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公开(公告)号：US20160326549A1
公开(公告)日：2016-11-10
申请号：US15053626
申请日：2016-02-25
申请人： Alexander DENNIG , Kurt FABER , Melanie Hall , Thomas Haas , Thomas Buelter , Stefan Gilch , Anja Thiessenhusen
发明人： Alexander DENNIG , Kurt FABER , Melanie Hall , Thomas Haas , Thomas Buelter , Stefan Gilch , Anja Thiessenhusen
CPC分类号： C12P5/00 , C12N9/0006 , C12N9/0065 , C12N9/0095 , C12P5/026 , C12Y111/02004 , C12Y118/01005
摘要： The present invention provides a microbial cell capable of producing at least one terminal alkene from at least one short chain fatty acid, wherein the cell is genetically modified to comprise at least a first genetic mutation that increases the expression relative to the wild type cell of an enzyme (E1) selected from the CYP152 peroxygenase family, and at least a second genetic mutation that increases the expression relative to the wild type cell of at least one NAD(P)+ oxidoreductase (E2) and the corresponding mediator protein, wherein the short chain fatty acid is a C4-C10 fatty acid.
摘要翻译： 本发明提供一种能够从至少一种短链脂肪酸产生至少一种末端烯烃的微生物细胞，其中所述细胞被遗传修饰为包括 - 至少第一种遗传突变，其增加相对于野生型细胞的表达 选自CYP152过氧化酶家族的酶（E 1）和至少一种增加相对于至少一种NAD（P）+氧化还原酶（E 2）的野生型细胞的表达的第二种遗传突变和相应的介体蛋白 ，其中短链脂肪酸是C 4 -C 10脂肪酸。
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公开(公告)号：US09005928B2
公开(公告)日：2015-04-14
申请号：US13812625
申请日：2011-07-20
CPC分类号： C12N15/78 , A01N43/16 , C12N9/1051 , C12N9/14 , C12N15/52 , C12N15/70 , C12N15/77 , C12P19/44 , C12Y306/04013 , Y02P20/52
摘要： The invention relates to cells and nucleic acids and also use thereof for producing rhamnolipids, and also methods for producing rhamnolipids.
摘要翻译： 本发明涉及细胞和核酸，以及其用于制备鼠李糖脂的用途，以及用于制备鼠李糖脂的方法。
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3.发明申请公开(公告)号：US20130035403A1
公开(公告)日：2013-02-07
申请号：US13509716
申请日：2010-10-19
IPC分类号： C12P19/44 , C12N1/19 , C12N1/15 , C12N15/52 , A61K8/92 , C12N9/10 , C12N9/02 , C12N9/14 , A61K47/26 , C12N5/10 , C12N15/63
CPC分类号： C12P19/44 , A61K31/704 , C12N9/0071 , C12N9/1029 , C12N9/1051 , C12P19/14
摘要： The invention relates to cells, nucleic acids, and enzymes, the use thereof for producing sophorolipids, and methods for producing sophorolipids.
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公开(公告)号：US20160177259A1
公开(公告)日：2016-06-23
申请号：US14969891
申请日：2015-12-15
申请人： Thomas HAAS , Thomas BUELTER , Martin DEMLER , Anja THIESSENHUSEN
发明人： Thomas HAAS , Thomas BUELTER , Martin DEMLER , Anja THIESSENHUSEN
摘要： A method of culturing at least one acetogenic bacteria, includes growing the bacteria in an aqueous medium comprising an amount of cysteine and/or cystine, wherein the cysteine and/or cystine concentration in the medium is maintained at a concentration of less than 0.20 g/L.
摘要翻译： 培养至少一种致生菌的方法包括在包含一定量的半胱氨酸和/或胱氨酸的水性介质中培养细菌，其中培养基中的半胱氨酸和/或胱氨酸浓度保持在小于0.20g / L.
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公开(公告)号：US20130130319A1
公开(公告)日：2013-05-23
申请号：US13812625
申请日：2011-07-20
IPC分类号： C12P19/44
CPC分类号： C12N15/78 , A01N43/16 , C12N9/1051 , C12N9/14 , C12N15/52 , C12N15/70 , C12N15/77 , C12P19/44 , C12Y306/04013 , Y02P20/52
摘要： The invention relates to cells and nucleic acids and also use thereof for producing rhamnolipids, and also methods for producing rhamnolipids.
