公开(公告)号：US20160228601A1

公开(公告)日：2016-08-11

申请号：US14838213

申请日：2015-08-27

申请人： Yuehua He ,  Aniko Takacs-Cox ,  Anthony BOey ,  Brent` Zaluski ,  Roger A. Smith ,  Audrey A. Deschamps ,  Rui Avelar

发明人： Yuehua He ,  Aniko Takacs-Cox ,  Anthony BOey ,  Brent` Zaluski ,  Roger A. Smith ,  Audrey A. Deschamps ,  Rui Avelar

IPC分类号： A61L26/00 ,  C08G65/00 ,  C08J3/075 ,  C07D403/14

CPC分类号： A61L26/0019 ,  A61K9/0024 ,  A61K9/06 ,  A61K47/34 ,  A61L24/0015 ,  A61L24/0031 ,  A61L24/0042 ,  A61L26/0066 ,  A61L26/008 ,  A61L26/009 ,  A61L31/145 ,  A61L31/148 ,  A61L31/16 ,  A61L2300/00 ,  A61L2300/204 ,  A61L2300/402 ,  C07D403/14 ,  C08G65/00 ,  C08G65/3312 ,  C08G65/3324 ,  C08G65/33317 ,  C08G65/33337 ,  C08G65/33368 ,  C08G65/3342 ,  C08G65/337 ,  C08J3/075 ,  C08J2371/00 ,  C08L2203/02

摘要： Disclosed are hydrogel compositions formed by the mixture of a tetramethylmethane substituted with one or more polyethylene glycols, and wherein each polyethylene glycol substituent is independently further substituted with one or more electrophilic groups, and a tetramethylmethane substituted with one or more polyethylene glycols, and wherein each polyethylene glycol substituent is independently further substituted with one or more nucleophilic groups. Disclosed are also methods of preparing the above hydrogels. The hydrogel compositions can further comprise pharmaceuticals, such as analgesics or local anesthetics. Disclosed are also methods of sealing a wound, preventing post-surgical adhesion, and reducing post-surgical pain using the disclosed hydrogels.

公开(公告)号：US09125814B2

公开(公告)日：2015-09-08

申请号：US12428411

申请日：2009-04-22

申请人： Yuehua He ,  Aniko Takacs-Cox ,  Anthony Boey ,  Brent Zaluski ,  Roger A. Smith ,  Audrey A. Deschamps ,  Rui Avelar

发明人： Yuehua He ,  Aniko Takacs-Cox ,  Anthony Boey ,  Brent Zaluski ,  Roger A. Smith ,  Audrey A. Deschamps ,  Rui Avelar

IPC分类号： A61K9/10 ,  A61K38/20 ,  A61K38/48 ,  A61K38/16 ,  A61K31/445 ,  A61K31/4025 ,  A61K31/10 ,  A61K31/08 ,  C07D403/14 ,  C07C317/00 ,  C07C43/04 ,  A61K9/06 ,  A61K9/00 ,  A61K47/34 ,  A61L24/00 ,  A61L26/00 ,  A61L31/14 ,  A61L31/16 ,  C08G65/331 ,  C08G65/332 ,  C08G65/333 ,  C08G65/334 ,  C08G65/337

CPC分类号： A61L26/0019 ,  A61K9/0024 ,  A61K9/06 ,  A61K47/34 ,  A61L24/0015 ,  A61L24/0031 ,  A61L24/0042 ,  A61L26/0066 ,  A61L26/008 ,  A61L26/009 ,  A61L31/145 ,  A61L31/148 ,  A61L31/16 ,  A61L2300/00 ,  A61L2300/204 ,  A61L2300/402 ,  C07D403/14 ,  C08G65/00 ,  C08G65/3312 ,  C08G65/3324 ,  C08G65/33317 ,  C08G65/33337 ,  C08G65/33368 ,  C08G65/3342 ,  C08G65/337 ,  C08J3/075 ,  C08J2371/00 ,  C08L2203/02

摘要： Disclosed are hydrogel compositions formed by the mixture of a tetramethylmethane substituted with one or more polyethylene glycols, and wherein each polyethylene glycol substituent is independently further substituted with one or more electrophilic groups, and a tetramethylmethane substituted with one or more polyethylene glycols, and wherein each polyethylene glycol substituent is independently further substituted with one or more nucleophilic groups. Disclosed are also methods of preparing the above hydrogels. The hydrogel compositions can further comprise pharmaceuticals, such as analgesics or local anesthetics. Disclosed are also methods of sealing a wound, preventing post-surgical adhesion, and reducing post-surgical pain using the disclosed hydrogels.

