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公开(公告)号：US20230364183A1
公开(公告)日：2023-11-16
申请号：US18177642
申请日：2023-03-02
Applicant: Fred Hutchinson Cancer Center , Blaze Bioscience, Inc.
Inventor： James OLSON , Andrew David Strand , Emily June Girard , Roland Strong , Christopher Mehlin , Colin Correnti , Natalie Nairn
IPC: A61K47/66 , A61K47/65 , A61K38/17 , A61K47/64 , C07K14/435 , A61P19/04 , A61K51/08 , A61K49/00 , A61P19/02
CPC classification number: A61K38/17 , A61K47/64 , A61K47/65 , A61K47/66 , A61K49/0032 , A61K49/0056 , A61K51/08 , A61P19/02 , A61P19/04 , C07K14/435
Abstract: Peptides that home, target, migrate to, are directed to, are retained by, or accumulate in and/or binds to the cartilage of a subject are disclosed. Pharmaceutical compositions and uses for peptides or peptide-active agent complexes comprising such peptides are also disclosed. Such compositions can be formulated for targeted delivery of a drug to a target region, tissue, structure or cell in the cartilage. Targeted compositions of the disclosure can deliver peptide or peptide-active agent complexes to target regions, tissues, structures or cells targeted by the peptide.
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公开(公告)号：US20230211000A1
公开(公告)日：2023-07-06
申请号：US17888072
申请日：2022-08-15
Applicant: Blaze Bioscience, Inc.
Inventor： Stacey J. Hansen , Claudia Jochheim , Dennis M. Miller , Natalie Winblade Nairn , Julia E. Novak , Mark R. Stroud , Valorie R. Wiss , Kelly Byrnes-Blake , Scott Presnell
IPC: A61K47/64 , A61K47/65 , A61P19/02 , A61P13/12 , A61B5/00 , A61B6/03 , A61B6/00 , A61K49/00 , A61K51/08 , C07K14/435 , C07K14/47 , C07K16/24
CPC classification number: A61K47/6415 , A61K47/65 , A61P19/02 , A61P13/12 , A61B5/0071 , A61B6/037 , A61B6/4057 , A61B6/481 , A61K49/0056 , A61K49/0058 , A61K51/08 , C07K14/43518 , C07K14/43522 , C07K14/4726 , C07K16/244 , C07K16/248 , A61B5/055
Abstract: Peptides that home, target, migrate to, are directed to, are retained by, or accumulate in and/or bind to the cartilage or kidney of a subject are disclosed. Pharmaceutical compositions and uses for peptides or peptide-active agent complexes comprising such peptides are also disclosed. Such compositions can be formulated for targeted delivery of an active agent to a target region, tissue, structure or cell in the cartilage. Targeted compositions of the disclosure can deliver peptide or peptide-active agent complexes to target regions, tissues, structures, or cells targeted by the peptide.
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公开(公告)号：US20210171589A1
公开(公告)日：2021-06-10
申请号：US16980787
申请日：2019-03-15
Applicant: BLAZE BIOSCIENCE, INC.
Inventor： Natalie Winblade NAIRN , Scott PRESNELL , Claudia JOCHHEIM , Mark STROUD
IPC: C07K14/47 , A61K47/64 , A61K47/65 , A61K51/08 , A61P19/04 , A61P19/02 , A61P13/12 , A61K49/00 , A61K9/00
Abstract: Truncated, variant, or mutated peptides that home, target, migrate to, are directed to, are retained by, or accumulate in and/or bind to the cartilage or kidney of a subject are disclosed. Pharmaceutical compositions and uses for truncated or mutated peptides or truncated or mutated peptide-active agent complexes comprising such peptides are also disclosed. Such compositions can be formulated for targeted delivery of an active agent to a target region, tissue, structure or cell in the cartilage. Targeted compositions of the disclosure can deliver truncated or mutated peptide or truncated, variant, or mutated peptides or peptide-active agent complexes to target regions, tissues, structures or cells targeted by the peptide.
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4.发明申请公开(公告)号：US20210130419A1
公开(公告)日：2021-05-06
申请号：US16954190
申请日：2018-12-18
Applicant: BLAZE BIOSCIENCE, INC.
Inventor： Natalie Winblade NAIRN , Julia NOVAK , Kenneth GRABSTEIN , Dennis MILLER , Greg T. HERMANSON , Scott R. PRESNELL , Mark STROUD
Abstract: Peptide-immuno-oncology agent complexes (“peptide-I/O complexes”) that can home, target, migrate to, are directed to, are retained by, accumulate in, penetrate, or bind to the tumor microenvironment, tumor tissues, or cells or compartments or cytosol of cells thereof, or any combination thereof, are disclosed. Additionally disclosed are peptide-I/O complexes that can cross the blood-brain barrier. Pharmaceutical compositions and uses for peptide-I/O complexes comprising such peptides are also disclosed. Such compositions can be formulated for targeted delivery of an immuno-oncology agent (“I/O”) to the tumor microenvironment. Targeted compositions of the disclosure can deliver peptide-I/O complexes to target regions, tissues, structures or cells targeted by the peptide.
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5.发明公开公开(公告)号：US20240309058A1
公开(公告)日：2024-09-19
申请号：US18518088
申请日：2023-11-22
Applicant: Blaze Bioscience, Inc.