摘要翻译： 本发明涉及细胞和核酸，以及其用于制备鼠李糖脂的用途，以及用于制备鼠李糖脂的方法。
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6.发明授权公开(公告)号：US09085787B2
公开(公告)日：2015-07-21
申请号：US14487765
申请日：2014-09-16
CPC分类号： C12P19/44 , A61K31/704 , C12N9/0071 , C12N9/1029 , C12N9/1051 , C12P19/14
摘要： The invention relates to cells, nucleic acids, and enzymes, the use thereof for producing sophorolipids, and methods for producing sophorolipids.
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7.发明授权Use of a protein homologous to a MeaB protein for increasing the enzymatic activity of a 3-hydroxycarboxylic acid-CoA mutase 有权使用与MeaB蛋白质同源的蛋白质来增加3-羟基羧酸-CoA变位酶的酶活性公开(公告)号：US08980594B2
公开(公告)日：2015-03-17
申请号：US13500041
申请日：2010-10-11
申请人： Liv Reinecke , Steffen Schaffer , Tim Koehler , Anja Thiessenhusen , Achim Marx , Markus Buchhaupt
发明人： Liv Reinecke , Steffen Schaffer , Tim Koehler , Anja Thiessenhusen , Achim Marx , Markus Buchhaupt
CPC分类号： C12P7/52 , C07K14/195 , C07K2319/00 , C12N9/90 , C12P7/42
摘要： The invention relates to the use of a protein homologous to a MeaB protein for increasing the enzymatic activity of a 3-hydroxycarboxylic acid-CoA mutase, a fusion protein comprising a 3-hydroxycarboxylic acid-CoA mutase and a protein sequence homologous to a MeaB protein and an enzymatic method for producing 2-hydroxyisobutryric acid.
摘要翻译： 本发明涉及使用与MeaB蛋白质同源的蛋白质来增加3-羟基羧酸-CoA变位酶的酶活性，包含3-羟基羧酸-CoA变位酶的融合蛋白和与MeaB蛋白质同源的蛋白质序列 以及用于生产2-羟基异丁酸的酶法。
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8.发明申请公开(公告)号：US20150056660A1
公开(公告)日：2015-02-26
申请号：US14487765
申请日：2014-09-16
IPC分类号： C12P19/44
CPC分类号： C12P19/44 , A61K31/704 , C12N9/0071 , C12N9/1029 , C12N9/1051 , C12P19/14
摘要： The invention relates to cells, nucleic acids, and enzymes, the use thereof for producing sophorolipids, and methods for producing sophorolipids.
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9.发明申请公开(公告)号：US20150056659A1
公开(公告)日：2015-02-26
申请号：US14487736
申请日：2014-09-16
IPC分类号： C12P19/44
CPC分类号： C12P19/44 , A61K31/704 , C12N9/0071 , C12N9/1029 , C12N9/1051 , C12P19/14
摘要： The invention relates to cells, nucleic acids, and enzymes, the use thereof for producing sophorolipids, and methods for producing sophorolipids.
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公开(公告)号：US09885060B2
公开(公告)日：2018-02-06
申请号：US15053626
申请日：2016-02-25
申请人： Alexander Dennig , Kurt Faber , Melanie Hall , Thomas Haas , Thomas Buelter , Stefan Gilch , Anja Thiessenhusen
发明人： Alexander Dennig , Kurt Faber , Melanie Hall , Thomas Haas , Thomas Buelter , Stefan Gilch , Anja Thiessenhusen
CPC分类号： C12P5/00 , C12N9/0006 , C12N9/0065 , C12N9/0095 , C12P5/026 , C12Y111/02004 , C12Y118/01005
摘要： The present invention provides a microbial cell capable of producing at least one terminal alkene from at least one short chain fatty acid, wherein the cell is genetically modified to comprise at least a first genetic mutation that increases the expression relative to the wild type cell of an enzyme (E1) selected from the CYP152 peroxygenase family, and at least a second genetic mutation that increases the expression relative to the wild type cell of at least one NAD(P)+ oxidoreductase (E2) and the corresponding mediator protein, wherein the short chain fatty acid is a C4-C10 fatty acid.
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