤维变性相关的一种或多种病症的药物。
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公开(公告)号：US08389764B2
公开(公告)日：2013-03-05
申请号：US12480348
申请日：2009-06-08
申请人： Christopher Kallus , Mark Broenstrup , Werngard Czechtizky , Andreas Evers , Markus Follmann , Nis Halland , Herman Schreuder
发明人： Christopher Kallus , Mark Broenstrup , Werngard Czechtizky , Andreas Evers , Markus Follmann , Nis Halland , Herman Schreuder
IPC分类号： C07C275/00 , C07C273/00 , C07C331/00 , C07C381/00
CPC分类号： A61K31/4164 , A61K31/17 , A61K31/18 , A61K31/198 , A61K31/223 , A61K31/36 , A61K31/381 , A61K31/40 , A61K31/4184 , A61K31/44 , A61K31/4402 , A61K31/4406 , A61K31/4409 , A61K31/4453 , A61K31/4465 , A61K45/06 , C07C307/06 , C07D207/06 , C07D209/20 , C07D211/34 , C07D211/58 , C07D213/40 , C07D213/55 , C07D213/73 , C07D235/14 , C07D261/08 , C07D295/185 , C07D317/58 , C07D333/20 , C07D487/08 , A61K2300/00
摘要： The invention relates to compounds of the formula I as defined herein, which are inhibitors of activated thrombin-activatable fibrinolysis inhibitor. The compounds of the formula I are suitable for manufacturing medicaments for the prophylaxis, secondary prevention and therapy of one or more disorders which are associated with thromboses, embolisms, hypercoagulability or fibrotic changes.
摘要翻译： 本发明涉及本文定义的式I化合物，其为活化凝血酶可激活的纤维蛋白溶解抑制剂的抑制剂。 式I的化合物适用于制备用于预防，二次预防和治疗与血栓形成，栓塞，高凝状态或纤维变性相关的一种或多种病症的药物。
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公开(公告)号：US20100035930A1
公开(公告)日：2010-02-11
申请号：US12480348
申请日：2009-06-08
申请人： Christopher KALLUS , Mark BROENSTRUP , Werngard CZECHTIZKY , Andreas EVERS , Markus FOLLMANN , Nis HALLAND , Herman SCHREUDER
发明人： Christopher KALLUS , Mark BROENSTRUP , Werngard CZECHTIZKY , Andreas EVERS , Markus FOLLMANN , Nis HALLAND , Herman SCHREUDER
IPC分类号： A61K31/195 , A61K31/27 , A61K31/42 , A61K31/40 , A61K31/381 , A61K31/4402 , A61K31/44 , A61K31/445 , A61P7/00 , C07C271/22 , C07C229/12 , C07D261/08 , C07D207/09 , C07D333/22 , C07D213/56 , C07D211/56
CPC分类号： A61K31/4164 , A61K31/17 , A61K31/18 , A61K31/198 , A61K31/223 , A61K31/36 , A61K31/381 , A61K31/40 , A61K31/4184 , A61K31/44 , A61K31/4402 , A61K31/4406 , A61K31/4409 , A61K31/4453 , A61K31/4465 , A61K45/06 , C07C307/06 , C07D207/06 , C07D209/20 , C07D211/34 , C07D211/58 , C07D213/40 , C07D213/55 , C07D213/73 , C07D235/14 , C07D261/08 , C07D295/185 , C07D317/58 , C07D333/20 , C07D487/08 , A61K2300/00
摘要： The invention relates to compounds of the formula I as defined herein, which are inhibitors of activated thrombin-activatable fibrinolysis inhibitor. The compounds of the formula I are suitable for manufacturing medicaments for the prophylaxis, secondary prevention and therapy of one or more disorders which are associated with thromboses, embolisms, hypercoagulability or fibrotic changes.
摘要翻译： 本发明涉及本文定义的式I化合物，其为活化凝血酶可激活的纤维蛋白溶解抑制剂的抑制剂。 式I的化合物适用于制备用于预防，二次预防和治疗与血栓形成，栓塞，高凝状态或纤维变性相关的一种或多种病症的药物。
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公开(公告)号：US20130336893A1
公开(公告)日：2013-12-19
申请号：US13916757
申请日：2013-06-13
CPC分类号： C07K14/00 , A61K38/16 , A61K38/22 , A61K38/26 , A61K38/28 , A61K45/06 , C07K14/605 , Y02A50/401 , A61K2300/00
摘要： The present invention relates to exendin-4 peptide analogues and their medical use, for example in the treatment of disorders of the metabolic syndrome, including diabetes and obesity, as well as reduction of excess food intake.
