公开(公告)号：US20240342099A1

公开(公告)日：2024-10-17

申请号：US18681845

申请日：2022-08-04

申请人： Massachusetts Institute of Technology ,  The Brigham and Women's Hospital, Inc. ,  Novo Nordisk A/S

发明人： Carlo Giovanni Traverso ,  Declan Gwynne ,  Jacob Wainer ,  Graham Arrick ,  Jesper Windum ,  Kuldeep Sanger ,  Adam Bohr ,  Brian Mouridsen ,  Nikolaj Eusebius Jakobsen ,  Morten Revsgaard Frederiksen ,  Jens Lolle Laursen ,  Ludwig Erik Aguilar

IPC分类号： A61K9/48

CPC分类号： A61K9/4808

摘要： An ingestible device may include one or more deployable limbs configured to orient the ingestible device in a desired orientation. The one or more limbs may be attached to body of the device and wrap around the device in an initial configuration (e.g., prior to deployment of the one or more limbs). The one or more limbs may be configured to deploy when exposed to a predetermined condition. Once the predetermined condition is met, the one or more limbs may extend outwards away from the body such that the one or more deployed limbs serve to orient the ingestible device.

公开(公告)号：US20240325563A1

公开(公告)日：2024-10-03

申请号：US18435158

申请日：2024-02-07

申请人： The Brigham and Women's Hospital, Inc.

发明人： Reza Abdi

IPC分类号： A61K47/68 ,  A61K31/436 ,  A61K47/69

CPC分类号： A61K47/6849 ,  A61K31/436 ,  A61K47/6803 ,  A61K47/6927 ,  A61K47/6937

摘要： The present disclosure provides, inter alia, compositions comprising drug-containing polymeric particles that mimic lymphocyte migration in vivo and can specifically deliver immunosuppressive or immunoregulatory drugs to lymphoid tissues and sites of chronic inflammation where T-cell activation and T-cell mediated injury are occurring. Methods of preparing and using these drug-containing polymeric particles are also provided.

公开(公告)号：US12103173B2

公开(公告)日：2024-10-01

申请号：US16091193

申请日：2017-04-20

申请人： THE BRIGHAM AND WOMEN'S HOSPITAL, INC.

发明人： Yu Shrike Zhang ,  Ali Khademhosseini

IPC分类号： B25J9/04 ,  A61L27/36 ,  B25J9/02 ,  B25J9/16 ,  B29C64/141 ,  B29C64/209 ,  B29C64/379 ,  B33Y10/00 ,  B33Y30/00 ,  B33Y70/00 ,  B33Y80/00

CPC分类号： B25J9/045 ,  A61L27/36 ,  B25J9/023 ,  B25J9/16 ,  B29C64/141 ,  B29C64/209 ,  B29C64/379 ,  B33Y70/00 ,  B33Y10/00 ,  B33Y30/00 ,  B33Y80/00

摘要： Described are systems and methods for in vivo multi-material bioprinting. The in vivo multi-material bioprinting can be used to fabricate biomedical constructs within a patient minimally invasively. The systems and methods can utilize a multi-material bioprinter, which includes a biocompatible portion. The biocompatible portion can include a single printhead for in vivo bioprinting. The single printhead can include a plurality of outlets, each linked to one of a plurality of reservoirs. Each of the plurality of reservoirs can each house a different bioink for bioprinting. Each of the plurality of outlets can be activated to release a respective bioink.

公开(公告)号：US12098380B2

公开(公告)日：2024-09-24

申请号：US16619416

申请日：2018-06-05

申请人： THE BRIGHAM AND WOMEN'S HOSPITAL, INC.

发明人： Feng Yao

IPC分类号： A61K39/245 ,  C07K14/005 ,  C12N5/071 ,  C12N5/16 ,  C12N7/02 ,  C12N15/86

CPC分类号： C12N15/86 ,  A61K39/245 ,  C07K14/005 ,  C12N5/0686 ,  C12N5/16 ,  C12N7/025 ,  C12N2710/16622 ,  C12N2710/16643 ,  C12N2710/16652 ,  C12N2830/003 ,  C12N2830/60

摘要： Provided herein are Vero cell lines that stably express Herpes Simplex Virus (HSV) ICP0 protein. These cells have the same morphology of Vero cells, exhibit stable expression of HSV ICP0 protein, and also efficiently complement replication of HSV ICP0 deficient virus for greater than 20, 30, or even 40 cell passages.

公开(公告)号：US12097021B2

公开(公告)日：2024-09-24

申请号：US17397785

申请日：2021-08-09

申请人： Massachusetts Institute of Technology ,  Novo Nordisk A/S ,  The Brigham and Women's Hospital, Inc.

发明人： Graham Arrick ,  Torben Sebastian Last ,  Declan Gwynne ,  Jacob Wainer ,  Carlo Giovanni Traverso ,  Drago Sticker ,  Cody Cleveland ,  Aghiad Ghazal ,  Adam Bohr ,  Jorrit Jeroen Water ,  Brian Mouridsen ,  Jacob Pyung Hwa Jepsen ,  Bozhidar Nikolaev Kozhuharov ,  Kim Frandsen ,  Robert Langer ,  Yi Lu ,  Niclas Roxhed ,  Siheng You

IPC分类号： A61B5/07 ,  A61B5/00

CPC分类号： A61B5/073 ,  A61B5/076 ,  A61B5/4839

摘要： A drug delivery device for administration to a subject is provided. In some embodiments, the drug delivery device includes a reservoir containing an active pharmaceutical ingredient and a potential energy source. The drug delivery device also includes a trigger operatively associated with the potential energy source, where the trigger is configured to actuate at a predetermined location within the subject. The drug delivery device also includes a rupturable membrane disposed along a flow path extending between the reservoir and an outlet, where the membrane is configured to rupture when the trigger is actuated. Once the trigger is actuated, the potential energy from the potential energy source may be released to expel the active pharmaceutical ingredient in a jet through the outlet.

