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公开(公告)号：US20230211000A1
公开(公告)日：2023-07-06
申请号：US17888072
申请日：2022-08-15
发明人： Stacey J. Hansen , Claudia Jochheim , Dennis M. Miller , Natalie Winblade Nairn , Julia E. Novak , Mark R. Stroud , Valorie R. Wiss , Kelly Byrnes-Blake , Scott Presnell
IPC分类号： A61K47/64 , A61K47/65 , A61P19/02 , A61P13/12 , A61B5/00 , A61B6/03 , A61B6/00 , A61K49/00 , A61K51/08 , C07K14/435 , C07K14/47 , C07K16/24
CPC分类号： A61K47/6415 , A61K47/65 , A61P19/02 , A61P13/12 , A61B5/0071 , A61B6/037 , A61B6/4057 , A61B6/481 , A61K49/0056 , A61K49/0058 , A61K51/08 , C07K14/43518 , C07K14/43522 , C07K14/4726 , C07K16/244 , C07K16/248 , A61B5/055
摘要： Peptides that home, target, migrate to, are directed to, are retained by, or accumulate in and/or bind to the cartilage or kidney of a subject are disclosed. Pharmaceutical compositions and uses for peptides or peptide-active agent complexes comprising such peptides are also disclosed. Such compositions can be formulated for targeted delivery of an active agent to a target region, tissue, structure or cell in the cartilage. Targeted compositions of the disclosure can deliver peptide or peptide-active agent complexes to target regions, tissues, structures, or cells targeted by the peptide.
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公开(公告)号：US20160096869A1
公开(公告)日：2016-04-07
申请号：US14855355
申请日：2015-09-15
发明人： Stacey J. Hansen , Claudia Jochheim , Dennis M. Miller , Natalie Nairn , Julia E. Novak , Mark Stroud , Valorie R. Wiss , Kelly Byrnes-Blake
IPC分类号： C07K14/435 , A61K49/00 , A61K47/48
CPC分类号： C07K14/43522 , A61K9/0019 , A61K9/19 , A61K38/00 , A61K47/26 , A61K47/6415 , A61K49/0032 , A61K49/0056 , C12N9/96 , G01N33/5743
摘要： Compositions, formulations and kits comprising chlorotoxin conjugate compounds are provided, including native and modified variants of chlorotoxin peptide conjugated to reporter molecules including fluorescent dyes. Methods of detecting and treating cancers and tumors with chlorotoxin conjugate compounds are also provided, including methods of imaging tumor tissues and cells. Dosing and pharmacokinetic profiles for therapeutic and diagnostic applications using chlorotoxin conjugate compounds are also provided.
摘要翻译： 提供了包含蝎氯毒素偶联化合物的组合物，制剂和试剂盒，包括与包括荧光染料在内的报道分子缀合的蝎氯毒素肽的天然和修饰变体。 还提供了检测和治疗与蝎氯毒素偶联化合物的癌症和肿瘤的方法，包括成像肿瘤组织和细胞的方法。 还提供了使用氯毒素缀合化合物的治疗和诊断应用的给药和药代动力学特征。
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公开(公告)号：US20230257428A1
公开(公告)日：2023-08-17
申请号：US18160954
申请日：2023-01-27
IPC分类号： C07K14/435 , A61K49/00 , A61K45/06 , A61P35/00 , A61K9/00
CPC分类号： C07K14/43522 , A61K49/0032 , A61K49/0056 , A61K45/06 , A61P35/00 , A61K9/0019 , A61K38/00
摘要： Compositions, formulations, and kits comprising chlorotoxin conjugate compounds are provided, including native and modified variants of chlorotoxin peptide conjugated to reporter molecules including fluorescent dyes or conjugated to cytotoxic agents. Dosing and pharmacokinetic profiles for therapeutic and diagnostic applications using chlorotoxin conjugate compounds are provided.
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公开(公告)号：US20190161523A1
公开(公告)日：2019-05-30
申请号：US16091692
申请日：2017-04-12
IPC分类号： C07K14/435 , A61K49/00 , A61K9/00 , A61P35/00
摘要： Compositions, formulations, and kits comprising chlorotoxin conjugate compounds are provided, including native and modified variants of chlorotoxin peptide conjugated to reporter molecules including fluorescent dyes or conjugated to cytotoxic agents. Dosing and pharmacokinetic profiles for therapeutic and diagnostic applications using chlorotoxin conjugate compounds are provided.
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公开(公告)号：US12048750B2
公开(公告)日：2024-07-30
申请号：US17888072
申请日：2022-08-15
发明人： Stacey J. Hansen , Claudia Jochheim , Dennis M. Miller , Natalie Winblade Nairn , Julia E. Novak , Mark R. Stroud , Valorie R. Wiss , Kelly Byrnes-Blake , Scott Presnell
IPC分类号： A61K38/00 , A61B5/00 , A61B6/00 , A61B6/03 , A61B6/40 , A61K47/64 , A61K47/65 , A61K49/00 , A61K51/08 , A61P13/12 , A61P19/02 , C07K14/435 , C07K14/47 , C07K16/24 , A61B5/055 , A61B8/08
CPC分类号： A61K47/6415 , A61B5/0071 , A61B6/037 , A61B6/4057 , A61B6/481 , A61K47/65 , A61K49/0056 , A61K49/0058 , A61K51/08 , A61P13/12 , A61P19/02 , C07K14/43518 , C07K14/43522 , C07K14/4726 , C07K16/244 , C07K16/248 , A61B5/055 , A61B8/481 , A61B2505/05 , C07K2319/30 , C07K2319/33 , C07K2319/50
摘要： Peptides that home, target, migrate to, are directed to, are retained by, or accumulate in and/or bind to the cartilage or kidney of a subject are disclosed. Pharmaceutical compositions and uses for peptides or peptide-active agent complexes comprising such peptides are also disclosed. Such compositions can be formulated for targeted delivery of an active agent to a target region, tissue, structure or cell in the cartilage. Targeted compositions of the disclosure can deliver peptide or peptide-active agent complexes to target regions, tissues, structures, or cells targeted by the peptide.
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公开(公告)号：US11559580B1
公开(公告)日：2023-01-24
申请号：US17409661
申请日：2021-08-23
发明人： Stacey J. Hansen , Claudia Jochheim , Dennis M. Miller , Natalie Winblade Nairn , Julia E. Novak , Mark R. Stroud , Valorie R. Wiss , Kelly Byrnes-Blake , Scott Presnell
IPC分类号： A61K38/00 , A61K47/64 , A61K47/65 , A61P19/02 , A61P13/12 , A61B5/00 , A61B6/03 , A61B6/00 , A61K49/00 , A61K51/08 , C07K14/435 , C07K14/47 , C07K16/24 , A61B5/055 , A61B8/08
摘要： Peptides that home, target, migrate to, are directed to, are retained by, or accumulate in and/or bind to the cartilage or kidney of a subject are disclosed. Pharmaceutical compositions and uses for peptides or peptide-active agent complexes comprising such peptides are also disclosed. Such compositions can be formulated for targeted delivery of an active agent to a target region, tissue, structure or cell in the cartilage. Targeted compositions of the disclosure can deliver peptide or peptide-active agent complexes to target regions, tissues, structures, or cells targeted by the peptide.
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