摘要翻译： 本发明涉及毒蜥外泌肽-4肽类似物及其医疗用途，例如用于治疗代谢综合征疾病，包括糖尿病和肥胖症，以及减少过量的食物摄入。
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公开(公告)号：US08722655B2
公开(公告)日：2014-05-13
申请号：US14048339
申请日：2013-10-08
申请人： Christopher Kallus , Mark Broenstrup , Andreas Evers , Anja Globisch , Herman Schreuder , Michael Wagner
发明人： Christopher Kallus , Mark Broenstrup , Andreas Evers , Anja Globisch , Herman Schreuder , Michael Wagner
IPC分类号： C07D413/14 , C07D273/01 , A61K31/553 , A61P7/00
CPC分类号： C07D273/01 , A61K31/395 , C07D267/00 , C07D273/02 , C07D413/12 , C07D413/14
摘要： The invention relates to compounds of the formula (I) which are inhibitors of activated thrombin-activable fibrinolysis inhibitor. The compounds of the formula I are suitable for producing medicaments for prophylaxis, secondary prevention and treatment of one or more disorders associated with thromboses, embolisms, hypercoagulability or fibrotic changes.
摘要翻译： 本发明涉及作为活化凝血酶激活性纤维蛋白溶解抑制剂抑制剂的式（I）化合物。 式I的化合物适用于制备用于预防，二次预防和治疗与血栓形成，栓塞，高凝状态或纤维变性相关的一种或多种病症的药物。
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7.发明申请公开(公告)号：US20140100156A1
公开(公告)日：2014-04-10
申请号：US14049597
申请日：2013-10-09
申请人： Torsten HAACK , Michael WAGNER , Bernd HENKEL , Siegfried STENGELIN , Andreas EVERS , Martin BOSSART
发明人： Torsten HAACK , Michael WAGNER , Bernd HENKEL , Siegfried STENGELIN , Andreas EVERS , Martin BOSSART
IPC分类号： C07K14/605 , A61K38/28 , A61K45/06 , A61K38/26
CPC分类号： A61K38/26 , A61K38/00 , A61K38/2264 , A61K38/28 , A61K45/06 , C07K14/605 , Y02A50/401 , A61K2300/00
摘要： The present invention relates to exendin-4 derivatives and their medical use, for example in the treatment of disorders of the metabolic syndrome, including diabetes and obesity, as well as reduction of excess food intake.
摘要翻译： 本发明涉及毒蜥外泌肽-4衍生物及其医疗用途，例如用于治疗代谢综合征疾病，包括糖尿病和肥胖症，以及减少过量的食物摄入。
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8.发明申请公开(公告)号：US20140039011A1
公开(公告)日：2014-02-06
申请号：US14048339
申请日：2013-10-08
申请人： Christopher Kallus , Mark Broenstrup , Andreas Evers , Anja Globisch , Herman Schreuder , Michael Wagner
发明人： Christopher Kallus , Mark Broenstrup , Andreas Evers , Anja Globisch , Herman Schreuder , Michael Wagner
IPC分类号： C07D273/02 , C07D413/12 , C07D273/01
CPC分类号： C07D273/01 , A61K31/395 , C07D267/00 , C07D273/02 , C07D413/12 , C07D413/14
摘要： The invention relates to compounds of the formula (I) which are inhibitors of activated thrombin-activable fibrinolysis inhibitor. The compounds of the formula I are suitable for producing medicaments for prophylaxis, secondary prevention and treatment of one or more disorders associated with thromboses, embolisms, hypercoagulability or fibrotic changes.
摘要翻译： 本发明涉及作为活化凝血酶激活性纤维蛋白溶解抑制剂抑制剂的式（I）化合物。 式I的化合物适用于制备用于预防，二次预防和治疗与血栓形成，栓塞，高凝状态或纤维变性相关的一种或多种病症的药物。
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9.发明申请公开(公告)号：US20110178130A1
公开(公告)日：2011-07-21
申请号：US12996460
申请日：2009-05-22
申请人： Christopher Kallus , Mark Broenstrup , Andreas Evers , Anja Globisch , Herman Schreuder , Michael Wagner
发明人： Christopher Kallus , Mark Broenstrup , Andreas Evers , Anja Globisch , Herman Schreuder , Michael Wagner
IPC分类号： A61K31/395 , C07D273/01 , A61K31/4427 , C07D273/08 , A61P9/10 , A61P7/02 , A61P29/00 , A61P3/04 , A61P35/00 , A61P27/02 , A61P17/02
CPC分类号： C07D273/01 , A61K31/395 , C07D267/00 , C07D273/02 , C07D413/12 , C07D413/14
摘要： The invention relates to compounds of the formula (I) which are inhibitors of activated thrombin-activable fibrinolysis inhibitor. The compounds of the formula I are suitable for producing medicaments for prophylaxis, secondary prevention and treatment of one or more disorders associated with thromboses, embolisms, hypercoagulability or fibrotic changes.
摘要翻译： 本发明涉及作为活化凝血酶激活性纤维蛋白溶解抑制剂抑制剂的式（I）化合物。 式I的化合物适用于制备用于预防，二次预防和治疗与血栓形成，栓塞，高凝状态或纤维变性相关的一种或多种病症的药物。
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