公开(公告)号：US12096960B2

公开(公告)日：2024-09-24

申请号：US17069827

申请日：2020-10-13

申请人： The Brigham and Women's Hospital, Inc.

发明人： Jon I. Einarsson

IPC分类号： A61B17/42 ,  A61B18/14 ,  A61M29/02 ,  A61B17/00 ,  A61B17/22 ,  A61B17/29 ,  A61B17/32 ,  A61B18/00 ,  A61B90/00 ,  A61B90/30

CPC分类号： A61B17/4241 ,  A61B18/1485 ,  A61M29/02 ,  A61B2017/00557 ,  A61B2017/00986 ,  A61B2017/22051 ,  A61B2017/22062 ,  A61B2017/22067 ,  A61B2017/22069 ,  A61B2017/291 ,  A61B2017/320052 ,  A61B2017/32006 ,  A61B2017/4216 ,  A61B2017/4225 ,  A61B2017/4233 ,  A61B2018/00202 ,  A61B2018/00285 ,  A61B2018/00559 ,  A61B2018/00601 ,  A61B2018/1412 ,  A61B2018/144 ,  A61B2090/036 ,  A61B2090/0811 ,  A61B2090/306 ,  A61B2090/309 ,  A61B2090/395 ,  A61B2218/002

摘要： A uterine manipulator can include a shaft including a first end, a second end, and a channel along an axis of the shaft, a handle coupled to the first end of the shaft, and a triangular balloon coupled to the second end of the shaft. The triangular balloon can be configured to inflate upon insertion into a vagina via a fluid injected into the channel of the shaft.

公开(公告)号：US20240262909A1

公开(公告)日：2024-08-08

申请号：US18566343

申请日：2022-06-03

申请人： THE BRIGHAM AND WOMEN'S HOSPITAL, INC. ,  THE BROAD INSTITUTE, INC ,  MASSACHUSETTS INSTITUTE OF TECHNOLOGY

发明人： Vijay K. KUCHROO ,  Karen Olivia DIXON ,  Marcin TABAKA ,  AVIV REGEV

IPC分类号： C07K16/28 ,  A61K39/00 ,  A61K47/69 ,  C12N15/113

CPC分类号： C07K16/2803 ,  A61K47/6931 ,  C12N15/113 ,  A61K2039/505 ,  C12N2310/11 ,  C12N2310/20

摘要： Provided herein are methods and compositions for selectively promoting inflammasome activity in myeloid cells.

公开(公告)号：US20240240181A1

公开(公告)日：2024-07-18

申请号：US18507432

申请日：2023-11-13

申请人： The Brigham and Women's Hospital, Inc.

发明人： Paul Anderson ,  Pavel Ivanov ,  Mohammed Emara

IPC分类号： C12N15/113 ,  C07H21/02 ,  C12N15/11

CPC分类号： C12N15/113 ,  C07H21/02 ,  C12N15/11 ,  C12N2310/18 ,  C12N2310/531

摘要： Provided herein are neuroprotective molecules containing a sequence of 25-35 contiguous nucleotides between nucleotide 1 and nucleotide 50 of a mature human tRNA and at least four contiguous guanosine-containing nucleotides, where the sequence of 25-35 contiguous nucleotides contains a D-loop stem structure, the at least four contiguous guanosine-containing nucleotides are located at the 5′ end of the neuroprotective molecule, and the neuroprotective molecule contains at least one deoxyribonucleotide. Also provided are neuroprotective molecules containing a sequence of 25-35 contiguous nucleotides between nucleotide 1 and nucleotide 50 of a mature human tRNACYS; and at least four contiguous guanosine-containing nucleotides, where the sequence of 25-35 contiguous nucleotides contains a D-loop stem structure and the at least four contiguous guanosine-containing nucleotides are located at the 5′ end of the neuroprotective molecule.

公开(公告)号：US20240238371A1

公开(公告)日：2024-07-18

申请号：US18363416

申请日：2023-08-01

申请人： THE BRIGHAM AND WOMEN'S HOSPITAL, INC.

发明人： Shinsuke ITO ,  Elena AIKAWA ,  Masanori AIKAWA

IPC分类号： A61K38/17 ,  A61K47/65 ,  G01N33/68

CPC分类号： A61K38/1741 ,  A61K47/65 ,  G01N33/6803

摘要： Sortilin is a sorting receptor that directs target proteins to the secretary or endocytic compartments of cells that is found in both extracellular vesicles and cells. Provided herein are methods and compositions for decreasing or inhibiting trafficking of sortilin to an extracellular vesicle, for example by inhibiting the formation of intermolecular sortilin dimers.

公开(公告)号：US12031977B2

公开(公告)日：2024-07-09

申请号：US17118267

申请日：2020-12-10

申请人： Massachusetts Institute of Technology ,  The Brigham and Women's Hospital, Inc.

发明人： Robert S. Langer ,  Carlo Giovanni Traverso ,  Yunhua Shi ,  Vance Soares ,  Daniel Reker

IPC分类号： G01N33/50

CPC分类号： G01N33/5088 ,  G01N33/5044

摘要： Methods and compositions for determining multiplex interactions between drugs and drug transporters using an intestinal tissue explant are provided.