摘要翻译： 公开了由一个被一个或多个聚乙二醇取代的四甲基甲烷的混合物形成的水凝胶组合物，其中每个聚乙二醇取代基独立地被一个或多个亲电基团进一步取代，和被一个或多个聚乙二醇取代的四甲基甲烷， 聚乙二醇取代基独立地被一个或多个亲核基团进一步取代。 还公开了制备上述水凝胶的方法。 水凝胶组合物可以进一步包含药物，例如止痛剂或局部麻醉剂。 还公开了使用所公开的水凝胶密封伤口，防止手术后粘连和减少手术后疼痛的方法。

公开(公告)号：US20090324720A1

公开(公告)日：2009-12-31

申请号：US12428411

申请日：2009-04-22

申请人： Yuehua He ,  Aniko Takacs-Cox ,  Anthony Boey ,  Brent Zaluski ,  Roger A. Smith ,  Audrey A. Deschamps ,  Rui Avelar

发明人： Yuehua He ,  Aniko Takacs-Cox ,  Anthony Boey ,  Brent Zaluski ,  Roger A. Smith ,  Audrey A. Deschamps ,  Rui Avelar

IPC分类号： A61K9/10 ,  A61K38/20 ,  A61K38/48 ,  A61K38/16 ,  A61K31/445 ,  A61K31/4025 ,  A61K31/10 ,  A61K31/08 ,  C07D403/14 ,  C07C317/00 ,  C07C43/04

CPC分类号： A61L26/0019 ,  A61K9/0024 ,  A61K9/06 ,  A61K47/34 ,  A61L24/0015 ,  A61L24/0031 ,  A61L24/0042 ,  A61L26/0066 ,  A61L26/008 ,  A61L26/009 ,  A61L31/145 ,  A61L31/148 ,  A61L31/16 ,  A61L2300/00 ,  A61L2300/204 ,  A61L2300/402 ,  C07D403/14 ,  C08G65/00 ,  C08G65/3312 ,  C08G65/3324 ,  C08G65/33317 ,  C08G65/33337 ,  C08G65/33368 ,  C08G65/3342 ,  C08G65/337 ,  C08J3/075 ,  C08J2371/00 ,  C08L2203/02

摘要： Disclosed are hydrogel compositions formed by the mixture of a tetramethylmethane substituted with one or more polyethylene glycols, and wherein each polyethylene glycol substituent is independently further substituted with one or more electrophilic groups, and a tetramethylmethane substituted with one or more polyethylene glycols, and wherein each polyethylene glycol substituent is independently further substituted with one or more nucleophilic groups. Disclosed are also methods of preparing the above hydrogels. The hydrogel compositions can further comprise pharmaceuticals, such as analgesics or local anesthetics. Disclosed are also methods of sealing a wound, preventing post-surgical adhesion, and reducing post-surgical pain using the disclosed hydrogels.

摘要翻译： 公开了由一个被一个或多个聚乙二醇取代的四甲基甲烷的混合物形成的水凝胶组合物，其中每个聚乙二醇取代基独立地被一个或多个亲电基团进一步取代，和被一个或多个聚乙二醇取代的四甲基甲烷， 聚乙二醇取代基独立地被一个或多个亲核基团进一步取代。 还公开了制备上述水凝胶的方法。 水凝胶组合物可以进一步包含药物，例如止痛剂或局部麻醉剂。 还公开了使用所公开的水凝胶密封伤口，防止手术后粘连和减少手术后疼痛的方法。