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    Method for predicting congenital heart defect
    1.
    发明授权
    Method for predicting congenital heart defect 有权

    公开(公告)号：US10745754B2

    公开(公告)日：2020-08-18

    申请号：US15039589

    申请日：2014-11-25

    申请人： BIOSCREENING AND DIAGNOSTICS LLC

    发明人： Ray O. Bahado-Singh

    IPC分类号： C12Q1/6883

    摘要： Particular aspects of the invention confirm significant differences in methylation of cytosine bases in many loci throughout the genome in cases of congenital heart defect (CHD) compared to normal cases without CHD. Additional aspects provide novel methods for the prediction of congenital heart defects that can be applied to embryos, fetuses, newborns and different stages of postnatal life including childhood and any time in later postnatal life, is disclosed. The method is applicable not only to deoxyribonucleic acid (DNA) found in body fluids such as blood, urine, sputum, amniotic fluid and other tissues of affected individuals in pre- and post-natal life. Statistical techniques for estimating an individual's risk of having CHD by comparing the degree of methylation of specific cytosine loci throughout the DNA in an individual being tested and comparing this to the percentage of cytosine at sites in two populations of individuals: one with CHD and the other a reference population of normal cases without CHD, are described. Individual risk for having specific types of CHD or CHD overall can also be determined based on the invention.

    EARLY TRIMESTER SCREENING FOR EARLY- AND LATE-ONSET PREECLAMPSIA
    2.
    发明申请
    EARLY TRIMESTER SCREENING FOR EARLY- AND LATE-ONSET PREECLAMPSIA 审中-公开
    早期和晚期预防性早期切除筛查

    公开(公告)号：US20150087553A1

    公开(公告)日：2015-03-26

    申请号：US14394167

    申请日：2013-04-12

    申请人： Bioscreening and Diagnostics, LLC

    发明人： Ray O. Bahado-Singh ,  Kypros Nicolaides

    IPC分类号： G01N33/68 ,  G01N33/50

    CPC分类号： G01N33/689 ,  G01N33/50 ,  G01N33/6812 ,  G01N2800/368 ,  G01N2800/50

    摘要： The present invention is directed to methods for predicting a pregnant woman's risk of developing early-onset preeclampsia or late-onset preeclampsia. The methods are based on measuring one or more metabolites obtained from a pregnant woman's bodily fluid, such as blood or urine, which were found to be predictive of early-onset preeclampsia and late-onset preeclampsia.

    摘要翻译： 本发明涉及用于预测孕妇发展早发型先兆子痫或迟发性先兆子痫的风险的方法。 这些方法基于测量从孕妇的体液（例如血液或尿液）获得的一种或多种代谢物，其被发现可预测早发型先兆子痫和晚发型先兆子痫。

    Method for Predicting Congenital Heart Defect
    4.
    发明申请
    Method for Predicting Congenital Heart Defect 审中-公开

    公开(公告)号：US20170166965A1

    公开(公告)日：2017-06-15

    申请号：US15039589

    申请日：2014-11-25

    申请人： William Beaumont Hospital ,  BIOSCREENING AND DIAGNOSTICS LLC

    发明人： Ray O. Bahado-Singh

    IPC分类号： C12Q1/68

    摘要： Particular aspects of the invention confirm significant differences in methylation of cytosine bases in many loci throughout the genome in cases of congenital heart defect (CHD) compared to normal cases without CHD. Additional aspects provide novel methods for the prediction of congenital heart defects that can be applied to embryos, fetuses, newborns and different stages of postnatal life including childhood and any time in later postnatal life, is disclosed. The method is applicable not only to deoxyribonucleic acid (DNA) found in body fluids such as blood, urine, sputum, amniotic fluid and other tissues of affected individuals in pre- and post-natal life. Statistical techniques for estimating an individual's risk of having CHD by comparing the degree of methylation of specific cytosine loci throughout the DNA in an individual being tested and comparing this to the percentage of cytosine at said sites in two populations of individuals: one with CHD and the other a reference population of normal cases without CHD, are described. Individual risk for having specific types of CHD or CHD overall can also be determined based on the invention.