Inventor： Natalie Winblade NAIRN , Julia NOVAK , Kenneth GRABSTEIN , Dennis MILLER , Greg T. HERMANSON , Scott R. PRESNELL , Mark STROUD
Abstract: Peptide-immuno-oncology agent complexes (“peptide-I/O complexes”) that can home, target, migrate to, are directed to, are retained by, accumulate in, penetrate, or bind to the tumor microenvironment, tumor tissues, or cells or compartments or cytosol of cells thereof, or any combination thereof, are disclosed. Additionally disclosed are peptide-I/O complexes that can cross the blood-brain barrier. Pharmaceutical compositions and uses for peptide-I/O complexes comprising such peptides are also disclosed. Such compositions can be formulated for targeted delivery of an immuno-oncology agent (“I/O”) to the tumor microenvironment. Targeted compositions of the disclosure can deliver peptide-I/O complexes to target regions, tissues, structures or cells targeted by the peptide.
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Patent Agency Ranking
公开(公告)号：US20240280490A1
公开(公告)日：2024-08-22
申请号：US18012621
申请日：2021-06-25
Applicant: Blaze Bioscience, Inc.
Inventor： Jeffrey Perry , David Kittle , Julia Novak , Teri Dee Koller , Dennis Miller
IPC: G01N21/64 , A61B1/00 , A61B1/04 , A61B1/06 , G01J1/42 , G02B21/00 , G02B21/36 , G02B27/00 , G06T5/50 , H04N7/18 , H04N23/11 , H04N23/50 , H04N23/55 , H04N23/56
CPC classification number: G01N21/6456 , A61B1/0005 , A61B1/043 , A61B1/0638 , G01J1/4257 , G01N21/6428 , G02B21/0032 , G02B21/0076 , G02B21/36 , G06T5/50 , H04N23/11 , H04N23/55 , H04N23/555 , H04N23/56 , G01N2021/6439 , G01N2201/0636 , G02B21/0012 , G02B27/0018 , G06T2207/10048 , G06T2207/10064 , G06T2207/20221 , G06T2207/20224 , G06T2207/30096
Abstract: Disclosed herein are imaging systems and methods for simultaneous near-infrared light or infrared and visible light imaging of a sample comprising: a detector to form a fluorescence image of the sample and a visible image of the sample; a light source configured to emit near infrared or infrared light to induce fluorescence from the sample; and a plurality of optics arranged to direct the near infrared or infrared light toward the sample and form the fluorescence image of the sample and the visible light image of the sample on the detector, including methods to reduce ghosting, shadowing and motion artifacts.
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公开(公告)号：US20230257428A1
公开(公告)日：2023-08-17
申请号：US18160954
申请日：2023-01-27
Applicant: Blaze Bioscience, Inc.
Inventor： Dennis M. Miller , Kelly Byrnes-Blake
IPC: C07K14/435 , A61K49/00 , A61K45/06 , A61P35/00 , A61K9/00
CPC classification number: C07K14/43522 , A61K49/0032 , A61K49/0056 , A61K45/06 , A61P35/00 , A61K9/0019 , A61K38/00
Abstract: Compositions, formulations, and kits comprising chlorotoxin conjugate compounds are provided, including native and modified variants of chlorotoxin peptide conjugated to reporter molecules including fluorescent dyes or conjugated to cytotoxic agents. Dosing and pharmacokinetic profiles for therapeutic and diagnostic applications using chlorotoxin conjugate compounds are provided.
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公开(公告)号：US20200222549A1
公开(公告)日：2020-07-16
申请号：US16621173
申请日：2018-06-14
Applicant: BLAZE BIOSCIENCE, INC.
Inventor： Julia E. Novak , Natalie Winblade Narin , Dennis M. Miller
Abstract: Peptides that home, target, migrate to, are directed to, are retained by, or accumulate in and/or bind to the kidney of a subject are disclosed. Pharmaceutical compositions and uses for peptides or peptide-active agent complexes comprising such peptide-active agent conjugates are also disclosed. Such compositions can be formulated for targeted delivery of an active agent to a target region, tissue, structure or cell in the kidney. Targeted compositions of the disclosure can deliver peptide or peptide-active agent complexes to targe regions, tissues, structures, or cells targeted by the peptide.
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公开(公告)号：US20200069812A1
公开(公告)日：2020-03-05
申请号：US16492914
申请日：2018-03-16
Applicant: BLAZE BIOSCIENCE, INC.
Inventor： Julia E. Novak , Natalie Winblade Naim , Dennis M. Miller , Scott Presnell , Claudia Jochheim , Mark Stroud
IPC: A61K47/64 , C07K16/24 , C07K14/435 , C07K14/47 , A61K49/00 , A61P19/02 , A61K51/08 , A61K47/65 , A61P13/12 , A61B5/00 , A61B6/03 , A61B6/00
Abstract: Peptides that home, target, migrate to, are directed to, are retained by, or accumulate in and/or bind to the cartilage or kidney of a subject are disclosed. Pharmaceutical compositions and uses for peptides or peptide-active agent complexes comprising such peptides are also disclosed. Such compositions can be formulated for targeted delivery of an active agent to a target region, tissue, structure or cell in the cartilage. Targeted compositions of the disclosure can deliver peptide or peptide-active agent complexes to target regions, tissues, structures, or cells targeted by the peptide.
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公开(公告)号：US20190161523A1
公开(公告)日：2019-05-30
申请号：US16091692
申请日：2017-04-12
Applicant: BLAZE BiOSCIENCE, INC.
Inventor： Dennis M. Miller , Kelly Byrnes-Blake
IPC: C07K14/435 , A61K49/00 , A61K9/00 , A61P35/00
Abstract: Compositions, formulations, and kits comprising chlorotoxin conjugate compounds are provided, including native and modified variants of chlorotoxin peptide conjugated to reporter molecules including fluorescent dyes or conjugated to cytotoxic agents. Dosing and pharmacokinetic profiles for therapeutic and diagnostic applications using chlorotoxin conjugate compounds are provided.
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